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A validated UHPLC-MS/MS method for determination of TQ-B3203 in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor.

Journal of separation science

Yang F, Zhou J, Bo Y, Yin H, Liu XH, Li J.
PMID: 33340437
J Sep Sci. 2021 Mar;44(5):945-953. doi: 10.1002/jssc.202001023. Epub 2021 Jan 18.

TQ-B3203 is a new topoisomerase I inhibitor derived from camptothecin. In this paper, a simple and reliable ultra high-performance liquid chromatography-tandem mass spectrometric method was developed and validated for determination of TQ-B3203 in human plasma with TQ-B3203-d

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Yang F, Zhou J, Bo Y, et al. A validated UHPLC-MS/MS method for determination of TQ-B3203 in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor. J Sep Sci. 2021;44(5):945-953doi: 10.1002/jssc.202001023.
Yang, F., Zhou, J., Bo, Y., Yin, H., Liu, X. H., & Li, J. (2021). A validated UHPLC-MS/MS method for determination of TQ-B3203 in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor. Journal of separation science, 44(5), 945-953. https://doi.org/10.1002/jssc.202001023
Yang, Fen, et al. "A validated UHPLC-MS/MS method for determination of TQ-B3203 in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor." Journal of separation science vol. 44,5 (2021): 945-953. doi: https://doi.org/10.1002/jssc.202001023
Yang F, Zhou J, Bo Y, Yin H, Liu XH, Li J. A validated UHPLC-MS/MS method for determination of TQ-B3203 in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor. J Sep Sci. 2021 Mar;44(5):945-953. doi: 10.1002/jssc.202001023. Epub 2021 Jan 18. PMID: 33340437.
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Pushing the Frontiers of Accessible Chemical Space to Unleash Design Creativity and Accelerate Drug Discovery.

Chimia

Fessard TC, Goncharenko K, Lefebvre Q, Salomé C.
PMID: 33115564
Chimia (Aarau). 2020 Oct 28;74(10):803-807. doi: 10.2533/chimia.2020.803.

In highly competitive research environments, the ability to access more complex structural spaces efficiently is a predictor of a company's ability to generate novel IP-protected small molecule candidates with adequate properties, hence filling their development pipelines. SpiroChem is consistently...

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Fessard TC, Goncharenko K, Lefebvre Q, et al. Pushing the Frontiers of Accessible Chemical Space to Unleash Design Creativity and Accelerate Drug Discovery. Chimia (Aarau). 2020;74(10):803-807doi: 10.2533/chimia.2020.803.
Fessard, T. C., Goncharenko, K., Lefebvre, Q., & Salomé, C. (2020). Pushing the Frontiers of Accessible Chemical Space to Unleash Design Creativity and Accelerate Drug Discovery. Chimia, 74(10), 803-807. https://doi.org/10.2533/chimia.2020.803
Fessard, Thomas C, et al. "Pushing the Frontiers of Accessible Chemical Space to Unleash Design Creativity and Accelerate Drug Discovery." Chimia vol. 74,10 (2020): 803-807. doi: https://doi.org/10.2533/chimia.2020.803
Fessard TC, Goncharenko K, Lefebvre Q, Salomé C. Pushing the Frontiers of Accessible Chemical Space to Unleash Design Creativity and Accelerate Drug Discovery. Chimia (Aarau). 2020 Oct 28;74(10):803-807. doi: 10.2533/chimia.2020.803. PMID: 33115564.
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An automated curation procedure for addressing chemical errors and inconsistencies in public datasets used in QSAR modelling.

SAR and QSAR in environmental research

Mansouri K, Grulke CM, Richard AM, Judson RS, Williams AJ.
PMID: 27885862
SAR QSAR Environ Res. 2016 Nov;27(11):939-965. doi: 10.1080/1062936X.2016.1253611.

The increasing availability of large collections of chemical structures and associated experimental data provides an opportunity to build robust QSAR models for applications in different fields. One common concern is the quality of both the chemical structure information and...

