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Open Targets: a platform for therapeutic target identification and validation.

Nucleic acids research

Koscielny G, An P, Carvalho-Silva D, Cham JA, Fumis L, Gasparyan R, Hasan S, Karamanis N, Maguire M, Papa E, Pierleoni A, Pignatelli M, Platt T, Rowland F, Wankar P, Bento AP, Burdett T, Fabregat A, Forbes S, Gaulton A, Gonzalez CY, Hermjakob H, Hersey A, Jupe S, Kafkas Ş, Keays M, Leroy C, Lopez FJ, Magarinos MP, Malone J, McEntyre J, Munoz-Pomer Fuentes A, O'Donovan C, Papatheodorou I, Parkinson H, Palka B, Paschall J, Petryszak R, Pratanwanich N, Sarntivijal S, Saunders G, Sidiropoulos K, Smith T, Sondka Z, Stegle O, Tang YA, Turner E, Vaughan B, Vrousgou O, Watkins X, Martin MJ, Sanseau P, Vamathevan J, Birney E, Barrett J, Dunham I.
PMID: 27899665
Nucleic Acids Res. 2017 Jan 04;45:D985-D994. doi: 10.1093/nar/gkw1055. Epub 2016 Nov 29.

We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up....

Cite
Koscielny G, An P, Carvalho-Silva D, et al. Open Targets: a platform for therapeutic target identification and validation. Nucleic Acids Res. 2016;45:D985-D994doi: 10.1093/nar/gkw1055.
Koscielny, G., An, P., Carvalho-Silva, D., Cham, J. A., Fumis, L., Gasparyan, R., Hasan, S., Karamanis, N., Maguire, M., Papa, E., Pierleoni, A., Pignatelli, M., Platt, T., Rowland, F., Wankar, P., Bento, A. P., Burdett, T., Fabregat, A., Forbes, S., Gaulton, A., Gonzalez, C. Y., Hermjakob, H., Hersey, A., Jupe, S., Kafkas, �. �., Keays, M., Leroy, C., Lopez, F. J., Magarinos, M. P., Malone, J., McEntyre, J., Munoz-Pomer Fuentes, A., O'Donovan, C., Papatheodorou, I., Parkinson, H., Palka, B., Paschall, J., Petryszak, R., Pratanwanich, N., Sarntivijal, S., Saunders, G., Sidiropoulos, K., Smith, T., Sondka, Z., Stegle, O., Tang, Y. A., Turner, E., Vaughan, B., Vrousgou, O., Watkins, X., Martin, M. J., Sanseau, P., Vamathevan, J., Birney, E., Barrett, J., & Dunham, I. (2017). Open Targets: a platform for therapeutic target identification and validation. Nucleic acids research, 45D985-D994. https://doi.org/10.1093/nar/gkw1055
Koscielny, Gautier, et al. "Open Targets: a platform for therapeutic target identification and validation." Nucleic acids research vol. 45 (2017): D985-D994. doi: https://doi.org/10.1093/nar/gkw1055
Koscielny G, An P, Carvalho-Silva D, Cham JA, Fumis L, Gasparyan R, Hasan S, Karamanis N, Maguire M, Papa E, Pierleoni A, Pignatelli M, Platt T, Rowland F, Wankar P, Bento AP, Burdett T, Fabregat A, Forbes S, Gaulton A, Gonzalez CY, Hermjakob H, Hersey A, Jupe S, Kafkas Ş, Keays M, Leroy C, Lopez FJ, Magarinos MP, Malone J, McEntyre J, Munoz-Pomer Fuentes A, O'Donovan C, Papatheodorou I, Parkinson H, Palka B, Paschall J, Petryszak R, Pratanwanich N, Sarntivijal S, Saunders G, Sidiropoulos K, Smith T, Sondka Z, Stegle O, Tang YA, Turner E, Vaughan B, Vrousgou O, Watkins X, Martin MJ, Sanseau P, Vamathevan J, Birney E, Barrett J, Dunham I. Open Targets: a platform for therapeutic target identification and validation. Nucleic Acids Res. 2017 Jan 04;45:D985-D994. doi: 10.1093/nar/gkw1055. Epub 2016 Nov 29. PMID: 27899665; PMCID: PMC5210543.
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PathExNET: A tool for extracting pathway expression networks from gene expression statistics.

Computational and structural biotechnology journal

Minadakis G, Muñoz-Pomer Fuentes A, Tsouloupas G, Papatheodorou I, Spyrou GM.
PMID: 34429851
Comput Struct Biotechnol J. 2021 Jul 29;19:4336-4344. doi: 10.1016/j.csbj.2021.07.033. eCollection 2021.

A fundamental issue related to the understanding of the molecular mechanisms, is the way in which common pathways act across different biological experiments related to complex diseases. Using network-based approaches, this work aims to provide a numeric characterization of...

Cite
Minadakis G, Muñoz-Pomer Fuentes A, Tsouloupas G, et al. PathExNET: A tool for extracting pathway expression networks from gene expression statistics. Comput Struct Biotechnol J. 2021;19:4336-4344doi: 10.1016/j.csbj.2021.07.033.
Minadakis, G., Muñoz-Pomer Fuentes, A., Tsouloupas, G., Papatheodorou, I., & Spyrou, G. M. (2021). PathExNET: A tool for extracting pathway expression networks from gene expression statistics. Computational and structural biotechnology journal, 194336-4344. https://doi.org/10.1016/j.csbj.2021.07.033
Minadakis, George, et al. "PathExNET: A tool for extracting pathway expression networks from gene expression statistics." Computational and structural biotechnology journal vol. 19 (2021): 4336-4344. doi: https://doi.org/10.1016/j.csbj.2021.07.033
Minadakis G, Muñoz-Pomer Fuentes A, Tsouloupas G, Papatheodorou I, Spyrou GM. PathExNET: A tool for extracting pathway expression networks from gene expression statistics. Comput Struct Biotechnol J. 2021 Jul 29;19:4336-4344. doi: 10.1016/j.csbj.2021.07.033. eCollection 2021. PMID: 34429851; PMCID: PMC8363825.
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