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Anti- or profibrillatory effects of Na(+) channel blockade depend on the site of application relative to gradients in repolarization.

Frontiers in physiology

Coronel R, Wilms-Schopman FJ, Janse MJ.
PMID: 21423353
Front Physiol. 2010 Jun 07;1:10. doi: 10.3389/fphys.2010.00010. eCollection 2010.

Sodium channel blockers are associated with arrhythmic sudden death, although they are considered antiarrhythmic agents. The mechanism of these opposing effects is unknown. We used a model of induction of ventricular fibrillation (VF) based on selective perfusion of the...

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