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Tumour karyotype may be important in the prognosis of human neuroblastoma.

Journal of cancer research and clinical oncology

Franke F, Rudolph B, Christiansen H, Harbott J, Lampert F.
PMID: 3733856
J Cancer Res Clin Oncol. 1986;111(3):266-72. doi: 10.1007/BF00389243.

When comparing clinical and tumour cytogenetic data on 14 neuroblastoma patients in different stages of disease we found a high incidence of 1p abnormalities (12/12), homogeneously staining regions/double minutes (9/12) and 2p abnormalities (4/12) in 12 unresectable and metastatic...

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Franke F, Rudolph B, Christiansen H, et al. Tumour karyotype may be important in the prognosis of human neuroblastoma. J Cancer Res Clin Oncol. 1986;111(3):266-72doi: 10.1007/BF00389243.
Franke, F., Rudolph, B., Christiansen, H., Harbott, J., & Lampert, F. (1986). Tumour karyotype may be important in the prognosis of human neuroblastoma. Journal of cancer research and clinical oncology, 111(3), 266-72. https://doi.org/10.1007/BF00389243
Franke, F, et al. "Tumour karyotype may be important in the prognosis of human neuroblastoma." Journal of cancer research and clinical oncology vol. 111,3 (1986): 266-72. doi: https://doi.org/10.1007/BF00389243
Franke F, Rudolph B, Christiansen H, Harbott J, Lampert F. Tumour karyotype may be important in the prognosis of human neuroblastoma. J Cancer Res Clin Oncol. 1986;111(3):266-72. doi: 10.1007/BF00389243. PMID: 3733856.
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Prognostic meaning of chromosome aberrations in acute lymphocytic leukemia and acute nonlymphocytic leukemia patients of the BFM Study Group.

Haematology and blood transfusion

Harbott J, Budde M, Creutzig U, Engel R, Fengler R, Rudolph B, Lampert F.
PMID: 3476381
Haematol Blood Transfus. 1987;30:497-503. doi: 10.1007/978-3-642-71213-5_87.

No abstract available.

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Harbott J, Budde M, Creutzig U, et al. Prognostic meaning of chromosome aberrations in acute lymphocytic leukemia and acute nonlymphocytic leukemia patients of the BFM Study Group. Haematol Blood Transfus. 1987;30:497-503doi: 10.1007/978-3-642-71213-5_87.
Harbott, J., Budde, M., Creutzig, U., Engel, R., Fengler, R., Rudolph, B., & Lampert, F. (1987). Prognostic meaning of chromosome aberrations in acute lymphocytic leukemia and acute nonlymphocytic leukemia patients of the BFM Study Group. Haematology and blood transfusion, 30497-503. https://doi.org/10.1007/978-3-642-71213-5_87
Harbott, J, et al. "Prognostic meaning of chromosome aberrations in acute lymphocytic leukemia and acute nonlymphocytic leukemia patients of the BFM Study Group." Haematology and blood transfusion vol. 30 (1987): 497-503. doi: https://doi.org/10.1007/978-3-642-71213-5_87
Harbott J, Budde M, Creutzig U, Engel R, Fengler R, Rudolph B, Lampert F. Prognostic meaning of chromosome aberrations in acute lymphocytic leukemia and acute nonlymphocytic leukemia patients of the BFM Study Group. Haematol Blood Transfus. 1987;30:497-503. doi: 10.1007/978-3-642-71213-5_87. PMID: 3476381.
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[Chromosome aberrations in acute leukemia in childhood: analysis of 1009 patients].

Klinische Padiatrie

Lampert F, Harbott J, Ritterbach J.
PMID: 1834889
Klin Padiatr. 1991 Jul-Aug;203(4):311-8. doi: 10.1055/s-2007-1025446.

Leukemia karyotypes were analyzed in 792 children with acute lymphoblastic leukemia (ALL) and 217 patients with acute myelocytic leukemia (AML). These patients were registered and uniformly treated in German multicentre trials from 1984-01-01 to 1989-12-31. In distinct leukemia subgroups...

