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Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy.

Scientific reports

Sicca F, Ambrosini E, Marchese M, Sforna L, Servettini I, Valvo G, Brignone MS, Lanciotti A, Moro F, Grottesi A, Catacuzzeno L, Baldini S, Hasan S, D'Adamo MC, Franciolini F, Molinari P, Santorelli FM, Pessia M.
PMID: 27677466
Sci Rep. 2016 Sep 28;6:34325. doi: 10.1038/srep34325.

Dysfunction of the inwardly-rectifying potassium channels Kir4.1 (KCNJ10) represents a pathogenic mechanism contributing to Autism-Epilepsy comorbidity. To define the role of Kir4.1 variants in the disorder, we sequenced KCNJ10 in a sample of affected individuals, and performed genotype-phenotype correlations....

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Sicca F, Ambrosini E, Marchese M, et al. Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy. Sci Rep. 2016;6:34325doi: 10.1038/srep34325.
Sicca, F., Ambrosini, E., Marchese, M., Sforna, L., Servettini, I., Valvo, G., Brignone, M. S., Lanciotti, A., Moro, F., Grottesi, A., Catacuzzeno, L., Baldini, S., Hasan, S., D'Adamo, M. C., Franciolini, F., Molinari, P., Santorelli, F. M., & Pessia, M. (2016). Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy. Scientific reports, 634325. https://doi.org/10.1038/srep34325
Sicca, Federico, et al. "Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy." Scientific reports vol. 6 (2016): 34325. doi: https://doi.org/10.1038/srep34325
Sicca F, Ambrosini E, Marchese M, Sforna L, Servettini I, Valvo G, Brignone MS, Lanciotti A, Moro F, Grottesi A, Catacuzzeno L, Baldini S, Hasan S, D'Adamo MC, Franciolini F, Molinari P, Santorelli FM, Pessia M. Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy. Sci Rep. 2016 Sep 28;6:34325. doi: 10.1038/srep34325. PMID: 27677466; PMCID: PMC5039625.
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Erratum to Benefit of dual-chamber pacing with Closed Loop Stimulation in tilt-induced cardio-inhibitory reflex syncope (BIOSync trial): study protocol for a randomized controlled trial.

Trials

Brignole M, Tomaino M, Aerts A, Ammirati F, Ayala-Paredes FA, Deharo JC, Del Rosso A, Hamdan MH, Lunati M, Moya A, Gargaro A.
PMID: 28595588
Trials. 2017 Jun 08;18(1):269. doi: 10.1186/s13063-017-1988-2.

No abstract available.

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Brignole M, Tomaino M, Aerts A, et al. Erratum to Benefit of dual-chamber pacing with Closed Loop Stimulation in tilt-induced cardio-inhibitory reflex syncope (BIOSync trial): study protocol for a randomized controlled trial. Trials. 2017;18(1):269doi: 10.1186/s13063-017-1988-2.
Brignole, M., Tomaino, M., Aerts, A., Ammirati, F., Ayala-Paredes, F. A., Deharo, J. C., Del Rosso, A., Hamdan, M. H., Lunati, M., Moya, A., Gargaro, A. (2017). Erratum to Benefit of dual-chamber pacing with Closed Loop Stimulation in tilt-induced cardio-inhibitory reflex syncope (BIOSync trial): study protocol for a randomized controlled trial. Trials, 18(1), 269. https://doi.org/10.1186/s13063-017-1988-2
Brignole, Michele, et al. "Erratum to Benefit of dual-chamber pacing with Closed Loop Stimulation in tilt-induced cardio-inhibitory reflex syncope (BIOSync trial): study protocol for a randomized controlled trial." Trials vol. 18,1 (2017): 269. doi: https://doi.org/10.1186/s13063-017-1988-2
Brignole M, Tomaino M, Aerts A, Ammirati F, Ayala-Paredes FA, Deharo JC, Del Rosso A, Hamdan MH, Lunati M, Moya A, Gargaro A. Erratum to Benefit of dual-chamber pacing with Closed Loop Stimulation in tilt-induced cardio-inhibitory reflex syncope (BIOSync trial): study protocol for a randomized controlled trial. Trials. 2017 Jun 08;18(1):269. doi: 10.1186/s13063-017-1988-2. PMID: 28595588; PMCID: PMC5465450.
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Detection of social group instability among captive rhesus macaques using joint network modeling.

