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Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice.

eLife

Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI.
PMID: 34652270
Elife. 2021 Oct 15;10. doi: 10.7554/eLife.69056.

Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition characterized by mechanical hypersensitivity. We previously identified microglial activation via release of colony-stimulating factor 1 (CSF1) from injured sensory neurons as a mechanism contributing to nerve injury-induced pain....

Cite
Kuhn JA, Vainchtein ID, Braz J, et al. Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice. Elife. 2021;10doi: 10.7554/eLife.69056.
Kuhn, J. A., Vainchtein, I. D., Braz, J., Hamel, K., Bernstein, M., Craik, V., Dahlgren, M. W., Ortiz-Carpena, J., Molofsky, A. B., Molofsky, A. V., & Basbaum, A. I. (2021). Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice. eLife, 10. https://doi.org/10.7554/eLife.69056
Kuhn, Julia A, et al. "Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.69056
Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI. Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice. Elife. 2021 Oct 15;10. doi: 10.7554/eLife.69056. PMID: 34652270; PMCID: PMC8639143.
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Spinal cord projection neurons: a superficial, and also deep, analysis.

Current opinion in physiology

Wercberger R, Basbaum AI.
PMID: 32864531
Curr Opin Physiol. 2019 Oct;11:109-115. doi: 10.1016/j.cophys.2019.10.002. Epub 2019 Oct 10.

Today there are extensive maps of the molecular heterogeneity of primary afferents and dorsal horn interneurons, yet there is a dearth of molecular and functional information regarding the projection neurons that transmit pain and itch information to the brain....

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Wercberger R, Basbaum AI. Spinal cord projection neurons: a superficial, and also deep, analysis. Curr Opin Physiol. 2019;11:109-115doi: 10.1016/j.cophys.2019.10.002.
Wercberger, R., & Basbaum, A. I. (2019). Spinal cord projection neurons: a superficial, and also deep, analysis. Current opinion in physiology, 11109-115. https://doi.org/10.1016/j.cophys.2019.10.002
Wercberger, Racheli, and Basbaum, Allan I. "Spinal cord projection neurons: a superficial, and also deep, analysis." Current opinion in physiology vol. 11 (2019): 109-115. doi: https://doi.org/10.1016/j.cophys.2019.10.002
Wercberger R, Basbaum AI. Spinal cord projection neurons: a superficial, and also deep, analysis. Curr Opin Physiol. 2019 Oct;11:109-115. doi: 10.1016/j.cophys.2019.10.002. Epub 2019 Oct 10. PMID: 32864531; PMCID: PMC7450810.
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Early antinociception delays edema but does not reduce the magnitude of persistent pain in the formalin test.

The journal of pain

Taylor BK, Basbaum AI.
PMID: 14622621
J Pain. 2000;1(3):218-28. doi: 10.1054/jpai.2000.7308.

Intraplantar formalin injection produces early (Phase 1, 0- to 5-minute) and late (Phase 2, 15-plus minutes after injection) nociceptive responses, including painlike behavior and activation of primary afferents and dorsal horn neurons. Although we and others have reported that...

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Taylor BK, Basbaum AI. Early antinociception delays edema but does not reduce the magnitude of persistent pain in the formalin test. J Pain. 2000;1(3):218-28doi: 10.1054/jpai.2000.7308.
Taylor, B. K., & Basbaum, A. I. (2000). Early antinociception delays edema but does not reduce the magnitude of persistent pain in the formalin test. The journal of pain, 1(3), 218-28. https://doi.org/10.1054/jpai.2000.7308
Taylor, B K, and Basbaum, A I. "Early antinociception delays edema but does not reduce the magnitude of persistent pain in the formalin test." The journal of pain vol. 1,3 (2000): 218-28. doi: https://doi.org/10.1054/jpai.2000.7308
Taylor BK, Basbaum AI. Early antinociception delays edema but does not reduce the magnitude of persistent pain in the formalin test. J Pain. 2000;1(3):218-28. doi: 10.1054/jpai.2000.7308. PMID: 14622621.
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The contribution of spinal cord neurokinin-1 receptor signaling to pain.

