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Showing 1 to 12 of 13 entries
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The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline.

eLife

Janosevic D, Myslinski J, McCarthy TW, Zollman A, Syed F, Xuei X, Gao H, Liu YL, Collins KS, Cheng YH, Winfree S, El-Achkar TM, Maier B, Melo Ferreira R, Eadon MT, Hato T, Dagher PC.
PMID: 33448928
Elife. 2021 Jan 15;10. doi: 10.7554/eLife.62270.

Sepsis is a dynamic state that progresses at variable rates and has life-threatening consequences. Staging patients along the sepsis timeline requires a thorough knowledge of the evolution of cellular and molecular events at the tissue level. Here, we investigated...

Transcriptomic regulation of seasonal coat color change in hares.

Ecology and evolution

Ferreira MS, Alves PC, Callahan CM, Giska I, Farelo L, Jenny H, Mills LS, Hackländer K, Good JM, Melo-Ferreira J.
PMID: 32076506
Ecol Evol. 2020 Jan 15;10(3):1180-1192. doi: 10.1002/ece3.5956. eCollection 2020 Feb.

Color molts from summer brown to winter white coats have evolved in several species to maintain camouflage year-round in environments with seasonal snow. Despite the eco-evolutionary relevance of this key phenological adaptation, its molecular regulation has only recently begun...

Clinical, histopathologic and molecular features of idiopathic and diabetic nodular mesangial sclerosis in humans.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Eadon MT, Lampe S, Baig MM, Collins KS, Melo Ferreira R, Mang H, Cheng YH, Barwinska D, El-Achkar TM, Schwantes-An TH, Winfree S, Temm CJ, Ferkowicz MJ, Dunn KW, Kelly KJ, Sutton TA, Moe SM, Moorthi RN, Phillips CL, Dagher PC.
PMID: 33537765
Nephrol Dial Transplant. 2021 Dec 31;37(1):72-84. doi: 10.1093/ndt/gfaa331.

BACKGROUND: Idiopathic nodular mesangial sclerosis, also called idiopathic nodular glomerulosclerosis (ING), is a rare clinical entity with an unclear pathogenesis. The hallmark of this disease is the presence of nodular mesangial sclerosis on histology without clinical evidence of diabetes...

Molecular characterization of the human kidney interstitium in health and disease.

Science advances

Barwinska D, El-Achkar TM, Melo Ferreira R, Syed F, Cheng YH, Winfree S, Ferkowicz MJ, Hato T, Collins KS, Dunn KW, Kelly KJ, Sutton TA, Rovin BH, Parikh SV, Phillips CL, Dagher PC, Eadon MT.
PMID: 33568476
Sci Adv. 2021 Feb 10;7(7). doi: 10.1126/sciadv.abd3359. Print 2021 Feb.

The gene expression signature of the human kidney interstitium is incompletely understood. The cortical interstitium (excluding tubules, glomeruli, and vessels) in reference nephrectomies (

Molecular characterization of the human kidney interstitium in health and disease.

Science advances

Barwinska D, El-Achkar TM, Melo Ferreira R, Syed F, Cheng YH, Winfree S, Ferkowicz MJ, Hato T, Collins KS, Dunn KW, Kelly KJ, Sutton TA, Rovin BH, Parikh SV, Phillips CL, Dagher PC, Eadon MT.
PMID: 33568476
Sci Adv. 2021 Feb 10;7(7). doi: 10.1126/sciadv.abd3359. Print 2021 Feb.

The gene expression signature of the human kidney interstitium is incompletely understood. The cortical interstitium (excluding tubules, glomeruli, and vessels) in reference nephrectomies (

The evolutionary pathways for local adaptation in mountain hares.

Molecular ecology

Giska I, Pimenta J, Farelo L, Boursot P, Hackländer K, Jenny H, Reid N, Montgomery WI, Prodöhl PA, Alves PC, Melo-Ferreira J.
PMID: 34995383
Mol Ecol. 2022 Jan 07; doi: 10.1111/mec.16338. Epub 2022 Jan 07.

Understanding the evolution of local adaptations is a central aim of evolutionary biology and key for the identification of unique populations and lineages of conservation relevance. By combining RAD sequencing and whole-genome sequencing, we identify genetic signatures of local...

