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An LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation in E. coli.

Nature protocols

Geddes EJ, Li Z, Hergenrother PJ.
PMID: 34480129
Nat Protoc. 2021 Oct;16(10):4833-4854. doi: 10.1038/s41596-021-00598-y. Epub 2021 Sep 03.

Novel classes of broad-spectrum antibiotics have been extremely difficult to discover, largely due to the impermeability of the Gram-negative membranes coupled with a poor understanding of the physicochemical properties a compound should possess to promote its accumulation inside the...

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Geddes EJ, Li Z, Hergenrother PJ. An LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation in E. coli. Nat Protoc. 2021;16(10):4833-4854doi: 10.1038/s41596-021-00598-y.
Geddes, E. J., Li, Z., & Hergenrother, P. J. (2021). An LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation in E. coli. Nature protocols, 16(10), 4833-4854. https://doi.org/10.1038/s41596-021-00598-y
Geddes, Emily J, et al. "An LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation in E. coli." Nature protocols vol. 16,10 (2021): 4833-4854. doi: https://doi.org/10.1038/s41596-021-00598-y
Geddes EJ, Li Z, Hergenrother PJ. An LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation in E. coli. Nat Protoc. 2021 Oct;16(10):4833-4854. doi: 10.1038/s41596-021-00598-y. Epub 2021 Sep 03. PMID: 34480129; PMCID: PMC8715754.
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An integrated outsourcing practice of nonclinical LC-MS bioanalysis and toxicokinetics at Novartis small molecule drug development.

Bioanalysis

Li W, Glick J, Hatsis P, Fu Y, Chin H, Moench P, Flarakos J.
PMID: 34081547
Bioanalysis. 2021 Jun;13(12):1001-1010. doi: 10.4155/bio-2021-0072. Epub 2021 Jun 03.

With decommissioning of internal regulated bioanalytical (BA) and toxicokinetic (TK) capabilities, Novartis has relied on external service providers (ESPs) for all nonclinical LC-MS BA and majority of the associated TK work since 2017. This paper outlines an integrated outsourcing...

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Li W, Glick J, Hatsis P, et al. An integrated outsourcing practice of nonclinical LC-MS bioanalysis and toxicokinetics at Novartis small molecule drug development. Bioanalysis. 2021;13(12):1001-1010doi: 10.4155/bio-2021-0072.
Li, W., Glick, J., Hatsis, P., Fu, Y., Chin, H., Moench, P., & Flarakos, J. (2021). An integrated outsourcing practice of nonclinical LC-MS bioanalysis and toxicokinetics at Novartis small molecule drug development. Bioanalysis, 13(12), 1001-1010. https://doi.org/10.4155/bio-2021-0072
Li, Wenkui, et al. "An integrated outsourcing practice of nonclinical LC-MS bioanalysis and toxicokinetics at Novartis small molecule drug development." Bioanalysis vol. 13,12 (2021): 1001-1010. doi: https://doi.org/10.4155/bio-2021-0072
Li W, Glick J, Hatsis P, Fu Y, Chin H, Moench P, Flarakos J. An integrated outsourcing practice of nonclinical LC-MS bioanalysis and toxicokinetics at Novartis small molecule drug development. Bioanalysis. 2021 Jun;13(12):1001-1010. doi: 10.4155/bio-2021-0072. Epub 2021 Jun 03. PMID: 34081547.
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Deep Profiling of Microgram-Scale Proteome by Tandem Mass Tag Mass Spectrometry.

Journal of proteome research

Liu D, Yang S, Kavdia K, Sifford JM, Wu Z, Xie B, Wang Z, Pagala VR, Wang H, Yu K, Dey KK, High AA, Serrano GE, Beach TG, Peng J.
PMID: 33175545
J Proteome Res. 2021 Jan 01;20(1):337-345. doi: 10.1021/acs.jproteome.0c00426. Epub 2020 Nov 11.

Tandem mass tag (TMT)-based mass spectrometry (MS) enables deep proteomic profiling of more than 10,000 proteins in complex biological samples but requires up to 100 μg protein in starting materials during a standard analysis. Here, we present a streamlined...

