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Showing 1 to 12 of 397 entries
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[The new drugs in pediatrics].

La Presse thermale et climatique

Bader JC.
PMID: 5897402
Presse Therm Clim. 1965;102(3):172-6.

No abstract available.

The Efficacy of IDegLira (Insulin Degludec/Liraglutide Combination) in Adults with Type 2 Diabetes Inadequately Controlled with a GLP-1 Receptor Agonist and Oral Therapy: DUAL III Randomized Clinical Trial.

Diabetes therapy : research, treatment and education of diabetes and related disorders

Linjawi S, Bode BW, Chaykin LB, Courrèges JP, Handelsman Y, Lehmann LM, Mishra A, Simpson RW.
PMID: 27943107
Diabetes Ther. 2017 Feb;8(1):101-114. doi: 10.1007/s13300-016-0218-3. Epub 2016 Dec 10.

INTRODUCTION: The progressive nature of type 2 diabetes necessitates treatment intensification. This often involves intensification with oral antidiabetic drugs (OADs) initially, followed by other agents, such as glucagon-like peptide-1 receptor agonists (GLP-1RAs), with the majority of patients eventually requiring...

Viva voce in postgraduate surgical examinations in anglophone west Africa.

Journal of the West African College of Surgeons

Bode C, Ugwu B, Donkor P.
PMID: 25452940
J West Afr Coll Surg. 2011 Jan;1(1):40-52.

The Viva Voce is a form of assessment dating back to antiquity. It is widely used by the English-speaking West African Postgraduate Medical Colleges for intermediate and exit level examinations. Although it is still popular till the present day,...

Synthesis of chemically and configurationally stable monofluoro acylboronates: effect of ligand structure on their formation, properties, and reactivities.

Journal of the American Chemical Society

Noda H, Bode JW.
PMID: 25723308
J Am Chem Soc. 2015 Mar 25;137(11):3958-66. doi: 10.1021/jacs.5b00822. Epub 2015 Mar 13.

The recent disclosures of two classes of acylborons, potassium acyltrifluoroborates (KATs) and N-methyliminodiacetyl (MIDA) acylboronates, demonstrated that certain acylboron species can be both remarkably stable and uniquely reactive. Here we report new classes of ligands for acylboronates that have...

Erratum: Prediction of human population responses to toxic compounds by a collaborative competition.

Nature biotechnology

Eduati F, Mangravite LM, Wang T, Tang H, Bare JC, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, Kosyk O, Friend S, Dearry A, Simeonov A, Tice RR, Rusyn I, Wright FA, Stolovitzky G, Xie Y, Saez-Rodriguez J.
PMID: 26448092
Nat Biotechnol. 2015 Oct;33(10):1109. doi: 10.1038/nbt1015-1109a.

No abstract available.

Synthesis of Bifunctional Potassium Acyltrifluoroborates.

Organic letters

Liu SM, Mazunin D, Pattabiraman VR, Bode JW.
PMID: 27709962
Org Lett. 2016 Oct 21;18(20):5336-5339. doi: 10.1021/acs.orglett.6b02652. Epub 2016 Oct 06.

New bifunctional potassium acyltrifluoroborate (KAT) substrates have been synthesized in gram scale using optimized reaction conditions. Chemoselective transformation of functional groups in the presence of an acyltrifluoroborate has been demonstrated, and orthogonal reactions of bifunctional KAT reagents are reported....

Synthesis of Acylborons by Ozonolysis of Alkenylboronates: Preparation of an Enantioenriched Amino Acid Acylboronate.

Angewandte Chemie (International ed. in English)

Taguchi J, Ikeda T, Takahashi R, Sasaki I, Ogasawara Y, Dairi T, Kato N, Yamamoto Y, Bode JW, Ito H.
PMID: 28905460
Angew Chem Int Ed Engl. 2017 Oct 23;56(44):13847-13851. doi: 10.1002/anie.201707933. Epub 2017 Sep 29.

A concise synthesis of acylborons was achieved by ozonolysis of alkenyl MIDA (N-methyliminodiacetic acid) boronates. This reaction exhibits excellent functional-group tolerance and is applicable to various acyl MIDA boronates and potassium acyltrifluroborates (KATs) which could not be synthesized by...

Cancer prevention and control: alarming challenges in China.

National science review

Bode AM, Dong Z, Wang H.
PMID: 27308066
Natl Sci Rev. 2016 Mar;3(1):117-127. doi: 10.1093/nsr/nwv054. Epub 2015 Aug 29.

China is geographically the third largest country in the world and the most populated low-to-middle-income country. Cancer incidence and mortality rates for some cancers in the USA and European countries have steadily decreased over the last decades, whereas the...

A novel, general method for the synthesis of nitrile oxides: dehydration of O-silylated hydroxamic acids.

Organic letters

Muri D, Bode JW, Carreira EM.
PMID: 10814371
Org Lett. 2000 Feb 24;2(4):539-41. doi: 10.1021/ol991396q.

[reaction: see text] O-Silylated hydroxamic acids serve as stable, readily accessible, crystalline precursors to nitrile oxides when treated with trifluoromethanesulfonic anhydride and triethylamine. Under these mild conditions in the presence of olefins O-silylated hydroxamic acids afford isoxazoline cycloadducts. This...

Facile construction and divergent transformation of polycyclic isoxazoles: direct access to polyketide architectures.

Organic letters

Bode JW, Hachisu Y, Matsuura T, Suzuki K.
PMID: 12583726
Org Lett. 2003 Feb 20;5(4):391-4. doi: 10.1021/ol027283f.

[reaction: see text] Base-promoted cyclocondensation of C-chloro oximes with cyclic 1,3-diketones affords functionalized isoxazoles in good yield and under convenient reaction conditions. This process enables the synthesis of highly substituted products with notable functional group tolerance. The products obtained...

Isoxazole --> benzisoxazole rearrangement promoted cascade reactions affording stereodefined polycycles.

Organic letters

Bode JW, Uesuka H, Suzuki K.
PMID: 12583727
Org Lett. 2003 Feb 20;5(4):395-8. doi: 10.1021/ol0272848.

[reaction: see text] A new chemo-, regio-, and stereoselective cascade reaction features a novel isoxazole --> benzisoxazole rearrangement and affords highly functionalized, differentially protected compounds. The products of this reaction are directly converted to a number of complex, structurally...

Catalytic enantioselective crossed aldehyde-ketone benzoin cyclization.

Angewandte Chemie (International ed. in English)

Takikawa H, Hachisu Y, Bode JW, Suzuki K.
PMID: 16637094
Angew Chem Int Ed Engl. 2006 May 19;45(21):3492-4. doi: 10.1002/anie.200600268.

No abstract available.

Showing 1 to 12 of 397 entries