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Showing 1 to 12 of 52 entries
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Effectiveness of a Core-Competency-based Program on Residents' Learning and Experience.

Canadian geriatrics journal : CGJ

Charles L, Triscott J, Dobbs B, Tian PG, Babenko O.
PMID: 27403213
Can Geriatr J. 2016 Jun 29;19(2):50-7. doi: 10.5770/cgj.19.213. eCollection 2016 Jun.

BACKGROUND: The Care of the Elderly (COE) Diploma Program is a six-to-twelve-month enhanced skills program taken after two years of core residency training in Family Medicine. In 2010, we developed and implemented a core-competency-based COE Diploma program (CC), in...

DksA-Dependent Transcriptional Regulation in Salmonella Experiencing Nitrosative Stress.

Frontiers in microbiology

Crawford MA, Henard CA, Tapscott T, Porwollik S, McClelland M, Vázquez-Torres A.
PMID: 27065993
Front Microbiol. 2016 Mar 31;7:444. doi: 10.3389/fmicb.2016.00444. eCollection 2016.

Redox-based signaling is fundamental to the capacity of bacteria to sense, and respond to, nitrosative and oxidative stress encountered in natural and host environments. The conserved RNA polymerase regulatory protein DksA is a thiol-based sensor of reactive nitrogen and...

Frontal Release Signs and Their Relationship With the Initiation and Perseveration Component of the Mattis Dementia Rating Scale in Persons With Dementia.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Vieweg WVR, Brashear HR, Sautter SW, Tabscott JA.
PMID: 28530909
Am J Geriatr Psychiatry. 1993 Autumn;1(4):310-315. doi: 10.1097/00019442-199300140-00005. Epub 2013 Jan 28.

As part of a longitudinal study of dementia, 35 elderly patients with dementia were studied, correlating frontal release signs and performance on components of the Mattis Dementia Rating Scale. A frontal release score was developed using glabellar, palmar grasp,...

Female athlete triad in monozygotic twins.

The Physician and sportsmedicine

Hind K, Truscott J, Carroll S.
PMID: 20048480
Phys Sportsmed. 2008 Dec;36(1):119-24. doi: 10.3810/psm.2008.12.20.

UNLABELLED: Female monozygotic twins, both international endurance athletes aged 18 years, presented for a dual energy x-ray absorptiometry (DXA) scan as part of a university clinical trial. Twin 1 had only menstruated twice since menarche; Twin 2 had not...

Quantifying the transmissibility of human influenza and its seasonal variation in temperate regions.

PLoS currents

Truscott J, Fraser C, Hinsley W, Cauchemez S, Donnelly C, Ghani A, Ferguson N.
PMID: 20029663
PLoS Curr. 2009 Oct 29;1:RRN1125. doi: 10.1371/currents.RRN1125.

Seasonal influenza has considerable impact around the world, both economically and in mortality among risk groups. The long term patterns of disease are hard to capture with simple models, while the interplay of epidemiological processes with antigenic evolution makes...

Immune Responses to rAAV6: The Influence of Canine Parvovirus Vaccination and Neonatal Administration of Viral Vector.

Frontiers in microbiology

Arnett AL, Garikipati D, Wang Z, Tapscott S, Chamberlain JS.
PMID: 22065964
Front Microbiol. 2011 Nov 03;2:220. doi: 10.3389/fmicb.2011.00220. eCollection 2011.

Recombinant adeno-associated viral (rAAV) vectors promote long-term gene transfer in many animal species. Significant effort has focused on the evaluation of rAAV delivery and the immune response in both murine and canine models of neuromuscular disease. However, canines provided...

A proteomics study identifying interactors of the FSHD2 gene product SMCHD1 reveals RUVBL1-dependent DUX4 repression.

Scientific reports

Goossens R, Tihaya MS, van den Heuvel A, Tabot-Ndip K, Willemsen IM, Tapscott SJ, González-Prieto R, Chang JG, Vertegaal ACO, Balog J, van der Maarel SM.
PMID: 34880314
Sci Rep. 2021 Dec 08;11(1):23642. doi: 10.1038/s41598-021-03030-3.

Structural Maintenance of Chromosomes Hinge Domain Containing 1 (SMCHD1) is a chromatin repressor, which is mutated in > 95% of Facioscapulohumeral dystrophy (FSHD) type 2 cases. In FSHD2, SMCHD1 mutations ultimately result in the presence of the cleavage stage...

Kimura disease: a rare cause of a recurrent cheek mass in a Jamaican man.

Journal of surgical case reports

Williams G, Neblett C, Arscott J, McLean S, Warren S, Blake G.
PMID: 33927850
J Surg Case Rep. 2021 Apr 20;2021(4):rjab100. doi: 10.1093/jscr/rjab100. eCollection 2021 Apr.

Kimura disease (KD) is a chronic, inflammatory, benign disorder endemic to Asia that typically manifests as a triad of painless masses in the head and neck region, elevated eosinophils and serum immunoglobulin. It usually affects young men in their...

miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells.

Skeletal muscle

Macquarrie KL, Yao Z, Young JM, Cao Y, Tapscott SJ.
PMID: 22541669
Skelet Muscle. 2012 Apr 29;2(1):7. doi: 10.1186/2044-5040-2-7.

BACKGROUND: Similar to replicating myoblasts, many rhabdomyosarcoma cells express the myogenic determination gene MyoD. In contrast to myoblasts, rhabdomyosarcoma cells do not make the transition from a regulative growth phase to terminal differentiation. Previously we demonstrated that the forced...

Controversy about the visual magnocellular deficit in developmental dyslexics.

Trends in cognitive sciences

Stein J, Talcott J, Walsh V.
PMID: 10827442
Trends Cogn Sci. 2000 Jun;4(6):209-211. doi: 10.1016/s1364-6613(00)01484-4.

No abstract available.

Immunity and AAV-Mediated Gene Therapy for Muscular Dystrophies in Large Animal Models and Human Trials.

Frontiers in microbiology

Wang Z, Tapscott SJ, Chamberlain JS, Storb R.
PMID: 21980317
Front Microbiol. 2011 Sep 26;2:201. doi: 10.3389/fmicb.2011.00201. eCollection 2011.

Adeno-associated viral (AAV) vector-mediated gene replacement for the treatment of muscular dystrophy represents a promising therapeutic strategy in modern medicine. One major obstacle in using AAV vectors for in vivo gene delivery is the development of host immune responses...

Comparison of endogenous and overexpressed MyoD shows enhanced binding of physiologically bound sites.

Skeletal muscle

Yao Z, Fong AP, Cao Y, Ruzzo WL, Gentleman RC, Tapscott SJ.
PMID: 23566431
Skelet Muscle. 2013 Apr 08;3(1):8. doi: 10.1186/2044-5040-3-8.

BACKGROUND: Transcription factor overexpression is common in biological experiments and transcription factor amplification is associated with many cancers, yet few studies have directly compared the DNA-binding profiles of endogenous versus overexpressed transcription factors.METHODS: We analyzed MyoD ChIP-seq data from...

Showing 1 to 12 of 52 entries