Current zoology

Beisner BA, Jin J, Fushing H, Mccowan B.
PMID: 26052339
Curr Zool. 2015 Feb;61(1):70-84. doi: 10.1093/czoolo/61.1.70.

Social stability in group-living animals is an emergent property which arises from the interaction amongst multiple behavioral networks. However, pinpointing when a social group is at risk of collapse is difficult. We used a joint network modeling approach to...

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Beisner BA, Jin J, Fushing H, et al. Detection of social group instability among captive rhesus macaques using joint network modeling. Curr Zool. 2015;61(1):70-84doi: 10.1093/czoolo/61.1.70.
Beisner, B. A., Jin, J., Fushing, H., & Mccowan, B. (2015). Detection of social group instability among captive rhesus macaques using joint network modeling. Current zoology, 61(1), 70-84. https://doi.org/10.1093/czoolo/61.1.70
Beisner, Brianne A, et al. "Detection of social group instability among captive rhesus macaques using joint network modeling." Current zoology vol. 61,1 (2015): 70-84. doi: https://doi.org/10.1093/czoolo/61.1.70
Beisner BA, Jin J, Fushing H, Mccowan B. Detection of social group instability among captive rhesus macaques using joint network modeling. Curr Zool. 2015 Feb;61(1):70-84. doi: 10.1093/czoolo/61.1.70. PMID: 26052339; PMCID: PMC4454484.
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Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73.

Thyroid research

Ragot T, Provost C, Prignon A, Cohen R, Lepoivre M, Lausson S.
PMID: 26273323
Thyroid Res. 2015 Aug 14;8:13. doi: 10.1186/s13044-015-0025-3. eCollection 2015.

BACKGROUND: Medullary thyroid cancer (MTC) is a C-cell neoplasm. Surgery remains its main treatment. Promising therapies based on tyrosine kinase inhibitors demand careful patient selection. We previously observed that two non-steroidal anti-inflammatory drugs (NSAID), indomethacin, celecoxib, and nitric oxide...

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Ragot T, Provost C, Prignon A, et al. Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73. Thyroid Res. 2015;8:13doi: 10.1186/s13044-015-0025-3.
Ragot, T., Provost, C., Prignon, A., Cohen, R., Lepoivre, M., & Lausson, S. (2015). Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73. Thyroid research, 813. https://doi.org/10.1186/s13044-015-0025-3
Ragot, Thierry, et al. "Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73." Thyroid research vol. 8 (2015): 13. doi: https://doi.org/10.1186/s13044-015-0025-3
Ragot T, Provost C, Prignon A, Cohen R, Lepoivre M, Lausson S. Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73. Thyroid Res. 2015 Aug 14;8:13. doi: 10.1186/s13044-015-0025-3. eCollection 2015. PMID: 26273323; PMCID: PMC4535850.
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MLC1 protein: a likely link between leukodystrophies and brain channelopathies.

Frontiers in cellular neuroscience

Brignone MS, Lanciotti A, Camerini S, De Nuccio C, Petrucci TC, Visentin S, Ambrosini E.
PMID: 25883547
Front Cell Neurosci. 2015 Apr 01;9:66. doi: 10.3389/fncel.2015.00106. eCollection 2015.

Megalencephalic leukoencephalopathy with subcortical cysts (MLCs) disease is a rare inherited, autosomal recessive form of childhood-onset spongiform leukodystrophy characterized by macrocephaly, deterioration of motor functions, epileptic seizures and mental decline. Brain edema, subcortical fluid cysts, myelin and astrocyte vacuolation...

