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Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes.

Human mutation

Welch RA, Lazaruk K, Haque KA, Hyland F, Xiao N, Wronka L, Burdett L, Chanock SJ, Ingber D, De La Vega FM, Yeager M.
PMID: 18327779
Hum Mutat. 2008 May;29(5):750-6. doi: 10.1002/humu.20703.

A class of genes, known as drug metabolism enzymes (DMEs) are responsible for the metabolism and transport of drugs and other xenobiotics. Variation in DME genes most likely accounts for a proportion of the variability in drug response in...

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Welch RA, Lazaruk K, Haque KA, et al. Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes. Hum Mutat. 2008;29(5):750-6doi: 10.1002/humu.20703.
Welch, R. A., Lazaruk, K., Haque, K. A., Hyland, F., Xiao, N., Wronka, L., Burdett, L., Chanock, S. J., Ingber, D., De La Vega, F. M., & Yeager, M. (2008). Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes. Human mutation, 29(5), 750-6. https://doi.org/10.1002/humu.20703
Welch, Robert A, et al. "Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes." Human mutation vol. 29,5 (2008): 750-6. doi: https://doi.org/10.1002/humu.20703
Welch RA, Lazaruk K, Haque KA, Hyland F, Xiao N, Wronka L, Burdett L, Chanock SJ, Ingber D, De La Vega FM, Yeager M. Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes. Hum Mutat. 2008 May;29(5):750-6. doi: 10.1002/humu.20703. PMID: 18327779.
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Lonza Error Prevention System (EPS) - Changing Human Performance in Pharmaceutical Operations.

Chimia

Bodmann K, Reinhard C, Mödler M, Tinson K, Johnson M.
PMID: 27646541
Chimia (Aarau). 2016;70(9):610-5. doi: 10.2533/chimia.2016.610.

Errors are a part of life. With human errors accounting for approximately 50% of quality incidents and related problems within the pharmaceutical industry, the need to improve human performance in manufacturing operations is obvious. The purpose of this article...

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Bodmann K, Reinhard C, Mödler M, et al. Lonza Error Prevention System (EPS) - Changing Human Performance in Pharmaceutical Operations. Chimia (Aarau). 2016;70(9):610-5doi: 10.2533/chimia.2016.610.
Bodmann, K., Reinhard, C., Mödler, M., Tinson, K., & Johnson, M. (2016). Lonza Error Prevention System (EPS) - Changing Human Performance in Pharmaceutical Operations. Chimia, 70(9), 610-5. https://doi.org/10.2533/chimia.2016.610
Bodmann, Kerstin, et al. "Lonza Error Prevention System (EPS) - Changing Human Performance in Pharmaceutical Operations." Chimia vol. 70,9 (2016): 610-5. doi: https://doi.org/10.2533/chimia.2016.610
Bodmann K, Reinhard C, Mödler M, Tinson K, Johnson M. Lonza Error Prevention System (EPS) - Changing Human Performance in Pharmaceutical Operations. Chimia (Aarau). 2016;70(9):610-5. doi: 10.2533/chimia.2016.610. PMID: 27646541.
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Ensemble-based docking: From hit discovery to metabolism and toxicity predictions.

Bioorganic & medicinal chemistry

Evangelista W, Weir RL, Ellingson SR, Harris JB, Kapoor K, Smith JC, Baudry J.
PMID: 27543390
Bioorg Med Chem. 2016 Oct 15;24(20):4928-4935. doi: 10.1016/j.bmc.2016.07.064. Epub 2016 Jul 29.

This paper describes and illustrates the use of ensemble-based docking, i.e., using a collection of protein structures in docking calculations for hit discovery, the exploration of biochemical pathways and toxicity prediction of drug candidates. We describe the computational engineering...