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Lampert F, Harbott J, Ritterbach J. Chromosomenaberrationen bei akuten Leukämien im Kindesalter: Analyse von 1009 Patienten. [Chromosome aberrations in acute leukemia in childhood: analysis of 1009 patients]. Klin Padiatr. 1991;203(4):311-8doi: 10.1055/s-2007-1025446.
Lampert, F., Harbott, J., & Ritterbach, J. (1991). Chromosomenaberrationen bei akuten Leukämien im Kindesalter: Analyse von 1009 Patienten. [Chromosome aberrations in acute leukemia in childhood: analysis of 1009 patients]. Klinische Padiatrie, 203(4), 311-8. https://doi.org/10.1055/s-2007-1025446
Lampert, F, et al. "Chromosomenaberrationen bei akuten Leukämien im Kindesalter: Analyse von 1009 Patienten." [Chromosome aberrations in acute leukemia in childhood: analysis of 1009 patients]. Klinische Padiatrie vol. 203,4 (1991): 311-8. doi: https://doi.org/10.1055/s-2007-1025446
Lampert F, Harbott J, Ritterbach J. Chromosomenaberrationen bei akuten Leukämien im Kindesalter: Analyse von 1009 Patienten. [Chromosome aberrations in acute leukemia in childhood: analysis of 1009 patients]. Klin Padiatr. 1991 Jul-Aug;203(4):311-8. doi: 10.1055/s-2007-1025446. German. PMID: 1834889.
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Alteration of blast phenotype after low-dose cytarabine in children with acute myeloid leukemia.

Haematology and blood transfusion

Berthold F, Harbott J, Ludwig WD, Lampert F.
PMID: 3497846
Haematol Blood Transfus. 1987;30:410-2. doi: 10.1007/978-3-642-71213-5_71.

Two children with acute myeloid leukemia (FAB M1 and M2) experienced bone marrow relapse during maintenance chemotherapy 7 and 10 months after diagnosis. Low-dose ARA-C monotherapy (2 X 10 mg/m2 per day s.c. for 14 days) was then initiated,...

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Berthold F, Harbott J, Ludwig WD, et al. Alteration of blast phenotype after low-dose cytarabine in children with acute myeloid leukemia. Haematol Blood Transfus. 1987;30:410-2doi: 10.1007/978-3-642-71213-5_71.
Berthold, F., Harbott, J., Ludwig, W. D., & Lampert, F. (1987). Alteration of blast phenotype after low-dose cytarabine in children with acute myeloid leukemia. Haematology and blood transfusion, 30410-2. https://doi.org/10.1007/978-3-642-71213-5_71
Berthold, F, et al. "Alteration of blast phenotype after low-dose cytarabine in children with acute myeloid leukemia." Haematology and blood transfusion vol. 30 (1987): 410-2. doi: https://doi.org/10.1007/978-3-642-71213-5_71
Berthold F, Harbott J, Ludwig WD, Lampert F. Alteration of blast phenotype after low-dose cytarabine in children with acute myeloid leukemia. Haematol Blood Transfus. 1987;30:410-2. doi: 10.1007/978-3-642-71213-5_71. PMID: 3497846.
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[Prognostic significance of eosinophilia in children with acute myeloid leukemia in the studies AML-BFM-78 and -83].

Klinische Padiatrie

Creutzig U, Ritter J, Niederbiermann-Koczy G, Harbott J, Schellong G.
PMID: 2674528
Klin Padiatr. 1989 Jul-Aug;201(4):220-6. doi: 10.1055/s-2007-1025307.

Initial eosinophilia (greater than or equal to 3%) in the bone marrow was found in 73 out of 269 (27%) patients studied in AML studies BFM-78 and -83. It was predominantly seen in children with FAB types M2 (44%)...

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Creutzig U, Ritter J, Niederbiermann-Koczy G, et al. Prognostische Bedeutung der Eosinophilie bei Kindern mit akuter myeloischer Leukämie in den Studien AML-BFM-78 und -83. [Prognostic significance of eosinophilia in children with acute myeloid leukemia in the studies AML-BFM-78 and -83]. Klin Padiatr. 1989;201(4):220-6doi: 10.1055/s-2007-1025307.
Creutzig, U., Ritter, J., Niederbiermann-Koczy, G., Harbott, J., & Schellong, G. (1989). Prognostische Bedeutung der Eosinophilie bei Kindern mit akuter myeloischer Leukämie in den Studien AML-BFM-78 und -83. [Prognostic significance of eosinophilia in children with acute myeloid leukemia in the studies AML-BFM-78 and -83]. Klinische Padiatrie, 201(4), 220-6. https://doi.org/10.1055/s-2007-1025307
Creutzig, U, et al. "Prognostische Bedeutung der Eosinophilie bei Kindern mit akuter myeloischer Leukämie in den Studien AML-BFM-78 und -83." [Prognostic significance of eosinophilia in children with acute myeloid leukemia in the studies AML-BFM-78 and -83]. Klinische Padiatrie vol. 201,4 (1989): 220-6. doi: https://doi.org/10.1055/s-2007-1025307
Creutzig U, Ritter J, Niederbiermann-Koczy G, Harbott J, Schellong G. Prognostische Bedeutung der Eosinophilie bei Kindern mit akuter myeloischer Leukämie in den Studien AML-BFM-78 und -83. [Prognostic significance of eosinophilia in children with acute myeloid leukemia in the studies AML-BFM-78 and -83]. Klin Padiatr. 1989 Jul-Aug;201(4):220-6. doi: 10.1055/s-2007-1025307. German. PMID: 2674528.
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Mapping of the breakpoints on the short arm of chromosome 17 in neoplasms with an i(17q).

