Derrick E, Flores M, Scherer K, Bancroft L.
Cureus. 2016 Apr 19;8(4):e577. doi: 10.7759/cureus.577.
The peroneus tertius (PT) muscle is a variably present muscle, uncommonly found in humans. Injury to the PT tendon is rare with virtually no cases reported in the literature. As a consequence of the rarity of this injury, there...
Pathogens (Basel, Switzerland)
Lehmann JS, Matthias MA, Vinetz JM, Fouts DE.
Pathogens. 2014 Apr 10;3(2):280-308. doi: 10.3390/pathogens3020280.
Leptospirosis, caused by pathogenic spirochetes belonging to the genus Leptospira, is a zoonosis with important impacts on human and animal health worldwide. Research on the mechanisms of Leptospira pathogenesis has been hindered due to slow growth of infectious strains,...
Llorente C, Jepsen P, Inamine T, Wang L, Bluemel S, Wang HJ, Loomba R, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Xu J, Kisseleva T, Ho SB, DePew J, Du X, Sørensen HT, Vilstrup H, Nelson KE, Brenner DA, Fouts DE, Schnabl B.
Nat Commun. 2017 Dec 12;8(1):2137. doi: 10.1038/s41467-017-01779-8.
In the original PDF version of this Article, which was published on 16 October 2017, the publication date was incorrectly given as 10 October 2017. This has now been corrected in the PDF; the HTML version of the paper...
Frontiers in physiology
Hartmann P, Lang S, Zeng S, Duan Y, Zhang X, Wang Y, Bondareva M, Kruglov A, Fouts DE, Stärkel P, Schnabl B.
Front Physiol. 2021 Jul 19;12:699253. doi: 10.3389/fphys.2021.699253. eCollection 2021.
BACKGROUND: Alcohol-associated liver disease (ALD) is an important cause of morbidity and mortality worldwide. The intestinal microbiota is involved in the development and progression of ALD; however, little is known about commensal fungi therein.METHODS: We studied the dynamic changes...
Wood DE, Lu J, Langmead B.
Genome Biol. 2019 Nov 28;20(1):257. doi: 10.1186/s13059-019-1891-0.
Although Kraken's k-mer-based approach provides a fast taxonomic classification of metagenomic sequence data, its large memory requirements can be limiting for some applications. Kraken 2 improves upon Kraken 1 by reducing memory usage by 85%, allowing greater amounts of...
Microbiology resource announcements
D'Souza R, White RC, Buzzeo R, Goglin K, Vashee S, Lee Y, Son B, Ryu S, Fouts DE.
Microbiol Resour Announc. 2020 Apr 16;9(16). doi: 10.1128/MRA.00114-20.
Pharmaceuticals (Basel, Switzerland)
Nguyen LP, Park CS, Pinto NA, Lee H, Seo HS, Vu TN, Mai H, Pham AHT, Jang E, Cho YL, Goglin K, Nguyen K, White R, D'Souza R, Fouts DE, Yong D.
Pharmaceuticals (Basel). 2021 Apr 16;14(4). doi: 10.3390/ph14040370.
The siderophore-antibiotic conjugate LCB10-0200 (a.k.a. GT-1) has been developed to combat multidrug-resistant Gram-negative bacteria. In this study, the in vitro activity of LCB10-0200 and LCB10-0200/avibactam (AVI) has been investigated against carbapenem-resistant
Journal of hepatology
Demir M, Lang S, Hartmann P, Duan Y, Martin A, Miyamoto Y, Bondareva M, Zhang X, Wang Y, Kasper P, Bang C, Roderburg C, Tacke F, Steffen HM, Goeser T, Kruglov A, Eckmann L, Stärkel P, Fouts DE, Schnabl B.
J Hepatol. 2021 Dec 09; doi: 10.1016/j.jhep.2021.11.029. Epub 2021 Dec 09.
BACKGROUND & AIMS: Studies investigating the gut-liver axis have largely focused on bacteria, whereas little is known about commensal fungi. We characterized fecal fungi in patients with non-alcoholic fatty liver disease (NAFLD) and investigated their role in a fecal...
Merchant S, Wood DE, Salzberg SL.
PeerJ. 2014 Nov 20;2:e675. doi: 10.7717/peerj.675. eCollection 2014.
The raw data from a genome sequencing project sometimes contains DNA from contaminating organisms, which may be introduced during sample collection or sequence preparation. In some instances, these contaminants remain in the sequence even after assembly and deposition of...
The Journal of urology
Garcia-Roig M, Ridley DE, McCracken C, Arlen AM, Cooper CS, Kirsch AJ.
J Urol. 2017 Apr;197(4):1150-1157. doi: 10.1016/j.juro.2016.12.008. Epub 2016 Dec 09.
PURPOSE: The Vesicoureteral Reflux Index is a validated tool that reliably predicts spontaneous resolution of reflux or at least 2 grades of improvement for patients diagnosed before age 24 months. We evaluated the Vesicoureteral Reflux Index in children older...
Journal of hepatology
Hsu CL, Duan Y, Fouts DE, Schnabl B.
J Hepatol. 2021 Dec;75(6):1465-1475. doi: 10.1016/j.jhep.2021.08.003. Epub 2021 Aug 24.
Humans harbour a large quantity of microbes in the intestinal tract and have evolved symbiotic relationships with many of them. However, several specific bacterial pathobionts are associated with liver disease pathogenesis. Although bacteriophages (phages) and eukaryotic viruses (collectively known...
Frontiers in bioengineering and biotechnology
Nath SC, Harper L, Rancourt DE.
Front Bioeng Biotechnol. 2020 Nov 26;8:599674. doi: 10.3389/fbioe.2020.599674. eCollection 2020.
Cell-based therapy (CBT) is attracting much attention to treat incurable diseases. In recent years, several clinical trials have been conducted using human pluripotent stem cells (hPSCs), and other potential therapeutic cells. Various private- and government-funded organizations are investing in...