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Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications.

The AAPS journal

Jeyaram A, Jay SM.
PMID: 29181730
AAPS J. 2017 Nov 27;20(1):1. doi: 10.1208/s12248-017-0160-y.

Recently, extracellular vesicles (EVs)-including exosomes, microvesicles, and others-have attracted interest as cell-derived biotherapeutics and drug delivery vehicles for a variety of applications. This interest stems from favorable properties of EVs, including their status as mediators of cell-cell communication via...

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Jeyaram A, Jay SM. Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications. AAPS J. 2017;20(1):1doi: 10.1208/s12248-017-0160-y.
Jeyaram, A., & Jay, S. M. (2017). Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications. The AAPS journal, 20(1), 1. https://doi.org/10.1208/s12248-017-0160-y
Jeyaram, Anjana, and Jay, Steven M. "Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications." The AAPS journal vol. 20,1 (2017): 1. doi: https://doi.org/10.1208/s12248-017-0160-y
Jeyaram A, Jay SM. Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications. AAPS J. 2017 Nov 27;20(1):1. doi: 10.1208/s12248-017-0160-y. PMID: 29181730; PMCID: PMC6582961.
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Cell-Derived Exosome Therapy: A Novel Approach to Treat Post-traumatic Brain Injury Mediated Neural Injury.

ACS chemical neuroscience

Ghosh S, Garg S, Ghosh S.
PMID: 32609493
ACS Chem Neurosci. 2020 Jul 15;11(14):2045-2047. doi: 10.1021/acschemneuro.0c00368. Epub 2020 Jul 01.

Traumatic brain injury (TBI) causes serious neuronal injury that often leads to death. To date there is no clinically successful treatment strategy that has been reported which offers repair of the brain injury or neural injury. Significant attempts have...

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Ghosh S, Garg S, Ghosh S. Cell-Derived Exosome Therapy: A Novel Approach to Treat Post-traumatic Brain Injury Mediated Neural Injury. ACS Chem Neurosci. 2020;11(14):2045-2047doi: 10.1021/acschemneuro.0c00368.
Ghosh, S., Garg, S., & Ghosh, S. (2020). Cell-Derived Exosome Therapy: A Novel Approach to Treat Post-traumatic Brain Injury Mediated Neural Injury. ACS chemical neuroscience, 11(14), 2045-2047. https://doi.org/10.1021/acschemneuro.0c00368
Ghosh, Satyajit, et al. "Cell-Derived Exosome Therapy: A Novel Approach to Treat Post-traumatic Brain Injury Mediated Neural Injury." ACS chemical neuroscience vol. 11,14 (2020): 2045-2047. doi: https://doi.org/10.1021/acschemneuro.0c00368
Ghosh S, Garg S, Ghosh S. Cell-Derived Exosome Therapy: A Novel Approach to Treat Post-traumatic Brain Injury Mediated Neural Injury. ACS Chem Neurosci. 2020 Jul 15;11(14):2045-2047. doi: 10.1021/acschemneuro.0c00368. Epub 2020 Jul 01. PMID: 32609493.
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Rapid Delivery of Hsa-miR-590-3p Using Targeted Exosomes to Treat Acute Myocardial Infarction Through Regulation of the Cell Cycle.

Journal of biomedical nanotechnology

Wang Y, Ding N, Guan G, Liu G, Huo D, Li Y, Wei K, Yang J, Cheng P, Zhu C.
PMID: 29883566
J Biomed Nanotechnol. 2018 May 01;14(5):968-977. doi: 10.1166/jbn.2018.2493.

Acute myocardial infarction leads to heart failure due to inadequate regeneration of cardiomyocytes. Therefore, promotion of cardiomyocyte proliferation is the key for the restoration of cardiac function. Induction of the cell cycle and the downregulation of genes that inhibit...

