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Mechanisms in combination therapy: isobologram analysis and sequencing.

International journal of radiation biology and related studies in physics, chemistry, and medicine

Redpath JL.
PMID: 6971277
Int J Radiat Biol Relat Stud Phys Chem Med. 1980 Sep;38(3):355-6. doi: 10.1080/09553008014551711.

No abstract available.

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Redpath JL. Mechanisms in combination therapy: isobologram analysis and sequencing. Int J Radiat Biol Relat Stud Phys Chem Med. 1980;38(3):355-6doi: 10.1080/09553008014551711.
Redpath, J. L. (1980). Mechanisms in combination therapy: isobologram analysis and sequencing. International journal of radiation biology and related studies in physics, chemistry, and medicine, 38(3), 355-6. https://doi.org/10.1080/09553008014551711
Redpath, J L. "Mechanisms in combination therapy: isobologram analysis and sequencing." International journal of radiation biology and related studies in physics, chemistry, and medicine vol. 38,3 (1980): 355-6. doi: https://doi.org/10.1080/09553008014551711
Redpath JL. Mechanisms in combination therapy: isobologram analysis and sequencing. Int J Radiat Biol Relat Stud Phys Chem Med. 1980 Sep;38(3):355-6. doi: 10.1080/09553008014551711. PMID: 6971277.
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Dose response studies. II. Analysis and interpretation.

Journal of biopharmaceutical statistics

Ruberg SJ.
PMID: 7613559
J Biopharm Stat. 1995 Mar;5(1):15-42. doi: 10.1080/10543409508835097.

The primary focus of this paper is to examine analysis strategies for parallel, randomized dose response studies with particular emphasis on identifying the minimum effective dose. Such studies have become a standard for drug development in the pharmaceutical industry....

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Ruberg SJ. Dose response studies. II. Analysis and interpretation. J Biopharm Stat. 1995;5(1):15-42doi: 10.1080/10543409508835097.
Ruberg, S. J. (1995). Dose response studies. II. Analysis and interpretation. Journal of biopharmaceutical statistics, 5(1), 15-42. https://doi.org/10.1080/10543409508835097
Ruberg, S J. "Dose response studies. II. Analysis and interpretation." Journal of biopharmaceutical statistics vol. 5,1 (1995): 15-42. doi: https://doi.org/10.1080/10543409508835097
Ruberg SJ. Dose response studies. II. Analysis and interpretation. J Biopharm Stat. 1995 Mar;5(1):15-42. doi: 10.1080/10543409508835097. PMID: 7613559.
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Analyzing randomized dose finding studies with a primary and a secondary endpoint.

Journal of biopharmaceutical statistics

Hothorn LA, Wassmer G.
PMID: 12729396
J Biopharm Stat. 2003 May;13(2):301-5. doi: 10.1081/BIP-120019273.

The identification of the minimum effective dose for both the primary and secondary endpoint under a priori importance ordering assumption is described. Stepwise testing procedures, which conditionally test each elementary hypotheses at level alpha, but control the experimentwise Type...

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Hothorn LA, Wassmer G. Analyzing randomized dose finding studies with a primary and a secondary endpoint. J Biopharm Stat. 2003;13(2):301-5doi: 10.1081/BIP-120019273.
Hothorn, L. A., & Wassmer, G. (2003). Analyzing randomized dose finding studies with a primary and a secondary endpoint. Journal of biopharmaceutical statistics, 13(2), 301-5. https://doi.org/10.1081/BIP-120019273
Hothorn, Ludwig A, and Wassmer, Gernot. "Analyzing randomized dose finding studies with a primary and a secondary endpoint." Journal of biopharmaceutical statistics vol. 13,2 (2003): 301-5. doi: https://doi.org/10.1081/BIP-120019273
Hothorn LA, Wassmer G. Analyzing randomized dose finding studies with a primary and a secondary endpoint. J Biopharm Stat. 2003 May;13(2):301-5. doi: 10.1081/BIP-120019273. PMID: 12729396.
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[Can exposure to low doses have effects?].