[Contextual and individual determinants of use of newborn hearing screening: the Brazilian National Health Survey, 2013].

Cadernos de saude publica

Melo-Ferreira V, Junger WL, Werneck GL.
PMID: 34816960
Cad Saude Publica. 2021 Nov 22;37(11):e00291920. doi: 10.1590/0102-311X00291920. eCollection 2021.

The current study assessed the effect of contextual and individual determinants of the use of newborn hearing screening in Brazilian state capitals and the Federal District. The conceptual theoretical model proposed by Andersen & Davidson (2014) oriented the analyses...

Clinical, histopathologic and molecular features of idiopathic and diabetic nodular mesangial sclerosis in humans.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Eadon MT, Lampe S, Baig MM, Collins KS, Melo Ferreira R, Mang H, Cheng YH, Barwinska D, El-Achkar TM, Schwantes-An TH, Winfree S, Temm CJ, Ferkowicz MJ, Dunn KW, Kelly KJ, Sutton TA, Moe SM, Moorthi RN, Phillips CL, Dagher PC.
PMID: 33537765
Nephrol Dial Transplant. 2021 Feb 04; doi: 10.1093/ndt/gfaa331. Epub 2021 Feb 04.

BACKGROUND: Idiopathic nodular mesangial sclerosis, also called idiopathic nodular glomerulosclerosis (ING), is a rare clinical entity with an unclear pathogenesis. The hallmark of this disease is the presence of nodular mesangial sclerosis on histology without clinical evidence of diabetes...

The Legacy of Recurrent Introgression during the Radiation of Hares.

Systematic biology

Ferreira MS, Jones MR, Callahan CM, Farelo L, Tolesa Z, Suchentrunk F, Boursot P, Mills LS, Alves PC, Good JM, Melo-Ferreira J.
PMID: 33263746
Syst Biol. 2021 Apr 15;70(3):593-607. doi: 10.1093/sysbio/syaa088.

Hybridization may often be an important source of adaptive variation, but the extent and long-term impacts of introgression have seldom been evaluated in the phylogenetic context of a radiation. Hares (Lepus) represent a widespread mammalian radiation of 32 extant...

The evolutionary pathways for local adaptation in mountain hares.

Molecular ecology

Giska I, Pimenta J, Farelo L, Boursot P, Hackländer K, Jenny H, Reid N, Montgomery WI, Prodöhl PA, Alves PC, Melo-Ferreira J.
PMID: 34995383
Mol Ecol. 2022 Jan 07; doi: 10.1111/mec.16338. Epub 2022 Jan 07.

Understanding the evolution of local adaptations is a central aim of evolutionary biology and key for the identification of unique populations and lineages of conservation relevance. By combining RAD sequencing and whole-genome sequencing, we identify genetic signatures of local...

Integration of spatial and single-cell transcriptomics localizes epithelial cell-immune cross-talk in kidney injury.

JCI insight

Melo Ferreira R, Sabo AR, Winfree S, Collins KS, Janosevic D, Gulbronson CJ, Cheng YH, Casbon L, Barwinska D, Ferkowicz MJ, Xuei X, Zhang C, Dunn KW, Kelly KJ, Sutton TA, Hato T, Dagher PC, El-Achkar TM, Eadon MT.
PMID: 34003797
JCI Insight. 2021 Jun 22;6(12). doi: 10.1172/jci.insight.147703.

Single-cell sequencing studies have characterized the transcriptomic signature of cell types within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional and affects cells heterogeneously. We first optimized coordination of spatial transcriptomics and single-nuclear sequencing...

Museomics Dissects the Genetic Basis for Adaptive Seasonal Coloration in the Least Weasel.

Molecular biology and evolution

Miranda I, Giska I, Farelo L, Pimenta J, Zimova M, Bryk J, Dalén L, Mills LS, Zub K, Melo-Ferreira J.
PMID: 34157721
Mol Biol Evol. 2021 Sep 27;38(10):4388-4402. doi: 10.1093/molbev/msab177.

Dissecting the link between genetic variation and adaptive phenotypes provides outstanding opportunities to understand fundamental evolutionary processes. Here, we use a museomics approach to investigate the genetic basis and evolution of winter coat coloration morphs in least weasels (Mustela...

Showing 1 to 12 of 13 entries