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Showing 1 to 12 of 39 entries
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Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids.

ACS central science

Huseman ED, Byl JAW, Chapp SM, Schley ND, Osheroff N, Townsend SD.
PMID: 34471677
ACS Cent Sci. 2021 Aug 25;7(8):1327-1337. doi: 10.1021/acscentsci.1c00040. Epub 2021 Jul 22.

The arimetamycin A glycan governs the compound's cytotoxicity (IC

Molecular pathogenesis of secondary acute promyelocytic leukemia.

Mediterranean journal of hematology and infectious diseases

Joannides M, Mays AN, Mistry AR, Hasan SK, Reiter A, Wiemels JL, Felix CA, Coco FL, Osheroff N, Solomon E, Grimwade D.
PMID: 22110895
Mediterr J Hematol Infect Dis. 2011;3(1):e2011045. doi: 10.4084/MJHID.2011.045. Epub 2011 Oct 24.

Balanced chromosomal translocations that generate chimeric oncoproteins are considered to be initiating lesions in the pathogenesis of acute myeloid leukemia. The most frequent is the t(15;17)(q22;q21), which fuses the PML and RARA genes, giving rise to acute promyelocytic leukemia...

Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons.

Phytochemistry reviews : proceedings of the Phytochemical Society of Europe

Ketron AC, Osheroff N.
PMID: 24678287
Phytochem Rev. 2014 Mar 01;13(1):19-35. doi: 10.1007/s11101-013-9291-7.

Phytochemicals are a rich source of anticancer drugs and chemopreventive agents. Several of these chemicals appear to exert at least some of their effects through interactions with topoisomerase II, an essential enzyme that regulates DNA supercoiling and removes knots...

From Theory to Practice: Utilizing Competency-based Milestones to Assess Professional Growth and Development in the Foundational Science Blocks of a Pre-Clerkship Medical School Curriculum.

Medical science educator

Pettepher CC, Lomis KD, Osheroff N.
PMID: 27752401
Med Sci Educ. 2016 Sep;26(3):491-497. doi: 10.1007/s40670-016-0262-7. Epub 2016 Jun 07.

Physicians-in-training require skills and attitudes beyond medical knowledge in order to mature into successful clinicians. However, because assessments in pre-clerkship curricula historically have focused almost exclusively on medical knowledge, faculty contributions to early student development often have been limited....

Topoisomerase IB-DNA interactions: X marks the spot.

Structure (London, England : 1993)

Zechiedrich L, Osheroff N.
PMID: 20541502
Structure. 2010 Jun 09;18(6):661-3. doi: 10.1016/j.str.2010.05.002.

The observation made twenty years ago that type IB topoisomerases bound DNA helix-helix juxtapositions was unexpected, given the controlled helical rotation mechanism of the enzyme. In this issue, Patel et al. (2010) provide an elegant structural explanation for this...

Application of laser Raman spectroscopy to the structural analysis of polypeptides in dilute aqueous solution.

FEBS letters

Wallach DF, Graham JM, Oseroff AR.
PMID: 11947507
FEBS Lett. 1970 May 01;7(4):330-334. doi: 10.1016/0014-5793(70)80197-1.

No abstract available.

Teaching Biochemistry and Genetics to Students of Dentistry, Medicine, and Pharmacy 6.

Medical science educator

Niederhoffer EC, Cline SD, Osheroff N, Simmons JM, Diekman AB, Franklin DS, Abali EE, Bateman RC, Fontes JD, Lindsley JE, Pearson D, Rubenstein PA, Slaughter CA, Bernstein JA, Hyland KM, Park VM, Sobering AK, Weiler TA, Dasgupta S.
PMID: 29291139
Med Sci Educ. 2017 Dec;27(4):855-859. doi: 10.1007/s40670-017-0441-1.

No abstract available.

Using Small Case-Based Learning Groups as a Setting for Teaching Medical Students How to Provide and Receive Peer Feedback.

Medical science educator

Bird EC, Osheroff N, Pettepher CC, Cutrer WB, Carnahan RH.
PMID: 29326856
Med Sci Educ. 2017 Dec;27(4):759-765. doi: 10.1007/s40670-017-0461-x. Epub 2017 Sep 20.

As future physicians, nearly all medical students will be required to provide face-to-face feedback. Moreover, receiving high quality feedback from multiple perspectives is particularly valuable during the pre-clerkship training period. To address these needs, we developed a straightforward, easy...

The COVID-19 Pandemic: a Year Lost, or a Year Found?.

Medical science educator

Osheroff N.
PMID: 34466278
Med Sci Educ. 2021 Aug 26;1-6. doi: 10.1007/s40670-021-01392-x. Epub 2021 Aug 26.

This commentary is based on the Leadership Plenary at the IAMSE 2021 Virtual Conference and describes the response of the International Association of Medical Science Educators (IAMSE) to the COVID-19 pandemic.

Teaching Biochemistry to Students of Medicine, Pharmacy & Dentistry: 5.

Medical science educator

Osheroff N, Niederhoffer EC, Sabina RL, Cline SD, Wimmer MJ, Franklin DS, Diekman AB, Hogg T, Kearney KR, King SC, Pearson D, Slaughter CA, Thompson K.
PMID: 26693393
Med Sci Educ. 2015 Dec;25(4):473-477. doi: 10.1007/s40670-015-0160-4. Epub 2015 Jul 22.

No abstract available.

Dynamics of the destruction and rebuilding of a dipole gap in glasses.

Physical review letters

Ludwig S, Nalbach P, Rosenberg D, Osheroff D.
PMID: 12689008
Phys Rev Lett. 2003 Mar 14;90(10):105501. doi: 10.1103/PhysRevLett.90.105501. Epub 2003 Mar 12.

After a strong electric bias field is applied to the polyester glass Mylar at temperatures in the mK range, its dielectric constant increases and then decays logarithmically in time. We observed its dielectric response for several temperatures and different...

Splashing of drops on shallow liquids.

Science (New York, N.Y.)

Hobbs PV, Osheroff T.
PMID: 17734307
Science. 1967 Dec 01;158(3805):1184-6. doi: 10.1126/science.158.3805.1184.

The events that follow the splashing of a drop on a liquid depend on the depth of the liquid. When the depth is less than about 5 millimeters the crown that is ejected is more unstable than that from...

Showing 1 to 12 of 39 entries