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Showing 1 to 12 of 86 entries
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Influence of Oral Progesterone Administration on Drug-Induced QT Interval Lengthening: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.

JACC. Clinical electrophysiology

Tisdale JE, Jaynes HA, Overholser BR, Sowinski KM, Flockhart DA, Kovacs RJ.
PMID: 28451647
JACC Clin Electrophysiol. 2016 Dec;2(7):765-774. doi: 10.1016/j.jacep.2016.02.015.

OBJECTIVES: We tested the hypothesis that oral progesterone administration attenuates drug-induced QT interval lengthening.BACKGROUND: Evidence from preclinical and human investigations suggests that higher serum progesterone concentrations may be protective against drug-induced QT interval lengthening.METHODS: In this prospective, double-blind, crossover...

Hot topics in antifungal susceptibility testing: A new drug, a bad bug, sweeping caspofungin testing under the rug, and solving the ECV shrug.

Clinical microbiology newsletter

Lockhart SR, Berkow EL.
PMID: 29545657
Clin Microbiol Newsl. 2016 Jul;38(13):103-108. doi: 10.1016/j.clinmicnews.2016.06.001.

There are several new hot topics in antifungals and antifungal susceptibility testing. In this review, four topics of general interest to the clinical microbiology community are discussed. The first topic is the introduction of isavuconazole, a new triazole approved...

Recent Taxonomic Developments with .

Current fungal infection reports

Brandt ME, Lockhart SR.
PMID: 26526658
Curr Fungal Infect Rep. 2012 Sep;6(3):170-177. doi: 10.1007/s12281-012-0094-x.

Increases in susceptible patient populations and advances in identification methods have resulted in the continued recognition of novel yeasts as agents of human infection. Most of these agents are members of the well-recognized genera

A SIGNIFICANCE TEST FOR THE LASSO.

Annals of statistics

Lockhart R, Taylor J, Tibshirani RJ, Tibshirani R.
PMID: 25574062
Ann Stat. 2014 Apr;42(2):413-468. doi: 10.1214/13-AOS1175.

In the sparse linear regression setting, we consider testing the significance of the predictor variable that enters the current lasso model, in the sequence of models visited along the lasso solution path. We propose a simple test statistic based...

Cytochrome P450 3A4*22, PPAR-α, and ARNT polymorphisms and clopidogrel response.

Clinical pharmacology : advances and applications

Kreutz RP, Owens J, Jin Y, Nystrom P, Desta Z, Kreutz Y, Breall JA, Li L, Chiang C, Kovacs RJ, Flockhart DA.
PMID: 24353446
Clin Pharmacol. 2013 Dec 09;5:185-92. doi: 10.2147/CPAA.S53151. eCollection 2013.

Recent candidate gene studies using a human liver bank and in vivo validation in healthy volunteers identified polymorphisms in cytochrome P450 (CYP) 3A4 gene (CYP3A4*22), Ah-receptor nuclear translocator (ARNT), and peroxisome proliferator-activated receptor-α (PPAR-α) genes that are associated with...

Sporting and industrial injuries.

The Australian journal of physiotherapy

Lockhart MR.
PMID: 25026232
Aust J Physiother. 1974 Jun;20(2):86-8. doi: 10.1016/S0004-9514(14)61181-8.

Legally, sporting injuries are of two kinds-they may occur to the participants in a game or to spectators who are observing the progress of a sport.

Two-axis bend measurement with Bragg gratings in multicore optical fiber.

Optics letters

Flockhart GM, MacPherson WN, Barton JS, Jones JD, Zhang L, Bennion I.
PMID: 12659255
Opt Lett. 2003 Mar 15;28(6):387-9. doi: 10.1364/ol.28.000387.

We describe what is to our knowledge the first use of fiber Bragg gratings written into three separate cores of a multicore fiber for two-axis curvature measurement. The gratings act as independent, but isothermal, fiber strain gauges for which...

Single isomer versus racemate: is there a difference? Clinical comparisons in allergy and gastroenterology.

CNS spectrums

Flockhart DA, Nelson HS.
PMID: 15131489
CNS Spectr. 2002 Apr;7(4):23-7. doi: 10.1017/s109285290002856x.

Many commonly prescribed drugs exist as a mixture of two distinct chiral isomer forms (enantiomers), each with its own unique chemistry, receptor affinity, and pharmacokinetic profile. Much is unknown concerning the clinical utility of these single enantiomers. This review...

Application of free-radical chromogens to determination of nitrite and nitrate ions by EPR spectrometry.

Talanta

Tsang EP, Burns DT, Flockhart BD.
PMID: 18965570
Talanta. 1992 Nov;39(11):1561-7. doi: 10.1016/0039-9140(92)80142-z.

Various azines and substituted phenylene diamines are oxidized by the nitrite ion to give stable radicals in an autocatalytic reaction. This finding has now been developed into highly sensitive methods for nitrite determination by EPR spectrometry. Thus, when the...

Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response.

Clinical pharmacology : advances and applications

Kreutz RP, Nystrom P, Kreutz Y, Miao J, Desta Z, Breall JA, Li L, Chiang C, Kovacs R, Flockhart DA, Jin Y.
PMID: 22427735
Clin Pharmacol. 2012;4:13-20. doi: 10.2147/CPAA.S27822. Epub 2012 Feb 20.

BACKGROUND: The metabolic activation of clopidogrel is a two-step process. It has been suggested that paraoxonase-1 (PON1) is a rate-limiting enzyme in the conversion of 2-oxo- clopidogrel to an active thiol metabolite. Conflicting results have been reported in regard...

Impact of the Interaction between 3'-UTR SNPs and microRNA on the Expression of Human Xenobiotic Metabolism Enzyme and Transporter Genes.

Frontiers in genetics

Wei R, Yang F, Urban TJ, Li L, Chalasani N, Flockhart DA, Liu W.
PMID: 23181071
Front Genet. 2012 Nov 21;3:248. doi: 10.3389/fgene.2012.00248. eCollection 2012.

Genetic variation in the expression of human xenobiotic metabolism enzymes and transporters (XMETs) leads to inter-individual variability in metabolism of therapeutic agents as well as differed susceptibility to various diseases. Recent expression quantitative traits loci (eQTL) mapping in a...

Optical characterization of fully programmable MEMS diffraction gratings.

Optics express

Zamkotsian F, Timotijevic B, Lockhart R, Stanley RP, Lanzoni P, Luetzelschwab M, Canonica M, Noell W, Tormen M.
PMID: 23187343
Opt Express. 2012 Nov 05;20(23):25267-74. doi: 10.1364/OE.20.025267.

We have fabricated and characterized fully programmable diffraction gratings consisting of 64 silicon micro-mirrors. The mirrors are 700µm long and 50µm wide with a fill factor of 90%. They are actuated electrostatically and move down by 1.25μm while showing...

Showing 1 to 12 of 86 entries