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Liu D, Yang S, Kavdia K, et al. Deep Profiling of Microgram-Scale Proteome by Tandem Mass Tag Mass Spectrometry. J Proteome Res. 2020;20(1):337-345doi: 10.1021/acs.jproteome.0c00426.
Liu, D., Yang, S., Kavdia, K., Sifford, J. M., Wu, Z., Xie, B., Wang, Z., Pagala, V. R., Wang, H., Yu, K., Dey, K. K., High, A. A., Serrano, G. E., Beach, T. G., & Peng, J. (2021). Deep Profiling of Microgram-Scale Proteome by Tandem Mass Tag Mass Spectrometry. Journal of proteome research, 20(1), 337-345. https://doi.org/10.1021/acs.jproteome.0c00426
Liu, Danting, et al. "Deep Profiling of Microgram-Scale Proteome by Tandem Mass Tag Mass Spectrometry." Journal of proteome research vol. 20,1 (2021): 337-345. doi: https://doi.org/10.1021/acs.jproteome.0c00426
Liu D, Yang S, Kavdia K, Sifford JM, Wu Z, Xie B, Wang Z, Pagala VR, Wang H, Yu K, Dey KK, High AA, Serrano GE, Beach TG, Peng J. Deep Profiling of Microgram-Scale Proteome by Tandem Mass Tag Mass Spectrometry. J Proteome Res. 2021 Jan 01;20(1):337-345. doi: 10.1021/acs.jproteome.0c00426. Epub 2020 Nov 11. PMID: 33175545; PMCID: PMC8262114.
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A technical overview of supercritical fluid chromatography-mass spectrometry (SFC-MS) and its recent applications in pharmaceutical research and development.

Drug discovery today. Technologies

Chen L, Dean B, Liang X.
PMID: 34916026
Drug Discov Today Technol. 2021 Dec;40:69-75. doi: 10.1016/j.ddtec.2021.10.002. Epub 2021 Oct 27.

In this paper, we review the growing development and applications of supercritical fluid chromatography-mass spectrometry (SFC-MS) for the analysis of small molecular analytes and biomarkers in drug discovery. As an alternative chromatographic technique, SFC instrumentation and methodology have dramatically...

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Chen L, Dean B, Liang X. A technical overview of supercritical fluid chromatography-mass spectrometry (SFC-MS) and its recent applications in pharmaceutical research and development. Drug Discov Today Technol. 2021;40:69-75doi: 10.1016/j.ddtec.2021.10.002.
Chen, L., Dean, B., & Liang, X. (2021). A technical overview of supercritical fluid chromatography-mass spectrometry (SFC-MS) and its recent applications in pharmaceutical research and development. Drug discovery today. Technologies, 4069-75. https://doi.org/10.1016/j.ddtec.2021.10.002
Chen, Liuxi, et al. "A technical overview of supercritical fluid chromatography-mass spectrometry (SFC-MS) and its recent applications in pharmaceutical research and development." Drug discovery today. Technologies vol. 40 (2021): 69-75. doi: https://doi.org/10.1016/j.ddtec.2021.10.002
Chen L, Dean B, Liang X. A technical overview of supercritical fluid chromatography-mass spectrometry (SFC-MS) and its recent applications in pharmaceutical research and development. Drug Discov Today Technol. 2021 Dec;40:69-75. doi: 10.1016/j.ddtec.2021.10.002. Epub 2021 Oct 27. PMID: 34916026.
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Precision-characterization and quantitative determination of main compounds in Si-Ni-San with UHPLC-MS/MS based targeted-profiling method.

Journal of pharmaceutical and biomedical analysis

Tian T, Xu X, Li X, Zhang W, Lu H.
PMID: 33339640
J Pharm Biomed Anal. 2021 Feb 05;194:113816. doi: 10.1016/j.jpba.2020.113816. Epub 2020 Dec 05.

Mass spectrometry based precision identification of natural products requires the validation of the reference compounds. This study attempted to develop a LC-QTOF MS combined with LC-TQ MS method to precisely characterize the chemicals of Si-Ni-San (SNS), a classic traditional...