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Mansouri K, Grulke CM, Richard AM, et al. An automated curation procedure for addressing chemical errors and inconsistencies in public datasets used in QSAR modelling. SAR QSAR Environ Res. 2016;27(11):939-965doi: 10.1080/1062936X.2016.1253611.
Mansouri, K., Grulke, C. M., Richard, A. M., Judson, R. S., & Williams, A. J. (2016). An automated curation procedure for addressing chemical errors and inconsistencies in public datasets used in QSAR modelling. SAR and QSAR in environmental research, 27(11), 939-965. https://doi.org/10.1080/1062936X.2016.1253611
Mansouri, K, et al. "An automated curation procedure for addressing chemical errors and inconsistencies in public datasets used in QSAR modelling." SAR and QSAR in environmental research vol. 27,11 (2016): 939-965. doi: https://doi.org/10.1080/1062936X.2016.1253611
Mansouri K, Grulke CM, Richard AM, Judson RS, Williams AJ. An automated curation procedure for addressing chemical errors and inconsistencies in public datasets used in QSAR modelling. SAR QSAR Environ Res. 2016 Nov;27(11):939-965. doi: 10.1080/1062936X.2016.1253611. PMID: 27885862.
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WebChem Viewer: a tool for the easy dissemination of chemical and structural data sets.

BMC bioinformatics

Durrant JD, Amaro RE.
PMID: 24886360
BMC Bioinformatics. 2014 May 23;15:159. doi: 10.1186/1471-2105-15-159.

BACKGROUND: Sharing sets of chemical data (e.g., chemical properties, docking scores, etc.) among collaborators with diverse skill sets is a common task in computer-aided drug design and medicinal chemistry. The ability to associate this data with images of the...

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Durrant JD, Amaro RE. WebChem Viewer: a tool for the easy dissemination of chemical and structural data sets. BMC Bioinformatics. 2014;15:159doi: 10.1186/1471-2105-15-159.
Durrant, J. D., & Amaro, R. E. (2014). WebChem Viewer: a tool for the easy dissemination of chemical and structural data sets. BMC bioinformatics, 15159. https://doi.org/10.1186/1471-2105-15-159
Durrant, Jacob D, and Amaro, Rommie E. "WebChem Viewer: a tool for the easy dissemination of chemical and structural data sets." BMC bioinformatics vol. 15 (2014): 159. doi: https://doi.org/10.1186/1471-2105-15-159
Durrant JD, Amaro RE. WebChem Viewer: a tool for the easy dissemination of chemical and structural data sets. BMC Bioinformatics. 2014 May 23;15:159. doi: 10.1186/1471-2105-15-159. PMID: 24886360; PMCID: PMC4094277.
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Fragment library design: using cheminformatics and expert chemists to fill gaps in existing fragment libraries.

Methods in molecular biology (Clifton, N.J.)

Kutchukian PS, So SS, Fischer C, Waller CL.
PMID: 25709032
Methods Mol Biol. 2015;1289:43-53. doi: 10.1007/978-1-4939-2486-8_5.

Fragment based screening (FBS) has emerged as a mainstream lead discovery strategy in academia, biotechnology start-ups, and large pharma. As a prerequisite of FBS, a structurally diverse library of fragments is desirable in order to identify chemical matter that...

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Kutchukian PS, So SS, Fischer C, et al. Fragment library design: using cheminformatics and expert chemists to fill gaps in existing fragment libraries. Methods Mol Biol. 2015;1289:43-53doi: 10.1007/978-1-4939-2486-8_5.
Kutchukian, P. S., So, S. S., Fischer, C., & Waller, C. L. (2015). Fragment library design: using cheminformatics and expert chemists to fill gaps in existing fragment libraries. Methods in molecular biology (Clifton, N.J.), 128943-53. https://doi.org/10.1007/978-1-4939-2486-8_5
Kutchukian, Peter S, et al. "Fragment library design: using cheminformatics and expert chemists to fill gaps in existing fragment libraries." Methods in molecular biology (Clifton, N.J.) vol. 1289 (2015): 43-53. doi: https://doi.org/10.1007/978-1-4939-2486-8_5
Kutchukian PS, So SS, Fischer C, Waller CL. Fragment library design: using cheminformatics and expert chemists to fill gaps in existing fragment libraries. Methods Mol Biol. 2015;1289:43-53. doi: 10.1007/978-1-4939-2486-8_5. PMID: 25709032.
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NMR in medicinal chemistry.

Ernst Schering Research Foundation workshop

Kessler H, Heller M, Gemmecker G, Diercks T, Planker E, Coles M.
PMID: 12664536
Ernst Schering Res Found Workshop. 2003;(42):59-85. doi: 10.1007/978-3-662-05314-0_6.

No abstract available.

