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Showing 1 to 12 of 45 entries
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The metabolism and pharmacokinetics of amlodipine in humans and animals.

Journal of cardiovascular pharmacology

Stopher DA, Beresford AP, Macrae PV, Humphrey MJ.
PMID: 2467130
J Cardiovasc Pharmacol. 1988;12:S55-9. doi: 10.1097/00005344-198812007-00012.

The disposition of amlodipine, a new calcium-channel blocker with a slow onset and long duration of action, has been investigated in humans and in the animal species used in the evaluation of drug efficacy and safety. Pharmacokinetic studies were...

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Stopher DA, Beresford AP, Macrae PV, et al. The metabolism and pharmacokinetics of amlodipine in humans and animals. J Cardiovasc Pharmacol. 1988;12:S55-9doi: 10.1097/00005344-198812007-00012.
Stopher, D. A., Beresford, A. P., Macrae, P. V., & Humphrey, M. J. (1988). The metabolism and pharmacokinetics of amlodipine in humans and animals. Journal of cardiovascular pharmacology, 12S55-9. https://doi.org/10.1097/00005344-198812007-00012
Stopher, D A, et al. "The metabolism and pharmacokinetics of amlodipine in humans and animals." Journal of cardiovascular pharmacology vol. 12 (1988): S55-9. doi: https://doi.org/10.1097/00005344-198812007-00012
Stopher DA, Beresford AP, Macrae PV, Humphrey MJ. The metabolism and pharmacokinetics of amlodipine in humans and animals. J Cardiovasc Pharmacol. 1988;12:S55-9. doi: 10.1097/00005344-198812007-00012. PMID: 2467130.
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Role of metabolism and pharmacokinetic studies in the discovery of new drugs--present and future perspectives.

Xenobiotica; the fate of foreign compounds in biological systems

Humphrey MJ, Smith DA.
PMID: 1455898
Xenobiotica. 1992 Jul;22(7):743-55. doi: 10.3109/00498259209053137.

1. The impact which pharmacokinetics and drug metabolism studies have made to drug discovery programmes is reviewed with examples from the anti-infective, cardiovascular, anti-inflammatory and CNS therapeutic areas. 2. Contributions that advances in analytical technology have made to the...

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Humphrey MJ, Smith DA. Role of metabolism and pharmacokinetic studies in the discovery of new drugs--present and future perspectives. Xenobiotica. 1992;22(7):743-55doi: 10.3109/00498259209053137.
Humphrey, M. J., & Smith, D. A. (1992). Role of metabolism and pharmacokinetic studies in the discovery of new drugs--present and future perspectives. Xenobiotica; the fate of foreign compounds in biological systems, 22(7), 743-55. https://doi.org/10.3109/00498259209053137
Humphrey, M J, and Smith, D A. "Role of metabolism and pharmacokinetic studies in the discovery of new drugs--present and future perspectives." Xenobiotica; the fate of foreign compounds in biological systems vol. 22,7 (1992): 743-55. doi: https://doi.org/10.3109/00498259209053137
Humphrey MJ, Smith DA. Role of metabolism and pharmacokinetic studies in the discovery of new drugs--present and future perspectives. Xenobiotica. 1992 Jul;22(7):743-55. doi: 10.3109/00498259209053137. PMID: 1455898.
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The pharmacokinetics and metabolism of idazoxan in the rat.

Xenobiotica; the fate of foreign compounds in biological systems

Lewis CJ, Havler ME, Humphrey MJ, Lloyd-Jones JG, McCleavy MA, Muir NC, Waltham K.
PMID: 2899932
Xenobiotica. 1988 May;18(5):519-32. doi: 10.3109/00498258809041689.

1. [2'-14C]Idazoxan was rapidly and completely absorbed after its oral administration to rats. 2. After administration of either [2'-14C] or [6,7-3H]idazoxan, radioactivity was taken up by a wide range of tissues and became localized, especially in the organs of...