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Wang Y, Ding N, Guan G, et al. Rapid Delivery of Hsa-miR-590-3p Using Targeted Exosomes to Treat Acute Myocardial Infarction Through Regulation of the Cell Cycle. J Biomed Nanotechnol. 2018;14(5):968-977doi: 10.1166/jbn.2018.2493.
Wang, Y., Ding, N., Guan, G., Liu, G., Huo, D., Li, Y., Wei, K., Yang, J., Cheng, P., & Zhu, C. (2018). Rapid Delivery of Hsa-miR-590-3p Using Targeted Exosomes to Treat Acute Myocardial Infarction Through Regulation of the Cell Cycle. Journal of biomedical nanotechnology, 14(5), 968-977. https://doi.org/10.1166/jbn.2018.2493
Wang, Yuxin, et al. "Rapid Delivery of Hsa-miR-590-3p Using Targeted Exosomes to Treat Acute Myocardial Infarction Through Regulation of the Cell Cycle." Journal of biomedical nanotechnology vol. 14,5 (2018): 968-977. doi: https://doi.org/10.1166/jbn.2018.2493
Wang Y, Ding N, Guan G, Liu G, Huo D, Li Y, Wei K, Yang J, Cheng P, Zhu C. Rapid Delivery of Hsa-miR-590-3p Using Targeted Exosomes to Treat Acute Myocardial Infarction Through Regulation of the Cell Cycle. J Biomed Nanotechnol. 2018 May 01;14(5):968-977. doi: 10.1166/jbn.2018.2493. PMID: 29883566.
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Exosomes as Targeted Drug Delivery Vehicles: Perspectives and Challenges.

Current drug metabolism

Liu D, Li X.
PMID: 31856701
Curr Drug Metab. 2019;20(10):772. doi: 10.2174/138920022010191205141812.

No abstract available.

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Liu D, Li X. Exosomes as Targeted Drug Delivery Vehicles: Perspectives and Challenges. Curr Drug Metab. 2019;20(10):772doi: 10.2174/138920022010191205141812.
Liu, D., & Li, X. (2019). Exosomes as Targeted Drug Delivery Vehicles: Perspectives and Challenges. Current drug metabolism, 20(10), 772. https://doi.org/10.2174/138920022010191205141812
Liu, Dali, and Li, Xiangkai. "Exosomes as Targeted Drug Delivery Vehicles: Perspectives and Challenges." Current drug metabolism vol. 20,10 (2019): 772. doi: https://doi.org/10.2174/138920022010191205141812
Liu D, Li X. Exosomes as Targeted Drug Delivery Vehicles: Perspectives and Challenges. Curr Drug Metab. 2019;20(10):772. doi: 10.2174/138920022010191205141812. PMID: 31856701.
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From structures to functions: insights into exosomes as promising drug delivery vehicles.

Biomaterials science

Ren J, He W, Zheng L, Duan H.
PMID: 26977477
Biomater Sci. 2016 May 24;4(6):910-21. doi: 10.1039/c5bm00583c.

Exosomes are small membrane vesicles secreted by most cell types, and appear ubiquitously in cell culture supernatants and body fluids. Increasing evidence supports that exosomes play important roles in intercellular communication, both locally and systemically, by transporting their contents...

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Ren J, He W, Zheng L, et al. From structures to functions: insights into exosomes as promising drug delivery vehicles. Biomater Sci. 2016;4(6):910-21doi: 10.1039/c5bm00583c.
Ren, J., He, W., Zheng, L., & Duan, H. (2016). From structures to functions: insights into exosomes as promising drug delivery vehicles. Biomaterials science, 4(6), 910-21. https://doi.org/10.1039/c5bm00583c
Ren, Jinghua, et al. "From structures to functions: insights into exosomes as promising drug delivery vehicles." Biomaterials science vol. 4,6 (2016): 910-21. doi: https://doi.org/10.1039/c5bm00583c
Ren J, He W, Zheng L, Duan H. From structures to functions: insights into exosomes as promising drug delivery vehicles. Biomater Sci. 2016 May 24;4(6):910-21. doi: 10.1039/c5bm00583c. PMID: 26977477.
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MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreak.

