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Rationale, Design, and Baseline Characteristics of the Utopia Trial for Preventing Diabetic Atherosclerosis Using an SGLT2 Inhibitor: A Prospective, Randomized, Open-Label, Parallel-Group Comparative Study.

Diabetes therapy : research, treatment and education of diabetes and related disorders

Katakami N, Mita T, Yoshii H, Shiraiwa T, Yasuda T, Okada Y, Umayahara Y, Kaneto H, Osonoi T, Yamamoto T, Kuribayashi N, Maeda K, Yokoyama H, Kosugi K, Ohtoshi K, Hayashi I, Sumitani S, Tsugawa M, Ohashi M, Taki H, Nakamura T, Kawashima S, Sato Y, Watada H, Shimomura I.
PMID: 28864997
Diabetes Ther. 2017 Oct;8(5):999-1013. doi: 10.1007/s13300-017-0292-1. Epub 2017 Sep 01.

INTRODUCTION: Sodium-glucose co-transporter-2 (SGLT2) inhibitors are anti-diabetic agents that improve glycemic control with a low risk of hypoglycemia and ameliorate a variety of cardiovascular risk factors. The aim of the ongoing study described herein is to investigate the preventive...

Centrality-Dependent Modification of Jet-Production Rates in Deuteron-Gold Collisions at √[s(NN)]=200 GeV.

