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Showing 1 to 12 of 21 entries
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Silymarin released from sterile wafers restores glucose impaired endothelial cell migration.

International journal of pharmaceutics

Gadad PC, Matthews KH, Knott RM.
PMID: 24055598
Int J Pharm. 2013 Nov 30;457(1):40-9. doi: 10.1016/j.ijpharm.2013.09.006. Epub 2013 Sep 18.

Reduced oxygen tension combined with high glucose concentration leads to chronic wounds in diabetic patients. Delayed wound healing is due in part to impaired angiogenesis as a result of reduced endothelial cell migration. Topical applications, in the form of...

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Gadad PC, Matthews KH, Knott RM. Silymarin released from sterile wafers restores glucose impaired endothelial cell migration. Int J Pharm. 2013;457(1):40-9doi: 10.1016/j.ijpharm.2013.09.006.
Gadad, P. C., Matthews, K. H., & Knott, R. M. (2013). Silymarin released from sterile wafers restores glucose impaired endothelial cell migration. International journal of pharmaceutics, 457(1), 40-9. https://doi.org/10.1016/j.ijpharm.2013.09.006
Gadad, Pramod C, et al. "Silymarin released from sterile wafers restores glucose impaired endothelial cell migration." International journal of pharmaceutics vol. 457,1 (2013): 40-9. doi: https://doi.org/10.1016/j.ijpharm.2013.09.006
Gadad PC, Matthews KH, Knott RM. Silymarin released from sterile wafers restores glucose impaired endothelial cell migration. Int J Pharm. 2013 Nov 30;457(1):40-9. doi: 10.1016/j.ijpharm.2013.09.006. Epub 2013 Sep 18. PMID: 24055598.
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Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 15652198
Int J Pharm. 2005 Jan 31;289(1):51-62. doi: 10.1016/j.ijpharm.2004.10.022. Epub 2004 Dec 30.

Lyophilised wafers have potential as drug delivery systems for suppurating wounds. A dual series of wafers made from low molecular weight sodium alginate (SA) and xanthan gum (XG) respectively, modified with high molecular weight methylcellulose (MC) were produced. The...

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Matthews KH, Stevens HN, Auffret AD, et al. Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier. Int J Pharm. 2004;289(1):51-62doi: 10.1016/j.ijpharm.2004.10.022.
Matthews, K. H., Stevens, H. N., Auffret, A. D., Humphrey, M. J., & Eccleston, G. M. (2005). Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier. International journal of pharmaceutics, 289(1), 51-62. https://doi.org/10.1016/j.ijpharm.2004.10.022
Matthews, K H, et al. "Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier." International journal of pharmaceutics vol. 289,1 (2005): 51-62. doi: https://doi.org/10.1016/j.ijpharm.2004.10.022
Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM. Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier. Int J Pharm. 2005 Jan 31;289(1):51-62. doi: 10.1016/j.ijpharm.2004.10.022. Epub 2004 Dec 30. PMID: 15652198.
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Gamma-irradiation of lyophilised wound healing wafers.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 16503387
Int J Pharm. 2006 Apr 26;313(1):78-86. doi: 10.1016/j.ijpharm.2006.01.023. Epub 2006 Feb 28.

Lyophilised wafers are being developed as drug delivery systems that can be applied directly to the surface of suppurating wounds. They are produced by the freeze-drying of polymer solutions and gels. This study investigates the possibility of sterilising these...