Journal of translational medicine

Jamalkhah M, Asaadi Y, Azangou-Khyavy M, Khanali J, Soleimani M, Kiani J, Arefian E.
PMID: 33888147
J Transl Med. 2021 Apr 22;19(1):164. doi: 10.1186/s12967-021-02840-3.

BACKGROUND: The onset of the SARS-CoV-2 pandemic has resulted in ever-increasing casualties worldwide, and after 15 months, standard therapeutic regimens are yet to be discovered.MAIN BODY: Due to the regenerative and immunomodulatory function of MSCs, they can serve as...

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Jamalkhah M, Asaadi Y, Azangou-Khyavy M, et al. MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreak. J Transl Med. 2021;19(1):164doi: 10.1186/s12967-021-02840-3.
Jamalkhah, M., Asaadi, Y., Azangou-Khyavy, M., Khanali, J., Soleimani, M., Kiani, J., & Arefian, E. (2021). MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreak. Journal of translational medicine, 19(1), 164. https://doi.org/10.1186/s12967-021-02840-3
Jamalkhah, Monire, et al. "MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreak." Journal of translational medicine vol. 19,1 (2021): 164. doi: https://doi.org/10.1186/s12967-021-02840-3
Jamalkhah M, Asaadi Y, Azangou-Khyavy M, Khanali J, Soleimani M, Kiani J, Arefian E. MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreak. J Transl Med. 2021 Apr 22;19(1):164. doi: 10.1186/s12967-021-02840-3. PMID: 33888147; PMCID: PMC8061879.
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Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities.

Stem cell research & therapy

Hassanzadeh A, Rahman HS, Markov A, Endjun JJ, Zekiy AO, Chartrand MS, Beheshtkhoo N, Kouhbanani MAJ, Marofi F, Nikoo M, Jarahian M.
PMID: 34020704
Stem Cell Res Ther. 2021 May 21;12(1):297. doi: 10.1186/s13287-021-02378-7.

Recently, mesenchymal stem/stromal cells (MSCs) and their widespread biomedical applications have attracted great consideration from the scientific community around the world. However, reports have shown that the main populations of the transplanted MSCs are trapped in the liver, spleen,...

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Hassanzadeh A, Rahman HS, Markov A, et al. Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities. Stem Cell Res Ther. 2021;12(1):297doi: 10.1186/s13287-021-02378-7.
Hassanzadeh, A., Rahman, H. S., Markov, A., Endjun, J. J., Zekiy, A. O., Chartrand, M. S., Beheshtkhoo, N., Kouhbanani, M. A. J., Marofi, F., Nikoo, M., & Jarahian, M. (2021). Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities. Stem cell research & therapy, 12(1), 297. https://doi.org/10.1186/s13287-021-02378-7
Hassanzadeh, Ali, et al. "Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities." Stem cell research & therapy vol. 12,1 (2021): 297. doi: https://doi.org/10.1186/s13287-021-02378-7
Hassanzadeh A, Rahman HS, Markov A, Endjun JJ, Zekiy AO, Chartrand MS, Beheshtkhoo N, Kouhbanani MAJ, Marofi F, Nikoo M, Jarahian M. Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities. Stem Cell Res Ther. 2021 May 21;12(1):297. doi: 10.1186/s13287-021-02378-7. PMID: 34020704; PMCID: PMC8138094.
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Engineering of Exosomes: Steps Towards Green Production of Drug Delivery System.

Current drug targets

Sherif AY, Harisa GI, Alanazi FK, Youssof AME.
PMID: 31309889
Curr Drug Targets. 2019;20(15):1537-1549. doi: 10.2174/1389450120666190715104100.

Targeting of therapeutic agents to their specific site of action not only increases the treatment efficacy, but also reduces systemic toxicity. Therefore, various drug delivery systems (DDSs) have been developed to achieve this target. However, most of those DDSs...

