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Showing 1 to 12 of 158 entries
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A 12-Week Double-Blind, Placebo-Controlled, Flexible-Dose Trial of Vilazodone in Generalized Social Anxiety Disorder.

The primary care companion for CNS disorders

Careri JM, Draine AE, Hanover R, Liebowitz MR.
PMID: 27057414
Prim Care Companion CNS Disord. 2015 Nov 26;17(6). doi: 10.4088/PCC.15m01831. eCollection 2015.

OBJECTIVE: To examine the efficacy, safety, and tolerability of vilazodone for subjects (aged 18-75 years) with generalized social anxiety disorder.METHOD: Forty-four subjects with generalized social anxiety disorder (DSM-IV-TR criteria) were randomized to vilazodone or placebo in a 12-week double-blind,...

Development and psychometric analysis of the student-teacher relationship scale - short form.

Frontiers in psychology

Settanni M, Longobardi C, Sclavo E, Fraire M, Prino LE.
PMID: 26167156
Front Psychol. 2015 Jun 26;6:898. doi: 10.3389/fpsyg.2015.00898. eCollection 2015.

The purpose of this study is the construction and validation of an Italian Short Form version of the Student-Teacher Relationship Scale (STRS; Fraire et al., 2013). The analyses were conducted on 1256 students and 210 teachers. The STRS is...

Evolution of Virulence in Natural Populations of the Satellite RNA of Cucumber mosaic virus.

Phytopathology

Escriu F, Fraile A, García-Arenal F.
PMID: 18944553
Phytopathology. 2000 May;90(5):480-5. doi: 10.1094/PHYTO.2000.90.5.480.

From 1986 to 1992, an epidemic of tomato necrosis caused by Cucumber mosaic virus (CMV) plus CMV satellite RNAs (satRNAs) occurred in eastern Spain. From 1989 onward, the frequency of tomato necrosis di-minshed, and it almost completely disappeared after...

Magnetoelastic nature of the dodecagonal anisotropy in holmium metal.

Physical review letters

Benito L, Ciria M, Fraile A, Fort D, Abell JS, Arnaudas JI.
PMID: 17678122
Phys Rev Lett. 2007 Jun 29;98(26):267201. doi: 10.1103/PhysRevLett.98.267201. Epub 2007 Jun 26.

We have investigated the magnetoelastic nature of the dodecagonal anisotropy in the magnetic anisotropy energy (MAE) in the basal plane of the hcp crystalline structure in holmium single crystal. We have proved that the origin of the second harmonic...

Teaching biochemistry at Lisbon University-Facing the challenge of the Bologna Declaration in the 25th anniversary of the biochemistry course.

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

Farinha CM, Freire AP.
PMID: 21591138
Biochem Mol Biol Educ. 2007 Nov;35(6):422-4. doi: 10.1002/bmb.114.

The biochemistry degree has been taught at Lisbon University for 25 years. Since its creation, the curriculum is characterized for being widely eclectic and multidisciplinary. The adoption of the concepts proposed in Europe by the Declaration of Bologna and...

Measuring intracellular enzyme concentrations: Assessing the effect of oxidative stress on the amount of glyoxalase I.

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

Vicente Miranda H, Ferreira AE, Quintas A, Cordeiro C, Freire AP.
PMID: 21591178
Biochem Mol Biol Educ. 2008 Mar;36(2):135-8. doi: 10.1002/bmb.20166.

Enzymology is one of the fundamental areas of biochemistry and involves the study of the structure, kinetics, and regulation of enzyme activity. Research in this area is often conducted with purified enzymes and extrapolated to in vivo conditions. The...

Vibron quasibound state in the noncentrosymmetric tetragonal heavy-fermion compound CeCuAl3.

Physical review letters

Adroja DT, del Moral A, de la Fuente C, Fraile A, Goremychkin EA, Taylor JW, Hillier AD, Fernandez-Alonso F.
PMID: 23003286
Phys Rev Lett. 2012 May 25;108(21):216402. doi: 10.1103/PhysRevLett.108.216402. Epub 2012 May 23.