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Evangelista W, Weir RL, Ellingson SR, et al. Ensemble-based docking: From hit discovery to metabolism and toxicity predictions. Bioorg Med Chem. 2016;24(20):4928-4935doi: 10.1016/j.bmc.2016.07.064.
Evangelista, W., Weir, R. L., Ellingson, S. R., Harris, J. B., Kapoor, K., Smith, J. C., & Baudry, J. (2016). Ensemble-based docking: From hit discovery to metabolism and toxicity predictions. Bioorganic & medicinal chemistry, 24(20), 4928-4935. https://doi.org/10.1016/j.bmc.2016.07.064
Evangelista, Wilfredo, et al. "Ensemble-based docking: From hit discovery to metabolism and toxicity predictions." Bioorganic & medicinal chemistry vol. 24,20 (2016): 4928-4935. doi: https://doi.org/10.1016/j.bmc.2016.07.064
Evangelista W, Weir RL, Ellingson SR, Harris JB, Kapoor K, Smith JC, Baudry J. Ensemble-based docking: From hit discovery to metabolism and toxicity predictions. Bioorg Med Chem. 2016 Oct 15;24(20):4928-4935. doi: 10.1016/j.bmc.2016.07.064. Epub 2016 Jul 29. PMID: 27543390; PMCID: PMC5073379.
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Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models.

Clinical pharmacology and therapeutics

Unadkat JD, Bartha F, Sheiner LB.
PMID: 3720181
Clin Pharmacol Ther. 1986 Jul;40(1):86-93. doi: 10.1038/clpt.1986.143.

Three models, linked in series, can be used to analyze combined pharmacokinetic (PK) and pharmacodynamic (PD) data arising from non--steady-state experiments. A PK model relates dose to plasma drug concentration (Cp); a link model relates Cp to drug concentration...

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Unadkat JD, Bartha F, Sheiner LB. Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models. Clin Pharmacol Ther. 1986;40(1):86-93doi: 10.1038/clpt.1986.143.
Unadkat, J. D., Bartha, F., & Sheiner, L. B. (1986). Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models. Clinical pharmacology and therapeutics, 40(1), 86-93. https://doi.org/10.1038/clpt.1986.143
Unadkat, J D, et al. "Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models." Clinical pharmacology and therapeutics vol. 40,1 (1986): 86-93. doi: https://doi.org/10.1038/clpt.1986.143
Unadkat JD, Bartha F, Sheiner LB. Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models. Clin Pharmacol Ther. 1986 Jul;40(1):86-93. doi: 10.1038/clpt.1986.143. PMID: 3720181.
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Frontiers in clinical pharmacology and therapeutic drug monitoring. Proceedings of a symposium. Toronto, June 6th and 7th, 1985.

Clinical biochemistry

[No authors listed]
PMID: 3708797
Clin Biochem. 1986 Apr;19(2):65-149.

No abstract available.

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Frontiers in clinical pharmacology and therapeutic drug monitoring. Proceedings of a symposium. Toronto, June 6th and 7th, 1985. Clin Biochem. 1986;19(2):65-149
(1986). Frontiers in clinical pharmacology and therapeutic drug monitoring. Proceedings of a symposium. Toronto, June 6th and 7th, 1985. Clinical biochemistry, 19(2), 65-149.
"Frontiers in clinical pharmacology and therapeutic drug monitoring. Proceedings of a symposium. Toronto, June 6th and 7th, 1985." Clinical biochemistry vol. 19,2 (1986): 65-149.
Frontiers in clinical pharmacology and therapeutic drug monitoring. Proceedings of a symposium. Toronto, June 6th and 7th, 1985. Clin Biochem. 1986 Apr;19(2):65-149. PMID: 3708797.
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Pharmacokinetic calculator program for generation of initial parameter estimates from a three-compartment infusion model.

Journal of pharmacological methods

Henderson JD, Olson RD, Ravis WR.
PMID: 3839870
J Pharmacol Methods. 1985 Aug;14(1):13-24. doi: 10.1016/0160-5402(85)90039-7.

A polyexponential curve-stripping program, KIN, is described for use on the HP-41CV programmable calculator. The program may be used in the analysis of plasma-concentration-time curves for a three-compartment intravenous bolus or infusion model with linear elimination processes. The coefficients...