Physical review letters

Adare A, Aidala C, Ajitanand NN, Akiba Y, Al-Bataineh H, Alexander J, Alfred M, Angerami A, Aoki K, Apadula N, Aramaki Y, Asano H, Atomssa ET, Averbeck R, Awes TC, Azmoun B, Babintsev V, Bai M, Baksay G, Baksay L, Bandara NS, Bannier B, Barish KN, Bassalleck B, Basye AT, Bathe S, Baublis V, Baumann C, Bazilevsky A, Beaumier M, Beckman S, Belikov S, Belmont R, Bennett R, Berdnikov A, Berdnikov Y, Bhom JH, Blau DS, Bok JS, Boyle K, Brooks ML, Bryslawskyj J, Buesching H, Bumazhnov V, Bunce G, Butsyk S, Campbell S, Caringi A, Chen CH, Chi CY, Chiu M, Choi IJ, Choi JB, Choudhury RK, Christiansen P, Chujo T, Chung P, Chvala O, Cianciolo V, Citron Z, Cole BA, Conesa Del Valle Z, Connors M, Csanád M, Csörgő T, Dahms T, Dairaku S, Danchev I, Danley TW, Das K, Datta A, Daugherity MS, David G, Dayananda MK, DeBlasio K, Dehmelt K, Denisov A, Deshpande A, Desmond EJ, Dharmawardane KV, Dietzsch O, Dion A, Diss PB, Do JH, Donadelli M, D'Orazio L, Drapier O, Drees A, Drees KA, Durham JM, Durum A, Dutta D, Edwards S, Efremenko YV, Ellinghaus F, Engelmore T, Enokizono A, En'yo H, Esumi S, Fadem B, Feege N, Fields DE, Finger M, Finger M, Fleuret F, Fokin SL, Fraenkel Z, Frantz JE, Franz A, Frawley AD, Fujiwara K, Fukao Y, Fusayasu T, Gal C, Gallus P, Garg P, Garishvili I, Ge H, Giordano F, Glenn A, Gong H, Gonin M, Goto Y, Granier de Cassagnac R, Grau N, Greene SV, Grim G, Grosse Perdekamp M, Gunji T, Gustafsson HÅ, Hachiya T, Haggerty JS, Hahn KI, Hamagaki H, Hamblen J, Hamilton HF, Han R, Han SY, Hanks J, Hasegawa S, Haseler TO, Hashimoto K, Haslum E, Hayano R, He X, Heffner M, Hemmick TK, Hester T, Hill JC, Hohlmann M, Hollis RS, Holzmann W, Homma K, Hong B, Horaguchi T, Hornback D, Hoshino T, Hotvedt N, Huang J, Huang S, Ichihara T, Ichimiya R, Ikeda Y, Imai K, Inaba M, Iordanova A, Isenhower D, Ishihara M, Issah M, Ivanishchev D, Iwanaga Y, Jacak BV, Jezghani M, Jia J, Jiang X, Jin J, Johnson BM, Jones T, Joo KS, Jouan D, Jumper DS, Kajihara F, Kamin J, Kanda S, Kang JH, Kapustinsky J, Karatsu K, Kasai M, Kawall D, Kawashima M, Kazantsev AV, Kempel T, Key JA, Khachatryan V, Khanzadeev A, Kijima KM, Kikuchi J, Kim A, Kim BI, Kim C, Kim DJ, Kim EJ, Kim GW, Kim M, Kim YJ, Kimelman B, Kinney E, Kiss Á, Kistenev E, Kitamura R, Klatsky J, Kleinjan D, Kline P, Koblesky T, Kochenda L, Komkov B, Konno M, Koster J, Kotov D, Král A, Kravitz A, Kunde GJ, Kurita K, Kurosawa M, Kwon Y, Kyle GS, Lacey R, Lai YS, Lajoie JG, Lebedev A, Lee DM, Lee J, Lee KB, Lee KS, Lee S, Lee SH, Leitch MJ, Leite MA, Li X, Lichtenwalner P, Liebing P, Lim SH, Linden Levy LA, Liška T, Liu H, Liu MX, Love B, Lynch D, Maguire CF, Makdisi YI, Makek M, Malik MD, Manion A, Manko VI, Mannel E, Mao Y, Masui H, Matathias F, McCumber M, McGaughey PL, McGlinchey D, McKinney C, Means N, Meles A, Mendoza M, Meredith B, Miake Y, Mibe T, Mignerey AC, Miki K, Milov A, Mishra DK, Mitchell JT, Miyasaka S, Mizuno S, Mohanty AK, Montuenga P, Moon HJ, Moon T, Morino Y, Morreale A, Morrison DP, Moukhanova TV, Murakami T, Murata J, Mwai A, Nagamiya S, Nagashima K, Nagle JL, Naglis M, Nagy MI, Nakagawa I, Nakagomi H, Nakamiya Y, Nakamura KR, Nakamura T, Nakano K, Nam S, Nattrass C, Netrakanti PK, Newby J, Nguyen M, Nihashi M, Niida T, Nishimura S, Nouicer R, Novák T, Novitzky N, Nyanin AS, Oakley C, O'Brien E, Oda SX, Ogilvie CA, Oka M, Okada K, Onuki Y, Orjuela Koop JD, Osborn JD, Oskarsson A, Ouchida M, Ozawa K, Pak R, Pantuev V, Papavassiliou V, Park IH, Park JS, Park S, Park SK, Park WJ, Pate SF, Patel M, Pei H, Peng JC, Pereira H, Perepelitsa DV, Perera GD, Peressounko DY, Perry J, Petti R, Pinkenburg C, Pinson R, Pisani RP, Proissl M, Purschke ML, Qu H, Rak J, Ramson BJ, Ravinovich I, Read KF, Rembeczki S, Reygers K, Reynolds D, Riabov V, Riabov Y, Richardson E, Rinn T, Roach D, Roche G, Rolnick SD, Rosati M, Rosen CA, Rosendahl SS, Rowan Z, Rubin JG, Ružička P, Sahlmueller B, Saito N, Sakaguchi T, Sakashita K, Sako H, Samsonov V, Sano S, Sarsour M, Sato S, Sato T, Sawada S, Schaefer B, Schmoll BK, Sedgwick K, Seele J, Seidl R, Sen A, Seto R, Sett P, Sexton A, Sharma D, Shein I, Shibata TA, Shigaki K, Shimomura M, Shoji K, Shukla P, Sickles A, Silva CL, Silvermyr D, Silvestre C, Sim KS, Singh BK, Singh CP, Singh V, Slunečka M, Snowball M, Soltz RA, Sondheim WE, Sorensen SP, Sourikova IV, Stankus PW, Stenlund E, Stepanov M, Stoll SP, Sugitate T, Sukhanov A, Sumita T, Sun J, Sziklai J, Takagui EM, Taketani A, Tanabe R, Tanaka Y, Taneja S, Tanida K, Tannenbaum MJ, Tarafdar S, Taranenko A, Themann H, Thomas D, Thomas TL, Tieulent R, Timilsina A, Todoroki T, Togawa M, Toia A, Tomášek L, Tomášek M, Torii H, Towell CL, Towell R, Towell RS, Tserruya I, Tsuchimoto Y, Vale C, Valle H, van Hecke HW, Vazquez-Zambrano E, Veicht A, Velkovska J, Vértesi R, Virius M, Vrba V, Vznuzdaev E, Wang XR, Watanabe D, Watanabe K, Watanabe Y, Watanabe YS, Wei F, Wei R, Wessels J, White AS, White SN, Winter D, Woody CL, Wright RM, Wysocki M, Xia B, Xue L, Yalcin S, Yamaguchi YL, Yamaura K, Yang R, Yanovich A, Ying J, Yokkaichi S, Yoo JH, Yoon I, You Z, Young GR, Younus I, Yu H, Yushmanov IE, Zajc WA, Zelenski A, Zhou S, Zou L.
PMID: 27058071
Phys Rev Lett. 2016 Mar 25;116(12):122301. doi: 10.1103/PhysRevLett.116.122301. Epub 2016 Mar 24.

