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Showing 1 to 12 of 28 entries
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Biomarkers and Periodontal Regenerative Approaches.

Dental clinics of North America

Gürsoy UK, Gürsoy M, Könönen E.
PMID: 34794552
Dent Clin North Am. 2022 Jan;66(1):157-167. doi: 10.1016/j.cden.2021.06.006. Epub 2021 Jul 31.

The ultimate goal in periodontal therapy is the complete re-establishment of the lost tissues. Dental researchers and clinicians are continuously working to develop current therapeutic techniques and technologies that can regenerate damaged periodontal tissues. Predicting the outcome of the...

Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP.

Journal of oral microbiology

Onyedibe KI, Elmanfi S, Aryal UK, Könönen E, Gürsoy UK, Sintim HO.
PMID: 34992733
J Oral Microbiol. 2021 Dec 29;14(1):2003617. doi: 10.1080/20002297.2021.2003617. eCollection 2022.

BACKGROUND: Constant exposure of human gingival fibroblasts (HGFs) to oral pathogens trigger selective immune responses. Recently, the activation of immune response to cyclic dinucleotides (CDNs) via STING has come to the forefront. Reports show that other proteins outside the...

Brain Response Induced with Paired Associative Stimulation Is Related to Repetition Suppression of Motor Evoked Potential.

Brain sciences

Kariminezhad S, Karhu J, Säisänen L, Reijonen J, Könönen M, Julkunen P.
PMID: 32993079
Brain Sci. 2020 Sep 26;10(10). doi: 10.3390/brainsci10100674.

Repetition suppression (RS), i.e., the reduction of neuronal activity upon repetition of an external stimulus, can be demonstrated in the motor system using transcranial magnetic stimulation (TMS). We evaluated the RS in relation to the neuroplastic changes induced by...

Effects of knee flexion and extension on the tibial tuberosity-trochlear groove (TT-TG) distance in adolescents.

Journal of experimental orthopaedics

Suomalainen JS, Regalado G, Joukainen A, Kääriäinen T, Könönen M, Manninen H, Sipola P, Kokki H.
PMID: 30116908
J Exp Orthop. 2018 Aug 16;5(1):31. doi: 10.1186/s40634-018-0149-1.

BACKGROUND: Measurement of the tibial tubercle-trochlear groove (TT-TG) distance is used to assess patellofemoral instability and rotation. Since patellofemoral instability and acute patellar dislocation are common among adolescents, it is important to clarify the relationship between TT-TG distance and...

Characterization of Actinomyces species isolated from failed dental implant fixtures.

Anaerobe

Sarkonen N, Könönen E, Eerola E, Könönen M, Jousimies-Somer H, Laine P.
PMID: 16701573
Anaerobe. 2005 Aug;11(4):231-7. doi: 10.1016/j.anaerobe.2005.01.002. Epub 2005 Apr 07.

In the oral cavity, Actinomyces form a fundamental component of the indigenous microflora, being among initial colonizers in polymicrobial biofilms. However, some differences may exist between different species in terms of their attachment not only to teeth but also...

Combining transcranial magnetic stimulation and electroencephalography may contribute to assess the severity of Alzheimer's disease.

International journal of Alzheimer's disease

Julkunen P, Jauhiainen AM, Könönen M, Pääkkönen A, Karhu J, Soininen H.
PMID: 21629763
Int J Alzheimers Dis. 2011;2011:654794. doi: 10.4061/2011/654794. Epub 2011 May 15.

Alzheimer's disease (AD) is the most common form of old age dementia, and mild cognitive impairment (MCI) often precedes AD. In our previous study (Julkunen et al. 2008), we found that the combination of transcranial magnetic stimulation (TMS) and...

Bacterial Cyclic Dinucleotides and the cGAS-cGAMP-STING Pathway: A Role in Periodontitis?.

