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Showing 25 to 36 of 1480 entries
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Order from chaos in the nucleus.

Molecular cell

Xu Z, Felsenfeld G.
PMID: 23141201
Mol Cell. 2012 Nov 09;48(3):327-8. doi: 10.1016/j.molcel.2012.10.021.

Although it might appear that chromatin is randomly packed within the nucleus, recent data (Hou et al., 2012, in this issue of Molecular Cell) show that it is organized into defined and functionally important domains marked by preferred intradomain...

PubTator: a web-based text mining tool for assisting biocuration.

Nucleic acids research

Wei CH, Kao HY, Lu Z.
PMID: 23703206
Nucleic Acids Res. 2013 Jul;41:W518-22. doi: 10.1093/nar/gkt441. Epub 2013 May 22.

Manually curating knowledge from biomedical literature into structured databases is highly expensive and time-consuming, making it difficult to keep pace with the rapid growth of the literature. There is therefore a pressing need to assist biocuration with automated text...

Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile.

BMC medicine

Penninx BW, Milaneschi Y, Lamers F, Vogelzangs N.
PMID: 23672628
BMC Med. 2013 May 15;11:129. doi: 10.1186/1741-7015-11-129.

Depression is the most common psychiatric disorder worldwide. The burden of disease for depression goes beyond functioning and quality of life and extends to somatic health. Depression has been shown to subsequently increase the risk of, for example, cardiovascular,...

The relationship between physical activity, functional performance and fatigue in sarcoidosis.

Journal of clinical nursing

Saligan LN.
PMID: 24460760
J Clin Nurs. 2014 Aug;23(15):2376-8. doi: 10.1111/jocn.12490. Epub 2014 Jan 27.

No abstract available.

Ogino et Al. Respond to "the 21st century epidemiologist".

American journal of epidemiology

Ogino S, Beck AH, King EE, Sherman ME, Milner DA, Giovannucci E.
PMID: 22935516
Am J Epidemiol. 2012 Oct 15;176(8):672-4. doi: 10.1093/aje/kws229. Epub 2012 Aug 30.

No abstract available.

Interdisciplinary education to integrate pathology and epidemiology: towards molecular and population-level health science.

American journal of epidemiology

Ogino S, King EE, Beck AH, Sherman ME, Milner DA, Giovannucci E.
PMID: 22935517
Am J Epidemiol. 2012 Oct 15;176(8):659-67. doi: 10.1093/aje/kws226. Epub 2012 Aug 30.

In recent decades, epidemiology, public health, and medical sciences have been increasingly compartmentalized into narrower disciplines. The authors recognize the value of integration of divergent scientific fields in order to create new methods, concepts, paradigms, and knowledge. Herein they...

Endoscopic molecular imaging of cancer.

Future oncology (London, England)

Ali T, Choyke PL, Kobayashi H.
PMID: 24106901
Future Oncol. 2013 Oct;9(10):1501-13. doi: 10.2217/fon.13.123.

White light endoscopy has proven to be a very powerful tool in oncology. There is still, however, a need for better endoscopic techniques to overcome the current limitations of white light optics. New technologies that allow higher sensitivity, improved...

Interaction and exposure modification: are we asking the right questions?.

American journal of epidemiology

Weinberg CR.
PMID: 22306562
Am J Epidemiol. 2012 Apr 01;175(7):602-5. doi: 10.1093/aje/kwr495. Epub 2012 Feb 03.

Most diseases arise not purely through genetic abnormalities nor purely through environmental causes, but as "complex" conditions brought about by the combined effects of genetic susceptibility factors, nongenetic experiences and exposures, and bad luck. Finding simple models capable of...

Epigenetic priming of both tumor and NK cells augments antibody-dependent cellular cytotoxicity elicited by the anti-PD-L1 antibody avelumab against multiple carcinoma cell types.

Oncoimmunology

Hicks KC, Fantini M, Donahue RN, Schwab A, Knudson KM, Tritsch SR, Jochems C, Clavijo PE, Allen CT, Hodge JW, Tsang KY, Schlom J, Gameiro SR.
PMID: 30377559
Oncoimmunology. 2018 Jul 30;7(11):e1466018. doi: 10.1080/2162402X.2018.1466018. eCollection 2018.

Checkpoint inhibitors targeting the PD-1/PD-L1 axis are promising immunotherapies shown to elicit objective responses against multiple tumor types, yet these agents fail to benefit most patients with carcinomas. This highlights the need to develop effective therapeutic strategies to increase...

M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine.

Oncoimmunology

Knudson KM, Hicks KC, Luo X, Chen JQ, Schlom J, Gameiro SR.
PMID: 29721396
Oncoimmunology. 2018 Feb 14;7(5):e1426519. doi: 10.1080/2162402X.2018.1426519. eCollection 2018.

Tumors evade host immune surveillance through multiple mechanisms, including the generation of a tumor microenvironment that suppresses immune effector function. Secretion of TGFβ and upregulation of immune checkpoint programmed cell death ligand-1 (PD-L1) are two main contributors to immune...

Validating the AMRFinder Tool and Resistance Gene Database by Using Antimicrobial Resistance Genotype-Phenotype Correlations in a Collection of Isolates.

Antimicrobial agents and chemotherapy

Feldgarden M, Brover V, Haft DH, Prasad AB, Slotta DJ, Tolstoy I, Tyson GH, Zhao S, Hsu CH, McDermott PF, Tadesse DA, Morales C, Simmons M, Tillman G, Wasilenko J, Folster JP, Klimke W.
PMID: 31427293
Antimicrob Agents Chemother. 2019 Oct 22;63(11). doi: 10.1128/AAC.00483-19. Print 2019 Nov.

Antimicrobial resistance (AMR) is a major public health problem that requires publicly available tools for rapid analysis. To identify AMR genes in whole-genome sequences, the National Center for Biotechnology Information (NCBI) has produced AMRFinder, a tool that identifies AMR...

PubMed Phrases, an open set of coherent phrases for searching biomedical literature.

Scientific data

Kim S, Yeganova L, Comeau DC, Wilbur WJ, Lu Z.
PMID: 29893755
Sci Data. 2018 Jun 12;5:180104. doi: 10.1038/sdata.2018.104.

In biomedicine, key concepts are often expressed by multiple words (e.g., 'zinc finger protein'). Previous work has shown treating a sequence of words as a meaningful unit, where applicable, is not only important for human understanding but also beneficial...

Showing 25 to 36 of 1480 entries