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Brignone MS, Lanciotti A, Camerini S, et al. MLC1 protein: a likely link between leukodystrophies and brain channelopathies. Front Cell Neurosci. 2015;9:66doi: 10.3389/fncel.2015.00106.
Brignone, M. S., Lanciotti, A., Camerini, S., De Nuccio, C., Petrucci, T. C., Visentin, S., & Ambrosini, E. (2015). MLC1 protein: a likely link between leukodystrophies and brain channelopathies. Frontiers in cellular neuroscience, 966. https://doi.org/10.3389/fncel.2015.00106
Brignone, Maria S, et al. "MLC1 protein: a likely link between leukodystrophies and brain channelopathies." Frontiers in cellular neuroscience vol. 9 (2015): 66. doi: https://doi.org/10.3389/fncel.2015.00106
Brignone MS, Lanciotti A, Camerini S, De Nuccio C, Petrucci TC, Visentin S, Ambrosini E. MLC1 protein: a likely link between leukodystrophies and brain channelopathies. Front Cell Neurosci. 2015 Apr 01;9:66. doi: 10.3389/fncel.2015.00106. eCollection 2015. PMID: 25883547; PMCID: PMC4381631.
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Isoforms, Distribution And Activities Of beta Spectrins And 4.1 Proteins In Brain.

Cellular & molecular biology letters

Baines AJ, Bignone PA, Hayes NV, Keating LF, Phillips GW, Scott C.
PMID: 11544642
Cell Mol Biol Lett. 2001;6(2):188.

No abstract available.

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Baines AJ, Bignone PA, Hayes NV, et al. Isoforms, Distribution And Activities Of beta Spectrins And 4.1 Proteins In Brain. Cell Mol Biol Lett. 2001;6(2):188
Baines, A. J., Bignone, P. A., Hayes, N. V., Keating, L. F., Phillips, G. W., & Scott, C. (2001). Isoforms, Distribution And Activities Of beta Spectrins And 4.1 Proteins In Brain. Cellular & molecular biology letters, 6(2), 188.
Baines, Anthony J, et al. "Isoforms, Distribution And Activities Of beta Spectrins And 4.1 Proteins In Brain." Cellular & molecular biology letters vol. 6,2 (2001): 188.
Baines AJ, Bignone PA, Hayes NV, Keating LF, Phillips GW, Scott C. Isoforms, Distribution And Activities Of beta Spectrins And 4.1 Proteins In Brain. Cell Mol Biol Lett. 2001;6(2):188. PMID: 11544642.
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Diffraction-limited polarized emission from a multimode ytterbium fiber amplifier after a nonlinear beam converter.

Optics letters

Lombard L, Brignon A, Huignard JP, Lallier E, Lucas-Leclin G, Georges P, Pauliat G, Roosen G.
PMID: 15143650
Opt Lett. 2004 May 01;29(9):989-91. doi: 10.1364/ol.29.000989.

The multimode and depolarized output beam of a highly multimode diode-pumped Yb-doped fiber amplifier is converted to a diffraction-limited, linearly polarized beam by a self-referencing two-wave-mixing process in an infrared-sensitive photorefractive crystal (Rh:BaTiO3). As much as 11.6 W of...

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Lombard L, Brignon A, Huignard JP, et al. Diffraction-limited polarized emission from a multimode ytterbium fiber amplifier after a nonlinear beam converter. Opt Lett. 2004;29(9):989-91doi: 10.1364/ol.29.000989.
Lombard, L., Brignon, A., Huignard, J. P., Lallier, E., Lucas-Leclin, G., Georges, P., Pauliat, G., & Roosen, G. (2004). Diffraction-limited polarized emission from a multimode ytterbium fiber amplifier after a nonlinear beam converter. Optics letters, 29(9), 989-91. https://doi.org/10.1364/ol.29.000989
Lombard, L, et al. "Diffraction-limited polarized emission from a multimode ytterbium fiber amplifier after a nonlinear beam converter." Optics letters vol. 29,9 (2004): 989-91. doi: https://doi.org/10.1364/ol.29.000989
Lombard L, Brignon A, Huignard JP, Lallier E, Lucas-Leclin G, Georges P, Pauliat G, Roosen G. Diffraction-limited polarized emission from a multimode ytterbium fiber amplifier after a nonlinear beam converter. Opt Lett. 2004 May 01;29(9):989-91. doi: 10.1364/ol.29.000989. PMID: 15143650.
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Kelvin-Helmholtz instability for relativistic fluids.