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Lewis CJ, Havler ME, Humphrey MJ, et al. The pharmacokinetics and metabolism of idazoxan in the rat. Xenobiotica. 1988;18(5):519-32doi: 10.3109/00498258809041689.
Lewis, C. J., Havler, M. E., Humphrey, M. J., Lloyd-Jones, J. G., McCleavy, M. A., Muir, N. C., & Waltham, K. (1988). The pharmacokinetics and metabolism of idazoxan in the rat. Xenobiotica; the fate of foreign compounds in biological systems, 18(5), 519-32. https://doi.org/10.3109/00498258809041689
Lewis, C J, et al. "The pharmacokinetics and metabolism of idazoxan in the rat." Xenobiotica; the fate of foreign compounds in biological systems vol. 18,5 (1988): 519-32. doi: https://doi.org/10.3109/00498258809041689
Lewis CJ, Havler ME, Humphrey MJ, Lloyd-Jones JG, McCleavy MA, Muir NC, Waltham K. The pharmacokinetics and metabolism of idazoxan in the rat. Xenobiotica. 1988 May;18(5):519-32. doi: 10.3109/00498258809041689. PMID: 2899932.
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Disposition of azole antifungal agents. II. Hepatic binding and clearance of dichlorophenyl-bis-triazolylpropanol (DTP) in the rat.

Pharmaceutical research

Bomont HL, Tarbit MH, Humphrey MJ, Houston JB.
PMID: 7937554
Pharm Res. 1994 Jul;11(7):951-60. doi: 10.1023/a:1018966800208.

DTP (dichlorophenyl-bis-triazolylpropanol) was evaluated as a probe of drug-cytochromes P450 interactions in vitro and in vivo. Studies with rat liver microsomes demonstrate that DTP shows similar P450 binding affinity to its analog, ketoconazole, as determined by P450 difference spectra...

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Bomont HL, Tarbit MH, Humphrey MJ, et al. Disposition of azole antifungal agents. II. Hepatic binding and clearance of dichlorophenyl-bis-triazolylpropanol (DTP) in the rat. Pharm Res. 1994;11(7):951-60doi: 10.1023/a:1018966800208.
Bomont, H. L., Tarbit, M. H., Humphrey, M. J., & Houston, J. B. (1994). Disposition of azole antifungal agents. II. Hepatic binding and clearance of dichlorophenyl-bis-triazolylpropanol (DTP) in the rat. Pharmaceutical research, 11(7), 951-60. https://doi.org/10.1023/a:1018966800208
Bomont, H L, et al. "Disposition of azole antifungal agents. II. Hepatic binding and clearance of dichlorophenyl-bis-triazolylpropanol (DTP) in the rat." Pharmaceutical research vol. 11,7 (1994): 951-60. doi: https://doi.org/10.1023/a:1018966800208
Bomont HL, Tarbit MH, Humphrey MJ, Houston JB. Disposition of azole antifungal agents. II. Hepatic binding and clearance of dichlorophenyl-bis-triazolylpropanol (DTP) in the rat. Pharm Res. 1994 Jul;11(7):951-60. doi: 10.1023/a:1018966800208. PMID: 7937554.
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Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 15652198
Int J Pharm. 2005 Jan 31;289(1):51-62. doi: 10.1016/j.ijpharm.2004.10.022. Epub 2004 Dec 30.

Lyophilised wafers have potential as drug delivery systems for suppurating wounds. A dual series of wafers made from low molecular weight sodium alginate (SA) and xanthan gum (XG) respectively, modified with high molecular weight methylcellulose (MC) were produced. The...

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Matthews KH, Stevens HN, Auffret AD, et al. Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier. Int J Pharm. 2004;289(1):51-62doi: 10.1016/j.ijpharm.2004.10.022.
Matthews, K. H., Stevens, H. N., Auffret, A. D., Humphrey, M. J., & Eccleston, G. M. (2005). Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier. International journal of pharmaceutics, 289(1), 51-62. https://doi.org/10.1016/j.ijpharm.2004.10.022
Matthews, K H, et al. "Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier." International journal of pharmaceutics vol. 289,1 (2005): 51-62. doi: https://doi.org/10.1016/j.ijpharm.2004.10.022
Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM. Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier. Int J Pharm. 2005 Jan 31;289(1):51-62. doi: 10.1016/j.ijpharm.2004.10.022. Epub 2004 Dec 30. PMID: 15652198.
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Gamma-irradiation of lyophilised wound healing wafers.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 16503387
Int J Pharm. 2006 Apr 26;313(1):78-86. doi: 10.1016/j.ijpharm.2006.01.023. Epub 2006 Feb 28.

Lyophilised wafers are being developed as drug delivery systems that can be applied directly to the surface of suppurating wounds. They are produced by the freeze-drying of polymer solutions and gels. This study investigates the possibility of sterilising these...