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Matthews KH, Stevens HN, Auffret AD, et al. Gamma-irradiation of lyophilised wound healing wafers. Int J Pharm. 2006;313(1):78-86doi: 10.1016/j.ijpharm.2006.01.023.
Matthews, K. H., Stevens, H. N., Auffret, A. D., Humphrey, M. J., & Eccleston, G. M. (2006). Gamma-irradiation of lyophilised wound healing wafers. International journal of pharmaceutics, 313(1), 78-86. https://doi.org/10.1016/j.ijpharm.2006.01.023
Matthews, K H, et al. "Gamma-irradiation of lyophilised wound healing wafers." International journal of pharmaceutics vol. 313,1 (2006): 78-86. doi: https://doi.org/10.1016/j.ijpharm.2006.01.023
Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM. Gamma-irradiation of lyophilised wound healing wafers. Int J Pharm. 2006 Apr 26;313(1):78-86. doi: 10.1016/j.ijpharm.2006.01.023. Epub 2006 Feb 28. PMID: 16503387.
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Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 18280068
Int J Pharm. 2008 May 22;356(1):110-20. doi: 10.1016/j.ijpharm.2007.12.043. Epub 2008 Jan 09.

Lyophilised wafers are being developed as topical drug delivery systems for the treatment of chronic wounds. This study describes the formulation of xanthan wafers containing a selective, insoluble MMP-3 inhibitor (UK-370,106) and a non-ionic surfactant, designed to release accurate...

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Matthews KH, Stevens HN, Auffret AD, et al. Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int J Pharm. 2008;356(1):110-20doi: 10.1016/j.ijpharm.2007.12.043.
Matthews, K. H., Stevens, H. N., Auffret, A. D., Humphrey, M. J., & Eccleston, G. M. (2008). Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. International journal of pharmaceutics, 356(1), 110-20. https://doi.org/10.1016/j.ijpharm.2007.12.043
Matthews, K H, et al. "Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant." International journal of pharmaceutics vol. 356,1 (2008): 110-20. doi: https://doi.org/10.1016/j.ijpharm.2007.12.043
Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM. Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int J Pharm. 2008 May 22;356(1):110-20. doi: 10.1016/j.ijpharm.2007.12.043. Epub 2008 Jan 09. PMID: 18280068.
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Rheological properties of gamma-irradiated antimicrobial wafers and in vitro efficacy against Pseudomonas aeruginosa.

International journal of pharmaceutics

Labovitiadi O, O'Driscoll NH, Lamb AJ, Matthews KH.
PMID: 23791735
Int J Pharm. 2013 Sep 10;453(2):462-72. doi: 10.1016/j.ijpharm.2013.06.005. Epub 2013 Jun 17.

Lyophilised polysaccharide solutions and gels incorporating the broad spectrum antimicrobial compound, chlorhexidine digluconate (CHD), have potential application as self-adhering, topical delivery systems for the prophylaxis and treatment of wound infections. It is desirable to sterilise these dosage forms but...

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Labovitiadi O, O'Driscoll NH, Lamb AJ, et al. Rheological properties of gamma-irradiated antimicrobial wafers and in vitro efficacy against Pseudomonas aeruginosa. Int J Pharm. 2013;453(2):462-72doi: 10.1016/j.ijpharm.2013.06.005.
Labovitiadi, O., O'Driscoll, N. H., Lamb, A. J., & Matthews, K. H. (2013). Rheological properties of gamma-irradiated antimicrobial wafers and in vitro efficacy against Pseudomonas aeruginosa. International journal of pharmaceutics, 453(2), 462-72. https://doi.org/10.1016/j.ijpharm.2013.06.005
Labovitiadi, Olga, et al. "Rheological properties of gamma-irradiated antimicrobial wafers and in vitro efficacy against Pseudomonas aeruginosa." International journal of pharmaceutics vol. 453,2 (2013): 462-72. doi: https://doi.org/10.1016/j.ijpharm.2013.06.005
Labovitiadi O, O'Driscoll NH, Lamb AJ, Matthews KH. Rheological properties of gamma-irradiated antimicrobial wafers and in vitro efficacy against Pseudomonas aeruginosa. Int J Pharm. 2013 Sep 10;453(2):462-72. doi: 10.1016/j.ijpharm.2013.06.005. Epub 2013 Jun 17. PMID: 23791735.
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Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces.

