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Human Milk Oligosaccharides Modulate the Risk for Preterm Birth in a Microbiome-Dependent and -Independent Manner.


Pausan MR, Kolovetsiou-Kreiner V, Richter GL, Madl T, Giselbrecht E, Obermayer-Pietsch B, Weiss EC, Jantscher-Krenn E, Moissl-Eichinger C.
PMID: 32518196
mSystems. 2020 Jun 09;5(3). doi: 10.1128/mSystems.00334-20.

Preterm birth (PTB) is one of the leading causes of neonatal mortality. The causes for spontaneous PTB are multifactorial and often remain unknown. In this study, we tested the hypothesis that human milk oligosaccharides (HMOs) in blood and urine...

Efficient Transfection of Large Plasmids Encoding HIV-1 into Human Cells-A High Potential Transfection System Based on a Peptide Mimicking Cationic Lipid.


Janich C, Ivanusic D, Giselbrecht J, Janich E, Pinnapireddy SR, Hause G, Bakowsky U, Langner A, Wölk C.
PMID: 32854383
Pharmaceutics. 2020 Aug 25;12(9). doi: 10.3390/pharmaceutics12090805.

One major disadvantage of nucleic acid delivery systems is the low transfection or transduction efficiency of large-sized plasmids into cells. In this communication, we demonstrate the efficient transfection of a 15.5 kb green fluorescent protein (GFP)-fused HIV-1 molecular clone...

Inactive pseudoenzyme subunits in heterotetrameric BbsCD, a novel short-chain alcohol dehydrogenase involved in anaerobic toluene degradation.

The FEBS journal

von Horsten S, Lippert ML, Geisselbrecht Y, Schühle K, Schall I, Essen LO, Heider J.
PMID: 34601806
FEBS J. 2021 Oct 03; doi: 10.1111/febs.16216. Epub 2021 Oct 03.

Anaerobic toluene degradation proceeds by fumarate addition to produce (R)-benzylsuccinate as first intermediate, which is further degraded via β-oxidation by five enzymes encoded in the conserved bbs operon. This study characterizes two enzymes of this pathway, (E)-benzylidenesuccinyl-CoA hydratase (BbsH),...

Coexistence of the Franz-Keldysh and Wannier-Stark effect in semiconductor superlattices.

Physical review. B, Condensed matter

Döhler GH, Geisselbrecht W, Grahn HT, Linder N, Ploog K, Schmidt KH, Schneider H.
PMID: 9981165
Phys Rev B Condens Matter. 1995 Dec 15;52(24):17352-17365. doi: 10.1103/physrevb.52.17352.

No abstract available.

Microthermoforming of flexible, not-buried hollow microstructures for chip-based life sciences applications.

IEE proceedings. Nanobiotechnology

Truckenmüller R, Giselbrecht S.
PMID: 16475862
IEE Proc Nanobiotechnol. 2004 Aug;151(4):163-6. doi: 10.1049/ip-nbt:20040823.

A new method is presented for the manufacturing of flexible, not buried and thin-walled hollow microstructures from polymer films. This low-cost method seems to be especially suited for the fabrication of plastic microstructures for fluidic one-way applications in the...

The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule: An Integrated Computational and In Vitro Study.


King J, Mihaila SM, Ahmed S, Truckenmüller R, Giselbrecht S, Masereeuw R, Carlier A.
PMID: 34678967
Toxins (Basel). 2021 Sep 22;13(10). doi: 10.3390/toxins13100674.

Research has shown that traditional dialysis is an insufficient long-term therapy for patients suffering from end-stage kidney disease due to the high retention of uremic toxins in the blood as a result of the absence of the active transport...

The famous versus the inconvenient - or the dawn and the rise of 3D-culture systems.

World journal of stem cells

Altmann B, Welle A, Giselbrecht S, Truckenmüller R, Gottwald E.
PMID: 21607106
World J Stem Cells. 2009 Dec 31;1(1):43-8. doi: 10.4252/wjsc.v1.i1.43.

One of the greatest impacts on in vitro cell biology was the introduction of three-dimensional (3D) culture systems more than six decades ago and this era may be called the dawn of 3D-tissue culture. Although the advantages were obvious,...

From Snapshots to Development: Identifying the Gaps in the Development of Stem Cell-based Embryo Models along the Embryonic Timeline.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Shankar V, van Blitterswijk C, Vrij E, Giselbrecht S.
PMID: 33898195
Adv Sci (Weinh). 2021 Mar 02;8(8):2004250. doi: 10.1002/advs.202004250. eCollection 2021 Apr.

In recent years, stem cell-based models that reconstruct mouse and human embryogenesis have gained significant traction due to their near-physiological similarity to natural embryos. Embryo models can be generated in large numbers, provide accessibility to a variety of experimental...

The Galapagos Chip Platform for High-Throughput Screening of Cell Adhesive Chemical Micropatterns.

Small (Weinheim an der Bergstrasse, Germany)

Tuvshindorj U, Trouillet V, Vasilevich A, Koch B, Vermeulen S, Carlier A, Alexander MR, Giselbrecht S, Truckenmüller R, de Boer J.
PMID: 34985808
Small. 2022 Jan 05;e2105704. doi: 10.1002/smll.202105704. Epub 2022 Jan 05.

In vivo cells reside in a complex extracellular matrix (ECM) that presents spatially distributed biochemical and -physical cues at the nano- to micrometer scales. Chemical micropatterning is successfully used to generate adhesive islands to control where and how cells...

Mechanistic Computational Models of Epithelial Cell Transporters-the Adorned Heroes of Pharmacokinetics.

Frontiers in pharmacology

King J, Giselbrecht S, Truckenmüller R, Carlier A.
PMID: 34803720
Front Pharmacol. 2021 Nov 04;12:780620. doi: 10.3389/fphar.2021.780620. eCollection 2021.

Epithelial membrane transporter kinetics portray an irrefutable role in solute transport in and out of cells. Mechanistic models are used to investigate the transport of solutes at the organ, tissue, cell or membrane scale. Here, we review the recent...

Microthermoforming as a novel technique for manufacturing scaffolds in tissue engineering (CellChips).

IEE proceedings. Nanobiotechnology

Giselbrecht S, Gietzelt T, Gottwald E, Guber AE, Trautmann C, Truckenmüller R, Weibezahn KF.
PMID: 16475860
IEE Proc Nanobiotechnol. 2004 Aug;151(4):151-7. doi: 10.1049/ip-nbt:20040824.

The CellChip is a microstructured polymer scaffold, which favours a three-dimensional cultivation of cells within an array of cubic microcontainers. The manufacturing process used so far is microinjection moulding combined with laser-based perforation. In a first attempt to simplify...

Dithiafulvenyl-Extended N-Heterotriangulenes and Their Interaction with C.

Chemistry (Weinheim an der Bergstrasse, Germany)

Gliemann BD, Strauss V, Hitzenberger JF, Dral PO, Hampel F, Gisselbrecht JP, Drewello T, Thiel W, Guldi DM, Kivala M.
PMID: 28574611
Chemistry. 2017 Sep 07;23(50):12353-12362. doi: 10.1002/chem.201701625. Epub 2017 Aug 01.

We describe the synthesis as well as the electronic and photophysical characterization of novel N-heterotriangulene derivatives decorated with methoxycarbonyl- and methyl-sulfanyl-substituted dithiafulvenyl moieties. The association of these electron-rich compounds with fullerene C

Showing 1 to 12 of 142 entries