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Showing 1 to 10 of 10 entries
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FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice.

EJNMMI research

Yousefi BH, von Reutern B, Scherübl D, Manook A, Schwaiger M, Grimmer T, Henriksen G, Förster S, Drzezga A, Wester HJ.
PMID: 25918674
EJNMMI Res. 2015 Mar 28;5:20. doi: 10.1186/s13550-015-0090-6. eCollection 2015.

BACKGROUND: Over the last decade, an increasing number of studies have been published on the use of amyloid-β (Aβ) PET imaging with different (18)F-radiopharmaceuticals for clinical characterization of Alzheimer's disease (AD) in different stages. However, distinct study cohorts and...

Transcription Factor Binding Affinities and DNA Shape Readout.

iScience

Schnepf M, von Reutern M, Ludwig C, Jung C, Gaul U.
PMID: 33163946
iScience. 2020 Oct 15;23(11):101694. doi: 10.1016/j.isci.2020.101694. eCollection 2020 Nov 20.

An essential event in gene regulation is the binding of a transcription factor (TF) to its target DNA. Models considering the interactions between the TF and the DNA geometry proved to be successful approaches to describe this binding event,...

Differential Effect of Retroactive Interference on Object and Spatial Memory in the Course of Healthy Aging and Neurodegeneration.

Frontiers in aging neuroscience

Muecke H, Richter N, von Reutern B, Kukolja J, Fink GR, Onur OA.
PMID: 30405401
Front Aging Neurosci. 2018 Oct 23;10:333. doi: 10.3389/fnagi.2018.00333. eCollection 2018.

No abstract available.

Successful Treatment of Myasthenia Gravis Following PD-1/CTLA-4 Combination Checkpoint Blockade in a Patient With Metastatic Melanoma.

Frontiers in oncology

Werner JM, Schweinsberg V, Schroeter M, von Reutern B, Malter MP, Schlaak M, Fink GR, Mauch C, Galldiks N.
PMID: 30828569
Front Oncol. 2019 Feb 14;9:84. doi: 10.3389/fonc.2019.00084. eCollection 2019.

Currently, the blockade of certain immune checkpoints such as the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death-1 (PD-1) using checkpoint inhibitors is standard of care in patients with metastatic melanoma, especially with BRAF wild-type. However, several checkpoint...

Author Correction: True equilibrium measurement of transcription factor-DNA binding affinities using automated polarization microscopy.

Nature communications

Jung C, Bandilla P, von Reutern M, Schnepf M, Rieder S, Unnerstall U, Gaul U.
PMID: 30723200
Nat Commun. 2019 Feb 05;10(1):689. doi: 10.1038/s41467-019-08556-9.

In the original version of this Article, equation three contained a sign error whereby the term RT was added when it should have been subtracted. This has now been corrected in the PDF and HTML versions of the Article.

Graph Theory Analysis Reveals Resting-State Compensatory Mechanisms in Healthy Aging and Prodromal Alzheimer's Disease.

Frontiers in aging neuroscience

Behfar Q, Behfar SK, von Reutern B, Richter N, Dronse J, Fassbender R, Fink GR, Onur OA.
PMID: 33192468
Front Aging Neurosci. 2020 Oct 22;12:576627. doi: 10.3389/fnagi.2020.576627. eCollection 2020.

Several theories of cognitive compensation have been suggested to explain sustained cognitive abilities in healthy brain aging and early neurodegenerative processes. The growing number of studies investigating various aspects of task-based compensation in these conditions is contrasted by the...

Concordance of Intrinsic Brain Connectivity Measures Is Disrupted in Alzheimer's Disease.

Brain connectivity

Chen X, Onur OA, Richter N, Fassbender R, Gramespacher H, Befahr Q, von Reutern B, Dillen K, Jacobs HIL, Kukolja J, Fink GR, Dronse J.
PMID: 34269605
Brain Connect. 2021 Sep 08; doi: 10.1089/brain.2020.0918. Epub 2021 Sep 08.

No abstract available.

Neural Network Connectivity During Post-encoding Rest: Linking Episodic Memory Encoding and Retrieval.

Frontiers in human neuroscience

Risius OJ, Onur OA, Dronse J, von Reutern B, Richter N, Fink GR, Kukolja J.
PMID: 30687046
Front Hum Neurosci. 2019 Jan 09;12:528. doi: 10.3389/fnhum.2018.00528. eCollection 2018.

Commonly, a switch between networks mediating memory encoding and those mediating retrieval is observed. This may not only be due to differential involvement of neural resources due to distinct cognitive processes but could also reflect the formation of new...

A Novel (18)F-Labeled Imidazo[2,1-b]benzothiazole (IBT) for High-Contrast PET Imaging of β-Amyloid Plaques.

ACS medicinal chemistry letters

Yousefi BH, Drzezga A, von Reutern B, Manook A, Schwaiger M, Wester HJ, Henriksen G.
PMID: 24900362
ACS Med Chem Lett. 2011 Jul 19;2(9):673-7. doi: 10.1021/ml200123w. eCollection 2011 Sep 08.

(18)F-labeled imidazo[2,1-b]benzothiazole ([(18)F]8) was synthesized and evaluated as a tracer for cerebral β-amyloid deposits (Aβ) by means of positron emission tomography (PET). [(18)F]8 exhibits a high affinity to Aβ and suitable brain uptake kinetics combined with a high metabolic...

On the Extraction and Analysis of Graphs From Resting-State fMRI to Support a Correct and Robust Diagnostic Tool for Alzheimer's Disease.

Frontiers in neuroscience

Bachmann C, Jacobs HIL, Porta Mana P, Dillen K, Richter N, von Reutern B, Dronse J, Onur OA, Langen KJ, Fink GR, Kukolja J, Morrison A.
PMID: 30323734
Front Neurosci. 2018 Sep 28;12:528. doi: 10.3389/fnins.2018.00528. eCollection 2018.

The diagnosis of Alzheimer's disease (AD), especially in the early stage, is still not very reliable and the development of new diagnosis tools is desirable. A diagnosis based on functional magnetic resonance imaging (fMRI) is a suitable candidate, since...

Showing 1 to 10 of 10 entries