Drug development and industrial pharmacy

Boateng JS, Stevens HN, Eccleston GM, Auffret AD, Humphrey MJ, Matthews KH.
PMID: 19365780
Drug Dev Ind Pharm. 2009 Aug;35(8):986-96. doi: 10.1080/03639040902744704.

Solvent-cast films from three polymers, carboxymethylcellulose (CMC), sodium alginate (SA), and xanthan gum, were prepared by drying the polymeric gels in air. Three methods, (a) passive hydration, (b) vortex hydration with heating, and (c) cold hydration, were investigated to...

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Boateng JS, Stevens HN, Eccleston GM, et al. Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces. Drug Dev Ind Pharm. 2009;35(8):986-96doi: 10.1080/03639040902744704.
Boateng, J. S., Stevens, H. N., Eccleston, G. M., Auffret, A. D., Humphrey, M. J., & Matthews, K. H. (2009). Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces. Drug development and industrial pharmacy, 35(8), 986-96. https://doi.org/10.1080/03639040902744704
Boateng, Joshua S, et al. "Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces." Drug development and industrial pharmacy vol. 35,8 (2009): 986-96. doi: https://doi.org/10.1080/03639040902744704
Boateng JS, Stevens HN, Eccleston GM, Auffret AD, Humphrey MJ, Matthews KH. Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces. Drug Dev Ind Pharm. 2009 Aug;35(8):986-96. doi: 10.1080/03639040902744704. PMID: 19365780.
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In vitro efficacy of antimicrobial wafers against methicillin-resistant Staphylococcus aureus.

Therapeutic delivery

Labovitiadi O, Lamb AJ, Matthews KH.
PMID: 22834076
Ther Deliv. 2012 Apr;3(4):443-55. doi: 10.4155/tde.12.27.

BACKGROUND: Lyophilized wafers have been developed as vehicles for the storage and delivery of therapeutic compounds to exuding wounds. The primary objective of this study was to incorporate a selection of antimicrobial compounds in karaya wafers and measure their...

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Labovitiadi O, Lamb AJ, Matthews KH. In vitro efficacy of antimicrobial wafers against methicillin-resistant Staphylococcus aureus. Ther Deliv. 2012;3(4):443-55doi: 10.4155/tde.12.27.
Labovitiadi, O., Lamb, A. J., & Matthews, K. H. (2012). In vitro efficacy of antimicrobial wafers against methicillin-resistant Staphylococcus aureus. Therapeutic delivery, 3(4), 443-55. https://doi.org/10.4155/tde.12.27
Labovitiadi, Olga, et al. "In vitro efficacy of antimicrobial wafers against methicillin-resistant Staphylococcus aureus." Therapeutic delivery vol. 3,4 (2012): 443-55. doi: https://doi.org/10.4155/tde.12.27
Labovitiadi O, Lamb AJ, Matthews KH. In vitro efficacy of antimicrobial wafers against methicillin-resistant Staphylococcus aureus. Ther Deliv. 2012 Apr;3(4):443-55. doi: 10.4155/tde.12.27. PMID: 22834076.
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Synthesis and blood compatibility evaluation of segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties.

Biomaterials

Li YJ, Yokawa T, Matthews KH, Chen TM, Wang YF, Kodama M, Nakaya T.
PMID: 8922604
Biomaterials. 1996 Nov;17(22):2179-89. doi: 10.1016/0142-9612(96)00048-8.

New segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties were synthesized. The soft segments used in this study were the poly(butadiene), poly(isoprene) or hydrogenated poly(isoprene) glycols; the hard segments of these segmented polyurethanes were composed of 4,4'-methylenediphenyl diisocyanate,...