The journal of pain

Trafton JA, Basbaum AI.
PMID: 14622844
J Pain. 2000 Sep;1(3):57-65. doi: 10.1054/jpai.2000.9806.

Discovery of the occurrence of neurokinin-1 (NK-1) receptor internalization in response to agonist activation has provided researchers with a new tool for studying tachykinin actions. Using the readily observable end point of NK-1 receptor internalization as an activity marker,...

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Trafton JA, Basbaum AI. The contribution of spinal cord neurokinin-1 receptor signaling to pain. J Pain. 2000;1(3):57-65doi: 10.1054/jpai.2000.9806.
Trafton, J. A., & Basbaum, A. I. (2000). The contribution of spinal cord neurokinin-1 receptor signaling to pain. The journal of pain, 1(3), 57-65. https://doi.org/10.1054/jpai.2000.9806
Trafton, J A, and Basbaum, A I. "The contribution of spinal cord neurokinin-1 receptor signaling to pain." The journal of pain vol. 1,3 (2000): 57-65. doi: https://doi.org/10.1054/jpai.2000.9806
Trafton JA, Basbaum AI. The contribution of spinal cord neurokinin-1 receptor signaling to pain. J Pain. 2000 Sep;1(3):57-65. doi: 10.1054/jpai.2000.9806. PMID: 14622844.
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Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn.

Neuron

Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, de Nooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, Basbaum AI, MacDermott AB, Scherrer G.
PMID: 28898633
Neuron. 2014 Mar 19;81(6):1443. doi: 10.1016/j.neuron.2014.03.006. Epub 2014 Mar 19.

No abstract available.

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Bardoni R, Tawfik VL, Wang D, et al. Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn. Neuron. 2014;81(6):1443doi: 10.1016/j.neuron.2014.03.006.
Bardoni, R., Tawfik, V. L., Wang, D., François, A., Solorzano, C., Shuster, S. A., Choudhury, P., Betelli, C., Cassidy, C., Smith, K., de Nooij, J. C., Mennicken, F., O'Donnell, D., Kieffer, B. L., Woodbury, C. J., Basbaum, A. I., MacDermott, A. B., & Scherrer, G. (2014). Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn. Neuron, 81(6), 1443. https://doi.org/10.1016/j.neuron.2014.03.006
Bardoni, Rita, et al. "Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn." Neuron vol. 81,6 (2014): 1443. doi: https://doi.org/10.1016/j.neuron.2014.03.006
Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, de Nooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, Basbaum AI, MacDermott AB, Scherrer G. Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn. Neuron. 2014 Mar 19;81(6):1443. doi: 10.1016/j.neuron.2014.03.006. Epub 2014 Mar 19. PMID: 28898633.
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Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls.

Pain reports

Juarez-Salinas DL, Braz JM, Hamel KA, Basbaum AI.
PMID: 30123855
Pain Rep. 2018 Jul 17;3(4):e659. doi: 10.1097/PR9.0000000000000659. eCollection 2018.

INTRODUCTION: Gabapentin regulates pain processing by direct action on primary afferent nociceptors and dorsal horn nociresponsive neurons. Through an action at supraspinal levels, gabapentin also engages descending noradrenergic inhibitory controls that indirectly regulate spinal cord pain processing. Although direct...