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Sherif AY, Harisa GI, Alanazi FK, et al. Engineering of Exosomes: Steps Towards Green Production of Drug Delivery System. Curr Drug Targets. 2019;20(15):1537-1549doi: 10.2174/1389450120666190715104100.
Sherif, A. Y., Harisa, G. I., Alanazi, F. K., & Youssof, A. M. E. (2019). Engineering of Exosomes: Steps Towards Green Production of Drug Delivery System. Current drug targets, 20(15), 1537-1549. https://doi.org/10.2174/1389450120666190715104100
Sherif, Abdelrahman Y, et al. "Engineering of Exosomes: Steps Towards Green Production of Drug Delivery System." Current drug targets vol. 20,15 (2019): 1537-1549. doi: https://doi.org/10.2174/1389450120666190715104100
Sherif AY, Harisa GI, Alanazi FK, Youssof AME. Engineering of Exosomes: Steps Towards Green Production of Drug Delivery System. Curr Drug Targets. 2019;20(15):1537-1549. doi: 10.2174/1389450120666190715104100. PMID: 31309889.
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Application of extracellular vesicles in the diagnosis and treatment of prostate cancer: Implications for clinical practice.

Critical reviews in oncology/hematology

Oey O, Ghaffari M, Li JJ, Hosseini-Beheshti E.
PMID: 34655743
Crit Rev Oncol Hematol. 2021 Nov;167:103495. doi: 10.1016/j.critrevonc.2021.103495. Epub 2021 Oct 13.

Extracellular vesicles (EV) are cell-derived lipid bilayer-delimited structures providing an important means of intercellular communication. Recent studies have shown that EV, particularly exosomes and large-oncosomes contain miRNA and proteins crucial in prostate cancer (PCa) progression, metastasis and treatment resistance....

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Oey O, Ghaffari M, Li JJ, et al. Application of extracellular vesicles in the diagnosis and treatment of prostate cancer: Implications for clinical practice. Crit Rev Oncol Hematol. 2021;167:103495doi: 10.1016/j.critrevonc.2021.103495.
Oey, O., Ghaffari, M., Li, J. J., & Hosseini-Beheshti, E. (2021). Application of extracellular vesicles in the diagnosis and treatment of prostate cancer: Implications for clinical practice. Critical reviews in oncology/hematology, 167103495. https://doi.org/10.1016/j.critrevonc.2021.103495
Oey, Oliver, et al. "Application of extracellular vesicles in the diagnosis and treatment of prostate cancer: Implications for clinical practice." Critical reviews in oncology/hematology vol. 167 (2021): 103495. doi: https://doi.org/10.1016/j.critrevonc.2021.103495
Oey O, Ghaffari M, Li JJ, Hosseini-Beheshti E. Application of extracellular vesicles in the diagnosis and treatment of prostate cancer: Implications for clinical practice. Crit Rev Oncol Hematol. 2021 Nov;167:103495. doi: 10.1016/j.critrevonc.2021.103495. Epub 2021 Oct 13. PMID: 34655743.
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Biogenesis of Extracellular Vesicles.

Sub-cellular biochemistry

Kang T, Atukorala I, Mathivanan S.
PMID: 33779912
Subcell Biochem. 2021;97:19-43. doi: 10.1007/978-3-030-67171-6_2.

Extracellular vesicles (EVs) refer to vesicles that are released by cells into the extracellular space. EVs mediate cell-to-cell communication via delivery of functional biomolecules between host and recipient cells. EVs can be categorised based on their mode of biogenesis...

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Kang T, Atukorala I, Mathivanan S. Biogenesis of Extracellular Vesicles. Subcell Biochem. 2021;97:19-43doi: 10.1007/978-3-030-67171-6_2.
Kang, T., Atukorala, I., & Mathivanan, S. (2021). Biogenesis of Extracellular Vesicles. Sub-cellular biochemistry, 9719-43. https://doi.org/10.1007/978-3-030-67171-6_2
Kang, Taeyoung, et al. "Biogenesis of Extracellular Vesicles." Sub-cellular biochemistry vol. 97 (2021): 19-43. doi: https://doi.org/10.1007/978-3-030-67171-6_2
Kang T, Atukorala I, Mathivanan S. Biogenesis of Extracellular Vesicles. Subcell Biochem. 2021;97:19-43. doi: 10.1007/978-3-030-67171-6_2. PMID: 33779912.
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Evaluation of exosome derivatives as bio-informational reprogramming therapy for cancer.