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Kessler H, Heller M, Gemmecker G, et al. NMR in medicinal chemistry. Ernst Schering Res Found Workshop. 2003;(42):59-85doi: 10.1007/978-3-662-05314-0_6.
Kessler, H., Heller, M., Gemmecker, G., Diercks, T., Planker, E., & Coles, M. (2003). NMR in medicinal chemistry. Ernst Schering Research Foundation workshop, (42), 59-85. https://doi.org/10.1007/978-3-662-05314-0_6
Kessler, H, et al. "NMR in medicinal chemistry." Ernst Schering Research Foundation workshop vol. ,42 (2003): 59-85. doi: https://doi.org/10.1007/978-3-662-05314-0_6
Kessler H, Heller M, Gemmecker G, Diercks T, Planker E, Coles M. NMR in medicinal chemistry. Ernst Schering Res Found Workshop. 2003;(42):59-85. doi: 10.1007/978-3-662-05314-0_6. PMID: 12664536.
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Molecular structure of nucleic acids. A structure for deoxyribose nucleic acid. 1953.

Annals of internal medicine

Watson JD, Crick FH.
PMID: 12667029
Ann Intern Med. 2003 Apr 01;138(7):581-2. doi: 10.7326/0003-4819-138-7-200304010-00015.

No abstract available.

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Watson JD, Crick FH. Molecular structure of nucleic acids. A structure for deoxyribose nucleic acid. 1953. Ann Intern Med. 2003;138(7):581-2doi: 10.7326/0003-4819-138-7-200304010-00015.
Watson, J. D., & Crick, F. H. (2003). Molecular structure of nucleic acids. A structure for deoxyribose nucleic acid. 1953. Annals of internal medicine, 138(7), 581-2. https://doi.org/10.7326/0003-4819-138-7-200304010-00015
Watson, J D, and Crick, F H C. "Molecular structure of nucleic acids. A structure for deoxyribose nucleic acid. 1953." Annals of internal medicine vol. 138,7 (2003): 581-2. doi: https://doi.org/10.7326/0003-4819-138-7-200304010-00015
Watson JD, Crick FH. Molecular structure of nucleic acids. A structure for deoxyribose nucleic acid. 1953. Ann Intern Med. 2003 Apr 01;138(7):581-2. doi: 10.7326/0003-4819-138-7-200304010-00015. PMID: 12667029.
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Functional diversity of compound libraries.

Current opinion in chemical biology

Gorse D, Lahana R.
PMID: 10826974
Curr Opin Chem Biol. 2000 Jun;4(3):287-94. doi: 10.1016/s1367-5931(00)00091-0.

The ideal designed screening library should contain compounds with a variety of structural shapes and molecular properties, while avoiding redundancies. Other requirements involve the need to find structurally distinct leads and to recognise drug-like molecules. Functional diversity analysis is...

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Gorse D, Lahana R. Functional diversity of compound libraries. Curr Opin Chem Biol. 2000;4(3):287-94doi: 10.1016/s1367-5931(00)00091-0.
Gorse, D., & Lahana, R. (2000). Functional diversity of compound libraries. Current opinion in chemical biology, 4(3), 287-94. https://doi.org/10.1016/s1367-5931(00)00091-0
Gorse, D, and Lahana, R. "Functional diversity of compound libraries." Current opinion in chemical biology vol. 4,3 (2000): 287-94. doi: https://doi.org/10.1016/s1367-5931(00)00091-0
Gorse D, Lahana R. Functional diversity of compound libraries. Curr Opin Chem Biol. 2000 Jun;4(3):287-94. doi: 10.1016/s1367-5931(00)00091-0. PMID: 10826974.
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Modeling chromatographic parameters by a novel graph theoretical sub-structural approach.

Journal of chromatography. A

Estrada E, Gutierrez Y.
PMID: 10551351
J Chromatogr A. 1999 Oct 15;858(2):187-99. doi: 10.1016/s0021-9673(99)00808-0.

A novel approach to the study of quantitative relationships between chromatographic parameters and the chemical structure is introduced. It is based on the computation of the spectral moments of the topological bond matrix by using different weights as diagonal...

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Estrada E, Gutierrez Y. Modeling chromatographic parameters by a novel graph theoretical sub-structural approach. J Chromatogr A. 1999;858(2):187-99doi: 10.1016/s0021-9673(99)00808-0.
Estrada, E., & Gutierrez, Y. (1999). Modeling chromatographic parameters by a novel graph theoretical sub-structural approach. Journal of chromatography. A, 858(2), 187-99. https://doi.org/10.1016/s0021-9673(99)00808-0
Estrada, E, and Gutierrez, Y. "Modeling chromatographic parameters by a novel graph theoretical sub-structural approach." Journal of chromatography. A vol. 858,2 (1999): 187-99. doi: https://doi.org/10.1016/s0021-9673(99)00808-0
Estrada E, Gutierrez Y. Modeling chromatographic parameters by a novel graph theoretical sub-structural approach. J Chromatogr A. 1999 Oct 15;858(2):187-99. doi: 10.1016/s0021-9673(99)00808-0. PMID: 10551351.
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A smart magnetic resonance contrast agent for selective copper sensing.