Genes, chromosomes & cancer

Scheurlen WG, Schwabe GC, Seranski P, Joos S, Harbott J, Metzke S, Döhner H, Poustka A, Wilgenbus K, Haas OA.
PMID: 10379869
Genes Chromosomes Cancer. 1999 Jul;25(3):230-40. doi: 10.1002/(sici)1098-2264(199907)25:3<230::aid-gcc5>3.0.co;2-e.

Isochromosomes are monocentric or dicentric chromosomes with homologous arms that are attached in a reverse configuration as mirror images. With an incidence of 3-4%, the i(17q) represents the most frequent isochromosome in human cancer. It is found in a...

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Scheurlen WG, Schwabe GC, Seranski P, et al. Mapping of the breakpoints on the short arm of chromosome 17 in neoplasms with an i(17q). Genes Chromosomes Cancer. 1999;25(3):230-40doi: 10.1002/(sici)1098-2264(199907)25:3<230::aid-gcc5>3.0.co;2-e.
Scheurlen, W. G., Schwabe, G. C., Seranski, P., Joos, S., Harbott, J., Metzke, S., Döhner, H., Poustka, A., Wilgenbus, K., & Haas, O. A. (1999). Mapping of the breakpoints on the short arm of chromosome 17 in neoplasms with an i(17q). Genes, chromosomes & cancer, 25(3), 230-40. https://doi.org/10.1002/(sici)1098-2264(199907)25:3<230::aid-gcc5>3.0.co;2-e
Scheurlen, W G, et al. "Mapping of the breakpoints on the short arm of chromosome 17 in neoplasms with an i(17q)." Genes, chromosomes & cancer vol. 25,3 (1999): 230-40. doi: https://doi.org/10.1002/(sici)1098-2264(199907)25:3<230::aid-gcc5>3.0.co;2-e
Scheurlen WG, Schwabe GC, Seranski P, Joos S, Harbott J, Metzke S, Döhner H, Poustka A, Wilgenbus K, Haas OA. Mapping of the breakpoints on the short arm of chromosome 17 in neoplasms with an i(17q). Genes Chromosomes Cancer. 1999 Jul;25(3):230-40. doi: 10.1002/(sici)1098-2264(199907)25:3<230::aid-gcc5>3.0.co;2-e. PMID: 10379869.
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Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster Study Group.

Blood

Borkhardt A, Cazzaniga G, Viehmann S, Valsecchi MG, Ludwig WD, Burci L, Mangioni S, Schrappe M, Riehm H, Lampert F, Basso G, Masera G, Harbott J, Biondi A.
PMID: 9226156
Blood. 1997 Jul 15;90(2):571-7.

The molecular approach for the analysis of leukemia associated chromosomal translocations has led to the identification of prognostic relevant subgroups. In pediatric acute lymphoblastic leukemia (ALL), the most common translocations, t(9;22) and t(4;11), have been associated with a poorer...

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Borkhardt A, Cazzaniga G, Viehmann S, et al. Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster Study Group. Blood. 1997;90(2):571-7
Borkhardt, A., Cazzaniga, G., Viehmann, S., Valsecchi, M. G., Ludwig, W. D., Burci, L., Mangioni, S., Schrappe, M., Riehm, H., Lampert, F., Basso, G., Masera, G., Harbott, J., & Biondi, A. (1997). Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster Study Group. Blood, 90(2), 571-7.
Borkhardt, A, et al. "Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster Study Group." Blood vol. 90,2 (1997): 571-7.
Borkhardt A, Cazzaniga G, Viehmann S, Valsecchi MG, Ludwig WD, Burci L, Mangioni S, Schrappe M, Riehm H, Lampert F, Basso G, Masera G, Harbott J, Biondi A. Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster Study Group. Blood. 1997 Jul 15;90(2):571-7. PMID: 9226156.
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Acute promyelocytic leukaemia with hypogranular bone marrow blasts in a 16-year-old girl: diagnostic value of different genetic methods.

