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Showing 1 to 12 of 204 entries
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Hepatic function after acute of subchronic nicotine administration in untreated mice and mice treated with hepatotoxic chemicals.

Priestly BG, Plaa GL.
PMID: 999392
Arch Int Pharmacodyn Ther. 1976 Sep;223(1):132-41.

Male mice treated with nicotine hydrochloride either acutely (5 mg/kg i.p.) or subchronically (5 mg/kg i.p. daily for 3 weeks; 25 mg/liter in drinking water for 2-3 months) showed no evidence of hepatic dysfunction, as measured by serum glutamic-pyruvic...

alpha-Naphthylisothiocyanate (ANIT) hepatotoxicity and irreversible binding to rat liver microsomes.

El-Hawari AM, Plaa GL.
PMID: 911339
Biochem Pharmacol. 1977 Oct 15;26(20):1857-66. doi: 10.1016/0006-2952(77)90159-9.

No abstract available.

The influence of acute diazepam pretreatment on the action and disposition of [14C]pentobarbital in rats.

de Repentigny L, Hanasono GK, Plaa GL.
PMID: 990998
Can J Physiol Pharmacol. 1976 Oct;54(5):671-4. doi: 10.1139/y76-093.

Diazepam (DZP) pretreatment (100mg/kg, ip) of rats 6 h before pentobarbital administration (45 mg/kg, ip) prolonged the barbiturate-induced narcosis. The concentrations of [14C]pentobarbital and total pentobarbital derivatives in blood or brain showed no differences between control and DZP-pretreated animals....

Metabolic alterations in organ function.

Plaa GL.
PMID: 1150605
J Assoc Off Anal Chem. 1975 Jul;58(4):672-82.

When the standardization of procedures is envisioned, problems arise regarding the selection of the test procedure and its ability to detect changes in organ function. Dose-response curves can be derived for the parameters used for assessing dysfunction. These curves...

Correlation between acetone-potentiated CCl4-induced liver injury and blood concentrations after inhalation or oral administration.

Charbonneau M, Brodeur J, du Souich P, Plaa GL.
PMID: 3715876
Toxicol Appl Pharmacol. 1986 Jun 30;84(2):286-94. doi: 10.1016/0041-008x(86)90136-5.

In studies of acetone-potentiated liver injury induced by haloalkanes, acetone is usually given by gavage, whereas industrial exposure to acetone normally occurs by inhalation. It was of interest to verify if the route of administration influences the potentiation. Male...

Animal models.

Plaa GL.
PMID: 2182062
Drug Saf. 1990;5:40-5. doi: 10.2165/00002018-199000051-00007.

A review of the major categories of animal test procedures used in the toxicological assessment of drugs is presented. Problems that persist include low incidence responses, the need for innovation in toxicological methods and current societal attitudes about drugs...

Hepatotoxicity of alpha-naphthylisothiocyanate congeners with particular emphasis on phenylisothiocyanate.

Becker BA, Plaa GL.
PMID: 5886717
Toxicol Appl Pharmacol. 1965 Nov;7(6):804-11. doi: 10.1016/0041-008x(65)90005-0.

No abstract available.

Relationship between the carbon skeleton length of ketonic solvents and potentiation of chloroform-induced hepatotoxicity in rats.

Hewitt WR, Brown EM, Plaa GL.
PMID: 6857725
Toxicol Lett. 1983 May;16(3):297-304. doi: 10.1016/0378-4274(83)90190-x.

Previous studies have suggested that ketonic solvents potentiate the hepatotoxic action of CHCl3 in rats. In addition, the relative potentiating capacity of the ketones appeared to be related to the length of their carbon skeleton. To test this hypothesis...

Temporal analysis of rat liver injury following potentiation of carbon tetrachloride hepatotoxicity with ketonic or ketogenic compounds.

Charbonneau M, Iijima M, Côté MG, Plaa GL.
PMID: 4002241
Toxicology. 1985 May;35(2):95-112. doi: 10.1016/0300-483x(85)90025-3.

The administration of some ketonic or ketogenic compounds prior to a challenging dose of CCl4 potentiates the hepatic damage induced by this haloalkane. However, nothing is known about the recovery from the liver injury in these cases of chemically...

Maximum biliary excretion of bilirubin and sulfobromophthalein during anesthesia-induced alteration of rectal temperature.

Roberts RJ, Klaassen CD, Plaa GL.
PMID: 6027548
Proc Soc Exp Biol Med. 1967 May;125(1):313-6. doi: 10.3181/00379727-125-32080.

No abstract available.

The effect of bile duct ligation, bile duct cannulation, and hypothermia on alpha-naphthylisothiocyanate-induced hyperbilirubinemia and cholestasis in rats.

Roberts RJ, Plaa GL.
PMID: 5212377
Gastroenterology. 1966 Jun;50(6):768-74.

The hyperbilirubinemic and cholestatic responses to alpha-naphthylisothiocyanate (ANIT) in the rat were altered by subjecting test animals to various environmental and surgical manipulations. Studies utilizing hypo- and hyperthermic conditions showed that a positive correlation exists between the rectal temperature...

The effect of carbon tetrachloride, administered in vivo, on the hemodynamics of the isolated perfused rat liver.

Rice AJ, Roberts RJ, Plaa GL.
PMID: 5586355
Toxicol Appl Pharmacol. 1967 Nov;11(3):422-31. doi: 10.1016/0041-008x(67)90043-9.

No abstract available.

Showing 1 to 12 of 204 entries