Giornale italiano di medicina del lavoro ed ergonomia

Apostoli P, Manno M.
PMID: 14582248
G Ital Med Lav Ergon. 2003 Jul-Sep;25(3):310-9.

This paper aims to discuss the scientific evidence to answer the question in the title. After a brief mention of the fundamental toxicological principles of risk assessment (hazard, exposure, susceptibility, risk), the concepts of dose-response, dose-effect and threshold-dose are...

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Apostoli P, Manno M. L'esposizione a basse dosi può produrre effetti? [Can exposure to low doses have effects?]. G Ital Med Lav Ergon. 2003;25(3):310-9
Apostoli, P., & Manno, M. (2003). L'esposizione a basse dosi può produrre effetti? [Can exposure to low doses have effects?]. Giornale italiano di medicina del lavoro ed ergonomia, 25(3), 310-9.
Apostoli, P, and Manno, M. "L'esposizione a basse dosi può produrre effetti?" [Can exposure to low doses have effects?]. Giornale italiano di medicina del lavoro ed ergonomia vol. 25,3 (2003): 310-9.
Apostoli P, Manno M. L'esposizione a basse dosi può produrre effetti? [Can exposure to low doses have effects?]. G Ital Med Lav Ergon. 2003 Jul-Sep;25(3):310-9. Italian. PMID: 14582248.
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Individual versus population effects in concentration-response modeling.

Integrated environmental assessment and management

Fox DR, Billoir E.
PMID: 21692173
Integr Environ Assess Manag. 2011 Jul;7(3):501-2. doi: 10.1002/ieam.199.

No abstract available.

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Fox DR, Billoir E. Individual versus population effects in concentration-response modeling. Integr Environ Assess Manag. 2011;7(3):501-2doi: 10.1002/ieam.199.
Fox, D. R., & Billoir, E. (2011). Individual versus population effects in concentration-response modeling. Integrated environmental assessment and management, 7(3), 501-2. https://doi.org/10.1002/ieam.199
Fox, David R, and Billoir, Elise. "Individual versus population effects in concentration-response modeling." Integrated environmental assessment and management vol. 7,3 (2011): 501-2. doi: https://doi.org/10.1002/ieam.199
Fox DR, Billoir E. Individual versus population effects in concentration-response modeling. Integr Environ Assess Manag. 2011 Jul;7(3):501-2. doi: 10.1002/ieam.199. PMID: 21692173.
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Dosing modifications of targeted cancer therapies in patients with special needs: evidence and controversies.

Critical reviews in oncology/hematology

Ng T, Chan A.
PMID: 21429761
Crit Rev Oncol Hematol. 2012 Jan;81(1):58-74. doi: 10.1016/j.critrevonc.2011.02.006. Epub 2011 Mar 22.

Targeted therapies have revolutionized the treatment of malignancies over the past decade. These agents are generally regarded to posses fewer systemic side effects than traditional cytotoxic chemotherapies. However, patients manifesting organ dysfunction or drug interactions with concurrent medications may...

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Ng T, Chan A. Dosing modifications of targeted cancer therapies in patients with special needs: evidence and controversies. Crit Rev Oncol Hematol. 2011;81(1):58-74doi: 10.1016/j.critrevonc.2011.02.006.
Ng, T., & Chan, A. (2012). Dosing modifications of targeted cancer therapies in patients with special needs: evidence and controversies. Critical reviews in oncology/hematology, 81(1), 58-74. https://doi.org/10.1016/j.critrevonc.2011.02.006
Ng, T, and Chan, A. "Dosing modifications of targeted cancer therapies in patients with special needs: evidence and controversies." Critical reviews in oncology/hematology vol. 81,1 (2012): 58-74. doi: https://doi.org/10.1016/j.critrevonc.2011.02.006
Ng T, Chan A. Dosing modifications of targeted cancer therapies in patients with special needs: evidence and controversies. Crit Rev Oncol Hematol. 2012 Jan;81(1):58-74. doi: 10.1016/j.critrevonc.2011.02.006. Epub 2011 Mar 22. PMID: 21429761.
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The importance of human exposure information: a need for exposure-related data bases to protect and promote public health.

