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Showing 1 to 12 of 14 entries
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Activin A Modulates CRIPTO-1/HNF4.

Stem cells international

Duelen R, Gilbert G, Patel A, de Schaetzen N, De Waele L, Roderick L, Sipido KR, Verfaillie CM, Buyse GM, Thorrez L, Sampaolesi M.
PMID: 28163723
Stem Cells Int. 2017;2017:4651238. doi: 10.1155/2017/4651238. Epub 2017 Jan 09.

The use of human pluripotent stem cells in basic and translational cardiac research requires efficient differentiation protocols towards cardiomyocytes. In vitro differentiation yields heterogeneous populations of ventricular-, atrial-, and nodal-like cells hindering their potential applications in regenerative therapies. We...

Alterations in excitation-contraction coupling in chronically ischemic or hibernating myocardium.

Experimental and clinical cardiology

Bito V, Heinzel FR, Claus P, Bijnens B, Verbeken E, Van der Velden J, Stienen G, Sipido KR.
PMID: 19641678
Exp Clin Cardiol. 2005;10(3):142-5.

In coronary artery disease, areas subtended by a severely stenotic artery or by collateral vessels can develop chronic contractile dysfunction in the absence of necrosis. This dysfunction is thought to be adaptive to the reduced flow reserve and can...

Edward Carmeliet (1930-2021)-channelling scientific curiosity: a tribute from the ESC Working Group on Cardiac Cellular Electrophysiology†.

Cardiovascular research

Ravens U, Gomez AM, Heijman J, Remme CA, Dobrev D, Smith G, Volders PGA, Cerbai E, Eisner DA, Casadei B, Zaza A, Richard S, Mugelli A, Vassort G, Brown HF, Sipido KR.
PMID: 34850866
Cardiovasc Res. 2021 Nov 30; doi: 10.1093/cvr/cvab333. Epub 2021 Nov 30.

No abstract available.

Discrete sites of frequent premature ventricular complexes cluster within the infarct border zone and coincide with high frequency of delayed afterdepolarizations under adrenergic stimulation.

Heart rhythm

Amoni M, Claus P, Dries E, Nagaraju C, De Buck S, Vandenberk B, Ingelaere S, Vermoortele D, Roderick HL, Sipido KR, Willems R.
PMID: 34371193
Heart Rhythm. 2021 Nov;18(11):1976-1987. doi: 10.1016/j.hrthm.2021.07.067. Epub 2021 Aug 08.

BACKGROUND: Sympathetic activation in ischemic heart disease can cause lethal arrhythmias. These often are preceded by premature ventricular complexes (PVCs), which at the cellular level could result from delayed afterdepolarizations.OBJECTIVE: The purpose of this study was to identify and...

Edward Carmeliet (1930-2021)-channelling scientific curiosity: a tribute from the ESC Working Group on Cardiac Cellular Electrophysiology†.

Cardiovascular research

Ravens U, Gomez AM, Heijman J, Remme CA, Dobrev D, Smith G, Volders PGA, Cerbai E, Eisner DA, Casadei B, Zaza A, Richard S, Mugelli A, Vassort G, Brown HF, Sipido KR.
PMID: 34850866
Cardiovasc Res. 2021 Dec 17;117(14):e171-e173. doi: 10.1093/cvr/cvab333.

No abstract available.

Health research and knowledge translation for achieving the sustainable development goals: tackling the hurdles.

European journal of public health

Sipido KR, Nagyova I.
PMID: 32391902
Eur J Public Health. 2020 Mar 01;30:i36-i40. doi: 10.1093/eurpub/ckaa032.

We are far from reaching the sustainable development goals (SDGs) for health despite a wealth of novel insights in disease mechanisms and possible solutions. Why have we failed in knowledge translation and implementation? Starting from the case of cardiovascular...

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart.

Cardiovascular research

van der Velden J, Asselbergs FW, Bakkers J, Batkai S, Bertrand L, Bezzina CR, Bot I, Brundel B, Carrier L, Chamuleau S, Ciccarelli M, Dawson D, Davidson SM, Dendorfer A, Duncker DJ, Eschenhagen T, Fabritz L, Falcão-Pires I, Ferdinandy P, Giacca M, Girao H, Gollmann-Tepeköylü C, Gyongyosi M, Guzik TJ, Hamdani N, Heymans S, Hilfiker A, Hilfiker-Kleiner D, Hoekstra AG, Hulot JS, Kuster DWD, van Laake LW, Lecour S, Leiner T, Linke WA, Lumens J, Lutgens E, Madonna R, Maegdefessel L, Mayr M, van der Meer P, Passier R, Perbellini F, Perrino C, Pesce M, Priori S, Remme CA, Rosenhahn B, Schotten U, Schulz R, Sipido K, Sluijter JPG, van Steenbeek F, Steffens S, Terracciano CM, Tocchetti CG, Vlasman P, Yeung KK, Zacchigna S, Zwaagman D, Thum T.
PMID: 34999816
Cardiovasc Res. 2022 Jan 06; doi: 10.1093/cvr/cvab370. Epub 2022 Jan 06.

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating research to improve diagnostics, and to discover and test novel preventive and curative therapies. All of which warrant experimental models that recapitulate human disease. The translation of basic...

Incomplete Assembly of the Dystrophin-Associated Protein Complex in 2D and 3D-Cultured Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Frontiers in cell and developmental biology

Gilbert G, Kadur Nagaraju C, Duelen R, Amoni M, Bobin P, Eschenhagen T, Roderick HL, Sampaolesi M, Sipido KR.
PMID: 34805146
Front Cell Dev Biol. 2021 Nov 04;9:737840. doi: 10.3389/fcell.2021.737840. eCollection 2021.

Human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM) are increasingly used to study genetic diseases on a human background. However, the lack of a fully mature adult cardiomyocyte phenotype of hiPSC-CM may be limiting the scope of these studies....

Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity.

Frontiers in physiology

De Coster T, Claus P, Seemann G, Willems R, Sipido KR, Panfilov AV.
PMID: 30344493
Front Physiol. 2018 Oct 04;9:1381. doi: 10.3389/fphys.2018.01381. eCollection 2018.

The onset of cardiac arrhythmias depends on the electrophysiological and structural properties of cardiac tissue. Electrophysiological remodeling of myocytes due to the presence of adipocytes constitutes a possibly important pathway in the pathogenesis of atrial fibrillation. In this paper...

Overcoming fragmentation of health research in Europe: lessons from COVID-19.

Lancet (London, England)

Sipido KR, Antoñanzas F, Celis J, Degos L, Frackowiak R, Fuster V, Ganten D, Gay S, Hofstraat H, Holgate ST, Krestin G, Manns M, Meunier F, Oertel W, Palkonen S, Pavalkis D, Rübsamen-Schaeff H, Smith U, Stallknecht BM, Zima T.
PMID: 32559417
Lancet. 2020 Jun 27;395(10242):1970-1971. doi: 10.1016/S0140-6736(20)31411-2. Epub 2020 Jun 16.

No abstract available.

Open access and Plan S: a 'prisoner's dilemma'.

European heart journal

Sipido KR.
PMID: 31811721
Eur Heart J. 2019 Dec 07;40(46):3745-3747. doi: 10.1093/eurheartj/ehz815.

No abstract available.

Edward Carmeliet: his contributions and scientific legacy.

The Journal of physiology

Sipido KR, Eisner DA.
PMID: 34533837
J Physiol. 2021 Nov;599(21):4727-4729. doi: 10.1113/JP282357. Epub 2021 Oct 11.

No abstract available.

Showing 1 to 12 of 14 entries