Journal of translational medicine

Gonzalez MJ, Kweh MF, Biava PM, Olalde J, Toro AP, Goldschmidt-Clermont PJ, White IA.
PMID: 33750417
J Transl Med. 2021 Mar 09;19(1):103. doi: 10.1186/s12967-021-02768-8.

Exosomes are nanoparticle sized (100 ± 50 nm) extracellular vesicles (ECVs) that play important roles in cell-to-cell communication. They do this by utilizing their natural ability to shuttle signaling molecules across the cellular microenvironment and promote paracrine signaling. Currently,...

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Gonzalez MJ, Kweh MF, Biava PM, et al. Evaluation of exosome derivatives as bio-informational reprogramming therapy for cancer. J Transl Med. 2021;19(1):103doi: 10.1186/s12967-021-02768-8.
Gonzalez, M. J., Kweh, M. F., Biava, P. M., Olalde, J., Toro, A. P., Goldschmidt-Clermont, P. J., & White, I. A. (2021). Evaluation of exosome derivatives as bio-informational reprogramming therapy for cancer. Journal of translational medicine, 19(1), 103. https://doi.org/10.1186/s12967-021-02768-8
Gonzalez, Michael J, et al. "Evaluation of exosome derivatives as bio-informational reprogramming therapy for cancer." Journal of translational medicine vol. 19,1 (2021): 103. doi: https://doi.org/10.1186/s12967-021-02768-8
Gonzalez MJ, Kweh MF, Biava PM, Olalde J, Toro AP, Goldschmidt-Clermont PJ, White IA. Evaluation of exosome derivatives as bio-informational reprogramming therapy for cancer. J Transl Med. 2021 Mar 09;19(1):103. doi: 10.1186/s12967-021-02768-8. PMID: 33750417; PMCID: PMC7944634.
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[Research Progress of Exosomes in Lung Cancer Diagnosis and Treatment].

Zhongguo fei ai za zhi = Chinese journal of lung cancer

Zou H, Wu H, Xu C.
PMID: 27866522
Zhongguo Fei Ai Za Zhi. 2016 Nov 20;19(11):778-783. doi: 10.3779/j.issn.1009-3419.2016.11.10.

As the leading cause of morbidity and cancer related-death worldwide, lung cancer has a serious threat to human health. Exosomes are nanoscale lipid membrane vesicles derived from multivesicles, which containing active biomolecules including proteins, lipids, nucleic acids and etc....

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Zou H, Wu H, Xu C. [Research Progress of Exosomes in Lung Cancer Diagnosis and Treatment]. Zhongguo Fei Ai Za Zhi. 2016;19(11):778-783doi: 10.3779/j.issn.1009-3419.2016.11.10.
Zou, H., Wu, H., & Xu, C. (2016). [Research Progress of Exosomes in Lung Cancer Diagnosis and Treatment]. Zhongguo fei ai za zhi = Chinese journal of lung cancer, 19(11), 778-783. https://doi.org/10.3779/j.issn.1009-3419.2016.11.10
Zou, Hongbo, et al. "[Research Progress of Exosomes in Lung Cancer Diagnosis and Treatment]." Zhongguo fei ai za zhi = Chinese journal of lung cancer vol. 19,11 (2016): 778-783. doi: https://doi.org/10.3779/j.issn.1009-3419.2016.11.10
Zou H, Wu H, Xu C. [Research Progress of Exosomes in Lung Cancer Diagnosis and Treatment]. Zhongguo Fei Ai Za Zhi. 2016 Nov 20;19(11):778-783. doi: 10.3779/j.issn.1009-3419.2016.11.10. Chinese. PMID: 27866522; PMCID: PMC5999640.
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Showing 13 to 24 of 60 entries