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Showing 3097 to 3108 of 3128 entries
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Recall of Genomic Testing Results Among Patients with Cancer.

The oncologist

Wing SE, Hu H, Lopez L, Solomon I, Shen J, Raquel C, Sur M, Chao J, Cristea M, Fakih M, Mortimer J, Pal S, Reckamp K, Yuan Y, Gray SW.
PMID: 34355454
Oncologist. 2021 Dec;26(12):e2302-e2305. doi: 10.1002/onco.13928. Epub 2021 Aug 26.

BACKGROUND: Genomic testing of somatic and germline DNA has transformed cancer care. However, low genetic knowledge among patients may compromise care and health outcomes. Given the rise in genomic testing, we sought to understand patients' knowledge of their genetic...

Developing an Index of Medical Conditions Associated with Outcomes after Moderate-to-Severe Traumatic Brain Injury.

Journal of neurotrauma

Whiteneck GG, Ketchum JM, Almeida EJ, Goldstein R, Brown AW, Corrigan JD, Hammond FM, Weintraub AH, Tefertiller C.
PMID: 33256501
J Neurotrauma. 2021 Mar;38(5):593-603. doi: 10.1089/neu.2020.7366. Epub 2021 Jan 07.

Medical conditions co-occurring with traumatic brain injury (TBI) are associated with outcomes, and comorbidity indices such as Charlson and Elixhauser are used in TBI research, but they are not TBI specific. The purpose of this research was to develop...

Pharmacokinetics of vaginally applied integrase inhibitors in macaques.

The Journal of antimicrobial chemotherapy

Nishiura K, Sharma S, Sterling M, Makarova N, Martin A, Dinh C, Mitchell J, García-Lerma JG, Heneine W, Dobard C.
PMID: 34423357
J Antimicrob Chemother. 2021 Oct 11;76(11):2894-2901. doi: 10.1093/jac/dkab293.

OBJECTIVES: We conducted a detailed pharmacokinetic assessment in macaques treated with vaginal gels formulated with HIV integrase strand transfer inhibitors (INSTIs) to better understand drug distribution and identify INSTI concentrations associated with previously demonstrated in vivo protection against vaginal...

Measuring Satisfaction and Comfort with Gender Identity and Gender Expression among Transgender Women: Development and Validation of the Psychological Gender Affirmation Scale.

International journal of environmental research and public health

Sevelius JM, Chakravarty D, Dilworth SE, Rebchook G, Neilands TB.
PMID: 33806834
Int J Environ Res Public Health. 2021 Mar 23;18(6). doi: 10.3390/ijerph18063298.

Among transgender and gender diverse people, psychological gender affirmation is an internal sense of valuing oneself as a transgender or gender diverse person, being comfortable with one's gender identity, and feeling satisfied with one's body and gender expression. Gender...

Developing Initial Middle Range Theories in Realist Evaluation: A Case of an Organisational Intervention.

International journal of environmental research and public health

Roodbari H, Nielsen K, Axtell C, Peters SE, Sorensen G.
PMID: 34444110
Int J Environ Res Public Health. 2021 Aug 07;18(16). doi: 10.3390/ijerph18168360.

(1) Background: Realist evaluation is a promising approach for evaluating organisational interventions. Crucial to realist evaluation is the development and testing of middle range theories (MRTs). MRTs are programme theories that outline how the intervention mechanisms work in a...

A Realist Evaluation of Team Interventions in Acute Hospital Contexts-Use of Two Case Studies to Test Initial Programme Theories.

International journal of environmental research and public health

Cunningham U, De Brún A, Willgerodt M, Abu-Rish Blakeney E, McAuliffe E.
PMID: 34444352
Int J Environ Res Public Health. 2021 Aug 14;18(16). doi: 10.3390/ijerph18168604.

BACKGROUND: Designing and implementing team interventions to improve quality and safety of care in acute hospital contexts is challenging. There is little emphasis in the literature on how contextual conditions impact interventions or how specific active ingredients of interventions...