We have investigated the noncentrosymmetric tetragonal heavy-fermion antiferromagnetic compound CeCuAl3 (T(N)=2.5 K) using inelastic neutron scattering (INS). Our INS results unequivocally reveal the presence of three magnetic excitations centered at 1.3, 9.8, and 20.5 meV. These spectral features cannot...

Olfactory dysfunction in patients with chronic rhinosinusitis.

International journal of otolaryngology

Sánchez-Vallecillo MV, Fraire ME, Baena-Cagnani C, Zernotti ME.
PMID: 22685462
Int J Otolaryngol. 2012;2012:327206. doi: 10.1155/2012/327206. Epub 2012 May 20.

Objectives. To measure the prevalence of and identify the clinical characteristics associated with olfactory decline in patients with chronic rhinosinusitis. Methods and Materials. There is analytical, prospective, and observational study in adult patients with a diagnosis of chronic rhinosinusitis....

Enzyme-Free Immunoassay Using Silver Nanoparticles for Detection of Gliadin at Ultralow Concentrations.

ACS omega

Mercadal PA, Fraire JC, Motrich RD, Coronado EA.
PMID: 31458532
ACS Omega. 2018 Feb 27;3(2):2340-2350. doi: 10.1021/acsomega.7b01840. eCollection 2018 Feb 28.

Determination of biomarkers in clinical or food samples is of crucial importance for monitoring, prevention, and care of public health. The standard procedure used for this purpose is the enzyme-linked immunosorbent assay (ELISA), which makes use of the specific...

BODIPY as electron withdrawing group for the activation of double bonds in asymmetric cycloaddition reactions.

Chemical science

Guerrero-Corella A, Asenjo-Pascual J, Pawar TJ, Díaz-Tendero S, Martín-Sómer A, Gómez CV, Belmonte-Vázquez JL, Ramírez-Ornelas DE, Peña-Cabrera E, Fraile A, Cruz DC, Alemán J.
PMID: 31057762
Chem Sci. 2019 Mar 20;10(15):4346-4351. doi: 10.1039/c9sc00959k. eCollection 2019 Apr 21.

In this work we have found that a BODIPY can be used as an electron withdrawing group for the activation of double bonds in asymmetric catalysis. The synthesis of cyclohexyl derivatives containing a BODIPY unit can easily be achieved

Intramolecular Hydrogen Bond Activation: Thiourea-Organocatalyzed Enantioselective 1,3-Dipolar Cycloaddition of Salicylaldehyde-Derived Azomethine Ylides with Nitroalkenes.

ACS catalysis

Esteban F, Cieślik W, Arpa EM, Guerrero-Corella A, Díaz-Tendero S, Perles J, Fernández-Salas JA, Fraile A, Alemán J.
PMID: 29527400
ACS Catal. 2018 Mar 02;8(3):1884-1890. doi: 10.1021/acscatal.7b03553. Epub 2018 Jan 31.

An organocatalytic strategy for the synthesis of tetrasubstituted pyrrolidines with monoactivated azomethine ylides in high enantiomeric excess and excellent exo/endo selectivity is presented. The key to success is the intramolecular activation via hydrogen bonding through an

Methyl sulfinates as electrophiles in Friedel-Crafts reactions. Synthesis of aryl sulfoxides.

The Journal of organic chemistry

Yuste F, Linares AH, Mastranzo VM, Ortiz B, Sánchez-Obregón R, Fraile A, Ruano JL.
PMID: 21506555
J Org Chem. 2011 Jun 03;76(11):4635-44. doi: 10.1021/jo2006335. Epub 2011 May 03.

The Friedel-Crafts reaction of methyl alkyl- and arylsulfinates with aromatic systems, activated by one or more electron-donating substituents (OH, OMe, NHR, NR(2)), provides alkyl aryl and diaryl sulfoxides under mild conditions and in moderate to good yields. The very...

Showing 1 to 12 of 158 entries