Physical review. E, Statistical, nonlinear, and soft matter physics

Bodo G, Mignone A, Rosner R.
PMID: 15524630
Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Sep;70(3):036304. doi: 10.1103/PhysRevE.70.036304. Epub 2004 Sep 13.

We reexamine the stability of an interface separating two nonmagnetized relativistic fluids in relative motion, showing that, in an appropriate reference frame, it is possible to find analytic solutions to the dispersion relation. Moreover, we show that the critical...

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Bodo G, Mignone A, Rosner R. Kelvin-Helmholtz instability for relativistic fluids. Phys Rev E Stat Nonlin Soft Matter Phys. 2004;70(3):036304doi: 10.1103/PhysRevE.70.036304.
Bodo, G., Mignone, A., & Rosner, R. (2004). Kelvin-Helmholtz instability for relativistic fluids. Physical review. E, Statistical, nonlinear, and soft matter physics, 70(3), 036304. https://doi.org/10.1103/PhysRevE.70.036304
Bodo, G, et al. "Kelvin-Helmholtz instability for relativistic fluids." Physical review. E, Statistical, nonlinear, and soft matter physics vol. 70,3 (2004): 036304. doi: https://doi.org/10.1103/PhysRevE.70.036304
Bodo G, Mignone A, Rosner R. Kelvin-Helmholtz instability for relativistic fluids. Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Sep;70(3):036304. doi: 10.1103/PhysRevE.70.036304. Epub 2004 Sep 13. PMID: 15524630.
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Spatial mode control of a diode-pumped Nd:YAG laser by use of an intracavity holographic phase plate.

Optics letters

Bourderionnet J, Huot N, Brignon A, Huignard JP.
PMID: 18066282
Opt Lett. 2000 Nov 01;25(21):1579-81. doi: 10.1364/ol.25.001579.

We present a new method of realizing phase plates by phase-volume holography on a photopolymer film. We implement such a component in a diode-pumped Nd:YAG oscillator to control the output spatial beam profile. Flattop super-Gaussian and square-shaped beams are...

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Bourderionnet J, Huot N, Brignon A, et al. Spatial mode control of a diode-pumped Nd:YAG laser by use of an intracavity holographic phase plate. Opt Lett. 2000;25(21):1579-81doi: 10.1364/ol.25.001579.
Bourderionnet, J., Huot, N., Brignon, A., & Huignard, J. P. (2000). Spatial mode control of a diode-pumped Nd:YAG laser by use of an intracavity holographic phase plate. Optics letters, 25(21), 1579-81. https://doi.org/10.1364/ol.25.001579
Bourderionnet, J, et al. "Spatial mode control of a diode-pumped Nd:YAG laser by use of an intracavity holographic phase plate." Optics letters vol. 25,21 (2000): 1579-81. doi: https://doi.org/10.1364/ol.25.001579
Bourderionnet J, Huot N, Brignon A, Huignard JP. Spatial mode control of a diode-pumped Nd:YAG laser by use of an intracavity holographic phase plate. Opt Lett. 2000 Nov 01;25(21):1579-81. doi: 10.1364/ol.25.001579. PMID: 18066282.
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IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study.

Journal of immune based therapies and vaccines

Brignone C, Grygar C, Marcu M, Perrin G, Triebel F.
PMID: 17394654
J Immune Based Ther Vaccines. 2007 Mar 29;5:5. doi: 10.1186/1476-8518-5-5.

BACKGROUND: LAG-3 (CD223) is a natural high affinity ligand for MHC class II. The soluble form (sLAG-3) induces maturation of monocyte-derived dendritic cells in vitro and is used as a potent Th1-like immune enhancer with many antigens in animal...

