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Showing 1 to 12 of 27 entries
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Aerosol Delivery of Surfactant Liposomes for Management of Pulmonary Fibrosis: An Approach Supporting Pulmonary Mechanics.

Pharmaceutics

Kotta S, Aldawsari HM, Badr-Eldin SM, Binmahfouz LS, Bakhaidar RB, Sreeharsha N, Nair AB, Ramnarayanan C.
PMID: 34834265
Pharmaceutics. 2021 Nov 03;13(11). doi: 10.3390/pharmaceutics13111851.

Excessive architectural re-modeling of tissues in pulmonary fibrosis due to proliferation of myofibroblasts and deposition of extracellular matrix adversely affects the elasticity of the alveoli and lung function. Progressively destructive chronic inflammatory disease, therefore, necessitates safe and effective non-invasive...

Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells.

Pharmaceutics

Alhakamy NA, A Fahmy U, Badr-Eldin SM, Ahmed OAA, Asfour HZ, Aldawsari HM, Algandaby MM, Eid BG, Abdel-Naim AB, Awan ZA, K Alruwaili N, Mohamed AI.
PMID: 32290412
Pharmaceutics. 2020 Apr 11;12(4). doi: 10.3390/pharmaceutics12040346.

Icariin (ICA) is a flavonol glycoside that has pleiotropic pharmacological actions. It has cytotoxic effects against ovarian cancer cells and increases their chemosensitivity to chemotherapeutic drugs. Phytosomes are identified for their potential in drug delivery of cytotoxic agents. Thus,...

Minor to Moderate Side Effects of Pfizer-BioNTech COVID-19 Vaccine Among Saudi Residents: A Retrospective Cross-Sectional Study.

International journal of general medicine

El-Shitany NA, Harakeh S, Badr-Eldin SM, Bagher AM, Eid B, Almukadi H, Alghamdi BS, Alahmadi AA, Hassan NA, Sindi N, Alghamdi SA, Almohaimeed HM, Mohammedsaleh ZM, Al-Shaikh TM, Almuhayawi MS, Ali SS, El-Hamamsy M.
PMID: 33907443
Int J Gen Med. 2021 Apr 19;14:1389-1401. doi: 10.2147/IJGM.S310497. eCollection 2021.

BACKGROUND: The Pfizer-BioNTech COVID-19 vaccine has recently received emergency approval from the US FDA. The mRNA technology was used to manufacture the Pfizer vaccine; however, as a pioneering technology that has never been used in the manufacture of vaccines,...

Lung Targeted Lipopolymeric Microspheres of Dexamethasone for the Treatment of ARDS.

Pharmaceutics

Kotta S, Aldawsari HM, Badr-Eldin SM, Binmahfouz LS, Bakhaidar RB, Sreeharsha N, Nair AB, Ramnarayanan C.
PMID: 34575422
Pharmaceutics. 2021 Aug 27;13(9). doi: 10.3390/pharmaceutics13091347.

Acute respiratory distress syndrome (ARDS), a catastrophic illness of multifactorial etiology, involves a rapid upsurge in inflammatory cytokines that leads to hypoxemic respiratory failure. Dexamethasone, a synthetic corticosteroid, mitigates the glucocorticoid-receptor-mediated inflammation and accelerates tissue homeostasis towards disease resolution....

Enhanced pharmacokinetic performance of dapoxetine hydrochloride via the formulation of instantly-dissolving buccal films with acidic pH modifier and hydrophilic cyclodextrin: Factorial analysis, .

Journal of advanced research

Aldawsari HM, Badr-Eldin SM.
PMID: 32419956
J Adv Res. 2020 May 01;24:281-290. doi: 10.1016/j.jare.2020.04.019. eCollection 2020 Jul.

Instantly dissolving buccal films have gained attention owing to their easy administration and capability to surmount the hepatic first pass effect of drugs. Dapoxetine hydrochloride (DPX) has a low oral bioavailability due to significant hepatic first pass metabolism. In...

Piceatannol-Loaded Emulsomes Exhibit Enhanced Cytostatic and Apoptotic Activities in Colon Cancer Cells.

Antioxidants (Basel, Switzerland)

Alhakamy NA, Badr-Eldin SM, Ahmed OAA, Asfour HZ, Aldawsari HM, Algandaby MM, Eid BG, Abdel-Naim AB, Awan ZA, Alghaith AF, Alaofi AL, Mohamed AI, Okbazghi SZ, Al-Rabia MW, Fahmy UA.
PMID: 32414040
Antioxidants (Basel). 2020 May 13;9(5). doi: 10.3390/antiox9050419.