European journal of pediatrics

Scherulen W, Harbott J, Janssen JW, Kühl J, Bartram CR.
PMID: 7641768
Eur J Pediatr. 1995 May;154(5):369-73. doi: 10.1007/BF02072105.

UNLABELLED: We report a 16-year-old girl who presented with anaemia, thrombocytopenia, leukocytosis and disseminated intravascular coagulation. Bone marrow analysis showed promyelocyte-like myeloblasts with rare Auer rods and very few granula. CD2 antigen was not expressed in bone marrow blasts....

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Scherulen W, Harbott J, Janssen JW, et al. Acute promyelocytic leukaemia with hypogranular bone marrow blasts in a 16-year-old girl: diagnostic value of different genetic methods. Eur J Pediatr. 1995;154(5):369-73doi: 10.1007/BF02072105.
Scherulen, W., Harbott, J., Janssen, J. W., Kühl, J., & Bartram, C. R. (1995). Acute promyelocytic leukaemia with hypogranular bone marrow blasts in a 16-year-old girl: diagnostic value of different genetic methods. European journal of pediatrics, 154(5), 369-73. https://doi.org/10.1007/BF02072105
Scherulen, W, et al. "Acute promyelocytic leukaemia with hypogranular bone marrow blasts in a 16-year-old girl: diagnostic value of different genetic methods." European journal of pediatrics vol. 154,5 (1995): 369-73. doi: https://doi.org/10.1007/BF02072105
Scherulen W, Harbott J, Janssen JW, Kühl J, Bartram CR. Acute promyelocytic leukaemia with hypogranular bone marrow blasts in a 16-year-old girl: diagnostic value of different genetic methods. Eur J Pediatr. 1995 May;154(5):369-73. doi: 10.1007/BF02072105. PMID: 7641768.
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DNA aneuploidy in childhood acute lymphoblastic leukemia: relation to clinical determinants and prognosis within four consecutive BFM trials.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer

Hiddemann W, Harbott J, Ludwig WD, Ritter J, Nehmer A, Reiter A, Kolkmeyer A, Laing T, Riehm H.
PMID: 8210632
Recent Results Cancer Res. 1993;131:113-21. doi: 10.1007/978-3-642-84895-7_11.

No abstract available.

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Hiddemann W, Harbott J, Ludwig WD, et al. DNA aneuploidy in childhood acute lymphoblastic leukemia: relation to clinical determinants and prognosis within four consecutive BFM trials. Recent Results Cancer Res. 1993;131:113-21doi: 10.1007/978-3-642-84895-7_11.
Hiddemann, W., Harbott, J., Ludwig, W. D., Ritter, J., Nehmer, A., Reiter, A., Kolkmeyer, A., Laing, T., & Riehm, H. (1993). DNA aneuploidy in childhood acute lymphoblastic leukemia: relation to clinical determinants and prognosis within four consecutive BFM trials. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 131113-21. https://doi.org/10.1007/978-3-642-84895-7_11
Hiddemann, W, et al. "DNA aneuploidy in childhood acute lymphoblastic leukemia: relation to clinical determinants and prognosis within four consecutive BFM trials." Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer vol. 131 (1993): 113-21. doi: https://doi.org/10.1007/978-3-642-84895-7_11
Hiddemann W, Harbott J, Ludwig WD, Ritter J, Nehmer A, Reiter A, Kolkmeyer A, Laing T, Riehm H. DNA aneuploidy in childhood acute lymphoblastic leukemia: relation to clinical determinants and prognosis within four consecutive BFM trials. Recent Results Cancer Res. 1993;131:113-21. doi: 10.1007/978-3-642-84895-7_11. PMID: 8210632.
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Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis.

Leukemia

Repp R, Borkhardt A, Haupt E, Kreuder J, Brettreich S, Hammermann J, Nishida K, Harbott J, Lampert F.
PMID: 7845020
Leukemia. 1995 Jan;9(1):210-5.

