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Showing 1 to 8 of 8 entries
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The efficacy of nurse implemented non-pharmacological strategies for the symptom management of agitation in persons with advanced dementia living in residential aged care facilities: a systematic review.

JBI library of systematic reviews

Blythe SL, Chang E, Johnson A, Griffiths R.
PMID: 27820539
JBI Libr Syst Rev. 2009;7(22):975-1003. doi: 10.11124/01938924-200907220-00001.

AIM: Agitation is a common symptom of dementia which becomes exacerbated in the advanced stages of the disease. The negative effects of this symptom are numerous and often result in institutionalisation. Given it is the registered nurse, with the...

Leukemia in children treated with growth hormone.

Trends in endocrinology and metabolism: TEM

Blethen SL.
PMID: 18406307
Trends Endocrinol Metab. 1998 Nov;9(9):367-70. doi: 10.1016/s1043-2760(98)00091-5.

An association between treatment with growth hormone (GH) and the development of leukemia was described in 1988. This perceived association is best explained by the fact that there are more children with GH deficiency (GHD) with risk factors predisposing...

A Review of Mathematics Determining Solute Uptake at the Blood-Brain Barrier in Normal and Pathological Conditions.

Pharmaceutics

Sprowls SA, Saralkar P, Arsiwala T, Adkins CE, Blethen KE, Pizzuti VJ, Shah N, Fladeland R, Lockman PR.
PMID: 34069733
Pharmaceutics. 2021 May 19;13(5). doi: 10.3390/pharmaceutics13050756.

The blood-brain barrier (BBB) limits movement of solutes from the lumen of the brain microvascular capillary system into the parenchyma. The unidirectional transfer constant,

Resonance between a Prolate and a Superprolate Structure of the Er Nucleus.

Proceedings of the National Academy of Sciences of the United States of America

Pauling L, Blethen J.
PMID: 16592173
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2905-7. doi: 10.1073/pnas.71.7.2905.

Observed energy levels of (162)Er from the normal state J = 0 to the excited rotational state J = 18 correspond to values of the moment of inertia and rotational frequency that indicate that a pronounced change in structure...

Overcoming the acquired resistance to gefitinib in lung cancer brain metastasis in vitro and in vivo.

Archives of toxicology

Liu Z, Shah N, Marshall KL, Sprowls SA, Saralkar P, Mohammad A, Blethen KE, Arsiwala TA, Fladeland R, Lockman PR, Gao W.
PMID: 34455456
Arch Toxicol. 2021 Nov;95(11):3575-3587. doi: 10.1007/s00204-021-03147-4. Epub 2021 Aug 28.

In our previous work, PC-9-Br, a PC-9 brain seeking line established via a preclinical animal model of lung cancer brain metastasis (LCBM), exhibited not only resistance to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) gefitinib in vitro, but also...

Evidence for electrical synapses between neurons of the nucleus reticularis thalami in the adult brain in vitro.

Thalamus & related systems

Blethyn KL, Hughes SW, Crunelli V.
PMID: 18701937
Thalamus Relat Syst. 2008 Mar;4(1):13-20. doi: 10.1017/S1472928807000325.

It has been conclusively demonstrated in juvenile rodents that the inhibitory neurons of the nucleus reticularis thalami (NRT) communicate with each other via connexin 36 (Cx36)-based electrical synapses. However, whether functional electrical synapses persist into adulthood is not fully...

Modulation of the blood-tumor barrier to enhance drug delivery and efficacy for brain metastases.

Neuro-oncology advances

Blethen KE, Arsiwala TA, Fladeland RA, Sprowls SA, Panchal DM, Adkins CE, Kielkowski BN, Earp LE, Glass MJ, Pritt TA, Cabuyao YM, Aulakh S, Lockman PR.
PMID: 34859240
Neurooncol Adv. 2021 Nov 27;3:v133-v143. doi: 10.1093/noajnl/vdab123. eCollection 2021 Nov.

The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low permeability is beneficial in the presence of toxins and pathogens in the blood. However, in the presence of metastatic brain...

Ultrasound-mediated disruption of the blood tumor barrier for improved therapeutic delivery.

Neoplasia (New York, N.Y.)

Arsiwala TA, Sprowls SA, Blethen KE, Adkins CE, Saralkar PA, Fladeland RA, Pentz W, Gabriele A, Kielkowski B, Mehta RI, Wang P, Carpenter JS, Ranjan M, Najib U, Rezai AR, Lockman PR.
PMID: 34139452
Neoplasia. 2021 Jul;23(7):676-691. doi: 10.1016/j.neo.2021.04.005. Epub 2021 Jun 14.

The blood-brain barrier (BBB) is a major anatomical and physiological barrier limiting the passage of drugs into brain. Central nervous system tumors can impair the BBB by changing the tumor microenvironment leading to the formation of a leaky barrier,...

Showing 1 to 8 of 8 entries