Jet production rates are measured in p+p and d+Au collisions at sqrt[s_{NN}]=200  GeV recorded in 2008 with the PHENIX detector at the Relativistic Heavy Ion Collider. Jets are reconstructed using the R=0.3 anti-k_{t} algorithm from energy deposits in the...

Crystal structure of bis-(tetra-phenyl-phospho-nium) bis-(cyanido-κC)(29H,31H-tetra-benzo[b,g,l,q]porphinato-κ(4) N (29),N (30),N (31),N (32))ferrate(II) acetone disolvate.

Acta crystallographica. Section E, Crystallographic communications

Nishi M, Matsuda M, Hoshino N, Akutagawa T.
PMID: 25878850
Acta Crystallogr E Crystallogr Commun. 2015 Jan 31;71:m48-9. doi: 10.1107/S2056989015001735. eCollection 2015 Feb 01.

The crystal structure of the title compound, (C24H20P)2[Fe(C36H20N4)(CN)2]·2C3H6O, is constructed from a tetra-hedral Ph4P(+) (tetra-phenyl-phospho-nium) cation, one [Fe(tbp)(CN)2](2-) anion (tbp = tetra-benzoporphyrin in its doubly deprotonated form), located on a centre of inversion, and an acetone mol-ecule as crystallization...

Transition-Metal-Free Catalytic Hydrodefluorination of Polyfluoroarenes by Concerted Nucleophilic Aromatic Substitution with a Hydrosilicate.

Angewandte Chemie (International ed. in English)

Kikushima K, Grellier M, Ohashi M, Ogoshi S.
PMID: 29072350
Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16191-16196. doi: 10.1002/anie.201708003. Epub 2017 Nov 22.

A transition-metal-free catalytic hydrodefluorination (HDF) reaction of polyfluoroarenes is described. The reaction involves direct hydride transfer from a hydrosilicate as the key intermediate, which is generated from a hydrosilane and a fluoride salt. The eliminated fluoride regenerates the hydrosilicate...

Nickel(0)-Mediated Transformation of Tetrafluoroethylene and Vinylarenes into Fluorinated Cyclobutyl Compounds.

Angewandte Chemie (International ed. in English)

Ohashi M, Ueda Y, Ogoshi S.
PMID: 28111870
Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2435-2439. doi: 10.1002/anie.201610047. Epub 2017 Jan 23.

In the presence of Ni

Nickel-Catalyzed Formation of 1,3-Dienes via a Highly Selective Cross-Tetramerization of Tetrafluoroethylene, Styrenes, Alkynes, and Ethylene.

Journal of the American Chemical Society

Kawashima T, Ohashi M, Ogoshi S.
PMID: 29149562
J Am Chem Soc. 2017 Dec 13;139(49):17795-17798. doi: 10.1021/jacs.7b12007. Epub 2017 Nov 28.