Pathogens (Basel, Switzerland)

Elmanfi S, Yilmaz M, Ong WWS, Yeboah KS, Sintim HO, Gürsoy M, Könönen E, Gürsoy UK.
PMID: 34070809
Pathogens. 2021 May 30;10(6). doi: 10.3390/pathogens10060675.

Host cells can recognize cytosolic double-stranded DNAs and endogenous second messengers as cyclic dinucleotides-including c-di-GMP, c-di-AMP, and cGAMP-of invading microbes via the critical and essential innate immune signaling adaptor molecule known as STING. This recognition activates the innate immune...

Influence of early life risk factors and lifestyle on systemic vascular resistance in later adulthood: the cardiovascular risk in young Finns study.

Blood pressure

Kähönen E, Aatola H, Lehtimäki T, Haarala A, Sipilä K, Juonala M, Raitakari OT, Kähönen M, Hutri-Kähönen N.
PMID: 34605743
Blood Press. 2021 Dec;30(6):367-375. doi: 10.1080/08037051.2021.1980372. Epub 2021 Oct 04.

PURPOSE: There are limited data available concerning the effects of lifetime risk factors and lifestyle on systemic hemodynamics, especially on systemic vascular resistance. The purpose of the study was to evaluate how lifetime cardiovascular risk factors (body mass index...

TMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer's Disease: A Proof-of-Concept Six Years Prospective Study.

Frontiers in aging neuroscience

Ferreri F, Guerra A, Vollero L, Ponzo D, Määtta S, Könönen M, Vecchio F, Pasqualetti P, Miraglia F, Simonelli I, Corbetta M, Rossini PM.
PMID: 34880743
Front Aging Neurosci. 2021 Nov 22;13:737281. doi: 10.3389/fnagi.2021.737281. eCollection 2021.

No abstract available.

Construction and characterization of a multilayered gingival keratinocyte culture model: the TURK-U model.

Cytotechnology

Gursoy UK, Gursoy M, Könönen E, Sintim HO, Uitto VJ, Syrjänen S.
PMID: 27752840
Cytotechnology. 2016 Dec;68(6):2345-2354. doi: 10.1007/s10616-016-0029-4. Epub 2016 Oct 17.

In construction of epithelial cells as multilayers, the cells are grown submerged to confluence on fibroblast-embedded collagen gels and, then, lifted to air to promote their stratification. We recently demonstrated that gingival epithelial cells form uniform monolayers on semi-permeable...

Monolithic perovskite/silicon tandem solar cell with >29% efficiency by enhanced hole extraction.

Science (New York, N.Y.)

Al-Ashouri A, Köhnen E, Li B, Magomedov A, Hempel H, Caprioglio P, Márquez JA, Morales Vilches AB, Kasparavicius E, Smith JA, Phung N, Menzel D, Grischek M, Kegelmann L, Skroblin D, Gollwitzer C, Malinauskas T, Jošt M, Matič G, Rech B, Schlatmann R, Topič M, Korte L, Abate A, Stannowski B, Neher D, Stolterfoht M, Unold T, Getautis V, Albrecht S.
PMID: 33303611
Science. 2020 Dec 11;370(6522):1300-1309. doi: 10.1126/science.abd4016.

Tandem solar cells that pair silicon with a metal halide perovskite are a promising option for surpassing the single-cell efficiency limit. We report a monolithic perovskite/silicon tandem with a certified power conversion efficiency of 29.15%. The perovskite absorber, with...

Properties of hemagglutination by Prevotella melaninogenica.

Anaerobe

Haraldsson G, Meurman JH, Könönen E, Holbrook WP.
PMID: 16701585
Anaerobe. 2005 Oct;11(5):285-9. doi: 10.1016/j.anaerobe.2005.02.004. Epub 2005 Apr 26.

Although Prevotella melaninogenica belongs to the commensal oral microbiota, some strains possess putative virulence factors. For example, we have previously described fimbriated, hemagglutinating strains of P. melaninogenica, isolated from patients with periodontal disease. The aim of this investigation was...

Showing 1 to 12 of 28 entries