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Pharmacokinetics of fenclofenac following single and multiple doses.

European journal of drug metabolism and pharmacokinetics

Henson R, Lloyd-Jones JG, Nichols JD, Jordan BJ.
PMID: 7250145
Eur J Drug Metab Pharmacokinet. 1980;5(4):217-23. doi: 10.1007/BF03189467.

The plasma concentration of the anti-inflammatory drug fenclofenac was investigated in volunteers following single oral doses of 200, 500 and 600 mg, as well as multiple doses of 600mg b.i.d. over five days, using gas chromatography with electron capture...

The pharmacokinetics after intravenous and oral administration in man of the alpha 2-adrenoreceptor antagonist idazoxan (RX781094).

European journal of clinical pharmacology

Muir NC, Lloyd-Jones JG, Nichols JD, Clifford JM.
PMID: 2872058
Eur J Clin Pharmacol. 1986;29(6):743-5. doi: 10.1007/BF00615972.

A high performance liquid chromatographic method was developed for the quantitative determination of idazoxan in plasma. The assay was used to study the disposition of the drug after intravenous infusion and oral administration to five normal subjects. After i.v....

The stereochemistry of hydrogen elimination from C-7 during biosynthesis of ecdysones in insects and plants.

The Biochemical journal

Cook IF, Lloyd-Jones JG, Rees HH, Goodwin TW.
PMID: 4772621
Biochem J. 1973 Sep;136(1):135-45. doi: 10.1042/bj1360135.
Free PMC Article

1. [7alpha-(3)H(1)]- and [7beta-(3)H(1)]-Cholesterol were synthesized by a modified method. 2. The stereochemistry of Delta(7)-bond formation during ecdysone and ecdysterone biosynthesis in the insect, Calliphora erythrocephala and the plants, Taxus baccata and Polypodium vulgare was investigated by using [4-(14)C,7alpha-(3)H(1)]cholesterol...

The pharmacokinetics and metabolism of idazoxan in the rat.

Xenobiotica; the fate of foreign compounds in biological systems

Lewis CJ, Havler ME, Humphrey MJ, Lloyd-Jones JG, McCleavy MA, Muir NC, Waltham K.
PMID: 2899932
Xenobiotica. 1988 May;18(5):519-32. doi: 10.3109/00498258809041689.

1. [2'-14C]Idazoxan was rapidly and completely absorbed after its oral administration to rats. 2. After administration of either [2'-14C] or [6,7-3H]idazoxan, radioactivity was taken up by a wide range of tissues and became localized, especially in the organs of...

Naloxone suppresses buprenorphine stimulation of plasma prolactin.

Journal of clinical psychopharmacology

Mendelson JH, Mello NK, Teoh SK, Lloyd-Jones JG, Clifford JM.
PMID: 2723127
J Clin Psychopharmacol. 1989 Apr;9(2):105-9. doi: 10.1097/00004714-198904000-00006.

The effects of parenterally-administered buprenorphine and simultaneous injection of naloxone was evaluated in six healthy adult males. Each subject was studied on six occasions, an average of 10 days apart, and received either two simultaneous intramuscular injections of saline,...

Pharmacokinetics of intravenous and oral tolmesoxide.

European journal of clinical pharmacology

Lloyd-Jones JG, Henson R, Nichols JD, Greenslade D, Clifford JM.
PMID: 7202471
Eur J Clin Pharmacol. 1981 Jan;19(2):119-25. doi: 10.1007/BF00568398.

A high pressure liquid chromatographic assay was developed for simultaneous measurement of the plasma levels of tolmesoxide and its principal metabolite, RX71112. The assay was used to study the disposition of intravenous and oral tolmesoxide in ten normotensive subjects....

Danazol plasma concentration in man.

The Journal of international medical research

Lloyd-Jones JG.
PMID: 913879
J Int Med Res. 1977;5:18-24.

No abstract available.

The radioimmunoassay of buprenorphine.

European journal of clinical pharmacology

Bartlett AJ, Lloyd-Jones JG, Rance MJ, Flockhart IR, Dockray GJ, Bennett MR, Moore RA.
PMID: 7439255
Eur J Clin Pharmacol. 1980 Oct;18(4):339-45. doi: 10.1007/BF00561392.

Antisera to buprenorphine were obtained in rabbits immunised with 3-0-carboxymethylbuprenorphine and N-hemisuccinyl-norbuprenorphine conjugated to bovine serum albumin. Using the latter antiserum and tritium labelled buprenorphine a radioimmunoassay have good accuracy and precision was developed for concentrations as low as...

The role of L-(methyl- 3 H, 14 C)methionine in the biosynthesis of polyprenoids. I. The incorporation of L-(methyl- 3 H, 14 C)methionine in cholesterol and 5 -cholest-7-en-3 -ol in vivo in the rat.

The Journal of biological chemistry

Lloyd-Jones JG, Heidel P, Yagen B, Doyle PJ, Friedell GH, Caspi E.
PMID: 4651650
J Biol Chem. 1972 Oct 10;247(19):6347-54.
Free Article

No abstract available.

Plasma concentration and disposition of buprenorphine after intravenous and intramuscular doses to baboons.

European journal of drug metabolism and pharmacokinetics

Lloyd-Jones JG, Robinson P, Henson R, Biggs SR, Taylor T.
PMID: 7250147
Eur J Drug Metab Pharmacokinet. 1980;5(4):233-9. doi: 10.1007/BF03189469.

Buprenorphine is a newly-developed strong analgesic. A selected ion monitoring method has been developed to measure its plasma levels over the concentration range 20-3000ng ml-1. Six baboons each received intravenous and intramuscular doses of buprenorphine hydrochloride at a level...

Showing 1 to 10 of 10 entries