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Showing 1 to 12 of 44 entries
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Screening for GPR101 defects in pediatric pituitary corticotropinomas.

Endocrine-related cancer

Trivellin G, Correa RR, Batsis M, Faucz FR, Chittiboina P, Bjelobaba I, Larco DO, Quezado M, Daly AF, Stojilkovic SS, Wu TJ, Beckers A, Lodish M, Stratakis CA.
PMID: 26962002
Endocr Relat Cancer. 2016 Jun 01;23(5):357-365. doi: 10.1530/ERC-16-0091.

Cushing disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as MEN1, CDKIs, AIP, and USP8 have been identified in pediatric CD, but the genetic defects in a significant...

Replication of the RNA of Bacteriophage f2.

Science (New York, N.Y.)

Lodish HF, Zinder ND.
PMID: 17775172
Science. 1966 Apr 15;152(3720):372-7. doi: 10.1126/science.152.3720.372.

Events occurring after infection of bacteria with wild-type and a temperature-sensitive mutant phage indicate that there are two enzymatic activities necessary to replicate phage RNA. One converts single strands into double strands, while the other uses double strands to...

The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction.

Trends in endocrinology and metabolism: TEM

Constantinescu SN, Ghaffari S, Lodish HF.
PMID: 10322390
Trends Endocrinol Metab. 1999 Dec;10(1):18-23. doi: 10.1016/s1043-2760(98)00101-5.

Erythropoietin (Epo) and its receptor (EpoR) are essential for proliferation, differentiation and survival of erythroid progenitors. Here, we review several mechanisms by which the EpoR can be activated. We also describe the many intracellular signal transduction pathways activated by...

Harvey Cushing Treated the First Known Patient With Carney Complex.

Journal of the Endocrine Society

Tsay CJ, Stratakis CA, Faucz FR, London E, Stathopoulou C, Allgauer M, Quezado M, Dagradi T, Spencer DD, Lodish M.
PMID: 29264456
J Endocr Soc. 2017 Sep 28;1(10):1312-1321. doi: 10.1210/js.2017-00283. eCollection 2017 Oct 01.

CONTEXT: Carney complex (CNC) is a syndrome characterized by hyperplasia of endocrine organs and may present with clinical features of Cushing syndrome and acromegaly due to functional adrenal and pituitary gland tumors. CNC has been linked to mutations in...

Cushing syndrome and glucocorticoids: T-cell lymphopenia, apoptosis, and rescue by IL-21.

The Journal of allergy and clinical immunology

Hwang S, Tatsi C, Kuehn HS, Niemela JE, Stoddard J, Su Y, Lodish M, Uzel G, Spolski R, Leonard WJ, Holland SM, Fleisher TA, Stratakis CA, Rosenzweig SD.
PMID: 34089750
J Allergy Clin Immunol. 2022 Jan;149(1):302-314. doi: 10.1016/j.jaci.2021.05.031. Epub 2021 Jun 02.

BACKGROUND: Pediatric endogenous Cushing syndrome (eCs) is mainly caused by pituitary corticotropin-producing adenomas, and most glucocorticoid-dependent effects progressively regress upon tumor removal. eCs reproduces long-term, high-dose glucocorticoid therapy, representing a clean, natural, and unbiased model in which to study...

Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease.

Endocrinology, diabetes & metabolism

Blain H, Sinaii N, Zeltser D, Lyssikatos C, Belyavskaya E, Keil M, Bluemke DA, Stratakis C, Bandettini WP, Lodish M.
PMID: 31008362
Endocrinol Diabetes Metab. 2019 Jan 15;2(2):e00054. doi: 10.1002/edm2.54. eCollection 2019 Apr.

OBJECTIVE: To investigate early signs of cardiovascular arterial remodelling in paediatric patients with Cushing syndrome (CS) in comparison with normative values from healthy children.STUDY DESIGN: The metrics used to assess cardiac health were from thoracic aorta and carotid MRI....

Processing and secretion of insulin-related peptides in an insulinoma cell line.

Biotechnology and bioengineering

Grampp GE, Lodish HF, Stephanopoulos G.
PMID: 18633982
Biotechnol Bioeng. 1997 Feb 05;53(3):283-9. doi: 10.1002/(SICI)1097-0290(19970205)53:3<283::AID-BIT6>3.0.CO;2-E.

Certain classes of prohormones and other neuroendocrine or endocrine-derived secretory proteins are post-translationally modified in the secretory storage granules. If such molecules were to be biosynthesized to acceptable quantity and yield using endocrine-derived cell lines, it would be important...

Molecular mechanism of long-chain fatty acid uptake.

Trends in cardiovascular medicine

Schaffer JE, Lodish HF.
PMID: 21232263
Trends Cardiovasc Med. 1995 Nov-Dec;5(6):218-24. doi: 10.1016/1050-1738(95)00102-6.

Most eukaryotic cells are capable of taking up long-chain fatty acids (LCFAs) to be used for a variety of cellular processes. Low levels of cellular uptake may occur by simple diffusion of these hydrophobic molecules through the plasma membrane....

Use of regulated secretion in protein production from animal cells: an evaluation with the AtT-20 model cell line.

Biotechnology and bioengineering

Sambanis A, Stephanopoulos G, Sinskey AJ, Lodish HF.
PMID: 18592577
Biotechnol Bioeng. 1990 Apr 05;35(8):771-80. doi: 10.1002/bit.260350804.

Regulated secretion, i.e., the ability of certain specialized animal cells to store secretory proteins intracellularly and release them upon stimulation, may be used to realize production schemes that facilitate downstream processing of protein products. Mouse AtT-20 cells expressing recombinant...

Pituitary abnormalities in patients with Fanconi anaemia.

Clinical endocrinology

Kanakatti Shankar R, Giri N, Lodish MB, Butman JA, Patronas NJ, Sinaii N, Keil M, Alter BP, Stratakis CA.
PMID: 26300308
Clin Endocrinol (Oxf). 2016 Feb;84(2):307-309. doi: 10.1111/cen.12883. Epub 2015 Sep 22.

No abstract available.

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Deshycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF, Ploegh HL.
PMID: 28270614
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3157-3162. doi: 10.1073/pnas.1701746114. Epub 2017 Mar 07.

Current therapies for autoimmune diseases rely on traditional immunosuppressive medications that expose patients to an increased risk of opportunistic infections and other complications. Immunoregulatory interventions that act prophylactically or therapeutically to induce antigen-specific tolerance might overcome these obstacles. Here...

Case report: Tension pneumomediastinum from opioid inhalation.

The American journal of emergency medicine

Nene RV, Hryniewicki AT, Roderick E, Chicotka S, Vazquez MH, Thistlewaite PA, Coffey C, Odish MF.
PMID: 34556391
Am J Emerg Med. 2021 Sep 04; doi: 10.1016/j.ajem.2021.09.008. Epub 2021 Sep 04.

Pneumomediastinum is a rare complication of substance use, likely due to a Valsalva maneuver after drug inhalation. There are no previously documented associations between pneumomediastinum and opioid use. A 30-year-old man with a history of recent heroin and fentanyl...

Showing 1 to 12 of 44 entries