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In vitro drug release studies of polymeric freeze-dried wafers and solvent-cast films using paracetamol as a model soluble drug.

International journal of pharmaceutics

Boateng JS, Matthews KH, Auffret AD, Humphrey MJ, Stevens HN, Eccleston GM.
PMID: 19477255
Int J Pharm. 2009 Aug 13;378(1):66-72. doi: 10.1016/j.ijpharm.2009.05.038. Epub 2009 May 27.

Drug dissolution and release characteristics from freeze-dried wafers and solvent-cast films prepared from sodium carboxymethylcellulose (CMC) have been investigated to determine the mechanisms of drug release from the two systems. The formulations were prepared by freeze-drying (wafers) or drying...

Development and physico-mechanical characterization of carrageenan and poloxamer-based lyophilized matrix as a potential buccal drug delivery system.

Drug development and industrial pharmacy

Kianfar F, Ayensu I, Boateng JS.
PMID: 23600651
Drug Dev Ind Pharm. 2014 Mar;40(3):361-9. doi: 10.3109/03639045.2012.762655. Epub 2013 Apr 19.

CONTEXT AND OBJECTIVES: The buccal mucosa presents a unique surface for non-invasive drug delivery and also avoids first-pass metabolism. The objective of this study was the formulation development of polymeric mucoadhesive lyophilized wafers as a matrix for potential buccal...

Preparation and optimization of PMAA-chitosan-PEG nanoparticles for oral drug delivery.

Colloids and surfaces. B, Biointerfaces

Pawar H, Douroumis D, Boateng JS.
PMID: 22037474
Colloids Surf B Biointerfaces. 2012 Feb 01;90:102-8. doi: 10.1016/j.colsurfb.2011.10.005. Epub 2011 Oct 12.

The objective of this study was to develop pH sensitive polymethacrylic acid-chitosan-polyethylene glycol (PCP) nanoparticles. This was achieved by dispersion polymerization of methacrylic acid (MAA), polyethylene glycol (PEG) and different chitosan (CS) grades in the presence of cross linking...

Preparation, optimisation and characterisation of novel wound healing film dressings loaded with streptomycin and diclofenac.

Colloids and surfaces. B, Biointerfaces

Pawar HV, Tetteh J, Boateng JS.
PMID: 23006557
Colloids Surf B Biointerfaces. 2013 Feb 01;102:102-10. doi: 10.1016/j.colsurfb.2012.08.014. Epub 2012 Aug 19.

Streptomycin (STP) and diclofenac (DLF) loaded film dressings were prepared by blending Polyox(®) (POL) with four hydrophilic polymers [hydroxypropylmethylcellulose (HPMC), carrageenan (CAR), sodium alginate (SA) or chitosan (CS)] using glycerol (GLY) as plasticiser. The films were characterised by scanning...

Chitosan-based films for the sustained release of peptides: a new era in buccal delivery?.

Therapeutic delivery

Boateng JS, Okeke O.
PMID: 24998268
Ther Deliv. 2014 May;5(5):497-500. doi: 10.4155/tde.14.21.

No abstract available.

Determination of homocysteine in human saliva by liquid chromatography and electrospray ionization quadrupole time-of-flight mass spectrometry: profiles in healthy adults.

Protein and peptide letters

Abaye DA, Nielsen B, Boateng JS.
PMID: 24261982
Protein Pept Lett. 2013 Dec;20(12):1382-9. doi: 10.2174/092986652012131112142531.

Homocysteine (Hcys) is a non-essential amino acid associated with a range of diseased and abnormal metabolic conditions. Hcys concentration in saliva is routinely determined by enzyme assays, which are broadly specific, but can be expensive and suffer from cross-reactivity....

Conversion of sustained release omeprazole loaded buccal films into fast dissolving strips using supercritical carbon dioxide (scCO2) processing, for potential paediatric drug delivery.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Khan S, Trivedi V, Mitchell J, Boateng JS.
PMID: 27497613
Eur J Pharm Sci. 2016 Oct 10;93:45-55. doi: 10.1016/j.ejps.2016.08.007. Epub 2016 Aug 04.

This study involves the development of thin oral solvent cast films for the potential delivery of the proton pump inhibitor, omeprazole (OME) via the buccal mucosa for paediatric patients. OME containing films were prepared from ethanolic gels (1% w/w)...

Composite Alginate-Hyaluronan Sponges for the Delivery of Tranexamic Acid in Postextractive Alveolar Wounds.

Journal of pharmaceutical sciences

Catanzano O, D'Esposito V, Formisano P, Boateng JS, Quaglia F.
PMID: 28987501
J Pharm Sci. 2018 Feb;107(2):654-661. doi: 10.1016/j.xphs.2017.09.026. Epub 2017 Oct 05.

The management of wounds in patients on anticoagulant therapy who require oral surgical procedures is problematic and often results in a nonsatisfactory healing process. Here, we report a method to prepare an advanced dressing able to avoid uncontrolled bleeding...

Development and evaluation of performance characteristics of timolol-loaded composite ocular films as potential delivery platforms for treatment of glaucoma.

International journal of pharmaceutics

Tighsazzadeh M, Mitchell JC, Boateng JS.
PMID: 31129346
Int J Pharm. 2019 Jul 20;566:111-125. doi: 10.1016/j.ijpharm.2019.05.059. Epub 2019 May 23.

Thin and erodible polymeric films were developed as potential ocular drug delivery systems to increase drug retention on the eye with the aim of improving bioavailability and achieving controlled drug release. Two biocompatible film forming polymers, hyaluronic acid (HA)...

In vitro, ex vivo and in vivo evaluation of taste masked low dose acetylsalicylic acid loaded composite wafers as platforms for buccal administration in geriatric patients with dysphagia.

International journal of pharmaceutics

Farias S, Boateng JS.
PMID: 32882368
Int J Pharm. 2020 Nov 15;589:119807. doi: 10.1016/j.ijpharm.2020.119807. Epub 2020 Sep 01.

This study reports the development and characterization of taste masked, freeze-dried composite wafers for potential oral and buccal delivery of low dose aspirin (acetylsalicylic acid) to prevent thrombosis in elderly patients with dysphagia. The wafers were formulated by combining...

Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): a potential approach for buccal delivery of macromolecules.

International journal of pharmaceutics

Giovino C, Ayensu I, Tetteh J, Boateng JS.
PMID: 22405987
Int J Pharm. 2012 May 30;428(1):143-51. doi: 10.1016/j.ijpharm.2012.02.035. Epub 2012 Mar 01.

Mucoadhesive chitosan based films, incorporated with insulin loaded nanoparticles (NPs) made of poly(ethylene glycol)methyl ether-block-polylactide (PEG-b-PLA) have been developed and characterised. Blank-NPs were prepared by double emulsion solvent evaporation technique with varying concentrations of the copolymer (5 and 10%,...

Development and optimization of ketoconazole oral strips by means of continuous hot-melt extrusion processing.

The Journal of pharmacy and pharmacology

Maniruzzaman M, Farias S, Slipper IJ, Boateng JS, Chowdhry BZ, Nair A, Douroumis D.
PMID: 27164996
J Pharm Pharmacol. 2016 Jul;68(7):890-900. doi: 10.1111/jphp.12569. Epub 2016 May 11.

OBJECTIVES: The aim of this study was to develop mucoadhesive oral strips using hot-melt extrusion as a continuous manufacturing process.METHODS: Powder blends of ketoconazole, a water-insoluble drug - either hydroxypropyl methylcellulose (HPMC) or soluplus (SOL), sorbitol (SRB) and magnesium...

Showing 1 to 12 of 43 entries