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Showing 1 to 12 of 435 entries
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Alzheimer's disease drug development pipeline: 2019

pipeline programs

Cummings J, Sabbagh M.
GSID: 7wsf4B2228IJ
J Cummings, G Lee, A Ritter, M Sabbagh… - Alzheimer's & Dementia …, 2019 - Elsevier

… Alzheimer's disease (AD) has few available treatments, and there is a high rate of failure in AD drug development programs. Study of the AD drug development pipeline can provide insight into the evolution of drug development and how...

Student perceptions of engineering entrepreneurship: An exploratory study

engineering education

Dabbagh N, Menascé DA.
GSID: wmIoE5G9Nc0J
N Dabbagh, DA Menascé - Journal of Engineering Education, 2006 - Wiley Online Library

This study examines students' overall perceptions of the engineering profession in a first‐year course in engineering, and the effect of a pedagogical approach aimed at exposing …

The Effect of Statins on Rate of Cognitive Decline in Mild Cognitive Impairment.

Alzheimer's & dementia (New York, N. Y.)

Smith KB, Kang P, Sabbagh MN.
PMID: 28480324
Alzheimers Dement (N Y). 2017 Jun;3(2):149-156. doi: 10.1016/j.trci.2017.01.001.

OBJECTIVE: This study's aims are to identify whether or not a relationship between statin use and rate of cognitive decline exists.BACKGROUND: The relationship between statins and MCI has been investigated in the past with the evidence showing mixed results.METHODS:...

Are Certain Lifestyle Habits Associated with Lower Alzheimer's Disease Risk?.

Journal of Alzheimer's disease : JAD

Arab L, Sabbagh MN.
PMID: 26445162
J Alzheimers Dis. 2015;48(3):877. doi: 10.3233/JAD-159004.

No abstract available.

Target Identification of .

Frontiers in pharmacology

Mugumbate G, Mendes V, Blaszczyk M, Sabbah M, Papadatos G, Lelievre J, Ballell L, Barros D, Abell C, Blundell TL, Overington JP.
PMID: 29018348
Front Pharmacol. 2017 Sep 26;8:681. doi: 10.3389/fphar.2017.00681. eCollection 2017.

Mycobacterium phenotypic hits are a good reservoir for new chemotypes for the treatment of tuberculosis. However, the absence of defined molecular targets and modes of action could lead to failure in drug development. Therefore, a combination of ligand-based and...

Correction: Phosphoproteomic analysis reveals Smad protein family activation following Rift Valley fever virus infection.

PloS one

de la Fuente C, Pinkham C, Dabbagh D, Beitzel B, Garrison A, Palacios G, Hodge KA, Petricoin EF, Schmaljohn C, Campbell CE, Narayanan A, Kehn-Hall K.
PMID: 29543894
PLoS One. 2018 Mar 15;13(3):e0194633. doi: 10.1371/journal.pone.0194633. eCollection 2018.

[This corrects the article DOI: 10.1371/journal.pone.0191983.].

Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome.

Journal of Alzheimer's disease & Parkinsonism

Decourt B, Mobley W, Reiman E, Shah RJ, Sabbagh MN.
PMID: 24782952
J Alzheimers Dis Parkinsonism. 2013 Mar 20;002. doi: 10.4172/2161-0460.S7-002.

Down syndrome is one of the most common genetic conditions occurring in one in 700 live births. The trisomy of chromosome 21 causes over-expression of APP which in turn is indicated in the increased production of Aβ associated with...

Risk factors for postoperative respiratory mortality and morbidity in patients undergoing coronary artery bypass grafting.

Anesthesiology and pain medicine

Rajaei S, Dabbagh A.
PMID: 24223339
Anesth Pain Med. 2012;2(2):60-5. doi: 10.5812/aapm.5228. Epub 2012 Sep 13.

ABSTRACT: Nowadays, coronary artery bypass grafting (CABG) is considered to be one of the most common surgical procedures. This procedure has been the main topic in many clinical research studies, which have assessed the effect of the procedure on...

Use of automated irrigation pumps improves quality of bowel preparation for colonoscopy.

World journal of gastrointestinal endoscopy

Ravi S, Sabbagh R, Antaki F.
PMID: 27014425
World J Gastrointest Endosc. 2016 Mar 25;8(6):295-300. doi: 10.4253/wjge.v8.i6.295.

AIM: To evaluate the effectiveness of automated irrigation pumps (AIPs) in improving the quality of the bowel preparation and the yield of colonoscopy.METHODS: A retrospective observational study was conducted at a single medical center. Outpatient colonoscopies performed during a...

Refractory Vasoplegic Syndrome in an Adult Patient with Infective Endocarditis: A Case Report and Literature Review.

The journal of Tehran Heart Center

Mirhosseini SM, Sanjari Moghaddam A, Tahmaseb Pour P, Dabbagh A.
PMID: 28469689
J Tehran Heart Cent. 2017 Jan;12(1):27-31.

Postoperative vasoplegic syndrome (VS) is characterized by low systemic vascular resistance, normal or elevated cardiac output, and poor response to volume expansion. The incidence of VS after cardiac surgery requiring cardiopulmonary bypass is about 20%. Sometimes, VS becomes refractory...

A Rare Case of .

Clinics and practice

Hannoodi F, Sabbagh H, Kulairi Z, Kumar S.
PMID: 28243433
Clin Pract. 2017 Jan 12;7(1):928. doi: 10.4081/cp.2017.928. eCollection 2017 Jan 11.

Liver abscesses are an uncommon disease that can present with vague symptoms.

PTSD and depression construct: prevalence and predictors of co-occurrence in a South Lebanese civilian sample.

European journal of psychotraumatology

Farhood LF, Fares S, Sabbagh R, Hamady C.
PMID: 27414815
Eur J Psychotraumatol. 2016 Jul 12;7:31509. doi: 10.3402/ejpt.v7.31509. eCollection 2016.

BACKGROUND: Armed conflict, occupation, and political and economic instability that are particularly experienced by the civilian Lebanese population of South Lebanon would almost inevitably affect these individuals psychologically. Therefore, identifying predictors of co-occurring mental disorders is paramount to sound...

Showing 1 to 12 of 435 entries