Piceatannol (PIC), a naturally occurring polyphenolic stilbene, has pleiotropic pharmacological activities. It has reported cytotoxic activities against different cancer cells. In the present study, PIC emulsomes (PIC-E) were formulated and assessed for cytotoxic activity. A Box-Behnken design was employed...

The Enhanced Cytotoxic and Pro-Apoptotic Effects of Optimized Simvastatin-Loaded Emulsomes on MCF-7 Breast Cancer Cells.

Pharmaceutics

Awan ZA, Fahmy UA, Badr-Eldin SM, Ibrahim TS, Asfour HZ, Al-Rabia MW, Alfarsi A, Alhakamy NA, Abdulaal WH, Al Sadoun H, Helmi N, Noor AO, Caraci F, Almasri DM, Caruso G.
PMID: 32604984
Pharmaceutics. 2020 Jun 27;12(7). doi: 10.3390/pharmaceutics12070597.

Statins, including simvastatin (SMV), are commonly used for the control of hyperlipidaemia and have also proven therapeutic and preventative effects in cardiovascular diseases. Besides that, there is an emerging interest in their use as antineoplastic drugs as demonstrated by...

Enhanced permeation parameters of optimized nanostructured simvastatin transdermal films: ex vivo and in vivo evaluation.

Pharmaceutical development and technology

El-Say KM, Ahmed TA, Badr-Eldin SM, Fahmy U, Aldawsari H, Ahmed OAA.
PMID: 25019166
Pharm Dev Technol. 2015 Dec;20(8):919-926. doi: 10.3109/10837450.2014.938859. Epub 2014 Jul 14.

OBJECTIVE: Detailed optimization process was carried out to enhance permeation parameters, and hence bioavailability, of simvastatin (SMV) transdermal films.METHODS: SMV solubility was investigated in various oils, surfactants and co-surfactants/co-solvents. Mixtures of the selected components were prepared to identify zone...

Exploring the Potential of Carbon Dots to Combat COVID-19.

Frontiers in molecular biosciences

Kotta S, Aldawsari HM, Badr-Eldin SM, Alhakamy NA, Md S, Nair AB, Deb PK.
PMID: 33425995
Front Mol Biosci. 2020 Dec 17;7:616575. doi: 10.3389/fmolb.2020.616575. eCollection 2020.

Viral diseases are considered as a global burden. The eradication of viral diseases is always a challenging task in medical research due to the high infectivity and mutation capability of the virus. The ongoing COVID-19 pandemic is still not...

Optimized Self-Nanoemulsifying Delivery System Based on Plant-Derived Oil Augments Alpha-Lipoic Acid Protective Effects Against Experimentally Induced Gastric Lesions.

Dose-response : a publication of International Hormesis Society

Badr-Eldin SM, Fahmy UA, Aldawsari HM, Ahmed OAA, Alhakamy NA, Okbazghi SZ, El-Moselhy MA, Alghaith AF, Anter A, Matouk AI, Mahdi WA, Alshehri S, Bakhaidar R.
PMID: 33867893
Dose Response. 2021 Mar 30;19(1):15593258211001259. doi: 10.1177/15593258211001259. eCollection 2021.

Peptic ulcer disease is an injury of the alimentary tract that leads to a mucosal defect reaching the submucosa. Alpha-lipoic acid (ALA), a natural potent antioxidant, has been known as a gastroprotective drug yet its low bioavailability may restrict...

Combating the Pandemic COVID-19: Clinical Trials, Therapies and Perspectives.

Frontiers in molecular biosciences

Kotta S, Aldawsari HM, Badr-Eldin SM, Alhakamy NA, Md S, Nair AB, Deb PK.
PMID: 33282914
Front Mol Biosci. 2020 Nov 17;7:606393. doi: 10.3389/fmolb.2020.606393. eCollection 2020.

The coronavirus disease-19 (COVID-19) is caused due to the infection by a unique single stranded enveloped RNA virus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The COVID-19 has claimed many lives around the globe, and a promising solution to end...

Development of an Icariin-Loaded Bilosome-Melittin Formulation with Improved Anticancer Activity against Cancerous Pancreatic Cells.

Pharmaceuticals (Basel, Switzerland)

Alhakamy NA, Badr-Eldin SM, Alharbi WS, Alfaleh MA, Al-Hejaili OD, Aldawsari HM, Eid BG, Bakhaidar R, Drago F, Caraci F, Caruso G.
PMID: 34959710
Pharmaceuticals (Basel). 2021 Dec 15;14(12). doi: 10.3390/ph14121309.

Pancreatic cancer currently represents a severe issue for the entire world. Therefore, much effort has been made to develop an effective treatment against it. Emerging evidence has shown that icariin, a flavonoid glycoside, is an effective anti-pancreatic cancer drug....

Showing 1 to 12 of 27 entries