Annual review of public health

Wagener DK, Selevan SG, Sexton K.
PMID: 7639866
Annu Rev Public Health. 1995;16:105-21. doi: 10.1146/annurev.pu.16.050195.000541.

As a subfield of public health, environmental health is concerned with evaluating and ameliorating the effects of people on the environment and the effects of the environment on people. Separating hazards from risks, and characterizing the magnitude, likelihood, and...

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Wagener DK, Selevan SG, Sexton K. The importance of human exposure information: a need for exposure-related data bases to protect and promote public health. Annu Rev Public Health. 1995;16:105-21doi: 10.1146/annurev.pu.16.050195.000541.
Wagener, D. K., Selevan, S. G., & Sexton, K. (1995). The importance of human exposure information: a need for exposure-related data bases to protect and promote public health. Annual review of public health, 16105-21. https://doi.org/10.1146/annurev.pu.16.050195.000541
Wagener, D K, et al. "The importance of human exposure information: a need for exposure-related data bases to protect and promote public health." Annual review of public health vol. 16 (1995): 105-21. doi: https://doi.org/10.1146/annurev.pu.16.050195.000541
Wagener DK, Selevan SG, Sexton K. The importance of human exposure information: a need for exposure-related data bases to protect and promote public health. Annu Rev Public Health. 1995;16:105-21. doi: 10.1146/annurev.pu.16.050195.000541. PMID: 7639866.
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Advanced computational modeling for in vitro nanomaterial dosimetry.

Particle and fibre toxicology

DeLoid GM, Cohen JM, Pyrgiotakis G, Pirela SV, Pal A, Liu J, Srebric J, Demokritou P.
PMID: 26497802
Part Fibre Toxicol. 2015 Oct 24;12:32. doi: 10.1186/s12989-015-0109-1.

BACKGROUND: Accurate and meaningful dose metrics are a basic requirement for in vitro screening to assess potential health risks of engineered nanomaterials (ENMs). Correctly and consistently quantifying what cells "see," during an in vitro exposure requires standardized preparation of...

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DeLoid GM, Cohen JM, Pyrgiotakis G, et al. Advanced computational modeling for in vitro nanomaterial dosimetry. Part Fibre Toxicol. 2015;12:32doi: 10.1186/s12989-015-0109-1.
DeLoid, G. M., Cohen, J. M., Pyrgiotakis, G., Pirela, S. V., Pal, A., Liu, J., Srebric, J., & Demokritou, P. (2015). Advanced computational modeling for in vitro nanomaterial dosimetry. Particle and fibre toxicology, 1232. https://doi.org/10.1186/s12989-015-0109-1
DeLoid, Glen M, et al. "Advanced computational modeling for in vitro nanomaterial dosimetry." Particle and fibre toxicology vol. 12 (2015): 32. doi: https://doi.org/10.1186/s12989-015-0109-1
DeLoid GM, Cohen JM, Pyrgiotakis G, Pirela SV, Pal A, Liu J, Srebric J, Demokritou P. Advanced computational modeling for in vitro nanomaterial dosimetry. Part Fibre Toxicol. 2015 Oct 24;12:32. doi: 10.1186/s12989-015-0109-1. PMID: 26497802; PMCID: PMC4619515.
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Probabilistic assessment method of the non-monotonic dose-responses-Part II: Robustness assessment.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Chevillotte G, Bernard A, Varret C, Ballet P, Bodin L, Roudot AC.
PMID: 29066410
Food Chem Toxicol. 2017 Dec;110:214-228. doi: 10.1016/j.fct.2017.10.030. Epub 2017 Oct 21.

In a previous study, we presented a new method that uses a large-scale sampling system to probabilistically assess non-monotonic dose-response curves. The statistical plausibility of the characterization was governed by the probability of the dominant category, but gave no...

