Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 12 entries
Sorted by: Best Match Show Resources per page
Link worker perspectives of early implementation of social prescribing: A 'Researcher-in-Residence' study.

Health & social care in the community

Hazeldine E, Gowan G, Wigglesworth R, Pollard J, Asthana S, Husk K.
PMID: 33528060
Health Soc Care Community. 2021 Nov;29(6):1844-1851. doi: 10.1111/hsc.13295. Epub 2021 Feb 02.

Social prescribing (SP) is increasing in popularity in the UK and can enable healthcare providers to respond more effectively to a range of non-clinical needs. With the NHS commitment to establish an SP link worker in all GP practices,...

Heparin resistance in severe thermal injury: A prospective cohort study.

Burns & trauma

Cato LD, Bailiff B, Price J, Ermogeneous C, Hazeldine J, Lester W, Lowe G, Wearn C, Bishop JRB, Lord JM, Moiemen N, Harrison P.
PMID: 34692855
Burns Trauma. 2021 Oct 20;9:tkab032. doi: 10.1093/burnst/tkab032. eCollection 2021.

BACKGROUND: Low molecular-weight heparin (LMWH) is routinely administered to burn patients for thromboprophylaxis. Some studies have reported heparin resistance, yet the mechanism(s) and prevalence have not been systematically studied. We hypothesized that nucleosomes, composed of histone structures with associated...

UK regulations: Could fracking creep under the radar?.

Nature

Smythe D, Haszeldine S.
PMID: 28836601
Nature. 2017 Aug 23;548(7668):393. doi: 10.1038/548393a.

No abstract available.

Heparin resistance in severe thermal injury: A prospective cohort study.

Burns & trauma

Cato LD, Bailiff B, Price J, Ermogeneous C, Hazeldine J, Lester W, Lowe G, Wearn C, Bishop JRB, Lord JM, Moiemen N, Harrison P.
PMID: 34692855
Burns Trauma. 2021 Oct 20;9:tkab032. doi: 10.1093/burnst/tkab032. eCollection 2021.

BACKGROUND: Low molecular-weight heparin (LMWH) is routinely administered to burn patients for thromboprophylaxis. Some studies have reported heparin resistance, yet the mechanism(s) and prevalence have not been systematically studied. We hypothesized that nucleosomes, composed of histone structures with associated...

Traumatic injury is associated with reduced deoxyribonuclease activity and dysregulation of the actin scavenging system.

Burns & trauma

Hazeldine J, Dinsdale RJ, Naumann DN, Acharjee A, Bishop JRB, Lord JM, Harrison P.
PMID: 33834079
Burns Trauma. 2021 Apr 01;9:tkab001. doi: 10.1093/burnst/tkab001. eCollection 2021 Jan.

BACKGROUND: Traumatic injury is associated with increased concentrations of cell-free DNA (cfDNA) in the circulation, which contribute to post-injury complications. The endonuclease deoxyribonuclease 1 (DNase-1) is responsible for removing 90% of circulating cfDNA. Recently, DNase activity was reported to...

Heparin resistance in severe thermal injury: A prospective cohort study.

Burns & trauma

Cato LD, Bailiff B, Price J, Ermogeneous C, Hazeldine J, Lester W, Lowe G, Wearn C, Bishop JRB, Lord JM, Moiemen N, Harrison P.
PMID: 34692855
Burns Trauma. 2021 Oct 20;9:tkab032. doi: 10.1093/burnst/tkab032. eCollection 2021.

BACKGROUND: Low molecular-weight heparin (LMWH) is routinely administered to burn patients for thromboprophylaxis. Some studies have reported heparin resistance, yet the mechanism(s) and prevalence have not been systematically studied. We hypothesized that nucleosomes, composed of histone structures with associated...

Traumatic Brain Injury and Peripheral Immune Suppression: Primer and Prospectus.

Frontiers in neurology

Hazeldine J, Lord JM, Belli A.
PMID: 26594196
Front Neurol. 2015 Nov 05;6:235. doi: 10.3389/fneur.2015.00235. eCollection 2015.

Nosocomial infections are a common occurrence in patients following traumatic brain injury (TBI) and are associated with an increased risk of mortality, longer length of hospital stay, and poor neurological outcome. Systemic immune suppression arising as a direct result...

Author Correction: Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury.

Scientific reports

Hill LJ, Di Pietro V, Hazeldine J, Davies D, Toman E, Logan A, Belli A.
PMID: 29531266
Sci Rep. 2018 Mar 12;8(1):4572. doi: 10.1038/s41598-018-22951-0.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

The diagnostic and prognostic value of systems biology research in major traumatic and thermal injury: a review.

Burns & trauma

Hazeldine J, Hampson P, Lord JM.
PMID: 27672669
Burns Trauma. 2016 Sep 21;4:33. doi: 10.1186/s41038-016-0059-3. eCollection 2016.

As secondary complications remain a significant cause of morbidity and mortality amongst hospitalised trauma patients, the need to develop novel approaches by which to identify patients at risk of adverse outcome is becoming increasingly important. Centred on the idea...

Polyamine-based small molecule epigenetic modulators.

MedChemComm

Sharma SK, Hazeldine S, Crowley ML, Hanson A, Beattie R, Varghese S, Senanayake TM, Hirata A, Hirata F, Huang Y, Wu Y, Steinbergs N, Murray-Stewart T, Bytheway I, Casero RA, Woster PM.
PMID: 23293738
Medchemcomm. 2012;3(1):14-21. doi: 10.1039/C1MD00220A. Epub 2011 Nov 26.

Chromatin remodelling enzymes such as the histone deacetylases (HDACs) and histone demethylases such as lysine-specific demethylase 1 (LSD1) have been validated as targets for cancer drug discovery. Although a number of HDAC inhibitors have been marketed or are in...

Survey of nutritional practices during therapeutic hypothermia for hypoxic-ischaemic encephalopathy.

BMJ paediatrics open

Hazeldine B, Thyagarajan B, Grant M, Chakkarapani E.
PMID: 29637095
BMJ Paediatr Open. 2017 Jul 26;1(1):e000022. doi: 10.1136/bmjpo-2017-000022. eCollection 2017.

OBJECTIVE: To evaluate current nutritional practices during and after therapeutic hypothermia (TH) for infants with hypoxic-ischaemic encephalopathy (HIE) in UK neonatal units.STUDY DESIGN: Email survey of neonatal clinicians.SETTING: UK neonatal units providing active TH.PATIENTS: Neonates cooled for HIE.METHODS: Email...

Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient.

Burns & trauma

Bentley C, Hazeldine J, Greig C, Lord J, Foster M.
PMID: 31388512
Burns Trauma. 2019 Aug 02;7:26. doi: 10.1186/s41038-019-0158-z. eCollection 2019.

Severe injuries are the major cause of death in those aged under 40, mainly due to road traffic collisions. Endocrine, metabolic and immune pathways respond to limit the tissue damage sustained and initiate wound healing, repair and regeneration mechanisms....

Showing 1 to 12 of 12 entries