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Showing 25 to 36 of 79 entries
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Evidence-based drug treatment for special patient populations through model-based approaches.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Krekels EHJ, van Hasselt JGC, van den Anker JN, Allegaert K, Tibboel D, Knibbe CAJ.
PMID: 28502674
Eur J Pharm Sci. 2017 Nov 15;109:S22-S26. doi: 10.1016/j.ejps.2017.05.022. Epub 2017 May 11.

The majority of marketed drugs remain understudied in some patient populations such as pregnant women, paediatrics, the obese, the critically-ill, and the elderly. As a consequence, currently used dosing regimens may not assure optimal efficacy or minimal toxicity in...

Selection of Informative Examples in Chemogenomic Datasets.

Methods in molecular biology (Clifton, N.J.)

Reker D, Brown JB.
PMID: 30334214
Methods Mol Biol. 2018;1825:369-410. doi: 10.1007/978-1-4939-8639-2_13.

High-throughput and high-content screening campaigns have resulted in the creation of large chemogenomic matrices. These matrices form the training data which is used to build ligand-target interaction models for pharmacological and chemical biology research. While academic, government, and industrial...

Population pharmacokinetics. Theory and clinical application.

Clinical pharmacokinetics

Whiting B, Kelman AW, Grevel J.
PMID: 3536257
Clin Pharmacokinet. 1986 Sep-Oct;11(5):387-401. doi: 10.2165/00003088-198611050-00004.

Good therapeutic practice should always be based on an understanding of pharmacokinetic variability. This ensures that dosage adjustments can be made to accommodate differences in pharmacokinetics due to genetic, environmental, physiological or pathological factors. The identification of the circumstances...

Human drug metabolism in vitro.

Pharmacology & therapeutics

Beaune PH, Guengerich FP.
PMID: 3290907
Pharmacol Ther. 1988;37(2):193-211. doi: 10.1016/0163-7258(88)90025-3.

No abstract available.

Basic concepts in drug metabolism: Part I.

Journal of clinical pharmacology

Woolf TF, Jordan RA.
PMID: 3316300
J Clin Pharmacol. 1987 Jan;27(1):15-7. doi: 10.1177/009127008702700102.

No abstract available.

Predicting drug-disease associations by using similarity constrained matrix factorization.

BMC bioinformatics

Zhang W, Yue X, Lin W, Wu W, Liu R, Huang F, Liu F.
PMID: 29914348
BMC Bioinformatics. 2018 Jun 19;19(1):233. doi: 10.1186/s12859-018-2220-4.

BACKGROUND: Drug-disease associations provide important information for the drug discovery. Wet experiments that identify drug-disease associations are time-consuming and expensive. However, many drug-disease associations are still unobserved or unknown. The development of computational methods for predicting unobserved drug-disease associations...

The Microbiome and Its Potential for Pharmacology.

Handbook of experimental pharmacology

Chavira A, Belda-Ferre P, Kosciolek T, Ali F, Dorrestein PC, Knight R.
PMID: 31820171
Handb Exp Pharmacol. 2019;260:301-326. doi: 10.1007/164_2019_317.

The human microbiota (the microscopic organisms that inhabit us) and microbiome (their genes) hold considerable potential for improving pharmacological practice. Recent advances in multi-"omics" techniques have dramatically improved our understanding of the constituents of the microbiome and their functions....

Rapid method of obtaining area under curve for any compartment of any linear pharmacokinetic model in terms of rate constants.

Journal of pharmacokinetics and biopharmaceutics

Wagner JG.
PMID: 978393
J Pharmacokinet Biopharm. 1976 Jun;4(3):281-5. doi: 10.1007/BF01063618.

No abstract available.

[Drugs and the culturing of hepatocytes].

Bulletin de l'Academie nationale de medecine

Bourel M, Guillouzo A, Guguen-Guillouzo C.
PMID: 2790528
Bull Acad Natl Med. 1989 Apr;173(4):409-12; discussion 412-4.

Two model systems are described for studying isolated hepatocytes in vitro: pure culture for short-term designs and co-culture with epithelial rat liver cells (for long duration procedures). Acute or chronic liver toxicities are discussed as well as indirect toxicities....

Curve fitting and modeling in pharmacokinetics.

Journal of pharmacokinetics and biopharmaceutics

Muir KT, Riegelman S.
PMID: 529031
J Pharmacokinet Biopharm. 1979 Dec;7(6):685-7. doi: 10.1007/BF01061216.

No abstract available.

Estimation of kinetic parameters from a two-point determination of the drug cumulation factor.

Clinical pharmacology and therapeutics

Bjornsson TD, Shand DG.
PMID: 498694
Clin Pharmacol Ther. 1979 Nov;26(5):540-7. doi: 10.1002/cpt1979265540.

A method is described which allows the calculation of kinetic parameters of drugs from two data points, involving a set of simple algebraic equations. This method is based on cumulation characteristics of drugs during multiple dosing. The necessary two...

[Significance of pharmacokinetics for the therapeutic practice].

Casopis lekaru ceskych

[No authors listed]
PMID: 427870
Cas Lek Cesk. 1979 Jan 26;118(4):126-7.

No abstract available.

Showing 25 to 36 of 79 entries