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Tian T, Xu X, Li X, et al. Precision-characterization and quantitative determination of main compounds in Si-Ni-San with UHPLC-MS/MS based targeted-profiling method. J Pharm Biomed Anal. 2020;194:113816doi: 10.1016/j.jpba.2020.113816.
Tian, T., Xu, X., Li, X., Zhang, W., & Lu, H. (2021). Precision-characterization and quantitative determination of main compounds in Si-Ni-San with UHPLC-MS/MS based targeted-profiling method. Journal of pharmaceutical and biomedical analysis, 194113816. https://doi.org/10.1016/j.jpba.2020.113816
Tian, Tian, et al. "Precision-characterization and quantitative determination of main compounds in Si-Ni-San with UHPLC-MS/MS based targeted-profiling method." Journal of pharmaceutical and biomedical analysis vol. 194 (2021): 113816. doi: https://doi.org/10.1016/j.jpba.2020.113816
Tian T, Xu X, Li X, Zhang W, Lu H. Precision-characterization and quantitative determination of main compounds in Si-Ni-San with UHPLC-MS/MS based targeted-profiling method. J Pharm Biomed Anal. 2021 Feb 05;194:113816. doi: 10.1016/j.jpba.2020.113816. Epub 2020 Dec 05. PMID: 33339640.
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Liquid chromatography coupled to Venturi easy ambient sonic spray ionization mass spectrometry.

Talanta

Oliveira LFC, Tega DU, Eberlin MN, Sussulini A.
PMID: 34857338
Talanta. 2022 Feb 01;238:123004. doi: 10.1016/j.talanta.2021.123004. Epub 2021 Oct 30.

Venturi easy ambient sonic spray ionization (V-EASI) is a soft ambient ionization (AI) source that has the advantages of being suitable to the analysis of samples in solution (differently from the majority of AI sources), performing self-pumping, voltage- and...

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Oliveira LFC, Tega DU, Eberlin MN, et al. Liquid chromatography coupled to Venturi easy ambient sonic spray ionization mass spectrometry. Talanta. 2021;238:123004doi: 10.1016/j.talanta.2021.123004.
Oliveira, L. F. C., Tega, D. U., Eberlin, M. N., & Sussulini, A. (2022). Liquid chromatography coupled to Venturi easy ambient sonic spray ionization mass spectrometry. Talanta, 238123004. https://doi.org/10.1016/j.talanta.2021.123004
Oliveira, Luan Felipe Campos, et al. "Liquid chromatography coupled to Venturi easy ambient sonic spray ionization mass spectrometry." Talanta vol. 238 (2022): 123004. doi: https://doi.org/10.1016/j.talanta.2021.123004
Oliveira LFC, Tega DU, Eberlin MN, Sussulini A. Liquid chromatography coupled to Venturi easy ambient sonic spray ionization mass spectrometry. Talanta. 2022 Feb 01;238:123004. doi: 10.1016/j.talanta.2021.123004. Epub 2021 Oct 30. PMID: 34857338.
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[Study on the Analytical Method of Solid Phase Extraction-Ultra Performance Liquid Chromatography Tandem Quadrupole Linear Ion Trap Mass Spectrometry for 12 Perfluorinated Compounds in Human Urine].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

Luo XY, Zhao X, Ren L, Wang WJ, Yong L, Yuan Y, Zeng HY, Zou XL.
PMID: 34323049
Sichuan Da Xue Xue Bao Yi Xue Ban. 2021 Jul;52(4):679-685. doi: 10.12182/20210760504.

OBJECTIVE: To establish a method for simultaneous determination of 12 kinds of perfluorinated compounds (PFCs) in human urine based on ultra performance liquid chromatography tandem quadrupole linear ion trap mass spectrometry (UPLC-QTtrap-MS).METHODS: After pH adjustment with 2% formic acid,...

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Luo XY, Zhao X, Ren L, et al. [Study on the Analytical Method of Solid Phase Extraction-Ultra Performance Liquid Chromatography Tandem Quadrupole Linear Ion Trap Mass Spectrometry for 12 Perfluorinated Compounds in Human Urine]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2021;52(4):679-685doi: 10.12182/20210760504.
Luo, X. Y., Zhao, X., Ren, L., Wang, W. J., Yong, L., Yuan, Y., Zeng, H. Y., & Zou, X. L. (2021). [Study on the Analytical Method of Solid Phase Extraction-Ultra Performance Liquid Chromatography Tandem Quadrupole Linear Ion Trap Mass Spectrometry for 12 Perfluorinated Compounds in Human Urine]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 52(4), 679-685. https://doi.org/10.12182/20210760504
Luo, Xin-Yue, et al. "[Study on the Analytical Method of Solid Phase Extraction-Ultra Performance Liquid Chromatography Tandem Quadrupole Linear Ion Trap Mass Spectrometry for 12 Perfluorinated Compounds in Human Urine]." Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition vol. 52,4 (2021): 679-685. doi: https://doi.org/10.12182/20210760504
Luo XY, Zhao X, Ren L, Wang WJ, Yong L, Yuan Y, Zeng HY, Zou XL. [Study on the Analytical Method of Solid Phase Extraction-Ultra Performance Liquid Chromatography Tandem Quadrupole Linear Ion Trap Mass Spectrometry for 12 Perfluorinated Compounds in Human Urine]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2021 Jul;52(4):679-685. doi: 10.12182/20210760504. Chinese. PMID: 34323049.
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Recent advances in liquid-phase separations for clinical metabolomics.

