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The metabolism and pharmacokinetics of amlodipine in humans and animals.

Journal of cardiovascular pharmacology

Stopher DA, Beresford AP, Macrae PV, Humphrey MJ.
PMID: 2467130
J Cardiovasc Pharmacol. 1988;12:S55-9. doi: 10.1097/00005344-198812007-00012.

The disposition of amlodipine, a new calcium-channel blocker with a slow onset and long duration of action, has been investigated in humans and in the animal species used in the evaluation of drug efficacy and safety. Pharmacokinetic studies were...

Role of metabolism and pharmacokinetic studies in the discovery of new drugs--present and future perspectives.

Xenobiotica; the fate of foreign compounds in biological systems

Humphrey MJ, Smith DA.
PMID: 1455898
Xenobiotica. 1992 Jul;22(7):743-55. doi: 10.3109/00498259209053137.

1. The impact which pharmacokinetics and drug metabolism studies have made to drug discovery programmes is reviewed with examples from the anti-infective, cardiovascular, anti-inflammatory and CNS therapeutic areas. 2. Contributions that advances in analytical technology have made to the...

The pharmacokinetics and metabolism of idazoxan in the rat.

Xenobiotica; the fate of foreign compounds in biological systems

Lewis CJ, Havler ME, Humphrey MJ, Lloyd-Jones JG, McCleavy MA, Muir NC, Waltham K.
PMID: 2899932
Xenobiotica. 1988 May;18(5):519-32. doi: 10.3109/00498258809041689.

1. [2'-14C]Idazoxan was rapidly and completely absorbed after its oral administration to rats. 2. After administration of either [2'-14C] or [6,7-3H]idazoxan, radioactivity was taken up by a wide range of tissues and became localized, especially in the organs of...

Disposition of azole antifungal agents. II. Hepatic binding and clearance of dichlorophenyl-bis-triazolylpropanol (DTP) in the rat.

Pharmaceutical research

Bomont HL, Tarbit MH, Humphrey MJ, Houston JB.
PMID: 7937554
Pharm Res. 1994 Jul;11(7):951-60. doi: 10.1023/a:1018966800208.

DTP (dichlorophenyl-bis-triazolylpropanol) was evaluated as a probe of drug-cytochromes P450 interactions in vitro and in vivo. Studies with rat liver microsomes demonstrate that DTP shows similar P450 binding affinity to its analog, ketoconazole, as determined by P450 difference spectra...

Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 15652198
Int J Pharm. 2005 Jan 31;289(1):51-62. doi: 10.1016/j.ijpharm.2004.10.022. Epub 2004 Dec 30.

Lyophilised wafers have potential as drug delivery systems for suppurating wounds. A dual series of wafers made from low molecular weight sodium alginate (SA) and xanthan gum (XG) respectively, modified with high molecular weight methylcellulose (MC) were produced. The...

Gamma-irradiation of lyophilised wound healing wafers.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 16503387
Int J Pharm. 2006 Apr 26;313(1):78-86. doi: 10.1016/j.ijpharm.2006.01.023. Epub 2006 Feb 28.

Lyophilised wafers are being developed as drug delivery systems that can be applied directly to the surface of suppurating wounds. They are produced by the freeze-drying of polymer solutions and gels. This study investigates the possibility of sterilising these...

Clinical determination of protein-bound iodine in plasma.

The Journal of clinical endocrinology and metabolism

PMID: 14778885
J Clin Endocrinol Metab. 1950 Sep;10(9):1136-41. doi: 10.1210/jcem-10-9-1136.

No abstract available.

A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers.

Journal of pharmaceutical sciences

McConville JT, Hodges LA, Jones T, Band JP, O'Mahony B, Lindsay B, Ross AC, Florence AJ, Stanley AJ, Humphrey MJ, Wilson CG, Stevens HN.
PMID: 19387976
J Pharm Sci. 2009 Nov;98(11):4251-63. doi: 10.1002/jps.21739.

Three time-delayed capsule (TDC) formulations were investigated in a pharmacoscintigraphic study, using a three-way crossover design in eight healthy male volunteers. Additionally, the pulsed release of a TDC was investigated with time-lapse photography, using a nondisintegrating riboflavin tablet. The...

Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 18280068
Int J Pharm. 2008 May 22;356(1):110-20. doi: 10.1016/j.ijpharm.2007.12.043. Epub 2008 Jan 09.

Lyophilised wafers are being developed as topical drug delivery systems for the treatment of chronic wounds. This study describes the formulation of xanthan wafers containing a selective, insoluble MMP-3 inhibitor (UK-370,106) and a non-ionic surfactant, designed to release accurate...

Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces.

Drug development and industrial pharmacy

Boateng JS, Stevens HN, Eccleston GM, Auffret AD, Humphrey MJ, Matthews KH.
PMID: 19365780
Drug Dev Ind Pharm. 2009 Aug;35(8):986-96. doi: 10.1080/03639040902744704.

Solvent-cast films from three polymers, carboxymethylcellulose (CMC), sodium alginate (SA), and xanthan gum, were prepared by drying the polymeric gels in air. Three methods, (a) passive hydration, (b) vortex hydration with heating, and (c) cold hydration, were investigated to...

Application of metabolism and pharmacokinetic studies to the drug discovery process.

Drug metabolism reviews

Humphrey MJ.
PMID: 8875124
Drug Metab Rev. 1996 Aug;28(3):473-89. doi: 10.3109/03602539608994012.

No abstract available.

Blood transfusion in the neonate: effects of dilution and age of blood on hemolysis.

The Journal of pediatrics

Humphrey MJ, Harrell-Bean HA, Eskelson C, Corrigan JJ.
PMID: 7119966
J Pediatr. 1982 Oct;101(4):605-7. doi: 10.1016/s0022-3476(82)80719-1.

No abstract available.

Showing 1 to 12 of 45 entries