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Juarez-Salinas DL, Braz JM, Hamel KA, et al. Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls. Pain Rep. 2018;3(4):e659doi: 10.1097/PR9.0000000000000659.
Juarez-Salinas, D. L., Braz, J. M., Hamel, K. A., & Basbaum, A. I. (2018). Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls. Pain reports, 3(4), e659. https://doi.org/10.1097/PR9.0000000000000659
Juarez-Salinas, Dina L, et al. "Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls." Pain reports vol. 3,4 (2018): e659. doi: https://doi.org/10.1097/PR9.0000000000000659
Juarez-Salinas DL, Braz JM, Hamel KA, Basbaum AI. Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls. Pain Rep. 2018 Jul 17;3(4):e659. doi: 10.1097/PR9.0000000000000659. eCollection 2018. PMID: 30123855; PMCID: PMC6085145.
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Structures of the σ.

Nature

Alon A, Lyu J, Braz JM, Tummino TA, Craik V, O'Meara MJ, Webb CM, Radchenko DS, Moroz YS, Huang XP, Liu Y, Roth BL, Irwin JJ, Basbaum AI, Shoichet BK, Kruse AC.
PMID: 34880501
Nature. 2021 Dec;600(7890):759-764. doi: 10.1038/s41586-021-04175-x. Epub 2021 Dec 08.

The σ

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Alon A, Lyu J, Braz JM, et al. Structures of the σ. Nature. 2021;600(7890):759-764doi: 10.1038/s41586-021-04175-x.
Alon, A., Lyu, J., Braz, J. M., Tummino, T. A., Craik, V., O'Meara, M. J., Webb, C. M., Radchenko, D. S., Moroz, Y. S., Huang, X. P., Liu, Y., Roth, B. L., Irwin, J. J., Basbaum, A. I., Shoichet, B. K., & Kruse, A. C. (2021). Structures of the σ. Nature, 600(7890), 759-764. https://doi.org/10.1038/s41586-021-04175-x
Alon, Assaf, et al. "Structures of the σ." Nature vol. 600,7890 (2021): 759-764. doi: https://doi.org/10.1038/s41586-021-04175-x
Alon A, Lyu J, Braz JM, Tummino TA, Craik V, O'Meara MJ, Webb CM, Radchenko DS, Moroz YS, Huang XP, Liu Y, Roth BL, Irwin JJ, Basbaum AI, Shoichet BK, Kruse AC. Structures of the σ. Nature. 2021 Dec;600(7890):759-764. doi: 10.1038/s41586-021-04175-x. Epub 2021 Dec 08. PMID: 34880501.
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Structures of the σ.

Nature

Alon A, Lyu J, Braz JM, Tummino TA, Craik V, O'Meara MJ, Webb CM, Radchenko DS, Moroz YS, Huang XP, Liu Y, Roth BL, Irwin JJ, Basbaum AI, Shoichet BK, Kruse AC.
PMID: 34880501
Nature. 2021 Dec 08; doi: 10.1038/s41586-021-04175-x. Epub 2021 Dec 08.

The σ

Cite
Alon A, Lyu J, Braz JM, et al. Structures of the σ. Nature. 2021;doi: 10.1038/s41586-021-04175-x.
Alon, A., Lyu, J., Braz, J. M., Tummino, T. A., Craik, V., O'Meara, M. J., Webb, C. M., Radchenko, D. S., Moroz, Y. S., Huang, X. P., Liu, Y., Roth, B. L., Irwin, J. J., Basbaum, A. I., Shoichet, B. K., & Kruse, A. C. (2021). Structures of the σ. Nature, . https://doi.org/10.1038/s41586-021-04175-x
Alon, Assaf, et al. "Structures of the σ." Nature vol. (2021). doi: https://doi.org/10.1038/s41586-021-04175-x
Alon A, Lyu J, Braz JM, Tummino TA, Craik V, O'Meara MJ, Webb CM, Radchenko DS, Moroz YS, Huang XP, Liu Y, Roth BL, Irwin JJ, Basbaum AI, Shoichet BK, Kruse AC. Structures of the σ. Nature. 2021 Dec 08; doi: 10.1038/s41586-021-04175-x. Epub 2021 Dec 08. PMID: 34880501.
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Contribution of colony-stimulating factor 1 to neuropathic pain.

