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Showing 1 to 12 of 66 entries
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Enhanced protective antibody to a mutant meningococcal factor H-binding protein with low-factor H binding.

JCI insight

Granoff DM, Giuntini S, Gowans FA, Lujan E, Sharkey K, Beernink PT.
PMID: 27668287
JCI Insight. 2016 Sep 08;1(14):e88907. doi: 10.1172/jci.insight.88907.

Meningococcal factor H-binding protein (FHbp) is an antigen in 2 serogroup B meningococcal vaccines. FHbp specifically binds human and some nonhuman primate complement FH. To investigate the effect of binding of FH to FHbp on protective antibody responses, we...

Relationship between Canadian medical school student career interest in emergency medicine and postgraduate training disposition.

Canadian medical education journal

Abu-Laban RB, Scott IM, Gowans MC.
PMID: 29098043
Can Med Educ J. 2017 Jun 30;8(3):e4-e12. eCollection 2017 Jun.

BACKGROUND: Canada has two independent routes of emergency medicine (EM) training and certification. This unique situation may encourage medical students with EM career aspirations to apply to family medicine (FM) residencies to subsequently acquire College of Family Physicians of...

The Relation of Eye, Ear, Nose, and Throat Surgery to General Surgery.

Journal of the National Medical Association

Gowens HL.
PMID: 20891895
J Natl Med Assoc. 1921 Jul;13(3):196.

No abstract available.

History of a Case of Myxoedema.

British medical journal

Gowans W.
PMID: 20750212
Br Med J. 1882 May 27;1(1117):772-3.

No abstract available.

An unusual nickel-copper-mediated alkyne homocoupling reaction for the active-template synthesis of [2]rotaxanes.

Journal of the American Chemical Society

Crowley JD, Goldup SM, Gowans ND, Leigh DA, Ronaldson VE, Slawin AM.
PMID: 20377187
J Am Chem Soc. 2010 May 05;132(17):6243-8. doi: 10.1021/ja101121j.

We report on an unusual Ni-/Cu-mediated alkyne homocoupling reaction, directed through the cavity of a bidentate macrocyclic ligand by chelated metal ions to furnish [2]rotaxanes in excellent (up to 95%) yields. This is the first active metal template reaction...

TGIF Mutations in Human Holoprosencephaly: Correlation between Genotype and Phenotype.

Molecular syndromology

Keaton AA, Solomon BD, Kauvar EF, El-Jaick KB, Gropman AL, Zafer Y, Meck JM, Bale SJ, Grange DK, Haddad BR, Gowans GC, Clegg NJ, Delgado MR, Hahn JS, Pineda-Alvarez DE, Lacbawan F, Vélez JI, Roessler E, Muenke M.
PMID: 22125506
Mol Syndromol. 2010;1(5):211-222. doi: 10.1159/000328203. Epub 2011 May 18.

Holoprosencephaly (HPE), which results from failed or incomplete midline forebrain division early in gestation, is the most common forebrain malformation. The etiology of HPE is complex and multifactorial. To date, at least 12 HPE-associated genes have been identified, including...

Variant analyses of candidate genes in orofacial clefts in multi-ethnic populations.

Oral diseases

Li M, Olotu J, Buxo-Martinez CJ, Mossey PA, Anand D, Busch T, Alade A, Gowans LJJ, Eshete M, Adeyemo WL, Naicker T, Awotoye WO, Gupta S, Adeleke C, Bravo V, Huang S, Adamson OO, Toraño AM, Bello CA, Soto M, Soto M, Ledesma R, Marquez M, Cordero JF, Lopez-Del Valle LM, Salcedo MI, Debs N, Petrin A, Malloy H, Elhadi K, James O, Ogunlewe MO, Abate F, Hailu A, Mohammed I, Gravem P, Deribew M, Gesses M, Hassan M, Pape J, Obiri-Yeboah S, Arthur FKN, Oti AA, Donkor P, Marazita ML, Lachke SA, Adeyemo AA, Murray JC, Butali A.
PMID: 34061439
Oral Dis. 2021 Jun 01; doi: 10.1111/odi.13932. Epub 2021 Jun 01.

OBJECTIVES: Cleft lip with/without cleft palate and cleft palate only is congenital birth defects where the upper lip and/or palate fail to fuse properly during embryonic facial development. Affecting ~1.2/1000 live births worldwide, these orofacial clefts impose significant social...

Ectopic gut colonization: a metagenomic study of the oral and gut microbiome in Crohn's disease.

Gut pathogens

Hu S, Png E, Gowans M, Ong DEH, de Sessions PF, Song J, Nagarajan N.
PMID: 33632307
Gut Pathog. 2021 Feb 25;13(1):13. doi: 10.1186/s13099-021-00409-5.

BACKGROUND: This study aims to characterize, the gut and oral microbiome in Asian subjects with Crohn's disease (CD) using whole genome shotgun sequencing, thereby allowing for strain-level comparison.METHODS: A case-control study with age, sex and ethnicity matched healthy controls...

In Vitro Infection Dynamics of Japanese Encephalitis Virus in Established Porcine Cell Lines.

Pathogens (Basel, Switzerland)

Adetunji SA, Smolensky D, Mitzel DN, Owens JL, Chitko-McKown CG, Cernicchiaro N, Noronha LE.
PMID: 34832623
Pathogens. 2021 Nov 12;10(11). doi: 10.3390/pathogens10111468.

Japanese encephalitis virus (JEV) is a zoonotic mosquito-borne pathogen that regularly causes severe neurological disease in humans in Southeast Asia and the Western Pacific region. Pigs are one of the main amplifying hosts of JEV and play a central...

Expanding the clinical phenotype of the 3q29 microdeletion syndrome and characterization of the reciprocal microduplication.

Molecular cytogenetics

Ballif BC, Theisen A, Coppinger J, Gowans GC, Hersh JH, Madan-Khetarpal S, Schmidt KR, Tervo R, Escobar LF, Friedrich CA, McDonald M, Campbell L, Ming JE, Zackai EH, Bejjani BA, Shaffer LG.
PMID: 18471269
Mol Cytogenet. 2008 Apr 28;1:8. doi: 10.1186/1755-8166-1-8.

BACKGROUND: Interstitial deletions of 3q29 have been recently described as a microdeletion syndrome mediated by nonallelic homologous recombination between low-copy repeats resulting in an ~1.6 Mb common-sized deletion. Given the molecular mechanism causing the deletion, the reciprocal duplication is...

Editorial: Why Vaccines to HIV, HCV, and Malaria Have So Far Failed-Challenges to Developing Vaccines Against Immunoregulating Pathogens.

Frontiers in microbiology

Li S, Plebanski M, Smooker P, Gowans EJ.
PMID: 26640461
Front Microbiol. 2015 Nov 27;6:1318. doi: 10.3389/fmicb.2015.01318. eCollection 2015.

No abstract available.

Heterogeneity of p53-pathway Protein Expression in Chemosensitive Chronic Lymphocytic Leukemia: A Pilot Study.

Journal of Cancer

Groves MJ, Maccallum SF, Boylan MT, Haydock S, Cunningham J, Gelly K, Gowans D, Kerr R, Coates PJ, Tauro S.
PMID: 22962562
J Cancer. 2012;3:354-61. doi: 10.7150/jca.4813. Epub 2012 Aug 24.

The presence of p53-pathway dysfunction in chronic lymphocytic leukemia (CLL) can be used to identify patients with chemotherapy-refractory disease. Therapeutic responses are known to vary between patients with chemosensitive CLL and may relate to differences in p53-pathway activity. We...

Showing 1 to 12 of 66 entries