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Matthews KH, Stevens HN, Auffret AD, et al. Gamma-irradiation of lyophilised wound healing wafers. Int J Pharm. 2006;313(1):78-86doi: 10.1016/j.ijpharm.2006.01.023.
Matthews, K. H., Stevens, H. N., Auffret, A. D., Humphrey, M. J., & Eccleston, G. M. (2006). Gamma-irradiation of lyophilised wound healing wafers. International journal of pharmaceutics, 313(1), 78-86. https://doi.org/10.1016/j.ijpharm.2006.01.023
Matthews, K H, et al. "Gamma-irradiation of lyophilised wound healing wafers." International journal of pharmaceutics vol. 313,1 (2006): 78-86. doi: https://doi.org/10.1016/j.ijpharm.2006.01.023
Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM. Gamma-irradiation of lyophilised wound healing wafers. Int J Pharm. 2006 Apr 26;313(1):78-86. doi: 10.1016/j.ijpharm.2006.01.023. Epub 2006 Feb 28. PMID: 16503387.
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Clinical determination of protein-bound iodine in plasma.

The Journal of clinical endocrinology and metabolism

BARKER SB, HUMPHREY MJ.
PMID: 14778885
J Clin Endocrinol Metab. 1950 Sep;10(9):1136-41. doi: 10.1210/jcem-10-9-1136.

No abstract available.

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BARKER SB, HUMPHREY MJ. Clinical determination of protein-bound iodine in plasma. J Clin Endocrinol Metab. 1950;10(9):1136-41doi: 10.1210/jcem-10-9-1136.
BARKER, S. B., & HUMPHREY, M. J. (1950). Clinical determination of protein-bound iodine in plasma. The Journal of clinical endocrinology and metabolism, 10(9), 1136-41. https://doi.org/10.1210/jcem-10-9-1136
BARKER, S B, and HUMPHREY, M J. "Clinical determination of protein-bound iodine in plasma." The Journal of clinical endocrinology and metabolism vol. 10,9 (1950): 1136-41. doi: https://doi.org/10.1210/jcem-10-9-1136
BARKER SB, HUMPHREY MJ. Clinical determination of protein-bound iodine in plasma. J Clin Endocrinol Metab. 1950 Sep;10(9):1136-41. doi: 10.1210/jcem-10-9-1136. PMID: 14778885.
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A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers.

Journal of pharmaceutical sciences

McConville JT, Hodges LA, Jones T, Band JP, O'Mahony B, Lindsay B, Ross AC, Florence AJ, Stanley AJ, Humphrey MJ, Wilson CG, Stevens HN.
PMID: 19387976
J Pharm Sci. 2009 Nov;98(11):4251-63. doi: 10.1002/jps.21739.

Three time-delayed capsule (TDC) formulations were investigated in a pharmacoscintigraphic study, using a three-way crossover design in eight healthy male volunteers. Additionally, the pulsed release of a TDC was investigated with time-lapse photography, using a nondisintegrating riboflavin tablet. The...

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McConville JT, Hodges LA, Jones T, et al. A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers. J Pharm Sci. 2009;98(11):4251-63doi: 10.1002/jps.21739.
McConville, J. T., Hodges, L. A., Jones, T., Band, J. P., O'Mahony, B., Lindsay, B., Ross, A. C., Florence, A. J., Stanley, A. J., Humphrey, M. J., Wilson, C. G., & Stevens, H. N. (2009). A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers. Journal of pharmaceutical sciences, 98(11), 4251-63. https://doi.org/10.1002/jps.21739
McConville, Jason T, et al. "A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers." Journal of pharmaceutical sciences vol. 98,11 (2009): 4251-63. doi: https://doi.org/10.1002/jps.21739
McConville JT, Hodges LA, Jones T, Band JP, O'Mahony B, Lindsay B, Ross AC, Florence AJ, Stanley AJ, Humphrey MJ, Wilson CG, Stevens HN. A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers. J Pharm Sci. 2009 Nov;98(11):4251-63. doi: 10.1002/jps.21739. PMID: 19387976.
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Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 18280068
Int J Pharm. 2008 May 22;356(1):110-20. doi: 10.1016/j.ijpharm.2007.12.043. Epub 2008 Jan 09.

Lyophilised wafers are being developed as topical drug delivery systems for the treatment of chronic wounds. This study describes the formulation of xanthan wafers containing a selective, insoluble MMP-3 inhibitor (UK-370,106) and a non-ionic surfactant, designed to release accurate...

