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Showing 13 to 24 of 176 entries
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[Management of adverse events associated with molecular targeted agents].

Hinyokika kiyo. Acta urologica Japonica

Fujisawa M, Sugimura Y.
PMID: 23254791
Hinyokika Kiyo. 2012 Nov;58(11):633.

In Japan, sorafenib and sunitinib, potential molecular targeted agents for advanced renal cell carcinoma, were approved in 2008. Currently, a total of four agents, including everolimus and temsirolimus in addition to these two agents, have been introduced into clinical...

Cardiac side effects of molecular targeted therapies: towards a better dialogue between oncologists and cardiologists.

Critical reviews in oncology/hematology

Ederhy S, Izzedine H, Massard C, Dufaitre G, Spano JP, Milano G, Meuleman C, Besse B, Boccara F, Kahyat D, Cohen A, Soria JC.
PMID: 21330149
Crit Rev Oncol Hematol. 2011 Dec;80(3):369-79. doi: 10.1016/j.critrevonc.2011.01.009. Epub 2011 Feb 16.

Molecular targeted therapies (MTTs) have become a major component of modern management of various hematological and solid malignancies. However, some MTTs have been associated with cardiotoxicity. MTT-induced cardiovascular side effects include left ventricular systolic dysfunction, heart failure, conduction abnormalities,...

[The brand new trend of colorectal carcinoma pathology].

Nihon rinsho. Japanese journal of clinical medicine

Tomita S, Yamauchi M, Ichikawa K, Mitomi H, Fujimori T.
PMID: 24597350
Nihon Rinsho. 2014 Jan;72(1):63-70.

Japanese classification of colorectal carcinoma continues to develop several decades. In 2015, the Japanese Society for Cancer of the Colon and Rectum published the eighth edition of the general rules for clinical and pathological studies on cancer of the...

Bioorthogonal approach to identify unsuspected drug targets in live cells.

Angewandte Chemie (International ed. in English)

Yang KS, Budin G, Tassa C, Kister O, Weissleder R.
PMID: 23960025
Angew Chem Int Ed Engl. 2013 Sep 27;52(40):10593-7. doi: 10.1002/anie.201304096. Epub 2013 Aug 19.

A proteomics method to pull down secondary drug targets from live cells is described. The drug of interest is modified with trans-cyclooctene (TCO) and incubated with live cells. Upon cell lysis, the modified drug bound to the protein is...

Therapy of mantle cell lymphoma: new treatment options in an old disease or vice versa?.

Seminars in hematology

Dreyling M.
PMID: 21782055
Semin Hematol. 2011 Jul;48(3):145-7. doi: 10.1053/j.seminhematol.2011.06.003.

No abstract available.

Molecular targeted approaches in mantle cell lymphoma.

Seminars in hematology

Weniger MA, Wiestner A.
PMID: 21782064
Semin Hematol. 2011 Jul;48(3):214-26. doi: 10.1053/j.seminhematol.2011.05.001.

Mantle cell lymphoma (MCL) is a malignancy of mature B cells characterized by the translocation t(11;14) that leads to aberrant expression of cyclin D1. Response to first-line chemotherapy is good, but most patients relapse, resulting in a median survival...

Putting molecular profiling to the test.

Cancer discovery

[No authors listed]
PMID: 25367966
Cancer Discov. 2014 Nov;4(11):OF4. doi: 10.1158/2159-8290.CD-NB2014-139. Epub 2014 Sep 18.

No abstract available.

A decade of promises in personalised cancer medicine: is the honeymoon over?.

The Medical journal of Australia

Ward RL.
PMID: 24528411
Med J Aust. 2014 Feb 17;200(3):132-3. doi: 10.5694/mja14.00018.

No abstract available.

Displaying chemical information on a biological network using Cytoscape.

Methods in molecular biology (Clifton, N.J.)

Wallace IM, Bader GD, Giaever G, Nislow C.
PMID: 21877291
Methods Mol Biol. 2011;781:363-76. doi: 10.1007/978-1-61779-276-2_18.

Cytoscape is an open-source software package that is widely used to integrate and visualize diverse data sets in biology. This chapter explains how to use Cytoscape to integrate open-source chemical information with a biological network. By visualizing information about...

Cost of illness in colorectal cancer: an international review.

PharmacoEconomics

Kriza C, Emmert M, Wahlster P, Niederländer C, Kolominsky-Rabas P.
PMID: 23636661
Pharmacoeconomics. 2013 Jul;31(7):577-88. doi: 10.1007/s40273-013-0055-4.

OBJECTIVES: Given the current-and increasing-pressure to limit expenditure on health care provision in many countries, a better understanding of the cost burden of colorectal cancer is needed. Cost-of-illness studies and reviews thereof can be a useful tool for analysing...

Are There Any Clinically Relevant Subgroups of Triple-Negative Breast Cancer in 2018?.

Journal of oncology practice

Chan JJ, Tan TJY, Dent RA.
PMID: 29746805
J Oncol Pract. 2018 May;14(5):281-289. doi: 10.1200/JOP.18.00034.

The working immunohistochemical definition of triple-negative breast cancer (TNBC) is admittedly reductionist and has only limited usefulness for informing oncologists about therapeutic decisions beyond chemotherapy. Early molecular taxonomies of TNBC based heavily on gene expression profiling, which is not...

Lung cancer as a paradigm for precision oncology in solid tumours.

Virchows Archiv : an international journal of pathology

Schallenberg S, Merkelbach-Bruse S, Buettner R.
PMID: 28730537
Virchows Arch. 2017 Aug;471(2):221-233. doi: 10.1007/s00428-017-2183-2. Epub 2017 Jul 20.

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the western world. However, the combination of molecular genotyping and subsequent systematic treatment of decoded target structures is a prime example of precision oncology in solid...

Showing 13 to 24 of 176 entries