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Showing 1 to 7 of 7 entries
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No indications for platelet activation in acute clinical myocardial or renal ischemia/reperfusion injury.

American journal of translational research

Kortekaas KA, de Vries DK, Roest M, Reinders ME, van der Veer EP, Klautz RJ, de Groot PG, Schaapherder AF, Lindeman JH.
PMID: 29636871
Am J Transl Res. 2018 Mar 15;10(3):816-826. eCollection 2018.

The pathophysiology of ischemia/reperfusion (I/R) injury is complex and poorly understood. Animal studies imply platelet activation as an initiator of the inflammatory response upon reperfusion. However, it remains unclear whether and how these results translate to clinical I/R. This...

Preclinical models versus clinical renal ischemia reperfusion injury: A systematic review based on metabolic signatures.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Lerink LJS, de Kok MJC, Mulvey JF, Le Dévédec SE, Markovski AA, Wüst RCI, Alwayn IPJ, Ploeg RJ, Schaapherder AFM, Bakker JA, Lindeman JHN.
PMID: 34657378
Am J Transplant. 2021 Oct 17; doi: 10.1111/ajt.16868. Epub 2021 Oct 17.

Despite decennia of research and numerous successful interventions in the preclinical setting, renal ischemia reperfusion (IR) injury remains a major problem in clinical practice, pointing toward a translational gap. Recently, two clinical studies on renal IR injury (manifested either...

Mesenchymal stromal cells in renal ischemia/reperfusion injury.

Frontiers in immunology

de Vries DK, Schaapherder AF, Reinders ME.
PMID: 22783252
Front Immunol. 2012 Jul 02;3:162. doi: 10.3389/fimmu.2012.00162. eCollection 2012.

Ischemia/reperfusion (I/R) injury is an inevitable consequence of organ transplantation and a major determinant of patient and graft survival in kidney transplantation. Renal I/R injury can lead to fibrosis and graft failure. Although the exact sequence of events in...

Acute Rejection After Kidney Transplantation Associates With Circulating MicroRNAs and Vascular Injury.

Transplantation direct

Bijkerk R, Florijn BW, Khairoun M, Duijs JMGJ, Ocak G, de Vries APJ, Schaapherder AF, Mallat MJK, de Fijter JW, Rabelink TJ, van Zonneveld AJ, Reinders MEJ.
PMID: 28706977
Transplant Direct. 2017 Jun 19;3(7):e174. doi: 10.1097/TXD.0000000000000699. eCollection 2017 Jul.

BACKGROUND: Acute rejection (AR) of kidney transplants is associated with the loss of endothelial integrity, microvascular rarefaction and, ultimately, graft dysfunction. Circulating angiogenic microRNAs (miRNAs) may serve as markers for microvascular injury. Here, we investigated the short- and long-term...

Equivalent Long-term Transplantation Outcomes for Kidneys Donated After Brain Death and Cardiac Death: Conclusions From a Nationwide Evaluation.

EClinicalMedicine

Schaapherder A, Wijermars LGM, de Vries DK, de Vries APJ, Bemelman FJ, van de Wetering J, van Zuilen AD, Christiaans MHL, Hilbrands LH, Baas MC, Nurmohamed AS, Berger SP, Alwayn IP, Bastiaannet E, Lindeman JHN.
PMID: 31193600
EClinicalMedicine. 2018 Oct 09;4:25-31. doi: 10.1016/j.eclinm.2018.09.007. eCollection 2018.

BACKGROUND: Despite growing waiting lists for renal transplants, hesitations persist with regard to the use of deceased after cardiac death (DCD) renal grafts. We evaluated the outcomes of DCD donations in The Netherlands, the country with the highest proportion...

[Probiotic prophylaxis in patients with predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial].

Nederlands tijdschrift voor geneeskunde

Besselink MG, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM, Nieuwenhuijs VB, Bollen TL, van Ramshorst B, Witteman BJ, Rosman C, Ploeg RJ, Brink MA, Schaapherder AF, Dejong CH, Wahab PJ, van Laarhoven CJ, van der Harst E, van Eijck CH, Cuesta MA, Akkermans LM, Gooszen HG.
PMID: 18438065
Ned Tijdschr Geneeskd. 2008 Mar 22;152(12):685-96.

OBJECTIVE: To evaluate whether enteral prophylaxis with probiotics in patients with predicted severe acute pancreatitis prevents infectious complications.DESIGN: Multicentre, randomised, double-blind, placebo-controlled trial.METHOD: A total of 296 patients with predicted severe acute pancreatitis (APACHE II score > or =...

Circumventing the Crabtree effect in cell culture: A systematic review.

Mitochondrion

de Kok MJC, Schaapherder AF, Wüst RCI, Zuiderwijk M, Bakker JA, Lindeman JHN, Le Dévédec SE.
PMID: 33812964
Mitochondrion. 2021 Jul;59:83-95. doi: 10.1016/j.mito.2021.03.014. Epub 2021 Apr 01.

Metabolic reprogramming and mitochondrial dysfunction are central elements in a broad variety of physiological and pathological processes. While cell culture established itself as a versatile technique for the elaboration of physiology and disease, studying metabolism using standard cell culture...

Showing 1 to 7 of 7 entries