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Insulin-like growth factor II-mediated proliferation of human neuroblastoma.

The Journal of clinical investigation

El-Badry OM, Helman LJ, Chatten J, Steinberg SM, Evans AE, Israel MA.
PMID: 1991849
J Clin Invest. 1991 Feb;87(2):648-57. doi: 10.1172/JCI115042.
Free PMC Article

Neuroblastoma is an embryonal tumor that typically arises in cells of the developing adrenal medulla. IGF-II mRNA is expressed at high levels in the adrenal cortex before birth but it is not detectable until after birth in the adrenal...

Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II.

The Journal of clinical investigation

El-Badry OM, Romanus JA, Helman LJ, Cooper MJ, Rechler MM, Israel MA.
PMID: 2547840
J Clin Invest. 1989 Sep;84(3):829-39. doi: 10.1172/JCI114243.
Free PMC Article

Insulin-like growth factor II (IGF-II) mRNA was increased in two of eight neuroblastomas and in eight of eight pheochromocytomas, tumors of the adrenal medulla that occur in childhood and adulthood, respectively. RNA encoding the type I IGF receptor, the...

Insulin-like growth factor II gene expression in human neuroblastoma.

Progress in clinical and biological research

el-Badry OM.
PMID: 2068141
Prog Clin Biol Res. 1991;366:249-56.

No abstract available.

Design and synthesis of novel imidazo[4,5-b]pyridine based compounds as potent anticancer agents with CDK9 inhibitory activity.

Bioorganic chemistry

Ghanem NM, Farouk F, George RF, Abbas SES, El-Badry OM.
PMID: 30025343
Bioorg Chem. 2018 Oct;80:565-576. doi: 10.1016/j.bioorg.2018.07.006. Epub 2018 Jul 06.

New imidazo[4,5-b]pyridine derivatives were designed, synthesized and screened for their anticancer activity against breast (MCF-7) and colon (HCT116) cancer cell lines. Nine compounds (I, II, IIIa, IIIb, IV, VI, VIIa, VIII, IX) showed significant activity against MCF-7, while six...

Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research

El-Badry OM, Minniti C, Kohn EC, Houghton PJ, Daughaday WH, Helman LJ.
PMID: 2177632
Cell Growth Differ. 1990 Jul;1(7):325-31.
Free Article

Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and appears to arise from developing striated muscle-forming cells. Since insulin-like growth factor II (IGF-II) is involved in normal muscle growth and maturation and elevated IGF-II mRNA levels have...

Design & synthesis of novel oxazolone & triazinone derivatives and their biological evaluation as COX-2 inhibitors.

Bioorganic chemistry

Mohamed LW, El-Badry OM, El-Ansary AK, Ismael A.
PMID: 28500957
Bioorg Chem. 2017 Jun;72:308-314. doi: 10.1016/j.bioorg.2017.04.012. Epub 2017 Apr 24.

A new series of oxazolones and triazinones were designed and synthesized and evaluated against both COX-1 and COX-2 enzymes. Full structure elucidation of the new derivatives was performed using microanalyses, IR, 1H NMR, 13C NMR and mass spectra. Most...

Growth regulation of human neuroblastoma.

Cancer treatment and research

el-Badry OM, Israel MA.
PMID: 1363353
Cancer Treat Res. 1992;63:105-28. doi: 10.1007/978-1-4615-3088-6_5.

No abstract available.

Medium conditioned by human neuroblastoma BE(2)-C cells contains an autocrine/paracrine acting growth factor with properties similar to insulin-like growth factor II.

Progress in clinical and biological research

el-Badry OM, Meyers MB, Spengler BA, Chang TD, Ross RA, Biedler JL.
PMID: 2068142
Prog Clin Biol Res. 1991;366:257-66.

No abstract available.

Showing 1 to 8 of 8 entries