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Chevillotte G, Bernard A, Varret C, et al. Probabilistic assessment method of the non-monotonic dose-responses-Part II: Robustness assessment. Food Chem Toxicol. 2017;110:214-228doi: 10.1016/j.fct.2017.10.030.
Chevillotte, G., Bernard, A., Varret, C., Ballet, P., Bodin, L., & Roudot, A. C. (2017). Probabilistic assessment method of the non-monotonic dose-responses-Part II: Robustness assessment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 110214-228. https://doi.org/10.1016/j.fct.2017.10.030
Chevillotte, Grégoire, et al. "Probabilistic assessment method of the non-monotonic dose-responses-Part II: Robustness assessment." Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association vol. 110 (2017): 214-228. doi: https://doi.org/10.1016/j.fct.2017.10.030
Chevillotte G, Bernard A, Varret C, Ballet P, Bodin L, Roudot AC. Probabilistic assessment method of the non-monotonic dose-responses-Part II: Robustness assessment. Food Chem Toxicol. 2017 Dec;110:214-228. doi: 10.1016/j.fct.2017.10.030. Epub 2017 Oct 21. PMID: 29066410.
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Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities.

CPT: pharmacometrics & systems pharmacology

Keizer RJ, Ter Heine R, Frymoyer A, Lesko LJ, Mangat R, Goswami S.
PMID: 30255663
CPT Pharmacometrics Syst Pharmacol. 2018 Dec;7(12):785-787. doi: 10.1002/psp4.12353. Epub 2018 Oct 16.

The development of model-informed precision dosing (MIPD) tools, especially in the form of native or web-based applications to be used at the bedside, has garnered marked attention in recent years. Their potential clinical benefit can be large, but it...

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Keizer RJ, Ter Heine R, Frymoyer A, et al. Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities. CPT Pharmacometrics Syst Pharmacol. 2018;7(12):785-787doi: 10.1002/psp4.12353.
Keizer, R. J., Ter Heine, R., Frymoyer, A., Lesko, L. J., Mangat, R., & Goswami, S. (2018). Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities. CPT: pharmacometrics & systems pharmacology, 7(12), 785-787. https://doi.org/10.1002/psp4.12353
Keizer, Ron J, et al. "Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities." CPT: pharmacometrics & systems pharmacology vol. 7,12 (2018): 785-787. doi: https://doi.org/10.1002/psp4.12353
Keizer RJ, Ter Heine R, Frymoyer A, Lesko LJ, Mangat R, Goswami S. Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities. CPT Pharmacometrics Syst Pharmacol. 2018 Dec;7(12):785-787. doi: 10.1002/psp4.12353. Epub 2018 Oct 16. PMID: 30255663; PMCID: PMC6310898.
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From Molecule to Patient and Ways to Get the Dose Precisely Right.

Clinical pharmacology and therapeutics

Vinks AA.
PMID: 30773626
Clin Pharmacol Ther. 2019 Mar;105(3):534-537. doi: 10.1002/cpt.1355.

No abstract available.

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Vinks AA. From Molecule to Patient and Ways to Get the Dose Precisely Right. Clin Pharmacol Ther. 2019;105(3):534-537doi: 10.1002/cpt.1355.
Vinks, A. A. (2019). From Molecule to Patient and Ways to Get the Dose Precisely Right. Clinical pharmacology and therapeutics, 105(3), 534-537. https://doi.org/10.1002/cpt.1355
Vinks, Alexander A. "From Molecule to Patient and Ways to Get the Dose Precisely Right." Clinical pharmacology and therapeutics vol. 105,3 (2019): 534-537. doi: https://doi.org/10.1002/cpt.1355
Vinks AA. From Molecule to Patient and Ways to Get the Dose Precisely Right. Clin Pharmacol Ther. 2019 Mar;105(3):534-537. doi: 10.1002/cpt.1355. PMID: 30773626.
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Showing 49 to 59 of 59 entries