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Matthews KH, Stevens HN, Auffret AD, et al. Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int J Pharm. 2008;356(1):110-20doi: 10.1016/j.ijpharm.2007.12.043.
Matthews, K. H., Stevens, H. N., Auffret, A. D., Humphrey, M. J., & Eccleston, G. M. (2008). Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. International journal of pharmaceutics, 356(1), 110-20. https://doi.org/10.1016/j.ijpharm.2007.12.043
Matthews, K H, et al. "Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant." International journal of pharmaceutics vol. 356,1 (2008): 110-20. doi: https://doi.org/10.1016/j.ijpharm.2007.12.043
Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM. Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int J Pharm. 2008 May 22;356(1):110-20. doi: 10.1016/j.ijpharm.2007.12.043. Epub 2008 Jan 09. PMID: 18280068.
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Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces.

Drug development and industrial pharmacy

Boateng JS, Stevens HN, Eccleston GM, Auffret AD, Humphrey MJ, Matthews KH.
PMID: 19365780
Drug Dev Ind Pharm. 2009 Aug;35(8):986-96. doi: 10.1080/03639040902744704.

Solvent-cast films from three polymers, carboxymethylcellulose (CMC), sodium alginate (SA), and xanthan gum, were prepared by drying the polymeric gels in air. Three methods, (a) passive hydration, (b) vortex hydration with heating, and (c) cold hydration, were investigated to...

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Boateng JS, Stevens HN, Eccleston GM, et al. Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces. Drug Dev Ind Pharm. 2009;35(8):986-96doi: 10.1080/03639040902744704.
Boateng, J. S., Stevens, H. N., Eccleston, G. M., Auffret, A. D., Humphrey, M. J., & Matthews, K. H. (2009). Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces. Drug development and industrial pharmacy, 35(8), 986-96. https://doi.org/10.1080/03639040902744704
Boateng, Joshua S, et al. "Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces." Drug development and industrial pharmacy vol. 35,8 (2009): 986-96. doi: https://doi.org/10.1080/03639040902744704
Boateng JS, Stevens HN, Eccleston GM, Auffret AD, Humphrey MJ, Matthews KH. Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces. Drug Dev Ind Pharm. 2009 Aug;35(8):986-96. doi: 10.1080/03639040902744704. PMID: 19365780.
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Application of metabolism and pharmacokinetic studies to the drug discovery process.

Drug metabolism reviews

Humphrey MJ.
PMID: 8875124
Drug Metab Rev. 1996 Aug;28(3):473-89. doi: 10.3109/03602539608994012.

No abstract available.

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Humphrey MJ. Application of metabolism and pharmacokinetic studies to the drug discovery process. Drug Metab Rev. 1996;28(3):473-89doi: 10.3109/03602539608994012.
Humphrey, M. J. (1996). Application of metabolism and pharmacokinetic studies to the drug discovery process. Drug metabolism reviews, 28(3), 473-89. https://doi.org/10.3109/03602539608994012
Humphrey, M J. "Application of metabolism and pharmacokinetic studies to the drug discovery process." Drug metabolism reviews vol. 28,3 (1996): 473-89. doi: https://doi.org/10.3109/03602539608994012
Humphrey MJ. Application of metabolism and pharmacokinetic studies to the drug discovery process. Drug Metab Rev. 1996 Aug;28(3):473-89. doi: 10.3109/03602539608994012. PMID: 8875124.
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Blood transfusion in the neonate: effects of dilution and age of blood on hemolysis.

The Journal of pediatrics

Humphrey MJ, Harrell-Bean HA, Eskelson C, Corrigan JJ.
PMID: 7119966
J Pediatr. 1982 Oct;101(4):605-7. doi: 10.1016/s0022-3476(82)80719-1.

No abstract available.

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Humphrey MJ, Harrell-Bean HA, Eskelson C, et al. Blood transfusion in the neonate: effects of dilution and age of blood on hemolysis. J Pediatr. 1982;101(4):605-7doi: 10.1016/s0022-3476(82)80719-1.
Humphrey, M. J., Harrell-Bean, H. A., Eskelson, C., & Corrigan, J. J. (1982). Blood transfusion in the neonate: effects of dilution and age of blood on hemolysis. The Journal of pediatrics, 101(4), 605-7. https://doi.org/10.1016/s0022-3476(82)80719-1
Humphrey, M J, et al. "Blood transfusion in the neonate: effects of dilution and age of blood on hemolysis." The Journal of pediatrics vol. 101,4 (1982): 605-7. doi: https://doi.org/10.1016/s0022-3476(82)80719-1
Humphrey MJ, Harrell-Bean HA, Eskelson C, Corrigan JJ. Blood transfusion in the neonate: effects of dilution and age of blood on hemolysis. J Pediatr. 1982 Oct;101(4):605-7. doi: 10.1016/s0022-3476(82)80719-1. PMID: 7119966.
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Showing 1 to 12 of 45 entries