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Showing 1 to 9 of 9 entries
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Two-Photon Uncaging of Glutamate.

Frontiers in synaptic neuroscience

Ellis-Davies GCR.
PMID: 30687075
Front Synaptic Neurosci. 2019 Jan 09;10:48. doi: 10.3389/fnsyn.2018.00048. eCollection 2018.

Two-photon microscopy produces the excited singlet state of a chromophore with wavelengths approximately double that used for normal excitation. Two photons are absorbed almost simultaneously, via a virtual state, and this makes the excitation technique inherently non-linear. It requires...

Chemical tuning of photoswitchable azobenzenes: a photopharmacological case study using nicotinic transmission.

Beilstein journal of organic chemistry

Sansalone L, Zhao J, Richers MT, Ellis-Davies GCR.
PMID: 31807216
Beilstein J Org Chem. 2019 Nov 21;15:2812-2821. doi: 10.3762/bjoc.15.274. eCollection 2019.

We have developed photochromic probes for the nicotinic acetylcholine receptor that exploit the unique chemical properties of the tetrafluoroazobenzene (4FAB) scaffold. Ultraviolet light switching and rapid thermal relaxation of the metastable

Development of anionically decorated 2-(ortho-nitrophenyl)-propyl-caged neurotransmitters for photolysis in vitro and in vivo.

Chembiochem : a European journal of chemical biology

Kantevari S, Makara JK, Losonczy A, Fellin T, Haydon PG, Magee JC, Ellis-Davies GC.
PMID: 21225599
Chembiochem. 2011 Jan 10; doi: 10.1002/cbic.201000254. Epub 2011 Jan 10.

Three new caged neurotransmitters were synthesized built around the 2-(ortho-nitrophenyl)propyl (NPP) caging chromophore. The NPP-caged L-glutamate (Glu) and γ-aminobutyric acid (GABA) derivatives, which have an extended π-electron system bearing two carboxylates or phosphates were highly soluble (>50 mM) and...

ATP-induced morphological changes in supporting cells of the developing cochlea.

Purinergic signalling

Tritsch NX, Zhang YX, Ellis-Davies G, Bergles DE.
PMID: 20806009
Purinergic Signal. 2010 Jun;6(2):155-66. doi: 10.1007/s11302-010-9189-4. Epub 2010 Jun 10.

The developing cochlea of mammals contains a large group of columnar-shaped cells, which together form a structure known as Kölliker's organ. Prior to the onset of hearing, these inner supporting cells periodically release adenosine 5'-triphosphate (ATP), which activates purinergic...

Determinants of Non-paid Task Division in Gay-, Lesbian-, and Heterosexual-Parent Families With Infants Conceived Using Artificial Reproductive Techniques.

Frontiers in psychology

Van Rijn-Van Gelderen L, Ellis-Davies K, Huijzer-Engbrenghof M, Jorgensen TD, Gross M, Winstanley A, Rubio B, Vecho O, Lamb ME, Bos HM.
PMID: 32477222
Front Psychol. 2020 May 13;11:914. doi: 10.3389/fpsyg.2020.00914. eCollection 2020.

No abstract available.

A chemist and biologist talk to each other about caged neurotransmitters.

Beilstein journal of organic chemistry

Ellis-Davies GC.
PMID: 23399979
Beilstein J Org Chem. 2013;9:64-73. doi: 10.3762/bjoc.9.8. Epub 2013 Jan 11.

Caged compounds are small organic molecules that can be photoactivated with brief pulses of light. They are widely used to study a great variety of biological processes by physiologists, cell biologists and neuroscientists. Initially made and invented by biologists...

Corrigendum: Determinants of Non-paid Task Division in Gay-, Lesbian-, and Heterosexual-Parent Families With Infants Conceived Using Artificial Reproductive Techniques.

Frontiers in psychology

Van Rijn-Van Gelderen L, Ellis-Davies K, Huijzer-Engbrenghof M, Jorgensen TD, Gross M, Winstanley A, Rubio B, Vecho O, Lamb ME, Bos HMW.
PMID: 32765353
Front Psychol. 2020 Jul 16;11:1544. doi: 10.3389/fpsyg.2020.01544. eCollection 2020.

[This corrects the article DOI: 10.3389/fpsyg.2020.00914.].

Coumarin-diene photoswitches for rapid and efficient isomerization with visible light.

Chemical communications (Cambridge, England)

Richers MT, Tran DD, Wachtveitl J, Ellis-Davies GCR.
PMID: 29707710
Chem Commun (Camb). 2018 May 10;54(39):4983-4986. doi: 10.1039/c8cc01091a.

We have developed 7-diethylaminocoumarin-based chromophores that photoisomerize with visible light. These photoswitches possess many desirable attributes, including large extinction coefficients (18 600-59 100 M-1 cm-1), high quantum yields (0.45-0.50) and resistance to photofatigue. Additionally, time-resolved spectroscopy indicates that both...

Two-photon microscopy for chemical neuroscience.

ACS chemical neuroscience

Ellis-Davies GC.
PMID: 21731799
ACS Chem Neurosci. 2011 Apr 20;2(4):185-197. doi: 10.1021/cn100111a.

Microscopes using non-linear excitation of chromophores with pulsed near-IR light can generate highly localized foci of molecules in the electronic singlet state that are concentrated in volumes of less than one femtoliter. The three-dimensional confinement of excitation arises from...

Showing 1 to 9 of 9 entries