In the presence of a catalytic amount of Ni(cod)

Multidisciplinary treatment including systemic chemotherapy for a malignant phyllodes tumour of the prostate.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

Murakami Y, Tabata K, Sugita A, Mochizuki K, Maeyama R, Okazaki M, Nishi M, Matsumoto K, Fujita T, Satoh T, Jiang SX, Saegusa M, Iwamura M.
PMID: 24839496
Can Urol Assoc J. 2014 Mar;8(3):E263-5. doi: 10.5489/cuaj.1648.

A 22-year-old man was referred to our hospital with macroscopic hematuria and consistent anal pain. Magnetic resonance imaging revealed an enlarged prostate tumour invading the bladder and rectum. A biopsy revealed an unclassified spindle cell sarcoma. Subsequently, radical cystoprostatectomy...

Pro198Leu missense polymorphism of the glutathione peroxidase 1 gene might be a common genetic predisposition of distal symmetric polyneuropathy and macrovascular disease in Japanese type 2 diabetic patients.

Journal of diabetes investigation

Matsuno S, Sasaki H, Yamasaki H, Yamaoka H, Ogawa K, Nakatani M, Hamanishi T, Doi A, Nakano Y, Wakasaki H, Furuta H, Nishi M, Akamizu T, Nanjo K.
PMID: 24843532
J Diabetes Investig. 2011 Nov 30;2(6):474-82. doi: 10.1111/j.2040-1124.2011.00127.x.

UNLABELLED: Aims/Introduction:  We have previously reported that the Pro198Leu missense polymorphism in the glutathione peroxidase 1 (GPx-1) gene was associated with frequent macrovascular disease (MVD). Our goal was to examine whether the GPx-1 genotype is associated with diabetic neuropathy.MATERIALS...

Clinical and functional characterization of the Pro1198Leu ABCC8 gene mutation associated with permanent neonatal diabetes mellitus.

Journal of diabetes investigation

Takagi T, Furuta H, Miyawaki M, Nagashima K, Shimada T, Doi A, Matsuno S, Tanaka D, Nishi M, Sasaki H, Inagaki N, Yoshikawa N, Nanjo K, Akamizu T.
PMID: 24843665
J Diabetes Investig. 2013 May 06;4(3):269-73. doi: 10.1111/jdi.12049. Epub 2013 Mar 11.

AIMS/INTRODUCTION: The adenosine triphosphate (ATP)-sensitive potassium (KATP) channel is a key component of insulin secretion in pancreatic β-cells. Activating mutations in ABCC8 encoding for the sulfonylurea receptor subunit of the KATP channel have been associated with the development of...

Our Experience with 131 Cases of Simultaneous Breast Implant Exhange with Fat (SIEF).

Plastic and reconstructive surgery. Global open

Ohashi M, Yamakawa M, Chiba A, Nagano H, Nakai H.
PMID: 27200253
Plast Reconstr Surg Glob Open. 2016 Apr 25;4(4):e691. doi: 10.1097/GOX.0000000000000601. eCollection 2016 Apr.

BACKGROUND: Breast augmentation with fat injection is a growing trend in Japan. Many Japanese patients experiencing breast implant complications are requesting to have their breast implants removed and simultaneously exchanged with autologous fat injection. The keys of our simultaneous...

Modeling the budget impact of long-acting injectable paliperidone palmitate in the treatment of schizophrenia in Japan.

ClinicoEconomics and outcomes research : CEOR

Mahlich J, Nishi M, Saito Y.
PMID: 26045674
Clinicoecon Outcomes Res. 2015 May 22;7:267-72. doi: 10.2147/CEOR.S85514. eCollection 2015.

BACKGROUND: The cost of schizophrenia in Japan is high and new long-acting injectable (LAI) antipsychotics might be able to reduce costs by causing a reduction of hospital stays. We aim to estimate budget effects of the introduction of a...

Efficient Approach to Reactive Molecular Dynamics with Accurate Forces.

Journal of chemical theory and computation

Higashi M, Truhlar DG.
PMID: 26609973
J Chem Theory Comput. 2009 Nov 10;5(11):2925-9. doi: 10.1021/ct900301d.

Density functional theory is a powerful and efficient method for calculating potential energy surfaces for chemical reactions, but its application to complex systems, such as reactions in enzymes, is often prohibitively expensive, even when high-level theory is applied only...

Showing 1 to 12 of 566 entries