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Li YJ, Yokawa T, Matthews KH, et al. Synthesis and blood compatibility evaluation of segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties. Biomaterials. 1996;17(22):2179-89doi: 10.1016/0142-9612(96)00048-8.
Li, Y. J., Yokawa, T., Matthews, K. H., Chen, T. M., Wang, Y. F., Kodama, M., & Nakaya, T. (1996). Synthesis and blood compatibility evaluation of segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties. Biomaterials, 17(22), 2179-89. https://doi.org/10.1016/0142-9612(96)00048-8
Li, Y J, et al. "Synthesis and blood compatibility evaluation of segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties." Biomaterials vol. 17,22 (1996): 2179-89. doi: https://doi.org/10.1016/0142-9612(96)00048-8
Li YJ, Yokawa T, Matthews KH, Chen TM, Wang YF, Kodama M, Nakaya T. Synthesis and blood compatibility evaluation of segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties. Biomaterials. 1996 Nov;17(22):2179-89. doi: 10.1016/0142-9612(96)00048-8. PMID: 8922604.
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Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis.

International journal of pharmaceutics

McKenzie B, Kay G, Matthews KH, Knott R, Cairns D.
PMID: 27771488
Int J Pharm. 2016 Dec 30;515(1):575-582. doi: 10.1016/j.ijpharm.2016.10.044. Epub 2016 Oct 19.

Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all organs. It is treated by regular administration of the aminothiol, cysteamine. Corneal crystal deposition is one of the most...

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McKenzie B, Kay G, Matthews KH, et al. Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis. Int J Pharm. 2016;515(1):575-582doi: 10.1016/j.ijpharm.2016.10.044.
McKenzie, B., Kay, G., Matthews, K. H., Knott, R., & Cairns, D. (2016). Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis. International journal of pharmaceutics, 515(1), 575-582. https://doi.org/10.1016/j.ijpharm.2016.10.044
McKenzie, Barbara, et al. "Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis." International journal of pharmaceutics vol. 515,1 (2016): 575-582. doi: https://doi.org/10.1016/j.ijpharm.2016.10.044
McKenzie B, Kay G, Matthews KH, Knott R, Cairns D. Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis. Int J Pharm. 2016 Dec 30;515(1):575-582. doi: 10.1016/j.ijpharm.2016.10.044. Epub 2016 Oct 19. PMID: 27771488.
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The hen's egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of a cysteamine-containing gel: Quantification using Photoshop® and ImageJ.

International journal of pharmaceutics

McKenzie B, Kay G, Matthews KH, Knott RM, Cairns D.
PMID: 25980731
Int J Pharm. 2015 Jul 25;490(1):1-8. doi: 10.1016/j.ijpharm.2015.05.023. Epub 2015 May 14.

A modified hen's egg chorioallantoic membrane (HET-CAM) test has been developed, combining ImageJ analysis with Adobe(®) Photoshop(®). The irritation potential of an ophthalmic medicine can be quantified using this method, by monitoring damage to blood vessels. The evaluation of...

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McKenzie B, Kay G, Matthews KH, et al. The hen's egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of a cysteamine-containing gel: Quantification using Photoshop® and ImageJ. Int J Pharm. 2015;490(1):1-8doi: 10.1016/j.ijpharm.2015.05.023.
McKenzie, B., Kay, G., Matthews, K. H., Knott, R. M., & Cairns, D. (2015). The hen's egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of a cysteamine-containing gel: Quantification using Photoshop® and ImageJ. International journal of pharmaceutics, 490(1), 1-8. https://doi.org/10.1016/j.ijpharm.2015.05.023
McKenzie, Barbara, et al. "The hen's egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of a cysteamine-containing gel: Quantification using Photoshop® and ImageJ." International journal of pharmaceutics vol. 490,1 (2015): 1-8. doi: https://doi.org/10.1016/j.ijpharm.2015.05.023
McKenzie B, Kay G, Matthews KH, Knott RM, Cairns D. The hen's egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of a cysteamine-containing gel: Quantification using Photoshop® and ImageJ. Int J Pharm. 2015 Jul 25;490(1):1-8. doi: 10.1016/j.ijpharm.2015.05.023. Epub 2015 May 14. PMID: 25980731.
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Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces.

