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Showing 1 to 3 of 3 entries
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Accelerated toxicity screening using NMR and pattern recognition-based methods.

Current opinion in drug discovery & development

Holmes E, Shockcor JP.
PMID: 19649840
Curr Opin Drug Discov Devel. 2000 Jan;3(1):72-8.

(1)H-NMR spectroscopy has proved to be a powerful and efficient means of monitoring the interaction of pharmacological agents with cells and tissues. The application of this technique to biofluid analysis, gives rise to a comprehensive metabolic profile of the...

In vivo isotopically labeled atherosclerotic aorta plaques in ApoE KO mice and molecular profiling by matrix-assisted laser desorption/ionization mass spectrometric imaging.

Rapid communications in mass spectrometry : RCM

Castro-Perez J, Hatcher N, Kofi Karikari N, Wang SP, Mendoza V, Shion H, Millar A, Shockcor J, Towers M, McLaren D, Shah V, Previs S, Akinsanya K, Cleary M, Roddy TP, Johns DG.
PMID: 25303476
Rapid Commun Mass Spectrom. 2014 Nov 30;28(22):2471-9. doi: 10.1002/rcm.7039.

RATIONALE: The ability to quantify rates of formation, regression and/or remodeling of atherosclerotic plaque should facilitate a better understanding of the pathogenesis and management of cardiovascular disease. In the current study, we coupled a stable isotope labeled tracer protocol...

omega-3 oil intake during weight loss in obese women results in remodelling of plasma triglyceride and fatty acids.

Metabolomics : Official journal of the Metabolomic Society

McCombie G, Browning LM, Titman CM, Song M, Shockcor J, Jebb SA, Griffin JL.
PMID: 20208976
Metabolomics. 2009 Sep;5(3):363-374. doi: 10.1007/s11306-009-0161-7. Epub 2009 Apr 26.

Previous studies have shown that a combination of weight loss and fish oil supplementation reduce cardiovascular disease and diabetes risks by increasing adiponectin and reducing triacylglyceride concentrations, while weight loss alone significantly improves insulin sensitivity and reduces inflammation. Here,...

Showing 1 to 3 of 3 entries