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Showing 1 to 5 of 5 entries
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Screening New Drugs for Immunotoxic Potential: I. Assessment of the Effects of Conventional Nonsteroidal Anti-Inflammatory Drugs and Selective COX-2 Inhibitors on In Vitro and In Vivo Phagocytic Activity.

Journal of immunotoxicology

Furst SM, Komocsar WJ, Khan KN, White KL, Peachee VL, Mennear JH.
PMID: 18958648
J Immunotoxicol. 2005 Jul 01;1(3):149-58. doi: 10.1080/15476910490916828.

Although both experimental and clinical literature contain reports suggestive of associations between enhanced susceptibility to soft tissue infections and nonsteroidal anti-inflammatory drug (NSAID) use, the immunotoxicological potential of this class of therapeutic agents has not been thoroughly investigated. In...

'Catch-22s' for family physician educators.

JAMA

Currie BF, Renner JH.
PMID: 7253136
JAMA. 1981 Aug 14;246(7):737-40.

No abstract available.

Screening New Drugs for Immunotoxic Potential: II. Assessment of the Effects of Selective and Nonselective COX-2 Inhibitors on Complement Activation, Superoxide Anion Production and Leukocyte Chemotaxis and Migration Through Endothelial Cells.

Journal of immunotoxicology

Furst SM, Khan KN, Komocsar WJ, Fan L, Mennear J.
PMID: 18958662
J Immunotoxicol. 2005 Apr 01;2(2):85-96. doi: 10.1080/15476910591002668.

Results from earlier experiments in our laboratories revealed that both selective and nonselective inhibitors of cyclooxygenase-2 possess little potential for decreasing in vitro phagocytosis by rat macrophages or canine neutrophils and no potential for decreasing in vivo phagocytosis by...

Screening new drugs for immunotoxic potential: III. assessment of the effects of selective and nonselective COX-2 inhibitors on T-cell-dependent antibody and natural killer cell responses in the rat.

Journal of immunotoxicology

Furst SM, Khan KN, Komocsar WJ, Mennear J.
PMID: 18958669
J Immunotoxicol. 2005 Jul 01;2(3):161-70. doi: 10.1080/15476910500290567.

Results from earlier experiments in our laboratories revealed that both selective and non-selective inhibitors of cyclooxygenase-2 possess little potential for decreasing in vitro phagocytosis by rat macrophages or canine neutrophils, and no potential for decreasing in vivo phagocytosis by...

Assessment of the effects of ISIS 2302, an anti-sense inhibitor of human ICAM-1, on cellular and humoral immunity in mice.

Journal of immunotoxicology

Henry SP, Levin AA, White K, Mennear JH.
PMID: 18958701
J Immunotoxicol. 2006 Dec 01;3(4):199-211. doi: 10.1080/15476910601046538.

ISIS 2302 is a phosphorothioate oligonucleotide designed to inhibit human ICAM-1 and is intended for treatment of inflammatory diseases. Molecules of this class are known to elicit pro-inflammatory effects, and immunotoxicity studies were performed in mice to elucidate the...

Showing 1 to 5 of 5 entries