Journal of the American Chemical Society

Que EL, Chang CJ.
PMID: 17165700
J Am Chem Soc. 2006 Dec 20;128(50):15942-3. doi: 10.1021/ja065264l.

We describe the synthesis and properties of Copper-Gad-1 (CG1), a new type of smart magnetic resonance (MR) sensor for selective detection of copper. CG1 is composed of a gadolinium contrast agent core tethered to copper-selective recognition motif. Cu2+-induced modulation...

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Que EL, Chang CJ. A smart magnetic resonance contrast agent for selective copper sensing. J Am Chem Soc. 2006;128(50):15942-3doi: 10.1021/ja065264l.
Que, E. L., & Chang, C. J. (2006). A smart magnetic resonance contrast agent for selective copper sensing. Journal of the American Chemical Society, 128(50), 15942-3. https://doi.org/10.1021/ja065264l
Que, Emily L, and Chang, Christopher J. "A smart magnetic resonance contrast agent for selective copper sensing." Journal of the American Chemical Society vol. 128,50 (2006): 15942-3. doi: https://doi.org/10.1021/ja065264l
Que EL, Chang CJ. A smart magnetic resonance contrast agent for selective copper sensing. J Am Chem Soc. 2006 Dec 20;128(50):15942-3. doi: 10.1021/ja065264l. PMID: 17165700.
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Langmuir-Blodgett patterning: a bottom-up way to build mesostructures over large areas.

Accounts of chemical research

Chen X, Lenhert S, Hirtz M, Lu N, Fuchs H, Chi L.
PMID: 17441679
Acc Chem Res. 2007 Jun;40(6):393-401. doi: 10.1021/ar600019r. Epub 2007 Apr 19.

This Account describes a new paradigm, Langmuir-Blodgett (LB) patterning, for large-area patterning with mesostructured features based on the well-established LB technique. This strategy uses a simple fabrication technique to control the alignment, size, shape, and periodicity of self-organized phospholipid...

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Chen X, Lenhert S, Hirtz M, et al. Langmuir-Blodgett patterning: a bottom-up way to build mesostructures over large areas. Acc Chem Res. 2007;40(6):393-401doi: 10.1021/ar600019r.
Chen, X., Lenhert, S., Hirtz, M., Lu, N., Fuchs, H., & Chi, L. (2007). Langmuir-Blodgett patterning: a bottom-up way to build mesostructures over large areas. Accounts of chemical research, 40(6), 393-401. https://doi.org/10.1021/ar600019r
Chen, Xiaodong, et al. "Langmuir-Blodgett patterning: a bottom-up way to build mesostructures over large areas." Accounts of chemical research vol. 40,6 (2007): 393-401. doi: https://doi.org/10.1021/ar600019r
Chen X, Lenhert S, Hirtz M, Lu N, Fuchs H, Chi L. Langmuir-Blodgett patterning: a bottom-up way to build mesostructures over large areas. Acc Chem Res. 2007 Jun;40(6):393-401. doi: 10.1021/ar600019r. Epub 2007 Apr 19. PMID: 17441679.
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'Screw-cap' clamp loader proteins that thread.

Nature structural & molecular biology

Zhuang Z, Spiering MM, Berdis AJ, Trakselis MA, Benkovic SJ.
PMID: 15221017
Nat Struct Mol Biol. 2004 Jul;11(7):580-1. doi: 10.1038/nsmb0704-580.

No abstract available.

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Zhuang Z, Spiering MM, Berdis AJ, et al. 'Screw-cap' clamp loader proteins that thread. Nat Struct Mol Biol. 2004;11(7):580-1doi: 10.1038/nsmb0704-580.
Zhuang, Z., Spiering, M. M., Berdis, A. J., Trakselis, M. A., & Benkovic, S. J. (2004). 'Screw-cap' clamp loader proteins that thread. Nature structural & molecular biology, 11(7), 580-1. https://doi.org/10.1038/nsmb0704-580
Zhuang, Zhihao, et al. "'Screw-cap' clamp loader proteins that thread." Nature structural & molecular biology vol. 11,7 (2004): 580-1. doi: https://doi.org/10.1038/nsmb0704-580
Zhuang Z, Spiering MM, Berdis AJ, Trakselis MA, Benkovic SJ. 'Screw-cap' clamp loader proteins that thread. Nat Struct Mol Biol. 2004 Jul;11(7):580-1. doi: 10.1038/nsmb0704-580. PMID: 15221017.
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Showing 25 to 36 of 158 entries