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Developing a learning community of engineers through an honors first-year seminar.

Johnson ML, Spear K.
UIID-AD: 4218
2017;88-105. doi: 10.4018/978-1-5225-2212-6.ch005.

First-year engineering majors face a myriad of obstacles as they begin college. Taking challenging foundational coursework, navigating new expectations for performance and experience, and understanding the broader impact of their academic interests are just a few of those obstacles....

Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients.

International archives of allergy and immunology

Theoharides TC, Boucher W, Spear K.
PMID: 12218373
Int Arch Allergy Immunol. 2002 Aug;128(4):344-50. doi: 10.1159/000063858.

BACKGROUND: Systemic mastocytosis (SM) is a condition typically characterized by an increased number of mast cells in the bone marrow or in skin areas known as urticaria pigmentosa. Patients may present with flushing, itching, gastrointestinal symptoms, arrhythmias, headaches and...

Azelastine's inhibition of histamine and tryptase release from human umbilical cord blood-derived cultured mast cells as well as rat skin mast cell-induced vascular permeability: comparison with olopatadine.

Allergy and asthma proceedings

Lytinas M, Kempuraj D, Huang M, Kandere K, Boucher W, Letourneau R, Jeudy S, Fitzgerald K, Spear K, Athanasiou A, Theoharides TC.
PMID: 11894734
Allergy Asthma Proc. 2002 Jan-Feb;23(1):45-51.

Mast cells are involved in early and late-phase reactions by releasing vasoactive molecules, proteases, and cytokines. Azelastine and olopatadine are histamine 1 receptor (H-1R) antagonists with antiallergic effects present in the ophthalmic solutions Optivar and Patanol, respectively. Because it...

A 2015-2016 Survey of American Board of Cardiovascular Perfusion Certified Clinical Perfusionists: Perfusion Profile and Clinical Trends.

The journal of extra-corporeal technology

Turnage C, DeLaney E, Kulat B, Guercio A, Palmer D, Ann Rosenberg C, Spear K, Boyne D, Johnson C, Riley W.
PMID: 28979037
J Extra Corpor Technol. 2017 Sep;49(3):137-149.

To document the current perfusion workforce status and to anticipate the future demands of an ever-changing perfusion workplace environment, a valid survey is needed to help guide the future of the perfusion workforce. The American Board of Cardiovascular Perfusion...

Design, synthesis, and structure-activity relationships of novel bicyclic azole-amines as negative allosteric modulators of metabotropic glutamate receptor 5.

Journal of medicinal chemistry

Burdi DF, Hunt R, Fan L, Hu T, Wang J, Guo Z, Huang Z, Wu C, Hardy L, Detheux M, Orsini MA, Quinton MS, Lew R, Spear K.
PMID: 20809633
J Med Chem. 2010 Oct 14;53(19):7107-18. doi: 10.1021/jm100736h.

A novel series of diaryl bicyclic azole-amines that are potent selective negative modulators of metabotropic glutamate receptor 5 (mGluR5) were identified through rational design. An initial hit compound 5a of modest potency (IC(50) = 1.2 μM) was synthesized. Evaluation...

Aerobic Dance Injuries.

The Physician and sportsmedicine

Vetter WL, Helfet DL, Spear K, Matthews LS.
PMID: 27421327
Phys Sportsmed. 1985 Feb;13(2):114-20. doi: 10.1080/00913847.1985.11708750.

In brief: During an 18-month period 61 patients who had problems associated with aerobic dance were evaluated. Fifty-four had overuse injuries, including all but two of the 24 patients who were instructors. The authors used three-phase radionuclide scintigraphy to...

Promoting Pre-exposure Prophylaxis to Prevent HIV Infections Among Sexual and Gender Minority Hispanics/Latinxs.

AIDS education and prevention : official publication of the International Society for AIDS Education

Page KR, Martinez O, Nieves-Lugo K, Zea MC, Grieb SD, Yamanis TJ, Spear K, Davis WW.
PMID: 29068715
AIDS Educ Prev. 2017 Oct;29(5):389-400. doi: 10.1521/aeap.2017.29.5.389.

Sexual and gender minority Hispanics/Latinxs (henceforth: Latinxs) continue to be disproportionately impacted by HIV/AIDS in the U.S. Pre-exposure prophylaxis (PrEP) is a biomedical prevention approach which holds significant promise for at risk and vulnerable populations. We discuss barriers and...

Changes to meat consumption.

The Veterinary record

Spear K.
PMID: 31296723
Vet Rec. 2019 Jul 13;185(2):57. doi: 10.1136/vr.l4595.

No abstract available.

TRUS-guided needle drainage of a prostatic cyst for treatment of male infertility.

Urology case reports

Graff J, Parekh N, Spear K.
PMID: 30094189
Urol Case Rep. 2018 Aug 04;21:3-4. doi: 10.1016/j.eucr.2018.08.002. eCollection 2018 Nov.

No abstract available.

Azelastine is more potent than olopatadine n inhibiting interleukin-6 and tryptase release from human umbilical cord blood-derived cultured mast cells.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

Kempuraj D, Huang M, Kandere K, Boucher W, Letourneau R, Jeudy S, Fitzgerald K, Spear K, Athanasiou A, Theoharides TC.
PMID: 12027072
Ann Allergy Asthma Immunol. 2002 May;88(5):501-6. doi: 10.1016/s1081-1206(10)62389-7.

BACKGROUND: Mast cells are involved in early- and late-phase reactions by releasing vasoactive molecules, proteases, and cytokines. Certain histamine-1 receptor antagonists and other antiallergic drugs seem to inhibit the release of mediators from rat and human mast cells.OBJECTIVE: Azelastine...

Reducing plastic waste.

The Veterinary record

Spear K.
PMID: 29440612
Vet Rec. 2018 Feb 10;182(6):173. doi: 10.1136/vr.k581.

No abstract available.

Discovery of Novel UDP-.

Journal of medicinal chemistry

Ryan MD, Parkes AL, Corbett D, Dickie AP, Southey M, Andersen OA, Stein DB, Barbeau OR, Sanzone A, Thommes P, Barker J, Cain R, Compper C, Dejob M, Dorali A, Etheridge D, Evans S, Faulkner A, Gadouleau E, Gorman T, Haase D, Holbrow-Wilshaw M, Krulle T, Li X, Lumley C, Mertins B, Napier S, Odedra R, Papadopoulos K, Roumpelakis V, Spear K, Trimby E, Williams J, Zahn M, Keefe AD, Zhang Y, Soutter HT, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Deng B, Hunt A, Sigel EA, Troast DM, DeJonge BLM.
PMID: 34569791
J Med Chem. 2021 Oct 14;64(19):14377-14425. doi: 10.1021/acs.jmedchem.1c00888. Epub 2021 Sep 27.

This study describes a novel series of UDP-

Showing 1 to 12 of 18 entries