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Henderson JD, Olson RD, Ravis WR. Pharmacokinetic calculator program for generation of initial parameter estimates from a three-compartment infusion model. J Pharmacol Methods. 1985;14(1):13-24doi: 10.1016/0160-5402(85)90039-7.
Henderson, J. D., Olson, R. D., & Ravis, W. R. (1985). Pharmacokinetic calculator program for generation of initial parameter estimates from a three-compartment infusion model. Journal of pharmacological methods, 14(1), 13-24. https://doi.org/10.1016/0160-5402(85)90039-7
Henderson, J D, et al. "Pharmacokinetic calculator program for generation of initial parameter estimates from a three-compartment infusion model." Journal of pharmacological methods vol. 14,1 (1985): 13-24. doi: https://doi.org/10.1016/0160-5402(85)90039-7
Henderson JD, Olson RD, Ravis WR. Pharmacokinetic calculator program for generation of initial parameter estimates from a three-compartment infusion model. J Pharmacol Methods. 1985 Aug;14(1):13-24. doi: 10.1016/0160-5402(85)90039-7. PMID: 3839870.
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Drug metabolite kinetics: noncompartmental analysis.

British journal of clinical pharmacology

Weiss M.
PMID: 4027130
Br J Clin Pharmacol. 1985 Jun;19(6):855-6. doi: 10.1111/j.1365-2125.1985.tb02730.x.
Free PMC Article

No abstract available.

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Weiss M. Drug metabolite kinetics: noncompartmental analysis. Br J Clin Pharmacol. 1985;19(6):855-6doi: 10.1111/j.1365-2125.1985.tb02730.x.
Weiss, M. (1985). Drug metabolite kinetics: noncompartmental analysis. British journal of clinical pharmacology, 19(6), 855-6. https://doi.org/10.1111/j.1365-2125.1985.tb02730.x
Weiss, M. "Drug metabolite kinetics: noncompartmental analysis." British journal of clinical pharmacology vol. 19,6 (1985): 855-6. doi: https://doi.org/10.1111/j.1365-2125.1985.tb02730.x
Weiss M. Drug metabolite kinetics: noncompartmental analysis. Br J Clin Pharmacol. 1985 Jun;19(6):855-6. doi: 10.1111/j.1365-2125.1985.tb02730.x. PMID: 4027130; PMCID: PMC1463887.
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Computation of model-independent pharmacokinetic parameters during multiple dosing.

Journal of pharmaceutical sciences

Chung M.
PMID: 6726649
J Pharm Sci. 1984 Apr;73(4):570-1. doi: 10.1002/jps.2600730436.

No abstract available.

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Chung M. Computation of model-independent pharmacokinetic parameters during multiple dosing. J Pharm Sci. 1984;73(4):570-1doi: 10.1002/jps.2600730436.
Chung, M. (1984). Computation of model-independent pharmacokinetic parameters during multiple dosing. Journal of pharmaceutical sciences, 73(4), 570-1. https://doi.org/10.1002/jps.2600730436
Chung, M. "Computation of model-independent pharmacokinetic parameters during multiple dosing." Journal of pharmaceutical sciences vol. 73,4 (1984): 570-1. doi: https://doi.org/10.1002/jps.2600730436
Chung M. Computation of model-independent pharmacokinetic parameters during multiple dosing. J Pharm Sci. 1984 Apr;73(4):570-1. doi: 10.1002/jps.2600730436. PMID: 6726649.
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Simplified physiologically based method to estimate steady-state volume of distribution.

Journal of pharmaceutical sciences

Chiou WL, Lam G.
PMID: 7310678
J Pharm Sci. 1981 Aug;70(8):967-8. doi: 10.1002/jps.2600700841.

No abstract available.

