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Showing 1 to 12 of 494 entries
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COPD: current therapeutic interventions and future approaches

interventions

Barnes PJ.
GSID: gHNSsnFWMGYJ
PJ Barnes, RA Stockley - European Respiratory Journal, 2005 - Eur Respiratory Soc

Although long-acting bronchodilators have been an important advance for the management of chronic obstructive pulmonary disease (COPD), these drugs do not deal with the underlying inflammatory process. No currently available treatments reduce the progression of COPD …

Prospects for new drugs for chronic obstructive pulmonary disease

interventions

Barnes PJ.
GSID: ZjMtGxlaZ-cJ
PJ Barnes, TT Hansel - The Lancet, 2004 - Elsevier

No currently available treatments have been shown to slow the progression of chronic obstructive pulmonary disease (COPD) or suppress the inflammation in small airways and …

Therapeutic Implications and Future Developments

interventions

Barnes PJ.
GSID: auPZLq6MEtIJ
PJ Barnes - Chronic Obstructive Pulmonary Disease, 2005 - api.taylorfrancis.com

Despite the enormous global impact of COPD and the increasing investment in research, there are no current therapies that have been shown to prevent the inevitable progression of …

Determining the critical particle size to induce enhanced emission in aggregates of a highly twisted triarylamine.

Chemphyschem : a European journal of chemical physics and physical chemistry

Kokil A, Chudomel JM, Yang B, Barnes MD, Lahti PM, Kumar J.
PMID: 24123964
Chemphyschem. 2013 Nov 11;14(16):3682-6. doi: 10.1002/cphc.201300667. Epub 2013 Oct 02.

Towards highly luminescent aggregates: A highly twisted triphenylamine displays aggregation-induced enhanced emission. A solvent-specific critical molecular aggregate size, once reached, gives rapid onset of enhanced emission in polar solvent mixtures that favor quenching of solvated individual molecule excited states.

Dye monolayers used as the hole transporting medium in dye-sensitized solar cells.

Advanced materials (Deerfield Beach, Fla.)

Moia D, Leijtens T, Noel N, Snaith HJ, Nelson J, Barnes PR.
PMID: 26308374
Adv Mater. 2015 Oct 21;27(39):5889-94. doi: 10.1002/adma.201501919. Epub 2015 Aug 26.

Dye-sensitized TiO2 can be used as the active layer of solar-cell devices without an additional hole-transporting material. In this architecture, holes are transported through the dye monolayer.

Work Function Modification in P3HT H/J Aggregate Nanostructures Revealed by Kelvin Probe Force Microscopy and Photoluminescence Imaging.

ACS nano

Baghgar M, Barnes MD.
PMID: 26095304
ACS Nano. 2015 Jul 28;9(7):7105-12. doi: 10.1021/acsnano.5b03422. Epub 2015 Jul 09.

We show that surface electronic properties of poly-3-hexylthiophene (P3HT) crystalline nanofibers as probed by Kelvin probe force microscopy (KPFM) depends sensitively on the degree of polymer packing order and dominant coupling type (e.g., H- or J-aggregate) as signaled by...

Carpenter's Rule Folding in Rigid-Flexible Block Copolymers with Conjugation-Interrupting, Flexible Tethers Between Oligophenylenevinylenes.

The journal of physical chemistry. A

Lucas JM, Labastide JA, Wei L, Tinkham JS, Barnes MD, Lahti PM.
PMID: 26125328
J Phys Chem A. 2015 Jul 23;119(29):8010-20. doi: 10.1021/acs.jpca.5b02295. Epub 2015 Jun 30.

Rigid-flexible segmented block copolymers were synthesized and characterized as 4.5-oligophenylenevinylene chromophores tethered by flexible, conjugation-interrupting 1,2-ethanedioxy or 1,4-butanedioxy units. The flexible tethers allow the possibility of collapsed order chromophore assemblies within individual polymers by chain folding at specific sites...