Journal of separation science

Kohler I, Giera M.
PMID: 27790840
J Sep Sci. 2017 Jan;40(1):93-108. doi: 10.1002/jssc.201600981. Epub 2016 Nov 28.

Over the last decades, several technological improvements have been achieved in liquid-based separation techniques, notably, with the advent of fully porous sub-2 μm particles and superficially porous sub-3 μm particles, the comeback of supercritical fluid chromatography, and the development...

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Kohler I, Giera M. Recent advances in liquid-phase separations for clinical metabolomics. J Sep Sci. 2016;40(1):93-108doi: 10.1002/jssc.201600981.
Kohler, I., & Giera, M. (2017). Recent advances in liquid-phase separations for clinical metabolomics. Journal of separation science, 40(1), 93-108. https://doi.org/10.1002/jssc.201600981
Kohler, Isabelle, and Giera, Martin. "Recent advances in liquid-phase separations for clinical metabolomics." Journal of separation science vol. 40,1 (2017): 93-108. doi: https://doi.org/10.1002/jssc.201600981
Kohler I, Giera M. Recent advances in liquid-phase separations for clinical metabolomics. J Sep Sci. 2017 Jan;40(1):93-108. doi: 10.1002/jssc.201600981. Epub 2016 Nov 28. PMID: 27790840.
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Targeting unique biological signals on the fly to improve MS/MS coverage and identification efficiency in metabolomics.

Analytica chimica acta

Cho K, Schwaiger-Haber M, Naser FJ, Stancliffe E, Sindelar M, Patti GJ.
PMID: 33551064
Anal Chim Acta. 2021 Mar 08;1149:338210. doi: 10.1016/j.aca.2021.338210. Epub 2021 Jan 12.

When using liquid chromatography/mass spectrometry (LC/MS) to perform untargeted metabolomics, it is common to detect thousands of features from a biological extract. Although it is impractical to collect non-chimeric MS/MS data for each in a single chromatographic run, this...

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Cho K, Schwaiger-Haber M, Naser FJ, et al. Targeting unique biological signals on the fly to improve MS/MS coverage and identification efficiency in metabolomics. Anal Chim Acta. 2021;1149:338210doi: 10.1016/j.aca.2021.338210.
Cho, K., Schwaiger-Haber, M., Naser, F. J., Stancliffe, E., Sindelar, M., & Patti, G. J. (2021). Targeting unique biological signals on the fly to improve MS/MS coverage and identification efficiency in metabolomics. Analytica chimica acta, 1149338210. https://doi.org/10.1016/j.aca.2021.338210
Cho, Kevin, et al. "Targeting unique biological signals on the fly to improve MS/MS coverage and identification efficiency in metabolomics." Analytica chimica acta vol. 1149 (2021): 338210. doi: https://doi.org/10.1016/j.aca.2021.338210
Cho K, Schwaiger-Haber M, Naser FJ, Stancliffe E, Sindelar M, Patti GJ. Targeting unique biological signals on the fly to improve MS/MS coverage and identification efficiency in metabolomics. Anal Chim Acta. 2021 Mar 08;1149:338210. doi: 10.1016/j.aca.2021.338210. Epub 2021 Jan 12. PMID: 33551064; PMCID: PMC8189644.
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Development and validation of LC-MS/MS method for simultaneous determination of dabigatran etexilate and its active metabolites in human plasma, and its application in a pharmacokinetic study.

Journal of pharmaceutical and biomedical analysis

Park IH, Park JW, Chung H, Kim JM, Lee S, Kim KA, Park JY.
PMID: 34175734
J Pharm Biomed Anal. 2021 Sep 05;203:114220. doi: 10.1016/j.jpba.2021.114220. Epub 2021 Jun 19.

Dabigatran is a direct thrombin inhibitor widely used for preventing various thrombotic events. Although there are several established LC-MS/MS based methods for quantification of plasma dabigatran etexilate and its active metabolites (dabigatran and dabigatran acylglucuronide), so far, there are...

