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Showing 13 to 24 of 279 entries
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The clinical relevance of pharmacokinetics.

The Journal of antimicrobial chemotherapy

Wright N.
PMID: 7107543
J Antimicrob Chemother. 1982 Jul;10(1):2-4. doi: 10.1093/jac/10.1.2.

No abstract available.

Metabolism, pharmacokinetics, and toxicokinetics defined.

Drug metabolism reviews

Di Carlo FJ.
PMID: 7084027
Drug Metab Rev. 1982;13(1):1-4. doi: 10.3109/03602538209002228.

No abstract available.

'Steady/equilibrium approximation' in relaxation and fluctuation. I. Procedure to simplify first-order reaction.

Biophysical chemistry

Kijima H, Kijima S.
PMID: 7171713
Biophys Chem. 1982 Nov;16(3):181-92. doi: 10.1016/0301-4622(82)87001-4.

A general procedure to simplify a complex first-order reaction by two approximations, the principle of fast equilibration and the steady-state approximation, is presented. Rate constants are classified into two groups: those of the order of unity and those of...

Microfluidic synthesis of nanomaterials.

Small (Weinheim an der Bergstrasse, Germany)

Song Y, Hormes J, Kumar CS.
PMID: 18535993
Small. 2008 Jun;4(6):698-711. doi: 10.1002/smll.200701029.

An overview of the current information and analyses on the microfluidic synthesis of different types of nanomaterial, including metallic and silica nanoparticles and quantum dots, is presented. Control of particle size, size distribution, and crystal structure of nanomaterials are...

Numerical integration of rate equations by computer: an update.

Trends in biochemical sciences

Frieden C.
PMID: 8016870
Trends Biochem Sci. 1994 Apr;19(4):181-2. doi: 10.1016/0968-0004(94)90282-8.

No abstract available.

Estimation of mean residence time from data obtained when multiple-dosing steady state has been reached.

Journal of pharmaceutical sciences

Pfeffer M.
PMID: 6737281
J Pharm Sci. 1984 Jun;73(6):854-6. doi: 10.1002/jps.2600730645.

No abstract available.

Unified view of kinetic-based analytical methods with emphasis on ruggedness. A review.

The Analyst

Pardue HL.
PMID: 8633792
Analyst. 1996 Apr;121(4):385-90. doi: 10.1039/an9962100385.

All analytical determinations can be grouped into two general categories, namely equilibrium-based and transient-based methods. This is an important grouping because most conventional approaches to transient-based methods are much less rugged than their equilibrium-based counterparts. As a result it...

Practical solution to the Michaelis-Menten equation.

Journal of pharmaceutical sciences

Veng-Pedersen P, Suaréz L.
PMID: 6663492
J Pharm Sci. 1983 Dec;72(12):1483-5. doi: 10.1002/jps.2600721232.

No abstract available.

Compartmental vs. noncompartmental modeling for two accessible pools.

The American journal of physiology

Cobelli C, Toffolo G.
PMID: 6476148
Am J Physiol. 1984 Sep;247(3):R488-96. doi: 10.1152/ajpregu.1984.247.3.R488.

We examine the limitations of noncompartmental vs. compartmental modeling when two accessible pools are available in kinetic experiments. Focus is on the estimation of mean residence time, whole-body mass, and steady-state equivalent distribution volume. Examples illustrate these points.

Mechanism of a Disassembly-Driven Sensing System Studied by Stopped-Flow Kinetics.

The Journal of organic chemistry

Gallo C, Thomas SS, Selinger AJ, Hof F, Bohne C.
PMID: 34260247
J Org Chem. 2021 Aug 06;86(15):10782-10787. doi: 10.1021/acs.joc.1c00959. Epub 2021 Jul 14.

We carried out steady-state and stopped-flow photophysical measurements to determine the kinetics of a discrete disassembly driven turn-on fluorescent system. On and off rates for both DimerDye1 assembly and nicotine binding were determined. Relative rates for these competing processes...

Pushing Camera-Based Single-Molecule Kinetic Measurements to the Frame Acquisition Limit with Stroboscopic smFRET.

The journal of physical chemistry. B

Nicholson DA, Nesbitt DJ.
PMID: 34097408
J Phys Chem B. 2021 Jun 17;125(23):6080-6089. doi: 10.1021/acs.jpcb.1c01036. Epub 2021 Jun 07.

Single-molecule fluorescence resonance energy transfer (smFRET) experiments permit detailed examination of microscopic dynamics. However, kinetic rate constants determined by smFRET are susceptible to systematic underestimation when the rate constants are comparable to the data acquisition rate. We demonstrate how...

A new phase for enzyme kinetics.

Nature chemical biology

O'Flynn BG, Mittag T.
PMID: 34035520
Nat Chem Biol. 2021 Jun;17(6):628-630. doi: 10.1038/s41589-021-00799-2.

No abstract available.

Showing 13 to 24 of 279 entries