Metabolic syndrome, metabolic comorbid conditions and risk of early-onset colorectal cancer.

Gut

Chen H, Zheng X, Zong X, Li Z, Li N, Hur J, Fritz CD, Chapman W, Nickel KB, Tipping A, Colditz GA, Giovannucci EL, Olsen MA, Fields RC, Cao Y.
PMID: 33037055
Gut. 2021 Jun;70(6):1147-1154. doi: 10.1136/gutjnl-2020-321661. Epub 2020 Oct 09.

OBJECTIVE: Factors that lead to metabolic dysregulation are associated with increased risk of early-onset colorectal cancer (CRC diagnosed under age 50). However, the association between metabolic syndrome (MetS) and early-onset CRC remains unexamined.DESIGN: We conducted a nested case-control study...

Health, Neighborhoods, and School Readiness from the Parent Perspective: A Qualitative Study of Contextual and Socio-Emotional Factors.

International journal of environmental research and public health

Dunaway LEF, Bazzano AN, Gray SAO, Theall KP.
PMID: 34501939
Int J Environ Res Public Health. 2021 Sep 04;18(17). doi: 10.3390/ijerph18179350.

The objective of this qualitative study was to address existing gaps in the literature by gathering parent perspectives on both health and school readiness in regard to neighborhood context, specifically parents' perceived level of neighborhood safety and support, on...

Preliminary Risk assessment for Acrylamide and Peripheral Neuropathy.

Neurotoxicology

Park RM.
PMID: 33892018
Neurotoxicology. 2021 Jul;85:10-17. doi: 10.1016/j.neuro.2021.04.004. Epub 2021 Apr 20.

Acrylamide (ACM) is a high-volume industrial chemical with diverse uses in manufacturing, construction and laboratory research. ACM is a well-established neurotoxic agent causing peripheral neuropathy with impairment in the arms and legs of exposed workers, most thoroughly studied in...

Evidence in oncology. The Janeway lecture 2000.

Cancer journal (Sudbury, Mass.)

Cox JD.
PMID: 11131481
Cancer J. 2000 Nov-Dec;6(6):351-7.

PURPOSE: The purpose of this address is to evaluate the types of evidence that have fashioned clinical decision making in oncology over the past century and to determine the appropriate weighting of evidence at the start of a new...

Demographic and substance use-related differences among high school adolescents who vape cannabis versus use other cannabis modalities.

Drug and alcohol dependence

Morean ME, Davis DR, Kong G, Bold KW, Camenga DR, Suttiratana S, Lee J, Rajeshkumar L, Krishnan-Sarin S.
PMID: 34607191
Drug Alcohol Depend. 2021 Nov 01;228:109104. doi: 10.1016/j.drugalcdep.2021.109104. Epub 2021 Sep 27.

BACKGROUND: Vaping is the second most common modality of using cannabis following smoking. We examined differences in demographics and substance use behaviors between adolescent cannabis vapers and those exclusively using other cannabis modalities.METHODS: In 2019, 4875 students from six...

P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.

The Journal of experimental medicine

He Y, Gallman AE, Xie C, Shen Q, Ma J, Wolfreys FD, Sandy M, Arsov T, Wu X, Qin Y, Zhang P, Jiang S, Stanley M, Wu P, Tan J, Ding H, Xue H, Chen W, Xu J, Criswell LA, Nititham J, Adamski M, Kitching AR, Cook MC, Cao L, Shen N, Cyster JG, Vinuesa CG.
PMID: 34889940
J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20211004. Epub 2021 Dec 10.

B cell self-tolerance is maintained through multiple checkpoints, including restraints on intracellular signaling and cell trafficking. P2RY8 is a receptor with established roles in germinal center (GC) B cell migration inhibition and growth regulation. Somatic P2RY8 variants are common...

Showing 3097 to 3108 of 3128 entries