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Showing 1 to 12 of 204 entries
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Hepatic function after acute of subchronic nicotine administration in untreated mice and mice treated with hepatotoxic chemicals.

Archives internationales de pharmacodynamie et de therapie

Priestly BG, Plaa GL.
PMID: 999392
Arch Int Pharmacodyn Ther. 1976 Sep;223(1):132-41.

Male mice treated with nicotine hydrochloride either acutely (5 mg/kg i.p.) or subchronically (5 mg/kg i.p. daily for 3 weeks; 25 mg/liter in drinking water for 2-3 months) showed no evidence of hepatic dysfunction, as measured by serum glutamic-pyruvic...

alpha-Naphthylisothiocyanate (ANIT) hepatotoxicity and irreversible binding to rat liver microsomes.

Biochemical pharmacology

El-Hawari AM, Plaa GL.
PMID: 911339
Biochem Pharmacol. 1977 Oct 15;26(20):1857-66. doi: 10.1016/0006-2952(77)90159-9.

No abstract available.

The influence of acute diazepam pretreatment on the action and disposition of [14C]pentobarbital in rats.

Canadian journal of physiology and pharmacology

de Repentigny L, Hanasono GK, Plaa GL.
PMID: 990998
Can J Physiol Pharmacol. 1976 Oct;54(5):671-4. doi: 10.1139/y76-093.

Diazepam (DZP) pretreatment (100mg/kg, ip) of rats 6 h before pentobarbital administration (45 mg/kg, ip) prolonged the barbiturate-induced narcosis. The concentrations of [14C]pentobarbital and total pentobarbital derivatives in blood or brain showed no differences between control and DZP-pretreated animals....

Metabolic alterations in organ function.

Journal - Association of Official Analytical Chemists

Plaa GL.
PMID: 1150605
J Assoc Off Anal Chem. 1975 Jul;58(4):672-82.

When the standardization of procedures is envisioned, problems arise regarding the selection of the test procedure and its ability to detect changes in organ function. Dose-response curves can be derived for the parameters used for assessing dysfunction. These curves...

Animal models.

Drug safety

Plaa GL.
PMID: 2182062
Drug Saf. 1990;5:40-5. doi: 10.2165/00002018-199000051-00007.

A review of the major categories of animal test procedures used in the toxicological assessment of drugs is presented. Problems that persist include low incidence responses, the need for innovation in toxicological methods and current societal attitudes about drugs...

Hepatotoxicity of alpha-naphthylisothiocyanate congeners with particular emphasis on phenylisothiocyanate.

Toxicology and applied pharmacology

Becker BA, Plaa GL.
PMID: 5886717
Toxicol Appl Pharmacol. 1965 Nov;7(6):804-11. doi: 10.1016/0041-008x(65)90005-0.

No abstract available.

Maximum biliary excretion of bilirubin and sulfobromophthalein during anesthesia-induced alteration of rectal temperature.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

Roberts RJ, Klaassen CD, Plaa GL.
PMID: 6027548
Proc Soc Exp Biol Med. 1967 May;125(1):313-6. doi: 10.3181/00379727-125-32080.

No abstract available.

The effect of carbon tetrachloride, administered in vivo, on the hemodynamics of the isolated perfused rat liver.

Toxicology and applied pharmacology

Rice AJ, Roberts RJ, Plaa GL.
PMID: 5586355
Toxicol Appl Pharmacol. 1967 Nov;11(3):422-31. doi: 10.1016/0041-008x(67)90043-9.

No abstract available.

Potentiation by methyl isobutyl ketone of the cholestasis induced in rats by a manganese-bilirubin combination or manganese alone.

Toxicology and applied pharmacology

Vézina M, Plaa GL.
PMID: 3424376
Toxicol Appl Pharmacol. 1987 Dec;91(3):477-83. doi: 10.1016/0041-008x(87)90069-x.

Haloalkane-induced hepatonecrogenesis can be potentiated by the prior administration of methyl isobutyl ketone (MIBK). In a previous study, MIBK was shown to potentiate the cholestasis induced by taurolithocholate in rats. We investigated the possibility that this ketone could potentiate...

The role of triglyceride accumulation and of necrosis in the hemodynamic responses of the isolated perfused rat liver after administration of carbon tetrachloride.

Toxicology and applied pharmacology

Rice AJ, Plaa GL.
PMID: 4975608
Toxicol Appl Pharmacol. 1969 Jan;14(1):151-62. doi: 10.1016/0041-008x(69)90175-6.

No abstract available.

Dose and time relationships in manganese-bilirubin cholestasis.

Toxicology and applied pharmacology

de Lamirande E, Plaa GL.
PMID: 494277
Toxicol Appl Pharmacol. 1979 Jun 30;49(2):257-63. doi: 10.1016/0041-008x(79)90249-7.

No abstract available.

Role of manganese, bilirubin and sulfobromophthalein in manganese-bilirubin cholestasis in rats.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

Lamirande ED, Plaa GL.
PMID: 674234
Proc Soc Exp Biol Med. 1978 Jun;158(2):283-7. doi: 10.3181/00379727-158-40189.

No abstract available.

Showing 1 to 12 of 204 entries