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Chiou WL, Lam G. Simplified physiologically based method to estimate steady-state volume of distribution. J Pharm Sci. 1981;70(8):967-8doi: 10.1002/jps.2600700841.
Chiou, W. L., & Lam, G. (1981). Simplified physiologically based method to estimate steady-state volume of distribution. Journal of pharmaceutical sciences, 70(8), 967-8. https://doi.org/10.1002/jps.2600700841
Chiou, W L, and Lam, G. "Simplified physiologically based method to estimate steady-state volume of distribution." Journal of pharmaceutical sciences vol. 70,8 (1981): 967-8. doi: https://doi.org/10.1002/jps.2600700841
Chiou WL, Lam G. Simplified physiologically based method to estimate steady-state volume of distribution. J Pharm Sci. 1981 Aug;70(8):967-8. doi: 10.1002/jps.2600700841. PMID: 7310678.
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Editorial.

Journal of pharmaceutical sciences

Audus KL.
PMID: 25594867
J Pharm Sci. 2015 Feb;104(2):288-9. doi: 10.1002/jps.24349. Epub 2015 Jan 15.

No abstract available.

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Audus KL. Editorial. J Pharm Sci. 2015;104(2):288-9doi: 10.1002/jps.24349.
Audus, K. L. (2015). Editorial. Journal of pharmaceutical sciences, 104(2), 288-9. https://doi.org/10.1002/jps.24349
Audus, Kenneth L. "Editorial." Journal of pharmaceutical sciences vol. 104,2 (2015): 288-9. doi: https://doi.org/10.1002/jps.24349
Audus KL. Editorial. J Pharm Sci. 2015 Feb;104(2):288-9. doi: 10.1002/jps.24349. Epub 2015 Jan 15. PMID: 25594867.
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A tiered approach to address regulatory drug metabolite-related issues in drug development.

Bioanalysis

Ma S, Chowdhury SK.
PMID: 24620798
Bioanalysis. 2014 Mar;6(5):587-90. doi: 10.4155/bio.14.40.

No abstract available.

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Ma S, Chowdhury SK. A tiered approach to address regulatory drug metabolite-related issues in drug development. Bioanalysis. 2014;6(5):587-90doi: 10.4155/bio.14.40.
Ma, S., & Chowdhury, S. K. (2014). A tiered approach to address regulatory drug metabolite-related issues in drug development. Bioanalysis, 6(5), 587-90. https://doi.org/10.4155/bio.14.40
Ma, Shuguang, and Chowdhury, Swapan K. "A tiered approach to address regulatory drug metabolite-related issues in drug development." Bioanalysis vol. 6,5 (2014): 587-90. doi: https://doi.org/10.4155/bio.14.40
Ma S, Chowdhury SK. A tiered approach to address regulatory drug metabolite-related issues in drug development. Bioanalysis. 2014 Mar;6(5):587-90. doi: 10.4155/bio.14.40. PMID: 24620798.
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Study of drug function based on similarity of pathway fingerprint.

Protein & cell

Ye H, Tang K, Yang L, Cao Z, Li Y.
PMID: 22426982
Protein Cell. 2012 Feb;3(2):132-9. doi: 10.1007/s13238-012-2011-z. Epub 2012 Mar 17.

Drugs sharing similar therapeutic function may not bind to the same group of targets. However, their targets may be involved in similar pathway profiles which are associated with certain pathological process. In this study, pathway fingerprint was introduced to...

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Ye H, Tang K, Yang L, et al. Study of drug function based on similarity of pathway fingerprint. Protein Cell. 2012;3(2):132-9doi: 10.1007/s13238-012-2011-z.
Ye, H., Tang, K., Yang, L., Cao, Z., & Li, Y. (2012). Study of drug function based on similarity of pathway fingerprint. Protein & cell, 3(2), 132-9. https://doi.org/10.1007/s13238-012-2011-z
Ye, Hao, et al. "Study of drug function based on similarity of pathway fingerprint." Protein & cell vol. 3,2 (2012): 132-9. doi: https://doi.org/10.1007/s13238-012-2011-z
Ye H, Tang K, Yang L, Cao Z, Li Y. Study of drug function based on similarity of pathway fingerprint. Protein Cell. 2012 Feb;3(2):132-9. doi: 10.1007/s13238-012-2011-z. Epub 2012 Mar 17. PMID: 22426982; PMCID: PMC4875411.
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Showing 61 to 72 of 79 entries