Pain reports

Yu X, Basbaum A, Guan Z.
PMID: 33981926
Pain Rep. 2021 Mar 09;6(1):e883. doi: 10.1097/PR9.0000000000000883. eCollection 2021.

Molecular and cellular interactions among spinal dorsal horn neurons and microglia, the resident macrophages of the central nervous system, contribute to the induction and maintenance of neuropathic pain after peripheral nerve injury. Emerging evidence also demonstrates that reciprocal interactions...

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Yu X, Basbaum A, Guan Z. Contribution of colony-stimulating factor 1 to neuropathic pain. Pain Rep. 2021;6(1):e883doi: 10.1097/PR9.0000000000000883.
Yu, X., Basbaum, A., & Guan, Z. (2021). Contribution of colony-stimulating factor 1 to neuropathic pain. Pain reports, 6(1), e883. https://doi.org/10.1097/PR9.0000000000000883
Yu, Xiaobing, et al. "Contribution of colony-stimulating factor 1 to neuropathic pain." Pain reports vol. 6,1 (2021): e883. doi: https://doi.org/10.1097/PR9.0000000000000883
Yu X, Basbaum A, Guan Z. Contribution of colony-stimulating factor 1 to neuropathic pain. Pain Rep. 2021 Mar 09;6(1):e883. doi: 10.1097/PR9.0000000000000883. eCollection 2021. PMID: 33981926; PMCID: PMC8108585.
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Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons.

Proceedings of the National Academy of Sciences of the United States of America

Wercberger R, Braz JM, Weinrich JA, Basbaum AI.
PMID: 34234018
Proc Natl Acad Sci U S A. 2021 Jul 13;118(28). doi: 10.1073/pnas.2105732118.

A remarkable molecular and functional heterogeneity of the primary sensory neurons and dorsal horn interneurons transmits pain- and or itch-relevant information, but the molecular signature of the projection neurons that convey the messages to the brain is unclear. Here,...

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Wercberger R, Braz JM, Weinrich JA, et al. Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons. Proc Natl Acad Sci U S A. 2021;118(28)doi: 10.1073/pnas.2105732118.
Wercberger, R., Braz, J. M., Weinrich, J. A., & Basbaum, A. I. (2021). Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons. Proceedings of the National Academy of Sciences of the United States of America, 118(28), . https://doi.org/10.1073/pnas.2105732118
Wercberger, Racheli, et al. "Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons." Proceedings of the National Academy of Sciences of the United States of America vol. 118,28 (2021). doi: https://doi.org/10.1073/pnas.2105732118
Wercberger R, Braz JM, Weinrich JA, Basbaum AI. Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28). doi: 10.1073/pnas.2105732118. PMID: 34234018; PMCID: PMC8285968.
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Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice.

eLife

Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI.
PMID: 34652270
Elife. 2021 Oct 15;10. doi: 10.7554/eLife.69056.

Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition characterized by mechanical hypersensitivity. We previously identified microglial activation via release of colony-stimulating factor 1 (CSF1) from injured sensory neurons as a mechanism contributing to nerve injury-induced pain....

Cite
Kuhn JA, Vainchtein ID, Braz J, et al. Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice. Elife. 2021;10doi: 10.7554/eLife.69056.
Kuhn, J. A., Vainchtein, I. D., Braz, J., Hamel, K., Bernstein, M., Craik, V., Dahlgren, M. W., Ortiz-Carpena, J., Molofsky, A. B., Molofsky, A. V., & Basbaum, A. I. (2021). Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice. eLife, 10. https://doi.org/10.7554/eLife.69056
Kuhn, Julia A, et al. "Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.69056
Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI. Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice. Elife. 2021 Oct 15;10. doi: 10.7554/eLife.69056. PMID: 34652270; PMCID: PMC8639143.
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Showing 1 to 11 of 11 entries