International journal of pharmaceutics

Boateng JS, Auffret AD, Matthews KH, Humphrey MJ, Stevens HN, Eccleston GM.
PMID: 20083177
Int J Pharm. 2010 Apr 15;389(1):24-31. doi: 10.1016/j.ijpharm.2010.01.008. Epub 2010 Jan 18.

Freeze-dried (lyophilised) wafers and solvent cast films from sodium alginate (ALG) and sodium carboxymethylcellulose (CMC) have been developed as potential drug delivery systems for mucosal surfaces including wounds. The wafers (ALG, CMC) and films (CMC) were prepared by freeze-drying...

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Boateng JS, Auffret AD, Matthews KH, et al. Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces. Int J Pharm. 2010;389(1):24-31doi: 10.1016/j.ijpharm.2010.01.008.
Boateng, J. S., Auffret, A. D., Matthews, K. H., Humphrey, M. J., Stevens, H. N., & Eccleston, G. M. (2010). Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces. International journal of pharmaceutics, 389(1), 24-31. https://doi.org/10.1016/j.ijpharm.2010.01.008
Boateng, Joshua S, et al. "Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces." International journal of pharmaceutics vol. 389,1 (2010): 24-31. doi: https://doi.org/10.1016/j.ijpharm.2010.01.008
Boateng JS, Auffret AD, Matthews KH, Humphrey MJ, Stevens HN, Eccleston GM. Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces. Int J Pharm. 2010 Apr 15;389(1):24-31. doi: 10.1016/j.ijpharm.2010.01.008. Epub 2010 Jan 18. PMID: 20083177.
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Comparison of the in vitro release characteristics of mucosal freeze-dried wafers and solvent-cast films containing an insoluble drug.

Drug development and industrial pharmacy

Boateng JS, Matthews KH, Auffret AD, Humphrey MJ, Eccleston GM, Stevens HN.
PMID: 21714725
Drug Dev Ind Pharm. 2012 Jan;38(1):47-54. doi: 10.3109/03639045.2011.590496. Epub 2011 Jun 30.

Drug release characteristics of freeze-dried wafers and solvent-cast films prepared from sodium carboxymethylcellulose have been investigated and compared. In vitro drug dissolution studies were performed using an exchange cell and drug release was measured by UV spectroscopy at 272...

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Boateng JS, Matthews KH, Auffret AD, et al. Comparison of the in vitro release characteristics of mucosal freeze-dried wafers and solvent-cast films containing an insoluble drug. Drug Dev Ind Pharm. 2011;38(1):47-54doi: 10.3109/03639045.2011.590496.
Boateng, J. S., Matthews, K. H., Auffret, A. D., Humphrey, M. J., Eccleston, G. M., & Stevens, H. N. (2012). Comparison of the in vitro release characteristics of mucosal freeze-dried wafers and solvent-cast films containing an insoluble drug. Drug development and industrial pharmacy, 38(1), 47-54. https://doi.org/10.3109/03639045.2011.590496
Boateng, Joshua S, et al. "Comparison of the in vitro release characteristics of mucosal freeze-dried wafers and solvent-cast films containing an insoluble drug." Drug development and industrial pharmacy vol. 38,1 (2012): 47-54. doi: https://doi.org/10.3109/03639045.2011.590496
Boateng JS, Matthews KH, Auffret AD, Humphrey MJ, Eccleston GM, Stevens HN. Comparison of the in vitro release characteristics of mucosal freeze-dried wafers and solvent-cast films containing an insoluble drug. Drug Dev Ind Pharm. 2012 Jan;38(1):47-54. doi: 10.3109/03639045.2011.590496. Epub 2011 Jun 30. PMID: 21714725.
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Showing 1 to 12 of 21 entries