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Showing 1 to 12 of 251 entries
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Fledglings in p53 signaling network.

Oncotarget

Tokino T, Idogawa M, Sasaki Y.
PMID: 28925413
Oncotarget. 2017 Jul 14;8(34):55768-55769. doi: 10.18632/oncotarget.19229. eCollection 2017 Aug 22.

No abstract available.

Programmed cell death-ligand 1 expression and immunoscore in stage II and III non-small cell lung cancer patients receiving adjuvant chemotherapy.

Oncotarget

Ishii H, Azuma K, Kawahara A, Matsuo N, Tokito T, Kinoshita T, Yamada K, Sasada T, Akiba J, Hoshino T.
PMID: 28977890
Oncotarget. 2017 Jun 27;8(37):61618-61625. doi: 10.18632/oncotarget.18651. eCollection 2017 Sep 22.

Programmed cell death 1 (PD-1) receptor-ligand interaction is a major pathway that is often hijacked by tumors to suppress immune control. Immunoscore (IS), a combinational index of CD3 and CD8 tumor-infiltrating lymphocyte (TIL) density in the tumor's center and...

A proposal of clinical ECG index "vagal score" for determining the mechanism of paroxysmal atrioventricular block.

Journal of arrhythmia

Komatsu S, Sumiyoshi M, Miura S, Kimura Y, Shiozawa T, Hirano K, Odagiri F, Tabuchi H, Hayashi H, Sekita G, Tokano T, Nakazato Y, Daida H.
PMID: 28607616
J Arrhythm. 2017 Jun;33(3):208-213. doi: 10.1016/j.joa.2016.10.004. Epub 2016 Nov 09.

BACKGROUND: Paroxysmal atrioventricular block (P-AVB) is a well-known cause of syncope; however, its underlying mechanism is difficult to determine. This study aimed to evaluate a new ECG index, the "vagal score (VS)," to determine the mechanism of P-AVB.METHODS: We...

Downregulation of miR-186 is associated with metastatic recurrence of gastrointestinal stromal tumors.

Oncology letters

Niinuma T, Kai M, Kitajima H, Yamamoto E, Harada T, Maruyama R, Nobuoka T, Nishida T, Kanda T, Hasegawa T, Tokino T, Sugai T, Shinomura Y, Nakase H, Suzuki H.
PMID: 29113198
Oncol Lett. 2017 Nov;14(5):5703-5710. doi: 10.3892/ol.2017.6911. Epub 2017 Sep 08.

Although dysregulation of microRNAs (miRNAs/miRs) is a common feature of human malignancies, its involvement in gastrointestinal stromal tumors (GISTs) is not fully understood. The present study aimed to identify the miRNAs that perform a role in GIST metastasis. miRNA...

MicroRNAs associated with the development of kidney diseases in humans and animals.

Journal of toxicologic pathology

Ichii O, Horino T.
PMID: 29479137
J Toxicol Pathol. 2018 Jan;31(1):23-34. doi: 10.1293/tox.2017-0051. Epub 2017 Oct 06.

Mature microRNAs (miRNAs) are single-stranded RNAs with approximately 18-25 bases, and their sequences are highly conserved among animals. miRNAs act as posttranscriptional regulators by binding mRNAs, and their main function involves the degradation of their target mRNAs. Recent studies...

Purely organic electroluminescent material realizing 100% conversion from electricity to light.

Nature communications

Kaji H, Suzuki H, Fukushima T, Shizu K, Suzuki K, Kubo S, Komino T, Oiwa H, Suzuki F, Wakamiya A, Murata Y, Adachi C.
PMID: 26477390
Nat Commun. 2015 Oct 19;6:8476. doi: 10.1038/ncomms9476.

Efficient organic light-emitting diodes have been developed using emitters containing rare metals, such as platinum and iridium complexes. However, there is an urgent need to develop emitters composed of more abundant materials. Here we show a thermally activated delayed...

Effect of distribution of educational material to mothers on duration and severity of diarrhoea and pneumonia, Midlands Province, Zimbabwe: a cluster randomized controlled trial.

International breastfeeding journal

Gabida M, Chemhuru M, Tshimanga M, Gombe NT, Takundwa L, Bangure D.
PMID: 26246847
Int Breastfeed J. 2015 Mar 27;10:13. doi: 10.1186/s13006-015-0037-6. eCollection 2015.

BACKGROUND: Exclusive breastfeeding rates remain low in most countries in sub-Saharan Africa. We assessed the effects of a mother-based intervention on duration of diarrhoea and pneumonia in communities that were trained and those not trained in community infant and...

Blockade of leukocyte function antigen-1 (LFA-1) in clinical islet transplantation.

Current diabetes reports

Fotino C, Pileggi A.
PMID: 21755435
Curr Diab Rep. 2011 Oct;11(5):337-44. doi: 10.1007/s11892-011-0214-y.

No abstract available.

Curvature analysis reveals new functions for ethylene signalling pathway in shape determination of seed poles and root apices.

Plant signaling & behavior

Tocino A, Cervantes E.
PMID: 19513223
Plant Signal Behav. 2008 Jun;3(6):362-6. doi: 10.4161/psb.3.6.5798.

IN MATHEMATICS, CURVATURE IS AN IMPORTANT MAGNITUDE IN THE DESCRIPTION OF PLANE CURVES: it represents the rate of change of direction of a curve with respect to distance along the curve. By looking at root tips of Arabidopsis, we...

Unusual negative photochromism via a short-lived imidazolyl radical of 1,1'-binaphthyl-bridged imidazole dimer.

Journal of the American Chemical Society

Hatano S, Horino T, Tokita A, Oshima T, Abe J.
PMID: 23402262
J Am Chem Soc. 2013 Feb 27;135(8):3164-72. doi: 10.1021/ja311344u. Epub 2013 Feb 18.

We have synthesized a new photochromic compound that exhibits unusual negative photochromism, in which the stable colored species photochemically converts into the metastable colorless species via a short-lived radical. This compound has a 1,1'-binaphthyl moiety bridging the two diphenylimidazole...

Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma.

Genome medicine

Aoki Y, Nojima M, Suzuki H, Yasui H, Maruyama R, Yamamoto E, Ashida M, Itagaki M, Asaoku H, Ikeda H, Hayashi T, Imai K, Mori M, Tokino T, Ishida T, Toyota M, Shinomura Y.
PMID: 23259664
Genome Med. 2012 Dec 22;4(12):101. doi: 10.1186/gm402. eCollection 2012.

BACKGROUND: The aim of this study was to clarify the role of global hypomethylation of repetitive elements in determining the genetic and clinical features of multiple myeloma (MM).METHODS: We assessed global methylation levels using four repetitive elements (long interspersed...

Evaluation of the new digital goldmann applanation tonometer for measuring intraocular pressure.

Journal of ophthalmology

Sakaue Y, Ueda J, Seki M, Tanaka T, Togano T, Yoshino T, Fukuchi T.
PMID: 25126423
J Ophthalmol. 2014;2014:461681. doi: 10.1155/2014/461681. Epub 2014 Jul 10.

Purpose. To compare a new digital Goldmann applanation tonometer (dGAT) that measures intraocular pressure (IOP) in 0.1 mmHg increments to a standard Goldmann applanation tonometer (sGAT). Methods. This study included 116 eyes of 60 subjects. A single examiner first...

Showing 1 to 12 of 251 entries