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Brignone C, Grygar C, Marcu M, et al. IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study. J Immune Based Ther Vaccines. 2007;5:5doi: 10.1186/1476-8518-5-5.
Brignone, C., Grygar, C., Marcu, M., Perrin, G., & Triebel, F. (2007). IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study. Journal of immune based therapies and vaccines, 55. https://doi.org/10.1186/1476-8518-5-5
Brignone, Chrystelle, et al. "IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study." Journal of immune based therapies and vaccines vol. 5 (2007): 5. doi: https://doi.org/10.1186/1476-8518-5-5
Brignone C, Grygar C, Marcu M, Perrin G, Triebel F. IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study. J Immune Based Ther Vaccines. 2007 Mar 29;5:5. doi: 10.1186/1476-8518-5-5. PMID: 17394654; PMCID: PMC1852106.
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Self-pumped phase-conjugate diode-pumped Nd:YAG loop resonator.

Optics letters

Sillard P, Brignon A, Huignard JP, Pocholle JP.
PMID: 18087438
Opt Lett. 1998 Jul 15;23(14):1093-5. doi: 10.1364/ol.23.001093.

We demonstrate a self-pumped phase-conjugate diode-pumped Nd:YAG loop resonator. In the injected configuration a maximum phase-conjugate reflectivity of 32 is obtained. The output beam has a pulse shape of ~30 ns , which shows the self- Q -switching ability...

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Sillard P, Brignon A, Huignard JP, et al. Self-pumped phase-conjugate diode-pumped Nd:YAG loop resonator. Opt Lett. 1998;23(14):1093-5doi: 10.1364/ol.23.001093.
Sillard, P., Brignon, A., Huignard, J. P., & Pocholle, J. P. (1998). Self-pumped phase-conjugate diode-pumped Nd:YAG loop resonator. Optics letters, 23(14), 1093-5. https://doi.org/10.1364/ol.23.001093
Sillard, P, et al. "Self-pumped phase-conjugate diode-pumped Nd:YAG loop resonator." Optics letters vol. 23,14 (1998): 1093-5. doi: https://doi.org/10.1364/ol.23.001093
Sillard P, Brignon A, Huignard JP, Pocholle JP. Self-pumped phase-conjugate diode-pumped Nd:YAG loop resonator. Opt Lett. 1998 Jul 15;23(14):1093-5. doi: 10.1364/ol.23.001093. PMID: 18087438.
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Carotid sinus syncope: the most frequent neurally mediated syncope in the elderly.

Archives of gerontology and geriatrics

Menozzi C, Brignole M, Tomasi C, Lolli G, Bottoni N, Oddone D, Gianfranchi L.
PMID: 15374250
Arch Gerontol Geriatr. 1995 Jan-Feb;20(1):7-14. doi: 10.1016/0167-4943(94)00599-3.

The present work reviews current literature and the authors' experience of carotid sinus syndrome (CSS), which is considered to be the most common cause of neurally mediated acute disorders of consciousness in the elderly. Although no definitive consensus about...

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Menozzi C, Brignole M, Tomasi C, et al. Carotid sinus syncope: the most frequent neurally mediated syncope in the elderly. Arch Gerontol Geriatr. 1995;20(1):7-14doi: 10.1016/0167-4943(94)00599-3.
Menozzi, C., Brignole, M., Tomasi, C., Lolli, G., Bottoni, N., Oddone, D., & Gianfranchi, L. (1995). Carotid sinus syncope: the most frequent neurally mediated syncope in the elderly. Archives of gerontology and geriatrics, 20(1), 7-14. https://doi.org/10.1016/0167-4943(94)00599-3
Menozzi, C, et al. "Carotid sinus syncope: the most frequent neurally mediated syncope in the elderly." Archives of gerontology and geriatrics vol. 20,1 (1995): 7-14. doi: https://doi.org/10.1016/0167-4943(94)00599-3
Menozzi C, Brignole M, Tomasi C, Lolli G, Bottoni N, Oddone D, Gianfranchi L. Carotid sinus syncope: the most frequent neurally mediated syncope in the elderly. Arch Gerontol Geriatr. 1995 Jan-Feb;20(1):7-14. doi: 10.1016/0167-4943(94)00599-3. PMID: 15374250.
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