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Chronopharmaceutical drug delivery from a pulsatile capsule device based on programmable erosion.

The Journal of pharmacy and pharmacology

Ross AC, MacRae RJ, Walther M, Stevens HN.
PMID: 11007060
J Pharm Pharmacol. 2000 Aug;52(8):903-9. doi: 10.1211/0022357001774787.

We report the development of a chronopharmaceutical capsule drug delivery system capable of releasing drug after pre-determined time delays. The drug formulation is sealed inside the insoluble capsule body by an erodible tablet (ET). The release time is determined...

The effect of wet granulation on the erosion behaviour of an HPMC-lactose tablet, used as a rate-controlling component in a pulsatile drug delivery capsule formulation.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

McConville JT, Ross AC, Chambers AR, Smith G, Florence AJ, Stevens HN.
PMID: 15093604
Eur J Pharm Biopharm. 2004 May;57(3):541-9. doi: 10.1016/j.ejpb.2004.01.004.

The purpose of this study was to investigate the variability in the performance of a pulsatile capsule delivery system induced by wet granulation of an erodible HPMC tablet, used to seal the contents within an insoluble capsule body. Erodible...

Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 15652198
Int J Pharm. 2005 Jan 31;289(1):51-62. doi: 10.1016/j.ijpharm.2004.10.022. Epub 2004 Dec 30.

Lyophilised wafers have potential as drug delivery systems for suppurating wounds. A dual series of wafers made from low molecular weight sodium alginate (SA) and xanthan gum (XG) respectively, modified with high molecular weight methylcellulose (MC) were produced. The...

Nasal residence of insulin containing lyophilised nasal insert formulations, using gamma scintigraphy.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

McInnes FJ, O'Mahony B, Lindsay B, Band J, Wilson CG, Hodges LA, Stevens HN.
PMID: 17368006
Eur J Pharm Sci. 2007 May;31(1):25-31. doi: 10.1016/j.ejps.2007.02.002. Epub 2007 Feb 11.

Bioadhesive dosage forms are a potential method for overcoming rapid mucociliary transport in the nose. A lyophilised nasal insert formulation previously investigated in sheep demonstrated prolonged absorption of nicotine hydrogen tartrate suggestive of extended nasal residence, and increased bioavailability....

Behaviour and transit of tamsulosin Oral Controlled Absorption System in the gastrointestinal tract.

Current medical research and opinion

Stevens HN, Speakman M.
PMID: 17257446
Curr Med Res Opin. 2006 Dec;22(12):2323-8. doi: 10.1185/030079906X154051.

OBJECTIVE: To assess the in vivo behaviour, gastric emptying time and gastrointestinal transit of the new tablet formulation of tamsulosin which uses the Oral Controlled Absorption System (OCAS) technology and to relate gastrointestinal transit parameters to the profile of...

Gamma-irradiation of lyophilised wound healing wafers.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 16503387
Int J Pharm. 2006 Apr 26;313(1):78-86. doi: 10.1016/j.ijpharm.2006.01.023. Epub 2006 Feb 28.

Lyophilised wafers are being developed as drug delivery systems that can be applied directly to the surface of suppurating wounds. They are produced by the freeze-drying of polymer solutions and gels. This study investigates the possibility of sterilising these...

Comparison of the rates of disintegration, gastric emptying, and drug absorption following administration of a new and a conventional paracetamol formulation, using gamma scintigraphy.

Pharmaceutical research

Kelly K, O'Mahony B, Lindsay B, Jones T, Grattan TJ, Rostami-Hodjegan A, Stevens HN, Wilson CG.
PMID: 14620524
Pharm Res. 2003 Oct;20(10):1668-73. doi: 10.1023/a:1026155822121.

PURPOSE: To investigate the hypothesis that faster drug absorption from a new paracetamol formulation containing sodium bicarbonate compared to that from a conventional formulation results from a combination of enhanced gastric emptying and disintegration/dissolution.METHODS: Each formulation was administered in...

A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers.

Journal of pharmaceutical sciences

McConville JT, Hodges LA, Jones T, Band JP, O'Mahony B, Lindsay B, Ross AC, Florence AJ, Stanley AJ, Humphrey MJ, Wilson CG, Stevens HN.
PMID: 19387976
J Pharm Sci. 2009 Nov;98(11):4251-63. doi: 10.1002/jps.21739.

Three time-delayed capsule (TDC) formulations were investigated in a pharmacoscintigraphic study, using a three-way crossover design in eight healthy male volunteers. Additionally, the pulsed release of a TDC was investigated with time-lapse photography, using a nondisintegrating riboflavin tablet. The...

Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 18280068
Int J Pharm. 2008 May 22;356(1):110-20. doi: 10.1016/j.ijpharm.2007.12.043. Epub 2008 Jan 09.

Lyophilised wafers are being developed as topical drug delivery systems for the treatment of chronic wounds. This study describes the formulation of xanthan wafers containing a selective, insoluble MMP-3 inhibitor (UK-370,106) and a non-ionic surfactant, designed to release accurate...

A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease.

Molecular pharmaceutics

Pritchard MF, Powell LC, Menzies GE, Lewis PD, Hawkins K, Wright C, Doull I, Walsh TR, Onsøyen E, Dessen A, Myrvold R, Rye PD, Myrset AH, Stevens HN, Hodges LA, MacGregor G, Neilly JB, Hill KE, Thomas DW.
PMID: 26833139
Mol Pharm. 2016 Mar 07;13(3):863-72. doi: 10.1021/acs.molpharmaceut.5b00794. Epub 2016 Feb 16.

The host- and bacteria-derived extracellular polysaccharide coating of the lung is a considerable challenge in chronic respiratory disease and is a powerful barrier to effective drug delivery. A low molecular weight 12-15-mer alginate oligosaccharide (OligoG CF-5/20), derived from plant...

Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces.

Drug development and industrial pharmacy

Boateng JS, Stevens HN, Eccleston GM, Auffret AD, Humphrey MJ, Matthews KH.
PMID: 19365780
Drug Dev Ind Pharm. 2009 Aug;35(8):986-96. doi: 10.1080/03639040902744704.

Solvent-cast films from three polymers, carboxymethylcellulose (CMC), sodium alginate (SA), and xanthan gum, were prepared by drying the polymeric gels in air. Three methods, (a) passive hydration, (b) vortex hydration with heating, and (c) cold hydration, were investigated to...

Intramuscular formulations of fluphenazine and their duration of activity in the rat [proceedings].

The Journal of pharmacy and pharmacology

Florence AT, Vezin WR, Ray-Johnson ML, Stevens HN.
PMID: 32282
J Pharm Pharmacol. 1978 Dec;30:28P. doi: 10.1111/j.2042-7158.1978.tb10735.x.

No abstract available.

Showing 1 to 12 of 33 entries