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Showing 937 to 948 of 961 entries
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Optimizing drug inventory management with a web-based information system: The TBTC Study 31/ACTG A5349 experience.

Contemporary clinical trials

Scott NA, Lee KK, Sadowski C, Kurbatova EV, Goldberg SV, Nsubuga P, Kitshoff R, Whitelaw C, Thuy HN, Batra K, Allen-Blige C, Davis H, Kim J, Phan M, Fedrick P, Chiu KW, Heilig CM, Sizemore E.
PMID: 33794353
Contemp Clin Trials. 2021 Jun;105:106377. doi: 10.1016/j.cct.2021.106377. Epub 2021 Mar 29.

INTRODUCTION: Efficient management of study drug inventory shipments is critical to keep research sites enrolling into multisite clinical treatment trials. A standard manual drug-management process used by the Tuberculosis Trials Consortium (TBTC), did not accommodate import permit approval timelines,...

Making Compassionate Use More Useful: Using real-world data, real-world evidence and digital twins to supplement or supplant randomized controlled trials.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Greenbaum D.
PMID: 33691002
Pac Symp Biocomput. 2021;26:38-49.

The coronavirus pandemic has placed renewed focus on expanded access (EA) programs to provide compassionate use exceptions to the waves of patients seeking medical care in treating the novel disease. While commendable, justifiable, and compassionate, EA programs are not...

Crystal Structure Prediction Methods for Organic Molecules: State of the Art.

Annual review of chemical and biomolecular engineering

Bowskill DH, Sugden IJ, Konstantinopoulos S, Adjiman CS, Pantelides CC.
PMID: 33770462
Annu Rev Chem Biomol Eng. 2021 Jun 07;12:593-623. doi: 10.1146/annurev-chembioeng-060718-030256. Epub 2021 Mar 26.

The prediction of the crystal structures that a given organic molecule is likely to form is an important theoretical problem of significant interest for the pharmaceutical and agrochemical industries, among others. As evidenced by a series of six blind...

Experimental and Compassionate Drug Use During the First Wave of the COVID-19 Pandemic: A Retrospective Single-Center Study.

Advances in therapy

Assouline O, Ben-Chetrit E, Helviz Y, Kurd R, Leone M, Einav S.
PMID: 34424502
Adv Ther. 2021 Oct;38(10):5165-5177. doi: 10.1007/s12325-021-01890-9. Epub 2021 Aug 22.

INTRODUCTION: Concomitant experimental/compassionate drug administration has been all-pervasive in the treatment of COVID-19 patients. The objective of this study was to study the relationship between patient severity, the number of experimental/compassionate medications received (main outcome measure), and patient outcomes...

Contingent, contested and constructed: a poststructuralist response to Stevens' ontological politics of drug policy.

The International journal on drug policy

Howarth D, Standring A, Huntly S.
PMID: 33032870
Int J Drug Policy. 2021 Jul;93:102965. doi: 10.1016/j.drugpo.2020.102965. Epub 2020 Oct 05.

No abstract available.

Peer support workers as a bridge: a qualitative study exploring the role of peer support workers in the care of people who use drugs during and after hospitalization.

Harm reduction journal

Lennox R, Lamarche L, O'Shea T.
PMID: 33593364
Harm Reduct J. 2021 Feb 16;18(1):19. doi: 10.1186/s12954-021-00467-7.

BACKGROUND: To describe the key qualities and unique roles of peer support workers in the care of people who inject drugs during and after hospitalization.METHODS: We conducted a qualitative study. Key stakeholders were recruited including: people who use drugs...

Patient-Reported Questionnaires to Identify Adverse Drug Reactions: A Systematic Review.

International journal of environmental research and public health

Lim R, Ellett LK, Roughead EE, Cheah PY, Masnoon N.
PMID: 34831635
Int J Environ Res Public Health. 2021 Nov 12;18(22). doi: 10.3390/ijerph182211877.

BACKGROUND: This systematic review aims to summarise available patient-reported questionnaires to detect adverse drug reactions (ADRs) that can be utilised by healthcare professionals in clinical practice and to summarise the psychometric properties (validity, reliability, and responsiveness) of the questionnaires.METHODS:...

Crossing the fourth hurdle.

British journal of clinical pharmacology

Rawlins MD.
PMID: 22404227
Br J Clin Pharmacol. 2012 Jun;73(6):855-60. doi: 10.1111/j.1365-2125.2012.04263.x.

The fourth hurdle, the requirement that pharmaceutical manufacturers can demonstrate that their new products represent good value for money as well as being of good quality, effective and safe, is increasingly being required by healthcare systems. In crossing this...

[The Research Status and Future Direction of Pharmaceutical Sciences and Pharmaceutical Materials in China].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

Zhang ZR.
PMID: 34323027
Sichuan Da Xue Xue Bao Yi Xue Ban. 2021 Jul;52(4):539-542. doi: 10.12182/20210760208.

Pharmaceutical sciences and pharmaceutical materials are a discipline that studies drug dosage forms, formulation technology, and drug release patterns and mechanisms. This article briefly discusses the fundamental research and application of pharmaceutical sciences/pharmaceutical materials, summarizes the hot research topics...

Classification of drugs for evaluating drug interaction in drug development and clinical management.

Drug metabolism and pharmacokinetics

Maeda K, Hisaka A, Ito K, Ohno Y, Ishiguro A, Sato R, Nagai N.
PMID: 34666290
Drug Metab Pharmacokinet. 2021 Dec;41:100414. doi: 10.1016/j.dmpk.2021.100414. Epub 2021 Jul 08.

During new drug development, clinical drug interaction studies are carried out in accordance with the mechanism of potential drug interactions evaluated by in vitro studies. The obtained information should be provided efficiently to medical experts through package inserts and...

A landscape for drug-target interactions based on network analysis.

PloS one

Galan-Vasquez E, Perez-Rueda E.
PMID: 33730052
PLoS One. 2021 Mar 17;16(3):e0247018. doi: 10.1371/journal.pone.0247018. eCollection 2021.

In this work, we performed an analysis of the networks of interactions between drugs and their targets to assess how connected the compounds are. For our purpose, the interactions were downloaded from the DrugBank database, and we considered all...

Factors influencing on development of COVID-19 pneumonia and association with oral anti-diabetic drugs in hospitalized patients with diabetes mellitus.

Primary care diabetes

Elibol A, Eren D, Erdoğan MD, Elmaağaç M, Dizdar OS, Çelik İ, Günal Aİ.
PMID: 34376379
Prim Care Diabetes. 2021 Oct;15(5):806-812. doi: 10.1016/j.pcd.2021.08.001. Epub 2021 Aug 04.

BACKGROUND: Diabetes mellitus (DM) increases mortality and morbidity in patients with coronavirus disease (COVID-19). In this study, it was aimed to assess factors influencing on COVID-19 pneumonia in hospitalized patients with diabetes and association with oral anti-diabetic drugs.MATERIALS AND...

Showing 937 to 948 of 961 entries