A nested polymerase chain reaction (PCR) protocol was developed for rapid detection of four different 11q23 abnormalities by a single PCR assay. During each of the two PCR rounds a sense primer located within exon 5 of the MLL...

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Repp R, Borkhardt A, Haupt E, et al. Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis. Leukemia. 1995;9(1):210-5
Repp, R., Borkhardt, A., Haupt, E., Kreuder, J., Brettreich, S., Hammermann, J., Nishida, K., Harbott, J., & Lampert, F. (1995). Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis. Leukemia, 9(1), 210-5.
Repp, R, et al. "Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis." Leukemia vol. 9,1 (1995): 210-5.
Repp R, Borkhardt A, Haupt E, Kreuder J, Brettreich S, Hammermann J, Nishida K, Harbott J, Lampert F. Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis. Leukemia. 1995 Jan;9(1):210-5. PMID: 7845020.
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Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complete remission.

Blood

Janssen JW, Ludwig WD, Borkhardt A, Spadinger U, Rieder H, Fonatsch C, Hossfeld DK, Harbott J, Schulz AS, Repp R.
PMID: 7949140
Blood. 1994 Dec 01;84(11):3835-42.

We used the polymerase chain reaction (PCR) to detect ALL1-AF4 rearrangements, the molecular hallmark of t(4;11) in a series of 46 pre-pre-B (CD19+, CD24+, CD10/CD20/cylgM/sIgM-) acute lymphoblastic leukemias (ALL). Eighteen patients (39%) exhibited fusion transcripts including 4 of 12...

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Janssen JW, Ludwig WD, Borkhardt A, et al. Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complete remission. Blood. 1994;84(11):3835-42
Janssen, J. W., Ludwig, W. D., Borkhardt, A., Spadinger, U., Rieder, H., Fonatsch, C., Hossfeld, D. K., Harbott, J., Schulz, A. S., & Repp, R. (1994). Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complete remission. Blood, 84(11), 3835-42.
Janssen, J W, et al. "Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complete remission." Blood vol. 84,11 (1994): 3835-42.
Janssen JW, Ludwig WD, Borkhardt A, Spadinger U, Rieder H, Fonatsch C, Hossfeld DK, Harbott J, Schulz AS, Repp R. Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complete remission. Blood. 1994 Dec 01;84(11):3835-42. PMID: 7949140.
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The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.

Proceedings of the National Academy of Sciences of the United States of America

Borkhardt A, Bojesen S, Haas OA, Fuchs U, Bartelheimer D, Loncarevic IF, Bohle RM, Harbott J, Repp R, Jaeger U, Viehmann S, Henn T, Korth P, Scharr D, Lampert F.
PMID: 10908648
Proc Natl Acad Sci U S A. 2000 Aug 01;97(16):9168-73. doi: 10.1073/pnas.150079597.

We have isolated the human GRAF gene (for GTPase regulator associated with the focal adhesion kinase pp125(FAK)). This gene was fused with MLL in a unique t(5;11)(q31;q23) that occurred in an infant with juvenile myelomonocytic leukemia. GRAF encodes a...

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Borkhardt A, Bojesen S, Haas OA, et al. The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. Proc Natl Acad Sci U S A. 2000;97(16):9168-73doi: 10.1073/pnas.150079597.
Borkhardt, A., Bojesen, S., Haas, O. A., Fuchs, U., Bartelheimer, D., Loncarevic, I. F., Bohle, R. M., Harbott, J., Repp, R., Jaeger, U., Viehmann, S., Henn, T., Korth, P., Scharr, D., & Lampert, F. (2000). The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. Proceedings of the National Academy of Sciences of the United States of America, 97(16), 9168-73. https://doi.org/10.1073/pnas.150079597
Borkhardt, A, et al. "The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q." Proceedings of the National Academy of Sciences of the United States of America vol. 97,16 (2000): 9168-73. doi: https://doi.org/10.1073/pnas.150079597
Borkhardt A, Bojesen S, Haas OA, Fuchs U, Bartelheimer D, Loncarevic IF, Bohle RM, Harbott J, Repp R, Jaeger U, Viehmann S, Henn T, Korth P, Scharr D, Lampert F. The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. Proc Natl Acad Sci U S A. 2000 Aug 01;97(16):9168-73. doi: 10.1073/pnas.150079597. PMID: 10908648; PMCID: PMC16840.
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