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Showing 25 to 36 of 109 entries
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F1000Research

Pertea G, Pertea M.
PMID: 32489650
F1000Res. 2020 Apr 28;9:304. doi: 10.12688/f1000research.23297.1. eCollection 2020.

No abstract available.

MapMan Visualization of RNA-Seq Data Using Mercator4 Functional Annotations.

Methods in molecular biology (Clifton, N.J.)

Bolger M, Schwacke R, Usadel B.
PMID: 34448161
Methods Mol Biol. 2021;2354:195-212. doi: 10.1007/978-1-0716-1609-3_9.

Plant omics research has advanced to the stage where it is feasible to generate data from multiple samples and multiple time points to gain insight into biological processes. This impressive array of data can prove challenging to interpret. In...

A computational interactome and functional annotation for the human proteome.

eLife

Garzón JI, Deng L, Murray D, Shapira S, Petrey D, Honig B.
PMID: 27770567
Elife. 2016 Oct 22;5. doi: 10.7554/eLife.18715.

We present a database, PrePPI (Predicting Protein-Protein Interactions), of more than 1.35 million predicted protein-protein interactions (PPIs). Of these at least 127,000 are expected to constitute direct physical interactions although the actual number may be much larger (~500,000). The...

Integrating proteomics profiling data sets: a network perspective.

Methods in molecular biology (Clifton, N.J.)

Bhat A, Dakna M, Mischak H.
PMID: 25384750
Methods Mol Biol. 2015;1243:237-53. doi: 10.1007/978-1-4939-1872-0_14.

Understanding disease mechanisms often requires complex and accurate integration of cellular pathways and molecular networks. Systems biology offers the possibility to provide a comprehensive map of the cell's intricate wiring network, which can ultimately lead to decipher the disease...

Data Warehousing with TargetMine for Omics Data Analysis.

Methods in molecular biology (Clifton, N.J.)

Chen YA, Tripathi LP, Mizuguchi K.
PMID: 31115884
Methods Mol Biol. 2019;1986:35-64. doi: 10.1007/978-1-4939-9442-7_3.

Most biological processes including diseases are multifactorial and determined by a complex interplay of various genetic and environmental factors. This chapter aims to provide a user guide to data querying, analysis, and visualization with TargetMine and the associated auxiliary...

CasLocusAnno: a web-based server for annotating cas loci and their corresponding (sub)types.

FEBS letters

Dong C, Zeng Z, Pu DK, Wen QF, Liu S, Du MZ, Sun Y, Gao YZ, Rao N, Huang J, Guo FB.
PMID: 31260103
FEBS Lett. 2019 Sep;593(18):2646-2654. doi: 10.1002/1873-3468.13519. Epub 2019 Jul 17.

In prokaryotes, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated protein (Cas) systems constitute adaptive immune systems against mobile genetic elements (MGEs). Here, we introduce the Markov cluster algorithm (MCL) to Makarova et al.'s method in order to...

An evaluation of noncoding genome annotation tools through enrichment analysis of 15 genome-wide association studies.

Briefings in bioinformatics

Li B, Lu Q, Zhao H.
PMID: 29106447
Brief Bioinform. 2019 May 21;20(3):995-1003. doi: 10.1093/bib/bbx131.

Functionally annotating genetic variations is an essential yet challenging topic in human genetics research. As large consortia including ENCODE and Roadmap Epigenomics Project continue to generate high-throughput transcriptomic and epigenomic data, many computational frameworks have been developed to integrate...

Text-mining-assisted biocuration workflows in Argo.

Database : the journal of biological databases and curation

Rak R, Batista-Navarro RT, Rowley A, Carter J, Ananiadou S.
PMID: 25037308
Database (Oxford). 2014 Jul 18;2014. doi: 10.1093/database/bau070. Print 2014.

Biocuration activities have been broadly categorized into the selection of relevant documents, the annotation of biological concepts of interest and identification of interactions between the concepts. Text mining has been shown to have a potential to significantly reduce the...

Update on activities at the Universal Protein Resource (UniProt) in 2013.

Nucleic acids research

[No authors listed]
PMID: 23161681
Nucleic Acids Res. 2013 Jan;41:D43-7. doi: 10.1093/nar/gks1068. Epub 2012 Nov 17.

The mission of the Universal Protein Resource (UniProt) (http://www.uniprot.org) is to support biological research by providing a freely accessible, stable, comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase. It integrates, interprets and standardizes data from numerous resources...

Molecular signatures database (MSigDB) 3.0.

Bioinformatics (Oxford, England)

Liberzon A, Subramanian A, Pinchback R, Thorvaldsdóttir H, Tamayo P, Mesirov JP.
PMID: 21546393
Bioinformatics. 2011 Jun 15;27(12):1739-40. doi: 10.1093/bioinformatics/btr260. Epub 2011 May 05.

MOTIVATION: Well-annotated gene sets representing the universe of the biological processes are critical for meaningful and insightful interpretation of large-scale genomic data. The Molecular Signatures Database (MSigDB) is one of the most widely used repositories of such sets.RESULTS: We...

Reorganizing the protein space at the Universal Protein Resource (UniProt).

Nucleic acids research

[No authors listed]
PMID: 22102590
Nucleic Acids Res. 2012 Jan;40:D71-5. doi: 10.1093/nar/gkr981. Epub 2011 Nov 18.

The mission of UniProt is to support biological research by providing a freely accessible, stable, comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase, with extensive cross-references and querying interfaces. UniProt is comprised of four major components, each...

Molecular mechanistic associations of human diseases.

BMC systems biology

Stegmaier P, Krull M, Voss N, Kel AE, Wingender E.
PMID: 20815942
BMC Syst Biol. 2010 Sep 06;4:124. doi: 10.1186/1752-0509-4-124.

BACKGROUND: The study of relationships between human diseases provides new possibilities for biomedical research. Recent achievements on human genetic diseases have stimulated interest to derive methods to identify disease associations in order to gain further insight into the network...

Showing 25 to 36 of 109 entries