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Park IH, Park JW, Chung H, et al. Development and validation of LC-MS/MS method for simultaneous determination of dabigatran etexilate and its active metabolites in human plasma, and its application in a pharmacokinetic study. J Pharm Biomed Anal. 2021;203:114220doi: 10.1016/j.jpba.2021.114220.
Park, I. H., Park, J. W., Chung, H., Kim, J. M., Lee, S., Kim, K. A., & Park, J. Y. (2021). Development and validation of LC-MS/MS method for simultaneous determination of dabigatran etexilate and its active metabolites in human plasma, and its application in a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis, 203114220. https://doi.org/10.1016/j.jpba.2021.114220
Park, In-Hwan, et al. "Development and validation of LC-MS/MS method for simultaneous determination of dabigatran etexilate and its active metabolites in human plasma, and its application in a pharmacokinetic study." Journal of pharmaceutical and biomedical analysis vol. 203 (2021): 114220. doi: https://doi.org/10.1016/j.jpba.2021.114220
Park IH, Park JW, Chung H, Kim JM, Lee S, Kim KA, Park JY. Development and validation of LC-MS/MS method for simultaneous determination of dabigatran etexilate and its active metabolites in human plasma, and its application in a pharmacokinetic study. J Pharm Biomed Anal. 2021 Sep 05;203:114220. doi: 10.1016/j.jpba.2021.114220. Epub 2021 Jun 19. PMID: 34175734.
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A Comprehensive Non-targeted Analysis Study of the Prenatal Exposome.

Environmental science & technology

Panagopoulos Abrahamsson D, Wang A, Jiang T, Wang M, Siddharth A, Morello-Frosch R, Park JS, Sirota M, Woodruff TJ.
PMID: 34260856
Environ Sci Technol. 2021 Aug 03;55(15):10542-10557. doi: 10.1021/acs.est.1c01010. Epub 2021 Jul 14.

Recent technological advances in mass spectrometry have enabled us to screen biological samples for a very broad spectrum of chemical compounds allowing us to more comprehensively characterize the human exposome in critical periods of development. The goal of this...

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Panagopoulos Abrahamsson D, Wang A, Jiang T, et al. A Comprehensive Non-targeted Analysis Study of the Prenatal Exposome. Environ Sci Technol. 2021;55(15):10542-10557doi: 10.1021/acs.est.1c01010.
Panagopoulos Abrahamsson, D., Wang, A., Jiang, T., Wang, M., Siddharth, A., Morello-Frosch, R., Park, J. S., Sirota, M., & Woodruff, T. J. (2021). A Comprehensive Non-targeted Analysis Study of the Prenatal Exposome. Environmental science & technology, 55(15), 10542-10557. https://doi.org/10.1021/acs.est.1c01010
Panagopoulos Abrahamsson, Dimitri, et al. "A Comprehensive Non-targeted Analysis Study of the Prenatal Exposome." Environmental science & technology vol. 55,15 (2021): 10542-10557. doi: https://doi.org/10.1021/acs.est.1c01010
Panagopoulos Abrahamsson D, Wang A, Jiang T, Wang M, Siddharth A, Morello-Frosch R, Park JS, Sirota M, Woodruff TJ. A Comprehensive Non-targeted Analysis Study of the Prenatal Exposome. Environ Sci Technol. 2021 Aug 03;55(15):10542-10557. doi: 10.1021/acs.est.1c01010. Epub 2021 Jul 14. PMID: 34260856; PMCID: PMC8338910.
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Editorial.

Biomedical chromatography : BMC

[No authors listed]
PMID: 25366171
Biomed Chromatogr. 2015 May;29(5):641-2. doi: 10.1002/bmc.3379. Epub 2014 Nov 04.

No abstract available.

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Editorial. Biomed Chromatogr. 2014;29(5):641-2doi: 10.1002/bmc.3379.
(2015). Editorial. Biomedical chromatography : BMC, 29(5), 641-2. https://doi.org/10.1002/bmc.3379
"Editorial." Biomedical chromatography : BMC vol. 29,5 (2015): 641-2. doi: https://doi.org/10.1002/bmc.3379
Editorial. Biomed Chromatogr. 2015 May;29(5):641-2. doi: 10.1002/bmc.3379. Epub 2014 Nov 04. PMID: 25366171.
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Showing 13 to 24 of 144 entries