A Mutation Associated with Stuttering Alters Mouse Pup Ultrasonic Vocalizations.

Current biology : CB

Barnes TD, Wozniak DF, Gutierrez J, Han TU, Drayna D, Holy TE.
PMID: 27151663
Curr Biol. 2016 Apr 13; doi: 10.1016/j.cub.2016.02.068. Epub 2016 Apr 13.

A promising approach to understanding the mechanistic basis of speech is to study disorders that affect speech without compromising other cognitive or motor functions. Stuttering, also known as stammering, has been linked to mutations in the lysosomal enzyme-targeting pathway,...

Correlation of rapid point-of-care .

World journal of gastrointestinal pharmacology and therapeutics

Rodriguez A, Yokomizo L, Christofferson M, Barnes D, Khavari N, Park KT.
PMID: 28533922
World J Gastrointest Pharmacol Ther. 2017 May 06;8(2):127-130. doi: 10.4292/wjgpt.v8.i2.127.

AIM: To assess the correlation between the send-out enzyme-linked immuno sorbent assay (ELISA) and the point-of-care (POC) calprotectin test in pediatric inflammatory bowel disease (IBD) patients.METHODS: We prospectively collected stool samples in pediatric IBD patients for concomitant send-out ELISA...

Land-use choices follow profitability at the expense of ecological functions in Indonesian smallholder landscapes.

Nature communications

Clough Y, Krishna VV, Corre MD, Darras K, Denmead LH, Meijide A, Moser S, Musshoff O, Steinebach S, Veldkamp E, Allen K, Barnes AD, Breidenbach N, Brose U, Buchori D, Daniel R, Finkeldey R, Harahap I, Hertel D, Holtkamp AM, Hörandl E, Irawan B, Jaya INS, Jochum M, Klarner B, Knohl A, Kotowska MM, Krashevska V, Kreft H, Kurniawan S, Leuschner C, Maraun M, Melati DN, Opfermann N, Pérez-Cruzado C, Prabowo WE, Rembold K, Rizali A, Rubiana R, Schneider D, Tjitrosoedirdjo SS, Tjoa A, Tscharntke T, Scheu S.
PMID: 27725673
Nat Commun. 2016 Oct 11;7:13137. doi: 10.1038/ncomms13137.

Smallholder-dominated agricultural mosaic landscapes are highlighted as model production systems that deliver both economic and ecological goods in tropical agricultural landscapes, but trade-offs underlying current land-use dynamics are poorly known. Here, using the most comprehensive quantification of land-use change...

Earthquakes drive large-scale submarine canyon development and sediment supply to deep-ocean basins.

Science advances

Mountjoy JJ, Howarth JD, Orpin AR, Barnes PM, Bowden DA, Rowden AA, Schimel ACG, Holden C, Horgan HJ, Nodder SD, Patton JR, Lamarche G, Gerstenberger M, Micallef A, Pallentin A, Kane T.
PMID: 29546245
Sci Adv. 2018 Mar 14;4(3):eaar3748. doi: 10.1126/sciadv.aar3748. eCollection 2018 Mar.

Although the global flux of sediment and carbon from land to the coastal ocean is well known, the volume of material that reaches the deep ocean-the ultimate sink-and the mechanisms by which it is transferred are poorly documented. Using...

Inhaled Corticosteroids.

Pharmaceuticals (Basel, Switzerland)

Barnes PJ.
PMID: 27713266
Pharmaceuticals (Basel). 2010 Mar 08;3(3):514-540. doi: 10.3390/ph3030514.

Inhaled corticosteroids (ICS) are the most effective controllers of asthma. They suppress inflammation mainly by switching off multiple activated inflammatory genes through reversing histone acetylation via the recruitment of histone deacetylase 2 (HDAC2). Through suppression of airway inflammation ICS...

Showing 1 to 12 of 494 entries