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Showing 13 to 24 of 64 entries
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Functional analysis of differentially expressed genes associated with glaucoma from DNA microarray data.

Genetics and molecular research : GMR

Wu Y, Zang WD, Jiang W.
PMID: 25501152
Genet Mol Res. 2014 Nov 11;13(4):9421-8. doi: 10.4238/2014.November.11.7.

Microarray data of astrocytes extracted from the optic nerves of donors with and without glaucoma were analyzed to screen for differentially expressed genes (DEGs). Functional exploration with bioinformatic tools was then used to understand the roles of the identified...

[Oncogenesis: theories and facts].

Epidemiologia e prevenzione

Luzzatto L.
PMID: 26499232
Epidemiol Prev. 2015 Jul-Aug;39(4):218-9.

No abstract available.

Analytical approximations for spatial stochastic gene expression in single cells and tissues.

Journal of the Royal Society, Interface

Smith S, Cianci C, Grima R.
PMID: 27146686
J R Soc Interface. 2016 May;13(118). doi: 10.1098/rsif.2015.1051.

Gene expression occurs in an environment in which both stochastic and diffusive effects are significant. Spatial stochastic simulations are computationally expensive compared with their deterministic counterparts, and hence little is currently known of the significance of intrinsic noise in...

Heart failure entails significant changes in human nucleocytoplasmic transport gene expression.

International journal of cardiology

Molina-Navarro MM, Roselló-Lletí E, Tarazón E, Ortega A, Sánchez-Izquierdo D, Lago F, González-Juanatey JR, García-Pavía P, Salvador A, Montero JA, Portolés M, Rivera M.
PMID: 23651824
Int J Cardiol. 2013 Oct 03;168(3):2837-43. doi: 10.1016/j.ijcard.2013.03.192. Epub 2013 May 04.

BACKGROUND: Heart failure (HF) induces alterations in nucleocytoplasmic transport, which is essential to the cardiomyocyte biology. The objective of this study was to analyze the changes in gene expression in human HF, particularly focusing on nucleocytoplasmic transport-related genes.METHODS AND...

Finding alternative expression quantitative trait loci by exploring sparse model space.

Journal of computational biology : a journal of computational molecular cell biology

Wang Z, Xu J, Shi X.
PMID: 24689773
J Comput Biol. 2014 May;21(5):385-93. doi: 10.1089/cmb.2014.0026. Epub 2014 Apr 01.

Sparse modeling, a feature selection method widely used in the machine-learning community, has been recently applied to identify associations in genetic studies including expression quantitative trait locus (eQTL) mapping. These genetic studies usually involve high dimensional data where the...

From genes to networks: in systematic points of view.

BMC systems biology

Zhang K, Liu Y, Yang JY, Arabnia HR, Niemierko A, Ghafoor A, Li W, Deng Y.
PMID: 22784614
BMC Syst Biol. 2011;5:I1. doi: 10.1186/1752-0509-5-S3-I1. Epub 2011 Dec 23.

We present a report of the BIOCOMP'10 - The 2010 International Conference on Bioinformatics & Computational Biology and other related work in the area of systems biology.

Small RNA regulators in bacteria: powerful tools for metabolic engineering and synthetic biology.

Applied microbiology and biotechnology

Kang Z, Zhang C, Zhang J, Jin P, Zhang J, Du G, Chen J.
PMID: 24519458
Appl Microbiol Biotechnol. 2014 Apr;98(8):3413-24. doi: 10.1007/s00253-014-5569-y. Epub 2014 Feb 12.

Small RNAs, a large class of ancient posttranscriptional regulators, have recently attracted considerable attention. A plethora of small RNAs has been identified and characterized, many of which belong to the major small noncoding RNA (sRNA) or riboswitch families. It...

Mature microRNAs identified in highly purified nuclei from HCT116 colon cancer cells.

RNA biology

Park CW, Zeng Y, Zhang X, Subramanian S, Steer CJ.
PMID: 20864815
RNA Biol. 2010 Sep-Oct;7(5):606-14. doi: 10.4161/rna.7.5.13215. Epub 2010 Sep 01.

MicroRNAs (miRNAs) have emerged as one of the major regulatory mechanisms of gene expression. A major function of miRNAs involves the post-transcriptional regulation of target mRNAs, which is reported to occur primarily in the cytoplasm. However, there is a...

Insights into the regulation of human CNV-miRNAs from the view of their target genes.

BMC genomics

Wu X, Zhang D, Li G.
PMID: 23244579
BMC Genomics. 2012 Dec 18;13:707. doi: 10.1186/1471-2164-13-707.

BACKGROUND: microRNAs (miRNAs) represent a class of small (typically 22 nucleotides in length) non-coding RNAs that can degrade their target mRNAs or block their translation. Recent research showed that copy number alterations of miRNAs and their target genes are...

A systems biology approach to understanding atherosclerosis.

EMBO molecular medicine

Ramsey SA, Gold ES, Aderem A.
PMID: 20201031
EMBO Mol Med. 2010 Mar;2(3):79-89. doi: 10.1002/emmm.201000063.

Atherosclerosis, a chronic inflammatory disease of the vascular system, presents significant challenges to developing effective molecular diagnostics and novel therapies. A systems biology approach integrating data from large-scale measurements (e.g. transcriptomics, proteomics and genomics) is successfully contributing to deciphering...

Estimation of gene induction enables a relevance-based ranking of gene sets.

Journal of computational biology : a journal of computational molecular cell biology

Bartholomé K, Kreutz C, Timmer J.
PMID: 19580524
J Comput Biol. 2009 Jul;16(7):959-67. doi: 10.1089/cmb.2008.0226.

In order to handle and interpret the vast amounts of data produced by microarray experiments, the analysis of sets of genes with a common biological functionality has been shown to be advantageous compared to single gene analyses. Some statistical...

Fruit improvement using intragenesis and artificial microRNA.

Trends in biotechnology

Molesini B, Pii Y, Pandolfini T.
PMID: 21871680
Trends Biotechnol. 2012 Feb;30(2):80-8. doi: 10.1016/j.tibtech.2011.07.005. Epub 2011 Aug 24.

Genetic engineering methods based on the use of transgenes have been successfully adopted to improve crops. A novel all-native DNA gene technology consists of the creation of intragenic constructs by isolating genetic elements from a crop, rearranging them in...

Showing 13 to 24 of 64 entries